Plasticity of the ligand binding pocket in the bitter taste receptor T2R7

Biochimica et Biophysica Acta - Biomembranes

Volumn 1860, Issue 5, 2018, Pages 991-999

  Liu, Kun ^a   Jaggupilli, Appalaraju ^a   Premnath, Dhanaraj ^a   Chelikani, Prashen ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Bitter agonists; Bitter taste receptor (T2R); Extracellular loop; Homology modeling; Mutagenesis

Indexed keywords

DEXTROMETHORPHAN; DIFENIDOL; DIPHENHYDRAMINE; G PROTEIN COUPLED RECEPTOR; QUININE; T2R7 PROTEIN; UNCLASSIFIED DRUG; LIGAND; PROTEIN BINDING; TASTE RECEPTORS, TYPE 2;

ARTICLE; CONTROLLED STUDY; EMBRYO; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; LOSS OF FUNCTION MUTATION; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUORUM SENSING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; AGONISTS; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; TASTE;

AMINO ACID SUBSTITUTION; BINDING SITES; HEK293 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; TASTE;

EID: 85041678601     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2018.01.014     Document Type: Article

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