Zika virus methyltransferase: Structure and functions for drug design perspectives

Journal of Virology

Volumn 91, Issue 5, 2017, Pages

  Coutard, Bruno ^a   Barral, Karine ^b   Lichière, Julie ^a   Selisko, Barbara ^a   Martin, Baptiste ^a   Aouadi, Wahiba ^a   Lombardia, Miguel Ortiz ^a   Debart, Françoise ^c   Vasseur, Jean Jacques ^c   Guillemot, Jean Claude ^a   Canard, Bruno ^a   Decroly, Etienne ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

Flavivirus; Methyltransferase; Protein structure function; RNA processing; Zika virus

Indexed keywords

METHYLTRANSFERASE; NONSTRUCTURAL PROTEIN 5; S ADENOSYLMETHIONINE; VIRUS ENZYME; ANTIVIRUS AGENT; PROTEIN BINDING; VIRAL PROTEIN;

ALPHA HELIX; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DENGUE VIRUS; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SYNTHESIS; IMMUNE RESPONSE; INNATE IMMUNITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN MOTIF; REGULATORY MECHANISM; RNA BINDING; VIRUS GENOME; VIRUS REPLICATION; ZIKA VIRUS; ALLOSTERIC SITE; BIOSYNTHESIS; CHEMISTRY; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYMOLOGY; ESCHERICHIA COLI; HYDROGEN BOND; MOLECULAR MODEL; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC SITE; ANTIVIRAL AGENTS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ESCHERICHIA COLI; HYDROGEN BONDING; METHYLTRANSFERASES; MODELS, MOLECULAR; PROTEIN BINDING; VIRAL NONSTRUCTURAL PROTEINS; ZIKA VIRUS;

EID: 85013947606     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02202-16     Document Type: Article

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