In vitro stabilization and in vivo improvement of ocular pharmacokinetics of the multi-therapeutic agent baicalin: Delineating the most suitable vesicular systems

International Journal of Pharmaceutics

Volumn 539, Issue 1-2, 2018, Pages 83-94

  Ashraf, Orchid ^a   Nasr, Maha ^b,c   Nebsen, Marianne ^d   Said, Azza Mohamed Ahmed ^e   Sammour, Omaima ^b  

^a Heliopolis University for Sustainable Development   (Egypt)

^b African Union Organization St Abbassia   (Egypt)

^c MUTAH UNIVERSITY   (Jordan)

^d CAIRO UNIVERSITY   (Egypt)

^e AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

Baicalin; Labrasol; Penetration enhancer; Pharmacokinetic studies; Stability; Vesicles

Indexed keywords

ASCORBIC ACID; BAICALIN; LABRASOL; LIPOSOME; PENETRATION ENHANCING AGENT; DRUG CARRIER; FLAVONOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISPERSITY; DPPH RADICAL SCAVENGING ASSAY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; EYE TISSUE; GAMMA RADIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HYPEREMIA; IC50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM CONCENTRATION; NONHUMAN; OSMOLALITY; PARTICLE SIZE; PH; PH MEASUREMENT; PHOSPHOLIPID BILAYER; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DRUG EFFECT; EYE; LEPORIDAE; METABOLISM; ULTRASTRUCTURE;

ANIMALS; ASCORBIC ACID; BIOLOGICAL AVAILABILITY; DRUG CARRIERS; DRUG LIBERATION; DRUG STABILITY; EYE; FLAVONOIDS; LIPOSOMES; PARTICLE SIZE; RABBITS;

EID: 85041679615     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2018.01.041     Document Type: Article

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