Two G(s)-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist

Molecular Pharmacology

Volumn 50, Issue 4, 1996, Pages 1031-1037

  Nishigaki, Nobuhiro ^a   Negishi, Manabu ^a   Ichikawa, Atsushi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR; RECEPTOR SUBTYPE; 13,14 DIHYDRO 15 OXOPROSTAGLANDIN E2; 15 OXOPROSTAGLANDIN E2; 15-KETO-13,14-DIHYDROPROSTAGLANDIN E2; 15-KETOPROSTAGLANDIN E2; DRUG DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; PROSTAGLANDIN E RECEPTOR; TRITIUM;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CHO CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; ANIMAL; BINDING COMPETITION; BIOTRANSFORMATION; CLASSIFICATION; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; HAMSTER; METABOLISM; SENSITIVITY AND SPECIFICITY; ULTRASTRUCTURE;

ANIMALS; BINDING, COMPETITIVE; BIOTRANSFORMATION; CHO CELLS; CRICETINAE; DINOPROSTONE; GTP-BINDING PROTEINS; RECEPTORS, PROSTAGLANDIN E; SENSITIVITY AND SPECIFICITY; TRITIUM;

EID: 0029661961     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Negishi, M., Y. Sugimoto, and A. Ichikawa. Molecular mechanisms of diverse actions of prostanoid receptors. Biochim. Biophysi. Acta 1259:109-120 (1995).
2. Samuelsson, B., M. Goldyne, E. Granström, M. Hamberg, S. Hammarstrom, and C. Malmsten. Prostaglandins and thromboxanes. Annu. Rev. Biochem. 47:997-1029 (1978).
3. Coleman, R. A., I. Kennedy, P. P. A. Humphrey, K. Bunce, and P. Lumley. Prostaglandins and their receptors, in Comprehensive Medicinal Chemistry (C. Hansch, P. G. Sammes, J. B. Taylor, and J. C. Emmett, eds.). Vol. 3. Pergamon Press, Oxford, 643-714 (1990).
4. Coleman, R. A., S. P. Grix, S. A. Head, J. B. Louttit, A. Mallett, and R. L. G. Sheldrick. A novel inhibitory prostanoid receptor in piglet saphenous vein. Prostaglandins 47:152-168 (1994).
5. Remold-O'Donnell, E. Stimulation and desensitization of macrophage adenylate cyclase by prostaglandin and catecholamines. J. Biol. Chem. 249: 3615-3621 (1974).
6. 2 subtype: cloning, expression, and Northern blot analysis. FEBS Lett. 372: 151-156 (1995).
7. Honda, A., Y. Sugimoto, T. Namba, A. Watabe, A. Irie, M. Negishi, S. Narumiya, and A. Ichikawa. Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype. J. Biol. Chem. 268:7759-7762 (1993).
8. Nishigaki, N., M. Negishi, A. Honda, Y. Sugimoto, T. Namba, S. Narumiya, and A. Ichikawa. Identification of prostaglandin E receptor EP2 cloned from mastocytoma cells as EP4 subtype. FEBS Lett. 364:339-341 (1995).
9. Lohse, M. J. Molecular mechanisms of membrane receptor desensitization. Biochim. Biophys. Acta 1179:171-188 (1993).
10. Lefkowitz, R. J. G protein-coupled receptor kinases. Cell 74:409-412 (1993).
11. 2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature (Lond.) 333:370-373 (1988).
12. 2-adrenergic receptor are involved in direct pathways of receptor desensitization. J. Biol. Chem. 264:12657-12665 (1989).
13. Kanai, N., R. Lu, J. A. Satriano, Y. Bao, A. W. Wolkoff, and V. L. Schuster. Identification and characterization of a prostaglandin transporter. Science (Washington D. C.) 268:866-869 (1995).
14. Granström, E., and M. Kumlin. Metabolism of prostaglandins and lipoxygenase products: relevance for eicosanoid assay, in Prostaglandins and Related Substances: A Practical Approach. (C. Benedetto, R. G. McDonald-Gibson, S. Nigam, and T. F. Slater, eds.). IRL Press, Oxford, 5-27 (1987).
15. 13-reductase in tissues of the swine. Acta Physiol. Scand. 81:396-404 (1971).
16. 2 and its three pulmonary metabolites. Br. J. Pharmacol. 54:397-399 (1975).
17. Hausdorff, W. P., P. T. Campbell, J. Ostrowaki, S. Yu, M. G. Caron, and R. J. Lefkowitz. A small region of the β-adrenergic receptor is selectively involved in its rapid regulation. Proc. Natl. Acad. Sci. USA 88:2979-2983 (1991).
18. 2-adrenergic receptor impair agonist activation of adenylate cyclase without affecting high affinity agonist binding. J. Biol. Chem. 265:1388-1393 (1990).
19. 2-adrenergic receptors. Proc. Natl. Acad. Sci. USA 86:3011-3015 (1989)
20. a-adrenergic receptor confer short term agonist-promoted desensitization. J. Biol. Chem. 267:4740-4746 (1992).
21. Negishi, M., S. Ito, T. Tanaka, H. Yokohama, H. Hayashi, T. Katada, M. Ui, and O. Hayaishi. Covalent cross-linking of prostaglandin E receptor from bovine adrenal medulla with a pertussis toxin-insensitive guanine nucleotide-binding protein. J. Biol. Chem. 262:12077-12084 (1987).
22. Birnbaumer, L., J. Abramowitz, and A. M. Brown. Receptor-effector coupling by G proteins. Biochim. Biophys. Acta 1031:163-224 (1990).
23. Regan, J. W., T. J. Bailey, D. J. Pepperl, K. L. Pierce, A. M. Bogardus, J. E. Donello, C. E. Fairbairn, K. M. Kedzie, D. F. Woodward, and D. W. Gil. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol. Pharmacol. 46:213-220 (1994).
24. Liggett, S. B., N. J. Freedman, D. A. Schwinn, and R. J. Lefkowitz. Structural basis for receptor subtype-specific regulation revealed by a chimeric β3/β2-adrenergic receptor. Proc. Natl. Acad. Sci. USA 90:3665-3669 (1993).
25. Onorato, J. J., K. Palczewski, J. W. Regan, M. G. Caron, R. J. Lefkowitz, and J. L. Benovic. Role of acidic amino acids in peptide substrates of the β-adrenergic receptor kinase and rhodopsin kinase. Biochemistry 30:5118-5125 (1991).
26. 2-adrenergic receptor in agonist-induced down-regulation of the receptor. Proc. Natl. Acad. Sci. USA 87:5089-5093 (1990).
27. Barak, L. S., M. Tiberi, N. J. Freedman, M. M. Kwatra, R. J. Lefkowitz, and M. G. Caron. A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated β2-adrenergic receptor sequestration. J. Biol. Chem. 269:2790-2795 (1994).
28. nY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization. Mol. Pharmacol. 49:89-95 (1996).
29. 1. Eur. J. Pharmacol. 14:66-70 (1971).
30. Samuelsson, B. Prostaglandins and related factors. J. Biol. Chem. 239: 4091-4096 (1964).
31. 2 in man. J. Biol. Chem. 246:6713-6721 (1971).
32. Roth, N. S., P. T. Campbell, M. G. Caron, R. J. Lefkowitz, and M. J. Lohse. Comparative rates of desensitization of β-adrenergic receptor by the β-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 88:6201-6204 (1991).