Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model

Antiviral Research

Volumn 137, Issue , 2017, Pages 14-22

  Julander, Justin G ^a   Siddharthan, Venkatraman ^a   Evans, Joe ^a   Taylor, Ray ^b   Tolbert, Kelsey ^a   Apuli, Chad ^c   Stewart, Jason ^a   Collins, Preston ^a   Gebre, Makda ^a   Neilson, Skot ^a   Van Wettere, Arnaud ^a   Lee, Young Min ^a   Sheridan, William P ^b   Morrey, John D ^a   Babu, Y S ^b  

^a UTAH STATE UNIVERSITY   (United States)

^b BIOCRYST PHARMACEUTICALS INC   (United States)

^c Steward Healthcare   (United States)

Author keywords

AG129 mice; Antiviral; BCX4430; Flavivirus; Ribavirin; Zika virus; ZIKV

Indexed keywords

GALIDESIVIR; RIBAVIRIN; VIRUS RNA; 2-(4-AMINO-5H-PYRROLO(3,2-D)PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)PYRROLIDINE-3,4-DIOL; ANTIVIRUS AGENT; PURINE NUCLEOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; ASSAY; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DISEASE SEVERITY; DRUG EFFICACY; DRUG POTENCY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; MYELITIS; NONHUMAN; PANDEMIC; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TISSUE SECTION; TREATMENT OUTCOME; VIRAL CONJUNCTIVITIS; VIREMIA; VIRUS ENCEPHALITIS; VIRUS LOAD; VIRUS REPLICATION; VIRUS YIELD REDUCTION ASSAY; ZIKA FEVER; ZIKA VIRUS; ANIMAL; BRAIN; CELL LINE; DISEASE MODEL; DRUG EFFECTS; TESTIS; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; BRAIN; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; MALE; MICE; PURINE NUCLEOSIDES; RNA, VIRAL; TESTIS; VIRAL LOAD; VIREMIA; VIRUS REPLICATION; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 84995580435     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2016.11.003     Document Type: Article

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