Development of a highly selective EP2-receptor agonist. Part 1: Identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 4, 2002, Pages 1093-1106

  Tani, Kousuke ^a   Naganawa, Atsushi ^a   Ishida, Akiharu ^a   Sagawa, Kenji ^a   Harada, Hiroyuki ^a   Ogawa, Mikio ^a   Maruyama, Takayuki ^a   Ohuchida, Shuichi ^a   Nakai, Hisao ^a   Kondo, Kigen ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY 16 HYDROXY 17,17 TRIMETHYLNEN OMEGA NORPROSTAGLANDIN E2; CYCLIC AMP; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2 DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; DINOPROSTONE; PROTEIN BINDING; RADIOLIGAND ASSAY; RECEPTORS, PROSTAGLANDIN E; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 18244408594     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00369-8     Document Type: Article

References (22)