Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus replication through in silico screening

Antiviral Research

Volumn 151, Issue , 2018, Pages 78-86

  Pattnaik, Aryamav ^a   Palermo, Nicholas ^a   Sahoo, Bikash R ^a   Yuan, Zhe ^b   Hu, Duoyi ^a   Annamalai, Arun S ^a   Vu, Hiep L X ^a   Correas, Ignacio ^a   Prathipati, Pavan Kumar ^c   Destache, Christopher J ^a,c   Li, Qingsheng ^a,b   Osorio, Fernando A ^a   Pattnaik, Asit K ^a   Xiang, Shi hua ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b UNIVERSITY OF NEBRASKA   (United States)

^c CREIGHTON UNIVERSITY   (United States)

Author keywords

In silico screening; Non nucleoside inhibitor (NNI); RNA dependent RNA polymerase (RdRp); TPB; Zika virus (ZIKV)

Indexed keywords

3 CHLORO N [[[4 [4 (2 THIENYLCARBONYL) 1 PIPERAZINYL]PHENYL]AMINO]CARBONOTHIOYL] 1 BENZOTHIPHENE 2 CARBOXAMIDE; IVERMECTIN; MYCOPHENOLIC ACID; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS RNA; ANTIVIRUS AGENT; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CC50; CELL MEDIATED CYTOTOXICITY; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; DENGUE VIRUS 3; DISEASE ASSOCIATION; DRUG DETERMINATION; DRUG POTENCY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MOLECULAR MODEL; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SYNTHESIS; SEQUENCE HOMOLOGY; VERO CELL LINE; VIREMIA; VIRUS INHIBITION; VIRUS REPLICATION; ZIKA FEVER; ZIKA VIRUS; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL SURVIVAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; COMPUTER SIMULATION; DRUG DEVELOPMENT; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MOLECULAR DOCKING; MOLECULAR LIBRARY; PHARMACOLOGY; PHYSIOLOGY; VIROLOGY; VIRUS LOAD;

ANIMALS; ANTIVIRAL AGENTS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COMPUTER SIMULATION; DRUG DISCOVERY; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MICE, INBRED BALB C; MOLECULAR DOCKING SIMULATION; RNA REPLICASE; SMALL MOLECULE LIBRARIES; VERO CELLS; VIRAL LOAD; VIRUS REPLICATION; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 85041690189     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2017.12.016     Document Type: Article

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