The crystal structure of Zika virus NS5 reveals conserved drug targets

EMBO Journal

Volumn 36, Issue 7, 2017, Pages 919-933

  Duan, Wenqian ^a,b   Song, Hao ^c   Wang, Haiyuan ^a,d   Chai, Yan ^a   Su, Chao ^a,e   Qi, Jianxun ^a   Shi, Yi ^a,b,c,f   Gao, George F ^a,b,c,f,g  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d GUANGXI UNIVERSITY   (China)

^e CHINA AGRICULTURAL UNIVERSITY   (China)

^f SHENZHEN THIRD PEOPLE S HOSPITAL   (China)

^g CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

crystal structure; methyltransferase; polymerase; RNA capping; Zika virus

Indexed keywords

ANTIVIRUS AGENT; METHYLTRANSFERASE; NONSTRUCTURAL PROTEIN 5; RNA POLYMERASE; NS5 PROTEIN, FLAVIVIRUS; PROTEIN BINDING; RNA DIRECTED RNA POLYMERASE; VIRAL PROTEIN;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DENGUE VIRUS; DRUG TARGETING; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION; WEST NILE VIRUS; ZIKA FEVER; ZIKA VIRUS; CHEMISTRY; METABOLISM; X RAY CRYSTALLOGRAPHY;

ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; METHYLTRANSFERASES; PROTEIN BINDING; RNA REPLICASE; VIRAL NONSTRUCTURAL PROTEINS; ZIKA VIRUS;

EID: 85014075153     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201696241     Document Type: Article

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