메뉴 건너뛰기




Volumn 49, Issue , 2018, Pages 75-87

Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: Implications for lung health and disease

Author keywords

[No Author keywords available]

Indexed keywords

1 ACETYL 2 (8 CHLORO 10,11 DIHYDRODIBENZ[B,F][1,4]OXAZEPINE 10 CARBONYL)HYDRAZINE; 11 DEOXY 16 PHENOXY 17,18,19,20 TETRANORPROSTAGLANDIN E1; 2 [4 (1 HYDROXYHEXYL)PHENYL] 5 OXOCYCLOPENTANEHEPTANOIC ACID; 3 [1 (2,4 DICHLOROBENZYL) 5 FLUORO 3 METHYL 1H INDOL 7 YL] N [(4,5 DICHLORO 2 THIENYL)SULFONYL]ACRYLAMIDE; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; 6 [2 [5 CHLORO 2 (2,4 DIFLUOROBENZYLOXY)PHENYL] 1 CYCLOPENTENYL] 2 PYRIDINECARBOXYLIC ACID; 6 [3 (4 CHLORO 2 METHYLPHENYLSULFONYLAMINOMETHYL)BICYCLO[2.2.2]OCTAN 2 YL] 5 HEXENOIC ACID; BUTAPROST; CM 9; CP 544326; EVATANEPAG; GR 63799X; L 826266; MISOPROSTOL; ONO 8713; ONO AE 1 259; ONO AE 1 329; ONO AE 1 734; ONO AE 248; ONO AE 3 240; ONO DI 004; PF 04418948; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; SC 51089; SULPROSTONE; TCS 2510; TEI 3356; TG 4 155; TG 6 10 1; TG 6 129; UNCLASSIFIED DRUG; UNINDEXED DRUG; ARACHIDONIC ACID;

EID: 85041680802     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2018.01.008     Document Type: Review
Times cited : (22)

References (140)
  • 1
    • 0028183018 scopus 로고
    • International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes
    • Coleman, R.A., Smith, W.L., Narumiya, S., International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46:2 (1994), 205–229.
    • (1994) Pharmacol. Rev. , vol.46 , Issue.2 , pp. 205-229
    • Coleman, R.A.1    Smith, W.L.2    Narumiya, S.3
  • 3
    • 84959047042 scopus 로고    scopus 로고
    • Cyclooxygenase 2: its regulation, role and impact in airway inflammation
    • Rumzhum, N.N., Ammit, A.J., Cyclooxygenase 2: its regulation, role and impact in airway inflammation. Clin. Exp. Allergy 46:3 (March 2016), 397–410.
    • (2016) Clin. Exp. Allergy , vol.46 , Issue.3 , pp. 397-410
    • Rumzhum, N.N.1    Ammit, A.J.2
  • 5
    • 0029913957 scopus 로고    scopus 로고
    • Suppression of prostaglandin E receptor signaling by the variant form of EP1 subtype
    • Okuda-Ashitaka, E., Sakamoto, K., Ezashi, T., Miwa, K., Ito, S., Hayaishi, O., Suppression of prostaglandin E receptor signaling by the variant form of EP1 subtype. J. Biol. Chem. 271:49 (1996), 31255–31261.
    • (1996) J. Biol. Chem. , vol.271 , Issue.49 , pp. 31255-31261
    • Okuda-Ashitaka, E.1    Sakamoto, K.2    Ezashi, T.3    Miwa, K.4    Ito, S.5    Hayaishi, O.6
  • 7
    • 77952338190 scopus 로고    scopus 로고
    • EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway
    • Ji, R., Chou, C.L., Xu, W., Chen, X.B., Woodward, D.F., Regan, J.W., EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway. Mol. Pharmacol. 77:6 (2010), 1025–1036.
    • (2010) Mol. Pharmacol. , vol.77 , Issue.6 , pp. 1025-1036
    • Ji, R.1    Chou, C.L.2    Xu, W.3    Chen, X.B.4    Woodward, D.F.5    Regan, J.W.6
  • 9
    • 0029025507 scopus 로고
    • Characterization of the signal transduction of prostaglandin E receptor EP1 subtype in cDNA-transfected Chinese hamster ovary cells
    • Katoh, H., Watabe, A., Sugimoto, Y., Ichikawa, A., Negishi, M., Characterization of the signal transduction of prostaglandin E receptor EP1 subtype in cDNA-transfected Chinese hamster ovary cells. Biochimica. et. biophysica acta 1244:1 (1995), 41–48.
    • (1995) Biochimica. et. biophysica acta , vol.1244 , Issue.1 , pp. 41-48
    • Katoh, H.1    Watabe, A.2    Sugimoto, Y.3    Ichikawa, A.4    Negishi, M.5
  • 10
    • 0036431951 scopus 로고    scopus 로고
    • Possible coupling of prostaglandin E receptor EP(1) to TRP5 expressed in Xenopus laevis oocytes
    • Tabata, H., Tanaka, S., Sugimoto, Y., Kanki, H., Kaneko, S., Ichikawa, A., Possible coupling of prostaglandin E receptor EP(1) to TRP5 expressed in Xenopus laevis oocytes. Biochem. Biophys. Res. Commun. 298:3 (2002), 398–402.
    • (2002) Biochem. Biophys. Res. Commun. , vol.298 , Issue.3 , pp. 398-402
    • Tabata, H.1    Tanaka, S.2    Sugimoto, Y.3    Kanki, H.4    Kaneko, S.5    Ichikawa, A.6
  • 11
    • 0028233402 scopus 로고
    • Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype
    • Bastien, L., Sawyer, N., Grygorczyk, R., Metters, K.M., Adam, M., Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. J. Biol. Chem. 269:16 (1994), 11873–11877.
    • (1994) J. Biol. Chem. , vol.269 , Issue.16 , pp. 11873-11877
    • Bastien, L.1    Sawyer, N.2    Grygorczyk, R.3    Metters, K.M.4    Adam, M.5
  • 14
    • 0029037548 scopus 로고
    • Identification of prostaglandin E receptor 'EP2' cloned from mastocytoma cells EP4 subtype
    • Nishigaki, N., Negishi, M., Honda, A., Sugimoto, Y., Namba, T., Narumiya, S., Ichikawa, A., Identification of prostaglandin E receptor 'EP2' cloned from mastocytoma cells EP4 subtype. FEBS Lett. 364:3 (1995), 339–341.
    • (1995) FEBS Lett. , vol.364 , Issue.3 , pp. 339-341
    • Nishigaki, N.1    Negishi, M.2    Honda, A.3    Sugimoto, Y.4    Namba, T.5    Narumiya, S.6    Ichikawa, A.7
  • 15
    • 0030871070 scopus 로고    scopus 로고
    • Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells
    • Kiriyama, M., Ushikubi, F., Kobayashi, T., Hirata, M., Sugimoto, Y., Narumiya, S., Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 122:2 (1997), 217–224.
    • (1997) Br. J. Pharmacol. , vol.122 , Issue.2 , pp. 217-224
    • Kiriyama, M.1    Ushikubi, F.2    Kobayashi, T.3    Hirata, M.4    Sugimoto, Y.5    Narumiya, S.6
  • 16
    • 0242321274 scopus 로고    scopus 로고
    • EP2 and EP4 prostanoid receptor signaling
    • Regan, J.W., EP2 and EP4 prostanoid receptor signaling. Life Sci. 74:2–3 (2003), 143–153.
    • (2003) Life Sci. , vol.74 , Issue.2-3 , pp. 143-153
    • Regan, J.W.1
  • 17
    • 0028915988 scopus 로고
    • Molecular evolution of receptors for eicosanoids
    • Toh, H., Ichikawa, A., Narumiya, S., Molecular evolution of receptors for eicosanoids. FEBS Lett. 361:1 (1995), 17–21.
    • (1995) FEBS Lett. , vol.361 , Issue.1 , pp. 17-21
    • Toh, H.1    Ichikawa, A.2    Narumiya, S.3
  • 18
    • 84859884891 scopus 로고    scopus 로고
    • Novel cAMP signalling paradigms: therapeutic implications for airway disease
    • Billington, C.K., Hall, I.P., Novel cAMP signalling paradigms: therapeutic implications for airway disease. Br. J. Pharmacol. 166:2 (2012), 401–410.
    • (2012) Br. J. Pharmacol. , vol.166 , Issue.2 , pp. 401-410
    • Billington, C.K.1    Hall, I.P.2
  • 19
    • 0032823306 scopus 로고    scopus 로고
    • Prostanoid receptors: structures, properties, and functions
    • Narumiya, S., Sugimoto, Y., Ushikubi, F., Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79:4 (1999), 1193–1226.
    • (1999) Physiol. Rev. , vol.79 , Issue.4 , pp. 1193-1226
    • Narumiya, S.1    Sugimoto, Y.2    Ushikubi, F.3
  • 20
    • 0033664001 scopus 로고    scopus 로고
    • Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration
    • Desai, S., April, H., Nwaneshiudu, C., Ashby, B., Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration. Mol. Pharmacol. 58:6 (2000), 1279–1286.
    • (2000) Mol. Pharmacol. , vol.58 , Issue.6 , pp. 1279-1286
    • Desai, S.1    April, H.2    Nwaneshiudu, C.3    Ashby, B.4
  • 21
    • 0029661961 scopus 로고    scopus 로고
    • Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist
    • Nishigaki, N., Negishi, M., Ichikawa, A., Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Mol. Pharmacol. 50:4 (1996), 1031–1037.
    • (1996) Mol. Pharmacol. , vol.50 , Issue.4 , pp. 1031-1037
    • Nishigaki, N.1    Negishi, M.2    Ichikawa, A.3
  • 22
    • 0037169557 scopus 로고    scopus 로고
    • Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2
    • Fujino, H., West, K.A., Regan, J.W., Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2. J. Biol. Chem. 277:4 (2002), 2614–2619.
    • (2002) J. Biol. Chem. , vol.277 , Issue.4 , pp. 2614-2619
    • Fujino, H.1    West, K.A.2    Regan, J.W.3
  • 23
    • 33644848353 scopus 로고    scopus 로고
    • EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein
    • Fujino, H., Regan, J.W., EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein. Mol. Pharmacol. 69:1 (2006), 5–10.
    • (2006) Mol. Pharmacol. , vol.69 , Issue.1 , pp. 5-10
    • Fujino, H.1    Regan, J.W.2
  • 24
    • 0032518695 scopus 로고    scopus 로고
    • Signal transduction by the Wnt family of ligands
    • Dale, T.C., Signal transduction by the Wnt family of ligands. Biochem. J. 329:Pt 2 (1998), 209–223.
    • (1998) Biochem. J. , vol.329 , pp. 209-223
    • Dale, T.C.1
  • 25
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryogenesis–a look outside the nucleus
    • Peifer, M., Polakis, P., Wnt signaling in oncogenesis and embryogenesis–a look outside the nucleus. Science 287:5458 (2000), 1606–1609.
    • (2000) Science , vol.287 , Issue.5458 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 26
    • 0042734625 scopus 로고    scopus 로고
    • Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer?
    • Fujino, H., Regan, J.W., Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer?. Trends Pharmacol. Sci. 24:7 (2003), 335–340.
    • (2003) Trends Pharmacol. Sci. , vol.24 , Issue.7 , pp. 335-340
    • Fujino, H.1    Regan, J.W.2
  • 28
    • 0035375104 scopus 로고    scopus 로고
    • Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration
    • Naga Prasad, S.V., Barak, L.S., Rapacciuolo, A., Caron, M.G., Rockman, H.A., Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. J. Biol. Chem. 276:22 (2001), 18953–18959.
    • (2001) J. Biol. Chem. , vol.276 , Issue.22 , pp. 18953-18959
    • Naga Prasad, S.V.1    Barak, L.S.2    Rapacciuolo, A.3    Caron, M.G.4    Rockman, H.A.5
  • 30
    • 0035430282 scopus 로고    scopus 로고
    • Transcriptional regulation by the phosphorylation-dependent factor CREB
    • Mayr, B., Montminy, M., Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2:8 (2001), 599–609.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , Issue.8 , pp. 599-609
    • Mayr, B.1    Montminy, M.2
  • 31
    • 22344439814 scopus 로고    scopus 로고
    • Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2
    • Fujino, H., Salvi, S., Regan, J.W., Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2. Mol. Pharmacol. 68:1 (2005), 251–259.
    • (2005) Mol. Pharmacol. , vol.68 , Issue.1 , pp. 251-259
    • Fujino, H.1    Salvi, S.2    Regan, J.W.3
  • 32
    • 13444282669 scopus 로고    scopus 로고
    • E-ring 8-isoprostanes are agonists at EP2- and EP4-prostanoid receptors on human airway smooth muscle cells and regulate the release of colony-stimulating factors by activating cAMP-dependent protein kinase
    • Clarke, D.L., Belvisi, M.G., Hardaker, E., Newton, R., Giembycz, M.A., E-ring 8-isoprostanes are agonists at EP2- and EP4-prostanoid receptors on human airway smooth muscle cells and regulate the release of colony-stimulating factors by activating cAMP-dependent protein kinase. Mol. Pharmaco. 67:2 (2005), 383–393.
    • (2005) Mol. Pharmaco. , vol.67 , Issue.2 , pp. 383-393
    • Clarke, D.L.1    Belvisi, M.G.2    Hardaker, E.3    Newton, R.4    Giembycz, M.A.5
  • 33
    • 0036594073 scopus 로고    scopus 로고
    • Prostaglandin receptors: advances in the study of EP3 receptor signaling
    • Hatae, N., Sugimoto, Y., Ichikawa, A., Prostaglandin receptors: advances in the study of EP3 receptor signaling. J. Biochem. 131:6 (2002), 781–784.
    • (2002) J. Biochem. , vol.131 , Issue.6 , pp. 781-784
    • Hatae, N.1    Sugimoto, Y.2    Ichikawa, A.3
  • 34
    • 0032945685 scopus 로고    scopus 로고
    • Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription
    • Audoly, L.P., Ma, L., Feoktistov, I., de Foe, S.K., Breyer, M.D., Breyer, R.M., Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription. J. Pharmacol. Exp. Ther. 289:1 (1999), 140–148.
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , Issue.1 , pp. 140-148
    • Audoly, L.P.1    Ma, L.2    Feoktistov, I.3    de Foe, S.K.4    Breyer, M.D.5    Breyer, R.M.6
  • 35
    • 62249100641 scopus 로고    scopus 로고
    • EP(3) prostanoid receptor isoforms utilize distinct mechanisms to regulate ERK 1/2 activation
    • Israel, D.D., Regan, J.W., EP(3) prostanoid receptor isoforms utilize distinct mechanisms to regulate ERK 1/2 activation. Biochimica et biophysica acta 1791:4 (2009), 238–245.
    • (2009) Biochimica et biophysica acta , vol.1791 , Issue.4 , pp. 238-245
    • Israel, D.D.1    Regan, J.W.2
  • 37
    • 4143144369 scopus 로고    scopus 로고
    • Human prostaglandin EP3 receptor isoforms show different agonist-induced internalization patterns
    • Bilson, H.A., Mitchell, D.L., Ashby, B., Human prostaglandin EP3 receptor isoforms show different agonist-induced internalization patterns. FEBS Lett. 572:1–3 (2004), 271–275.
    • (2004) FEBS Lett. , vol.572 , Issue.1-3 , pp. 271-275
    • Bilson, H.A.1    Mitchell, D.L.2    Ashby, B.3
  • 39
    • 0028809229 scopus 로고
    • Splice variants of the human EP3 receptor for prostaglandin E2
    • Schmid, A., Thierauch, K.H., Schleuning, W.D., Dinter, H., Splice variants of the human EP3 receptor for prostaglandin E2. Eur. J. Biochem. 228:1 (1995), 23–30.
    • (1995) Eur. J. Biochem. , vol.228 , Issue.1 , pp. 23-30
    • Schmid, A.1    Thierauch, K.H.2    Schleuning, W.D.3    Dinter, H.4
  • 40
    • 0030999720 scopus 로고    scopus 로고
    • Constitutive activity of human prostaglandin E receptor EP3 isoforms
    • Jin, J., Mao, G.F., Ashby, B., Constitutive activity of human prostaglandin E receptor EP3 isoforms. Br. J. Pharmacol. 121:2 (1997), 317–323.
    • (1997) Br. J. Pharmacol. , vol.121 , Issue.2 , pp. 317-323
    • Jin, J.1    Mao, G.F.2    Ashby, B.3
  • 41
    • 33645848172 scopus 로고    scopus 로고
    • Evaluation of selective prostaglandin E2 (PGE2) receptor agonists as therapeutic agents for the treatment of asthma
    • pe47
    • Chung, K.F., Evaluation of selective prostaglandin E2 (PGE2) receptor agonists as therapeutic agents for the treatment of asthma. Sci. STKE 2005, 303, 2005 pe47.
    • (2005) Sci. STKE 2005 , vol.303
    • Chung, K.F.1
  • 42
    • 0029056741 scopus 로고
    • Activation of mitogen-activated protein kinase by the human prostaglandin EP3A receptor
    • Burkey, T.H., Regan, J.W., Activation of mitogen-activated protein kinase by the human prostaglandin EP3A receptor. Biochem. Biophys. Res. Commun. 211:1 (1995), 152–158.
    • (1995) Biochem. Biophys. Res. Commun. , vol.211 , Issue.1 , pp. 152-158
    • Burkey, T.H.1    Regan, J.W.2
  • 43
    • 28444491736 scopus 로고    scopus 로고
    • The EP3 receptor stimulates ceramide and diacylglycerol release and inhibits growth of primary keratinocytes
    • Konger, R.L., Brouxhon, S., Partillo, S., VanBuskirk, J., Pentland, A.P., The EP3 receptor stimulates ceramide and diacylglycerol release and inhibits growth of primary keratinocytes. Exp. Dermatol. 14:12 (2005), 914–922.
    • (2005) Exp. Dermatol. , vol.14 , Issue.12 , pp. 914-922
    • Konger, R.L.1    Brouxhon, S.2    Partillo, S.3    VanBuskirk, J.4    Pentland, A.P.5
  • 44
    • 5444265539 scopus 로고    scopus 로고
    • Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713
    • Norel, X., de Montpreville, V., Brink, C., Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. Prostaglandins Other Lipid Mediat. 74:1–4 (2004), 101–112.
    • (2004) Prostaglandins Other Lipid Mediat. , vol.74 , Issue.1-4 , pp. 101-112
    • Norel, X.1    de Montpreville, V.2    Brink, C.3
  • 45
    • 0034455647 scopus 로고    scopus 로고
    • The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs
    • Suzawa, T., Miyaura, C., Inada, M., Maruyama, T., Sugimoto, Y., Ushikubi, F., Ichikawa, A., Narumiya, S., Suda, T., The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology 141:4 (2000), 1554–1559.
    • (2000) Endocrinology , vol.141 , Issue.4 , pp. 1554-1559
    • Suzawa, T.1    Miyaura, C.2    Inada, M.3    Maruyama, T.4    Sugimoto, Y.5    Ushikubi, F.6    Ichikawa, A.7    Narumiya, S.8    Suda, T.9
  • 47
    • 18744435476 scopus 로고    scopus 로고
    • Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice
    • Watanabe, K., Kawamori, T., Nakatsugi, S., Ohta, T., Ohuchida, S., Yamamoto, H., Maruyama, T., Kondo, K., Narumiya, S., Sugimura, T., Wakabayashi, K., Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice. Cancer Lett. 156:1 (2000), 57–61.
    • (2000) Cancer Lett. , vol.156 , Issue.1 , pp. 57-61
    • Watanabe, K.1    Kawamori, T.2    Nakatsugi, S.3    Ohta, T.4    Ohuchida, S.5    Yamamoto, H.6    Maruyama, T.7    Kondo, K.8    Narumiya, S.9    Sugimura, T.10    Wakabayashi, K.11
  • 50
    • 0034633263 scopus 로고    scopus 로고
    • A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture
    • Durocher, Y., Perret, S., Thibaudeau, E., Gaumond, M.H., Kamen, A., Stocco, R., Abramovitz, M., A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture. Anal Biochem. 284:2 (2000), 316–326.
    • (2000) Anal Biochem. , vol.284 , Issue.2 , pp. 316-326
    • Durocher, Y.1    Perret, S.2    Thibaudeau, E.3    Gaumond, M.H.4    Kamen, A.5    Stocco, R.6    Abramovitz, M.7
  • 52
    • 33744549867 scopus 로고    scopus 로고
    • Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery
    • Hung, G.H., Jones, R.L., Lam, F.F., Chan, K.M., Hidaka, H., Suzuki, M., Sasaki, Y., Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery. Prostaglandins Leukot Essent Fatty Acids 74:6 (2006), 401–415.
    • (2006) Prostaglandins Leukot Essent Fatty Acids , vol.74 , Issue.6 , pp. 401-415
    • Hung, G.H.1    Jones, R.L.2    Lam, F.F.3    Chan, K.M.4    Hidaka, H.5    Suzuki, M.6    Sasaki, Y.7
  • 53
    • 0015245283 scopus 로고
    • Prostaglandin inhibition with a dibenzoxazepine hydrazide derivative and morphine
    • Sanner, J., Prostaglandin inhibition with a dibenzoxazepine hydrazide derivative and morphine. Ann. N. Y. Acad. Sci. 180 (1971), 396–409.
    • (1971) Ann. N. Y. Acad. Sci. , vol.180 , pp. 396-409
    • Sanner, J.1
  • 54
    • 0021261354 scopus 로고
    • Antagonistic effect of SC-19220 on the responses of Guinea-pig gastric muscles to prostaglandins E1, E2 and F2 alpha
    • Rakovska, A., Milenov, K., Antagonistic effect of SC-19220 on the responses of Guinea-pig gastric muscles to prostaglandins E1, E2 and F2 alpha. Arch. Int. Pharmacodyn. Ther. 268:1 (1984), 59–69.
    • (1984) Arch. Int. Pharmacodyn. Ther. , vol.268 , Issue.1 , pp. 59-69
    • Rakovska, A.1    Milenov, K.2
  • 55
    • 0021978802 scopus 로고
    • Characterisation of the prostanoid receptors mediating contraction of Guinea-pig isolated trachea
    • Coleman, R.A., Kennedy, I., Characterisation of the prostanoid receptors mediating contraction of Guinea-pig isolated trachea. Prostaglandins 29:3 (1985), 363–375.
    • (1985) Prostaglandins , vol.29 , Issue.3 , pp. 363-375
    • Coleman, R.A.1    Kennedy, I.2
  • 59
    • 84901264631 scopus 로고    scopus 로고
    • Prostanoid receptor EP2 as a therapeutic target
    • Ganesh, T., Prostanoid receptor EP2 as a therapeutic target. J. Med. Chem. 57:11 (2014), 4454–4465.
    • (2014) J. Med. Chem. , vol.57 , Issue.11 , pp. 4454-4465
    • Ganesh, T.1
  • 63
    • 0028849877 scopus 로고
    • 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist
    • Woodward, D.F., Pepperl, D.J., Burkey, T.H., Regan, J.W., 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. Biochem. Pharmacol. 50:10 (1995), 1731–1733.
    • (1995) Biochem. Pharmacol. , vol.50 , Issue.10 , pp. 1731-1733
    • Woodward, D.F.1    Pepperl, D.J.2    Burkey, T.H.3    Regan, J.W.4
  • 64
    • 81355128966 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP(2) receptor antagonist
    • af Forselles, K.J., Root, J., Clarke, T., Davey, D., Aughton, K., Dack, K., Pullen, N., In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP(2) receptor antagonist. Br. J. Pharmacol. 164:7 (2011), 1847–1856.
    • (2011) Br. J. Pharmacol. , vol.164 , Issue.7 , pp. 1847-1856
    • af Forselles, K.J.1    Root, J.2    Clarke, T.3    Davey, D.4    Aughton, K.5    Dack, K.6    Pullen, N.7
  • 65
    • 81355124775 scopus 로고    scopus 로고
    • At last, a truly selective EP(2) receptor antagonist
    • Birrell, M.A., Nials, A.T., At last, a truly selective EP(2) receptor antagonist. Br. J. Pharmacol. 164:7 (2011), 1845–1846.
    • (2011) Br. J. Pharmacol. , vol.164 , Issue.7 , pp. 1845-1846
    • Birrell, M.A.1    Nials, A.T.2
  • 66
    • 84872856839 scopus 로고    scopus 로고
    • Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the Guinea pig EP2 receptor
    • Birrell, M.A., Maher, S.A., Buckley, J., Dale, N., Bonvini, S., Raemdonck, K., Pullen, N., Giembycz, M.A., Belvisi, M.G., Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the Guinea pig EP2 receptor. Br. J. Pharmacol. 168:1 (2013), 129–138.
    • (2013) Br. J. Pharmacol. , vol.168 , Issue.1 , pp. 129-138
    • Birrell, M.A.1    Maher, S.A.2    Buckley, J.3    Dale, N.4    Bonvini, S.5    Raemdonck, K.6    Pullen, N.7    Giembycz, M.A.8    Belvisi, M.G.9
  • 68
    • 84880142216 scopus 로고    scopus 로고
    • Discovery and characterization of carbamothioylacrylamides as EP selective antagonists
    • Ganesh, T., Jiang, J., Shashidharamurthy, R., Dingledine, R., Discovery and characterization of carbamothioylacrylamides as EP selective antagonists. ACS Med. Chem. Lett. 4:7 (2013), 616–621.
    • (2013) ACS Med. Chem. Lett. , vol.4 , Issue.7 , pp. 616-621
    • Ganesh, T.1    Jiang, J.2    Shashidharamurthy, R.3    Dingledine, R.4
  • 69
    • 0032966016 scopus 로고    scopus 로고
    • Reduction of myocardial injury by the EP3 receptor agonist TEI-3356. Role of protein kinase C and of K(ATP)-channels
    • Zacharowski, K., Olbrich, A., Thiemermann, C., Reduction of myocardial injury by the EP3 receptor agonist TEI-3356. Role of protein kinase C and of K(ATP)-channels. Euro. J. Pharmacol. 367:1 (1999), 33–39.
    • (1999) Euro. J. Pharmacol. , vol.367 , Issue.1 , pp. 33-39
    • Zacharowski, K.1    Olbrich, A.2    Thiemermann, C.3
  • 70
    • 0035223915 scopus 로고    scopus 로고
    • Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: studies using mice deficient in prostanoid receptors
    • Okada, Y., Hara, A., Ma, H., Xiao, C.Y., Takahata, O., Kohgo, Y., Narumiya, S., Ushikubi, F., Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: studies using mice deficient in prostanoid receptors. Br. J. Pharmacol. 131:4 (2000), 745–755.
    • (2000) Br. J. Pharmacol. , vol.131 , Issue.4 , pp. 745-755
    • Okada, Y.1    Hara, A.2    Ma, H.3    Xiao, C.Y.4    Takahata, O.5    Kohgo, Y.6    Narumiya, S.7    Ushikubi, F.8
  • 72
    • 0028885078 scopus 로고
    • Suppression of naloxone-precipitated withdrawal jumps in morphine-dependent mice by stimulation of prostaglandin EP3 receptor
    • Nakagawa, T., Minami, M., Katsumata, S., Ienaga, Y., Satoh, M., Suppression of naloxone-precipitated withdrawal jumps in morphine-dependent mice by stimulation of prostaglandin EP3 receptor. Br. J. Pharmacol. 116:6 (1995), 2661–2666.
    • (1995) Br. J. Pharmacol. , vol.116 , Issue.6 , pp. 2661-2666
    • Nakagawa, T.1    Minami, M.2    Katsumata, S.3    Ienaga, Y.4    Satoh, M.5
  • 73
    • 0027431102 scopus 로고
    • Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase
    • Irie, A., Sugimoto, Y., Namba, T., Harazono, A., Honda, A., Watabe, A., Negishi, M., Narumiya, S., Ichikawa, A., Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase. Eur. J. Biochem. 217:1 (1993), 313–318.
    • (1993) Eur. J. Biochem. , vol.217 , Issue.1 , pp. 313-318
    • Irie, A.1    Sugimoto, Y.2    Namba, T.3    Harazono, A.4    Honda, A.5    Watabe, A.6    Negishi, M.7    Narumiya, S.8    Ichikawa, A.9
  • 76
    • 70449528788 scopus 로고    scopus 로고
    • Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy
    • Maher, S.A., Birrell, M.A., Belvisi, M.G., Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy. Am. J. Res. Critical Care Med. 180:10 (2009), 923–928.
    • (2009) Am. J. Res. Critical Care Med. , vol.180 , Issue.10 , pp. 923-928
    • Maher, S.A.1    Birrell, M.A.2    Belvisi, M.G.3
  • 81
    • 34347403843 scopus 로고    scopus 로고
    • Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists
    • Xiao, Y., Araldi, G.L., Zhao, Z., Brugger, N., Karra, S., Fischer, D., Palmer, E., Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists. Bioorg. Med. Chem. Lett. 17:15 (2007), 4323–4327.
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , Issue.15 , pp. 4323-4327
    • Xiao, Y.1    Araldi, G.L.2    Zhao, Z.3    Brugger, N.4    Karra, S.5    Fischer, D.6    Palmer, E.7
  • 87
    • 49449107477 scopus 로고    scopus 로고
    • Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype
    • Foudi, N., Kotelevets, L., Louedec, L., Leseche, G., Henin, D., Chastre, E., Norel, X., Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype. Br. J. Pharmacol. 154:8 (2008), 1631–1639.
    • (2008) Br. J. Pharmacol. , vol.154 , Issue.8 , pp. 1631-1639
    • Foudi, N.1    Kotelevets, L.2    Louedec, L.3    Leseche, G.4    Henin, D.5    Chastre, E.6    Norel, X.7
  • 88
    • 79955575162 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress
    • Woodward, D.F., Jones, R.L., Narumiya, S., International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol. Rev. 63:3 (2011), 471–538.
    • (2011) Pharmacol. Rev. , vol.63 , Issue.3 , pp. 471-538
    • Woodward, D.F.1    Jones, R.L.2    Narumiya, S.3
  • 90
    • 0033845789 scopus 로고    scopus 로고
    • Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor
    • Davis, T.L., Sharif, N.A., Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor. Br. J. Pharmacol. 130:8 (2000), 1919–1926.
    • (2000) Br. J. Pharmacol. , vol.130 , Issue.8 , pp. 1919-1926
    • Davis, T.L.1    Sharif, N.A.2
  • 92
    • 37649015323 scopus 로고    scopus 로고
    • In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP(4) receptor antagonist
    • Murase, A., Taniguchi, Y., Tonai-Kachi, H., Nakao, K., Takada, J., In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP(4) receptor antagonist. Life Sci. 82:3–4 (2008), 226–232.
    • (2008) Life Sci. , vol.82 , Issue.3-4 , pp. 226-232
    • Murase, A.1    Taniguchi, Y.2    Tonai-Kachi, H.3    Nakao, K.4    Takada, J.5
  • 94
    • 0037110742 scopus 로고    scopus 로고
    • Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor
    • Takayama, K., Garcia-Cardena, G., Sukhova, G.K., Comander, J., Gimbrone, M.A. Jr., Libby, P., Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J. Biol. Chem. 277:46 (2002), 44147–44154.
    • (2002) J. Biol. Chem. , vol.277 , Issue.46 , pp. 44147-44154
    • Takayama, K.1    Garcia-Cardena, G.2    Sukhova, G.K.3    Comander, J.4    Gimbrone, M.A.5    Libby, P.6
  • 98
    • 84940465627 scopus 로고    scopus 로고
    • Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype
    • Birrell, M.A., Maher, S.A., Dekkak, B., Jones, V., Wong, S., Brook, P., Belvisi, M.G., Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype. Thorax 70:8 (2015), 740–747.
    • (2015) Thorax , vol.70 , Issue.8 , pp. 740-747
    • Birrell, M.A.1    Maher, S.A.2    Dekkak, B.3    Jones, V.4    Wong, S.5    Brook, P.6    Belvisi, M.G.7
  • 102
    • 24044529450 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites
    • Bradbury, D., Clarke, D., Seedhouse, C., Corbett, L., Stocks, J., Knox, A., Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites. J. Biol. Chem. 280:34 (2005), 29993–30000.
    • (2005) J. Biol. Chem. , vol.280 , Issue.34 , pp. 29993-30000
    • Bradbury, D.1    Clarke, D.2    Seedhouse, C.3    Corbett, L.4    Stocks, J.5    Knox, A.6
  • 103
    • 79958785669 scopus 로고    scopus 로고
    • Effects of specific prostanoid EP receptor agonists on cell proliferation and intracellular Ca(2+) concentrations in human airway smooth muscle cells
    • Mori, A., Ito, S., Morioka, M., Aso, H., Kondo, M., Sokabe, M., Hasegawa, Y., Effects of specific prostanoid EP receptor agonists on cell proliferation and intracellular Ca(2+) concentrations in human airway smooth muscle cells. Euro. J. Pharmaco. 659:1 (2011), 72–78.
    • (2011) Euro. J. Pharmaco. , vol.659 , Issue.1 , pp. 72-78
    • Mori, A.1    Ito, S.2    Morioka, M.3    Aso, H.4    Kondo, M.5    Sokabe, M.6    Hasegawa, Y.7
  • 104
    • 70350320406 scopus 로고    scopus 로고
    • Increased vascular permeability precedes cellular inflammation as asthma control deteriorates
    • Khor, Y.H., Teoh, A.K., Lam, S.M., Mo, D.C., Weston, S., Reid, D.W., Walters, E.H., Increased vascular permeability precedes cellular inflammation as asthma control deteriorates. Clin. Exp. Allergy 39:11 (2009), 1659–1667.
    • (2009) Clin. Exp. Allergy , vol.39 , Issue.11 , pp. 1659-1667
    • Khor, Y.H.1    Teoh, A.K.2    Lam, S.M.3    Mo, D.C.4    Weston, S.5    Reid, D.W.6    Walters, E.H.7
  • 106
    • 0035671188 scopus 로고    scopus 로고
    • Prostanoid EP(1)- and TP-receptors involved in the contraction of human pulmonary veins
    • Walch, L., de Montpreville, V., Brink, C., Norel, X., Prostanoid EP(1)- and TP-receptors involved in the contraction of human pulmonary veins. Br. J. Pharmacol. 134:8 (2001), 1671–1678.
    • (2001) Br. J. Pharmacol. , vol.134 , Issue.8 , pp. 1671-1678
    • Walch, L.1    de Montpreville, V.2    Brink, C.3    Norel, X.4
  • 108
    • 0035217668 scopus 로고    scopus 로고
    • Human mast cell and airway smooth muscle cell interactions: implications for asthma
    • Page, S., Ammit, A.J., Black, J.L., Armour, C.L., Human mast cell and airway smooth muscle cell interactions: implications for asthma. Am. J. Physiol. Lung Cellular Mol. Physiol. 281:6 (2001), L1313–L1323.
    • (2001) Am. J. Physiol. Lung Cellular Mol. Physiol. , vol.281 , Issue.6 , pp. L1313-L1323
    • Page, S.1    Ammit, A.J.2    Black, J.L.3    Armour, C.L.4
  • 110
    • 0031806385 scopus 로고    scopus 로고
    • Influence of receptor reserve on beta-adrenoceptor-mediated responses in human lung mast cells
    • Drury, D.E., Chong, L.K., Ghahramani, P., Peachell, P.T., Influence of receptor reserve on beta-adrenoceptor-mediated responses in human lung mast cells. Br. J. Pharmacol. 124:4 (1998), 711–718.
    • (1998) Br. J. Pharmacol. , vol.124 , Issue.4 , pp. 711-718
    • Drury, D.E.1    Chong, L.K.2    Ghahramani, P.3    Peachell, P.T.4
  • 111
    • 33645553017 scopus 로고    scopus 로고
    • Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation
    • Kay, L.J., Yeo, W.W., Peachell, P.T., Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation. Br. J. Pharmacol. 147:7 (2006), 707–713.
    • (2006) Br. J. Pharmacol. , vol.147 , Issue.7 , pp. 707-713
    • Kay, L.J.1    Yeo, W.W.2    Peachell, P.T.3
  • 112
    • 84879525264 scopus 로고    scopus 로고
    • Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2 on IgE-dependent secretion from human lung mast cells
    • Kay, L.J., Gilbert, M., Pullen, N., Skerratt, S., Farrington, J., Seward, E.P., Peachell, P.T., Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2 on IgE-dependent secretion from human lung mast cells. Clin. Exp. Allergy 43:7 (2013), 741–751.
    • (2013) Clin. Exp. Allergy , vol.43 , Issue.7 , pp. 741-751
    • Kay, L.J.1    Gilbert, M.2    Pullen, N.3    Skerratt, S.4    Farrington, J.5    Seward, E.P.6    Peachell, P.T.7
  • 113
    • 85027929067 scopus 로고    scopus 로고
    • Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor
    • e1
    • Safholm, J., Manson, M.L., Bood, J., Delin, I., Orre, A.C., Bergman, P., Al-Ameri, M., Dahlen, S.E., Adner, M., Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor. J. Allergy Clin. Immunol. 136:5 (2015), 1232–1239 e1.
    • (2015) J. Allergy Clin. Immunol. , vol.136 , Issue.5 , pp. 1232-1239
    • Safholm, J.1    Manson, M.L.2    Bood, J.3    Delin, I.4    Orre, A.C.5    Bergman, P.6    Al-Ameri, M.7    Dahlen, S.E.8    Adner, M.9
  • 114
    • 84880045926 scopus 로고    scopus 로고
    • Pathogenesis of exercise-induced bronchoconstriction
    • (vii)
    • Kippelen, P., Anderson, S.D., Pathogenesis of exercise-induced bronchoconstriction. Immunol. Allergy Clin. N. Am. 33:3 (2013), 299–312 (vii).
    • (2013) Immunol. Allergy Clin. N. Am. , vol.33 , Issue.3 , pp. 299-312
    • Kippelen, P.1    Anderson, S.D.2
  • 115
    • 84908191493 scopus 로고    scopus 로고
    • Prostaglandin E2 prevents hyperosmolar-induced human mast cell activation through prostanoid receptors EP2 and EP4
    • Torres-Atencio, I., Ainsua-Enrich, E., de Mora, F., Picado, C., Martin, M., Prostaglandin E2 prevents hyperosmolar-induced human mast cell activation through prostanoid receptors EP2 and EP4. PLoS One, 9(10), 2014, e110870.
    • (2014) PLoS One , vol.9 , Issue.10
    • Torres-Atencio, I.1    Ainsua-Enrich, E.2    de Mora, F.3    Picado, C.4    Martin, M.5
  • 116
    • 0028911427 scopus 로고
    • Bronchoprotective role for endogenous prostaglandin E2
    • Pavord, I.D., Tattersfield, A.E., Bronchoprotective role for endogenous prostaglandin E2. Lancet 345:8947 (1995), 436–438.
    • (1995) Lancet , vol.345 , Issue.8947 , pp. 436-438
    • Pavord, I.D.1    Tattersfield, A.E.2
  • 117
    • 0032909759 scopus 로고    scopus 로고
    • Prostanoid receptors involved in the relaxation of human bronchial preparations
    • Norel, X., Walch, L., Labat, C., Gascard, J.P., Dulmet, E., Brink, C., Prostanoid receptors involved in the relaxation of human bronchial preparations. Br. J. Pharmacol. 126:4 (1999), 867–872.
    • (1999) Br. J. Pharmacol. , vol.126 , Issue.4 , pp. 867-872
    • Norel, X.1    Walch, L.2    Labat, C.3    Gascard, J.P.4    Dulmet, E.5    Brink, C.6
  • 118
    • 0022359704 scopus 로고
    • Characteristics of prostaglandin induced cough in man
    • Costello, J.F., Dunlop, L.S., Gardiner, P.J., Characteristics of prostaglandin induced cough in man. Br. J. Clin. Pharmacol. 20:4 (1985), 355–359.
    • (1985) Br. J. Clin. Pharmacol. , vol.20 , Issue.4 , pp. 355-359
    • Costello, J.F.1    Dunlop, L.S.2    Gardiner, P.J.3
  • 119
    • 77949273337 scopus 로고    scopus 로고
    • Prostanoids and the cough reflex
    • Maher, S.A., Belvisi, M.G., Prostanoids and the cough reflex. Lung 188:Suppl 1 (2010), S9–S12.
    • (2010) Lung , vol.188 , pp. S9-S12
    • Maher, S.A.1    Belvisi, M.G.2
  • 120
    • 84866090064 scopus 로고    scopus 로고
    • Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin
    • Grace, M., Birrell, M.A., Dubuis, E., Maher, S.A., Belvisi, M.G., Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin. Thorax 67:10 (2012), 891–900.
    • (2012) Thorax , vol.67 , Issue.10 , pp. 891-900
    • Grace, M.1    Birrell, M.A.2    Dubuis, E.3    Maher, S.A.4    Belvisi, M.G.5
  • 121
    • 85022007752 scopus 로고    scopus 로고
    • Cough and airway disease: the role of ion channels
    • Epub 2017 Jun 29
    • Bonvini, S.J., Belvisi, M.G., Cough and airway disease: the role of ion channels. Pulm. Pharmacol. Ther. 47 (2017 Dec), 21–28, 10.1016/j.pupt.2017.06.009 Epub 2017 Jun 29.
    • (2017) Pulm. Pharmacol. Ther. , vol.47 , pp. 21-28
    • Bonvini, S.J.1    Belvisi, M.G.2
  • 124
    • 85013098594 scopus 로고    scopus 로고
    • Senescence in COPD and its comorbidities
    • Barnes, P.J., Senescence in COPD and its comorbidities. Ann. Rev. Physiol. 79 (2017), 517–539.
    • (2017) Ann. Rev. Physiol. , vol.79 , pp. 517-539
    • Barnes, P.J.1
  • 126
    • 84940767877 scopus 로고    scopus 로고
    • Prostanoids as anti-inflammatory therapy: separating the good from the bad
    • Knox, A.J., Prostanoids as anti-inflammatory therapy: separating the good from the bad. Thorax 70:8 (2015), 711–712.
    • (2015) Thorax , vol.70 , Issue.8 , pp. 711-712
    • Knox, A.J.1
  • 127
    • 0034530199 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth-muscle cells. Modulation by cyclic adenosine monophosphate
    • Ammit, A.J., Hoffman, R.K., Amrani, Y., Lazaar, A.L., Hay, D.W., Torphy, T.J., Penn, R.B., Panettieri, R.A. Jr., Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth-muscle cells. Modulation by cyclic adenosine monophosphate. Am. J. Resp. Cell and Mol. Biol. 23:6 (2000), 794–802.
    • (2000) Am. J. Resp. Cell and Mol. Biol. , vol.23 , Issue.6 , pp. 794-802
    • Ammit, A.J.1    Hoffman, R.K.2    Amrani, Y.3    Lazaar, A.L.4    Hay, D.W.5    Torphy, T.J.6    Penn, R.B.7    Panettieri, R.A.8
  • 128
    • 0034746479 scopus 로고    scopus 로고
    • Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy
    • Lazzeri, N., Belvisi, M.G., Patel, H.J., Yacoub, M.H., Chung, K.F., Mitchell, J.A., Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy. Am. J. Resp. Cell and Mol. Biol. 24:1 (2001), 44–48.
    • (2001) Am. J. Resp. Cell and Mol. Biol. , vol.24 , Issue.1 , pp. 44-48
    • Lazzeri, N.1    Belvisi, M.G.2    Patel, H.J.3    Yacoub, M.H.4    Chung, K.F.5    Mitchell, J.A.6
  • 129
    • 2342646152 scopus 로고    scopus 로고
    • Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF
    • Clarke, D.L., Belvisi, M.G., Catley, M.C., Yacoub, M.H., Newton, R., Giembycz, M.A., Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF. Br. J. Pharmacol. 141:7 (2004), 1141–1150.
    • (2004) Br. J. Pharmacol. , vol.141 , Issue.7 , pp. 1141-1150
    • Clarke, D.L.1    Belvisi, M.G.2    Catley, M.C.3    Yacoub, M.H.4    Newton, R.5    Giembycz, M.A.6
  • 130
    • 37349117437 scopus 로고    scopus 로고
    • Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells
    • Kaur, M., Chivers, J.E., Giembycz, M.A., Newton, R., Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells. Mol. Pharmacol. 73:1 (2008), 203–214.
    • (2008) Mol. Pharmacol. , vol.73 , Issue.1 , pp. 203-214
    • Kaur, M.1    Chivers, J.E.2    Giembycz, M.A.3    Newton, R.4
  • 132
    • 0036009461 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists
    • Ammit, A.J., Lazaar, A.L., Irani, C., O'Neill, G.M., Gordon, N.D., Amrani, Y., Penn, R.B., Panettieri, R.A. Jr., Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists. Am. J. Resp. Cell and Mol. Biol. 26:4 (2002), 465–474.
    • (2002) Am. J. Resp. Cell and Mol. Biol. , vol.26 , Issue.4 , pp. 465-474
    • Ammit, A.J.1    Lazaar, A.L.2    Irani, C.3    O'Neill, G.M.4    Gordon, N.D.5    Amrani, Y.6    Penn, R.B.7    Panettieri, R.A.8
  • 133
    • 84875330999 scopus 로고    scopus 로고
    • Long-acting beta2-agonists increase fluticasone propionate-induced mitogen-activated protein kinase phosphatase 1 (MKP-1) in airway smooth muscle cells
    • Manetsch, M., Rahman, M.M., Patel, B.S., Ramsay, E.E., Rumzhum, N.N., Alkhouri, H., Ge, Q., Ammit, A.J., Long-acting beta2-agonists increase fluticasone propionate-induced mitogen-activated protein kinase phosphatase 1 (MKP-1) in airway smooth muscle cells. PLoS One, 8(3), 2013, e59635.
    • (2013) PLoS One , vol.8 , Issue.3
    • Manetsch, M.1    Rahman, M.M.2    Patel, B.S.3    Ramsay, E.E.4    Rumzhum, N.N.5    Alkhouri, H.6    Ge, Q.7    Ammit, A.J.8
  • 134
    • 84864507046 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells
    • Che, W., Manetsch, M., Quante, T., Rahman, M.M., Patel, B.S., Ge, Q., Ammit, A.J., Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells. Biochimica et biophysica acta 1823:10 (2012), 1658–1665.
    • (2012) Biochimica et biophysica acta , vol.1823 , Issue.10 , pp. 1658-1665
    • Che, W.1    Manetsch, M.2    Quante, T.3    Rahman, M.M.4    Patel, B.S.5    Ge, Q.6    Ammit, A.J.7
  • 135
    • 84863709901 scopus 로고    scopus 로고
    • Corticosteroids and beta(2)-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms
    • Manetsch, M., Ramsay, E.E., King, E.M., Seidel, P., Che, W., Ge, Q., Hibbs, D.E., Newton, R., Ammit, A.J., Corticosteroids and beta(2)-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms. Br. J. Pharmacol. 166:7 (2012), 2049–2059.
    • (2012) Br. J. Pharmacol. , vol.166 , Issue.7 , pp. 2049-2059
    • Manetsch, M.1    Ramsay, E.E.2    King, E.M.3    Seidel, P.4    Che, W.5    Ge, Q.6    Hibbs, D.E.7    Newton, R.8    Ammit, A.J.9
  • 136
    • 84929466885 scopus 로고    scopus 로고
    • Inhibitors of phosphodiesterase 4, but not phosphodiesterase 3, increase beta2-agonist-induced expression of antiinflammatory mitogen-activated protein kinase phosphatase 1 in airway smooth muscle cells
    • Patel, B.S., Prabhala, P., Oliver, B.G., Ammit, A.J., Inhibitors of phosphodiesterase 4, but not phosphodiesterase 3, increase beta2-agonist-induced expression of antiinflammatory mitogen-activated protein kinase phosphatase 1 in airway smooth muscle cells. Am. J. Resp. Cell and Mol. Biol. 52:5 (2015), 634–640.
    • (2015) Am. J. Resp. Cell and Mol. Biol. , vol.52 , Issue.5 , pp. 634-640
    • Patel, B.S.1    Prabhala, P.2    Oliver, B.G.3    Ammit, A.J.4
  • 137
    • 85017386748 scopus 로고    scopus 로고
    • Roflumilast N-Oxide in combination with formoterol enhances the antiinflammatory effect of dexamethasone in airway smooth muscle cells
    • Patel, B.S., Rahman, M.M., Baehring, G., Xenaki, D., Tang, F.S., Oliver, B.G., Ammit, A.J., Roflumilast N-Oxide in combination with formoterol enhances the antiinflammatory effect of dexamethasone in airway smooth muscle cells. Am. J. Resp. Cell and Mol. Biol. 56:4 (2017), 532–538.
    • (2017) Am. J. Resp. Cell and Mol. Biol. , vol.56 , Issue.4 , pp. 532-538
    • Patel, B.S.1    Rahman, M.M.2    Baehring, G.3    Xenaki, D.4    Tang, F.S.5    Oliver, B.G.6    Ammit, A.J.7
  • 138
    • 84964556426 scopus 로고    scopus 로고
    • Prostaglandin E2 induces expression of MAPK phosphatase 1 (MKP-1) in airway smooth muscle cells
    • Rumzhum, N.N., Ammit, A.J., Prostaglandin E2 induces expression of MAPK phosphatase 1 (MKP-1) in airway smooth muscle cells. Euro. J. Pharmacol. 782 (2016), 1–5.
    • (2016) Euro. J. Pharmacol. , vol.782 , pp. 1-5
    • Rumzhum, N.N.1    Ammit, A.J.2
  • 139
    • 84990175796 scopus 로고    scopus 로고
    • The anti-inflammatory effects of PGE2 on human lung macrophages are mediated by the EP4 receptor
    • Gill, S.K., Yao, Y., Kay, L.J., Bewley, M.A., Marriott, H.M., Peachell, P.T., The anti-inflammatory effects of PGE2 on human lung macrophages are mediated by the EP4 receptor. Br. J. Pharmacol. 173:21 (2016), 3099–3109.
    • (2016) Br. J. Pharmacol. , vol.173 , Issue.21 , pp. 3099-3109
    • Gill, S.K.1    Yao, Y.2    Kay, L.J.3    Bewley, M.A.4    Marriott, H.M.5    Peachell, P.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.