An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head

Science

Volumn 308, Issue 5720, 2005, Pages 381-385

  Mace, Kimberly A ^a,b   Pearson, Joseph C ^a   McGinnis, William ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; ENZYMES; GENES; SKIN;

EMBRYOS; EPIDERMAL CELLS; KINASE; SURFACE BARRIERS;

GENETIC ENGINEERING;

DROSOPHILA PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GRAINY HEAD; UNCLASSIFIED DRUG;

INSECT;

ARTICLE; BINDING SITE; COMPARATIVE STUDY; CONSERVATION BIOLOGY; CONTROLLED STUDY; CUTICLE; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; EPIDERMIS; GENE ACTIVATION; GENETIC CONSERVATION; GENETIC SIMILARITY; IMMUNE RESPONSE GENE; INNATE IMMUNITY; INSECT GENETICS; MAMMAL; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; REPORTER GENE; SIGNAL TRANSDUCTION; SKIN INJURY; TRANSCRIPTION REGULATION; UPREGULATION; WILD TYPE; WOUND HEALING;

ANIMALS; BASE SEQUENCE; BINDING SITES; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-BINDING PROTEINS; DOPA DECARBOXYLASE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; ENHANCER ELEMENTS (GENETICS); EPIDERMIS; EPITHELIUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; GENES, HOMEOBOX; GENES, INSECT; HOMEODOMAIN PROTEINS; MAP KINASE SIGNALING SYSTEM; MOLECULAR SEQUENCE DATA; MUTATION; NF-KAPPA B; NUCLEAR PROTEINS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TYROSINE 3-MONOOXYGENASE; WOUND HEALING;

ANIMALIA; INSECTA; MAMMALIA;

EID: 17244367891     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1107573     Document Type: Article

References (41)

1. A. J. Nappi, E. Ottaviani, Bioessays 22, 469 (2000).
2. H. G. Boman, D. Hultmark, Annu. Rev. Microbiol. 41, 103 (1987).
3. M. J. Galko, M. A. Krasnow, PLoS Biol. 2, E239 (2004).
4. P. N. Walsh, S. S. Ahmad, Essays Biochem. 38, 95 (2002).
5. J. A. Hoffmann, J. M. Reichhart, Nat. Immunol. 3, 121 (2002).
6. S. Thoma-Uszynski et al., Science 291, 1544 (2001).
7. N. Silverman, T. Maniatis, Genes Dev. 15, 2321 (2001).
8. P. Martin, Science 276, 75 (1997).
9. W. Wood et al., Nat. Cell Biol. 4, 907 (2002).
10. M. Ramet, R. Lanot, D. Zachary, P. Manfruelli, Dev. Biol. 241, 145 (2002).
11. A. Jacinto, A. Martinez-Arias, P. Martin, Nat. Cell Biol. 3, E117 (2001).
12. L. Kockel, J. G. Homsy, D. Bohmann, Oncogene 20, 2347 (2001).
13. S. Werner, R. Grose, Physiol. Rev. 83, 835 (2003).
14. G. Li et al., Dev. Cell 4, 865 (2003).
15. E. B. Lewis, Nature 276, 565 (1978).
16. G. Struhl, J. Embryol. Exp. Morphol. 76, 297 (1983).
17. A. Macias, G. Morata, EMBO J. 15, 334 (1996).
18. E. L. Wiellette et al., Development 126, 5373 (1999).
19. T. R. Wright, J. Hered. 87, 175 (1996).
20. J. Schaefer et al., Science 235, 1200 (1987).
21. Materials and methods are available as supporting material on Science Online.
22. S. B. Scholnick, S. J. Bray, B. A. Morgan, C. A. McCormick, J. Hirsh, Science 234, 998 (1986).
23. L. Chen et al., MOD 114, 95 (2002).
24. K. A. Mace, J. C. Pearson, W. McGinnis, data not shown.
25. S. J. Bray, F. C. Kafatos, Genes Dev. 5, 1672 (1991).
26. A. E. Uv, E. J. Harrison, S. J. Bray, Mol. Cell. Biol. 17, 6727 (1997).
27. C. Nusslein-Volhard, E. Wieschaus, H. Kluding, Rouxs Arch. Dev. Biol. 193, 267 (1984).
28. S. Ostrowski, H. A. Dierick, A. Bejsovec, Genetics 161, 171 (2002).
29. J. Hemphala, A. Uv, R. Cantera, S. Bray, C. Samakovlis, Development 130, 249 (2003).
30. H. Lee, P. N. Adler, Mech. Dev. 121, 37 (2004).
31. S. Barolo, B. Castro, J. W. Posakony, Biotechniques 36, 436 (2004).
32. B. K. Dieckgraefe, D. M. Weems, Am. J. Physiol. 276, G322 (1999).
33. G. J. Liaw et al., Genes Dev. 9, 3163 (1995).
34. M. Ashida, P. T. Brey, Proc. Natl. Acad. Sci. U.S.A. 92, 10698 (1995).
35. K. Venkatesan, H. R. McManus, C. C. Mello, T. F. Smith, U. Hansen, Nucleic Acids Res. 31, 4304 (2003).
36. T. Wilanowski et al., Mech. Dev. 114, 37 (2002).
37. S. B. Ting et al., Biochem. J. 370, 953 (2003).
38. E. I. Kudryavtseva et al., Dev. Dyn. 226, 604 (2003).
39. S. B. Ting et al., Nat. Med. 9, 1513 (2003).
40. S. B. Ting et al., Science 308, 411 (2005).
41. We thank S. Jane for communication of unpublished results, A. Tugores for the Ddc genomic clone, O. Drivenes for enhancer stains, and M. Ronshaugen for rhodamine-dextran injections and manuscript suggestions. L. Chen, R. Hodgetts, S. Barolo, J. Posakony, S. Wasserman, and T. Ip provided materials, and D. Kosman helped with confocal microscopy. W.M. is funded by R01HD28315, and J.C.P. is funded by T32GM07240.