메뉴 건너뛰기




Volumn 84, Issue 1, 2014, Pages 63-74

Identification of novel compounds for human bitter taste receptors

Author keywords

bitter compounds; calcium imaging; molecular descriptors; TAS2Rs

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PROTEIN TAS2R1; PROTEIN TAS2R10; PROTEIN TAS2R13; PROTEIN TAS2R14; PROTEIN TAS2R16; PROTEIN TAS2R3; PROTEIN TAS2R38; PROTEIN TAS2R39; PROTEIN TAS2R41; PROTEIN TAS2R42; PROTEIN TAS2R44; PROTEIN TAS2R45; PROTEIN TAS2R46; PROTEIN TAS2R47; PROTEIN TAS2R48; PROTEIN TAS2R60; PROTEIN TAS2R7; PROTEIN TAS2R8; UNCLASSIFIED DRUG; CALCIUM; LIGAND; TASTE RECEPTORS, TYPE 2;

EID: 84902838969     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12293     Document Type: Article
Times cited : (41)

References (44)
  • 1
    • 0030194456 scopus 로고    scopus 로고
    • Taste reception
    • Lindemann B., (1996) Taste reception. Physiol Rev; 76: 718-766.
    • (1996) Physiol Rev , vol.76 , pp. 718-766
    • Lindemann, B.1
  • 2
    • 27944434112 scopus 로고    scopus 로고
    • Elucidation of mammalian bitter taste
    • Meyerhof W., (2005) Elucidation of mammalian bitter taste. Rev Physiol Biochem Pharmacol; 154: 37-72.
    • (2005) Rev Physiol Biochem Pharmacol , vol.154 , pp. 37-72
    • Meyerhof, W.1
  • 3
  • 5
    • 14544295509 scopus 로고    scopus 로고
    • Evolution of bitter taste receptors in humans and apes
    • Fischer A., Gilad Y., Man O., Paabo S., (2005) Evolution of bitter taste receptors in humans and apes. Mol Biol Evol; 22: 432-436.
    • (2005) Mol Biol Evol , vol.22 , pp. 432-436
    • Fischer, A.1    Gilad, Y.2    Man, O.3    Paabo, S.4
  • 6
    • 0042040501 scopus 로고    scopus 로고
    • Evolutionary relationships of the Tas2r receptor gene families in mouse and human
    • Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J., (2003) Evolutionary relationships of the Tas2r receptor gene families in mouse and human. Physiol Genomics; 14: 73-82.
    • (2003) Physiol Genomics , vol.14 , pp. 73-82
    • Conte, C.1    Ebeling, M.2    Marcuz, A.3    Nef, P.4    Andres-Barquin, P.J.5
  • 9
    • 36248977649 scopus 로고    scopus 로고
    • Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells
    • Behrens M., Foerster S., Staehler F., Raguse J.D., Meyerhof W., (2007) Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. J Neurosci; 27: 12630-12640.
    • (2007) J Neurosci , vol.27 , pp. 12630-12640
    • Behrens, M.1    Foerster, S.2    Staehler, F.3    Raguse, J.D.4    Meyerhof, W.5
  • 10
    • 33746639193 scopus 로고    scopus 로고
    • Bitter taste receptors and human bitter taste perception
    • Behrens M., Meyerhof W., (2006) Bitter taste receptors and human bitter taste perception. Cell Mol Life Sci; 63: 1501-1509.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 1501-1509
    • Behrens, M.1    Meyerhof, W.2
  • 12
    • 0034611738 scopus 로고    scopus 로고
    • A family of candidate taste receptors in human and mouse
    • Matsunami H., Montmayeur J.P., Buck L.B., (2000) A family of candidate taste receptors in human and mouse. Nature; 404: 601-604.
    • (2000) Nature , vol.404 , pp. 601-604
    • Matsunami, H.1    Montmayeur, J.P.2    Buck, L.B.3
  • 15
    • 84868610108 scopus 로고    scopus 로고
    • T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
    • Lee R.J., Xiong G., Kofonow J.M., Chen B., Lysenko A., Jiang P., Abraham V., et al,. (2012) T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest; 122: 4145-4159.
    • (2012) J Clin Invest , vol.122 , pp. 4145-4159
    • Lee, R.J.1    Xiong, G.2    Kofonow, J.M.3    Chen, B.4    Lysenko, A.5    Jiang, P.6    Abraham, V.7
  • 16
    • 0029908546 scopus 로고    scopus 로고
    • Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin
    • Hofer D., Puschel B., Drenckhahn D., (1996) Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci USA; 93: 6631-6634.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6631-6634
    • Hofer, D.1    Puschel, B.2    Drenckhahn, D.3
  • 22
    • 0036844351 scopus 로고    scopus 로고
    • The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
    • Bufe B., Hofmann T., Krautwurst D., Raguse J.D., Meyerhof W., (2002) The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. Nat Genet; 32: 397-401.
    • (2002) Nat Genet , vol.32 , pp. 397-401
    • Bufe, B.1    Hofmann, T.2    Krautwurst, D.3    Raguse, J.D.4    Meyerhof, W.5
  • 23
    • 13944250257 scopus 로고    scopus 로고
    • The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception
    • Bufe B., Breslin P.A., Kuhn C., Reed D.R., Tharp C.D., Slack J.P., Kim U.K., Drayna D., Meyerhof W., (2005) The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol; 5: 322-327.
    • (2005) Curr Biol , vol.5 , pp. 322-327
    • Bufe, B.1    Breslin, P.A.2    Kuhn, C.3    Reed, D.R.4    Tharp, C.D.5    Slack, J.P.6    Kim, U.K.7    Drayna, D.8    Meyerhof, W.9
  • 24
    • 34547802810 scopus 로고    scopus 로고
    • Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium
    • Brockhoff A., Behrens M., Massarotti A., Appendino G., Meyerhof W., (2007) Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium. J Agric Food Chem; 55: 6236-6243.
    • (2007) J Agric Food Chem , vol.55 , pp. 6236-6243
    • Brockhoff, A.1    Behrens, M.2    Massarotti, A.3    Appendino, G.4    Meyerhof, W.5
  • 26
    • 84871753673 scopus 로고    scopus 로고
    • The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands
    • Born S., Levit A., Niv M.Y., Meyerhof W., Behrens M., (2013) The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. J Neurosci; 33: 201-213.
    • (2013) J Neurosci , vol.33 , pp. 201-213
    • Born, S.1    Levit, A.2    Niv, M.Y.3    Meyerhof, W.4    Behrens, M.5
  • 28
    • 84878451181 scopus 로고    scopus 로고
    • Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol
    • Thalmann S., Behrens M., Meyerhof W., (2013) Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. Biochem Biophys Res Commun; 435: 267-273.
    • (2013) Biochem Biophys Res Commun , vol.435 , pp. 267-273
    • Thalmann, S.1    Behrens, M.2    Meyerhof, W.3
  • 30
    • 0032417641 scopus 로고    scopus 로고
    • Identification of ligands for olfactory receptors by functional expression of a receptor library
    • Krautwurst D., Yau K.W., Reed R.R., (1998) Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell; 95: 917-926.
    • (1998) Cell , vol.95 , pp. 917-926
    • Krautwurst, D.1    Yau, K.W.2    Reed, R.R.3
  • 31
    • 0042739015 scopus 로고    scopus 로고
    • Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells
    • Ueda T., Ugawa S., Yamamura H., Imaizumi Y., Shimada S., (2003) Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells. J Neurosci; 23: 7376-7380.
    • (2003) J Neurosci , vol.23 , pp. 7376-7380
    • Ueda, T.1    Ugawa, S.2    Yamamura, H.3    Imaizumi, Y.4    Shimada, S.5
  • 32
    • 8844270180 scopus 로고    scopus 로고
    • RTP family members induce functional expression of mammalian odorant receptors
    • Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H., (2004) RTP family members induce functional expression of mammalian odorant receptors. Cell; 119: 679-691.
    • (2004) Cell , vol.119 , pp. 679-691
    • Saito, H.1    Kubota, M.2    Roberts, R.W.3    Chi, Q.4    Matsunami, H.5
  • 33
    • 51649104139 scopus 로고    scopus 로고
    • Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells
    • Zhuang H., Matsunami H., (2008) Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells. Nat Protoc; 3: 1402-1413.
    • (2008) Nat Protoc , vol.3 , pp. 1402-1413
    • Zhuang, H.1    Matsunami, H.2
  • 34
    • 84872117698 scopus 로고    scopus 로고
    • Amino acids and peptides activate at least five members of the human bitter taste receptor family
    • Kohl S., Behrens M., Dunkel A., Hofmann T., Meyerhof W., (2013) Amino acids and peptides activate at least five members of the human bitter taste receptor family. J Agric Food Chem; 61: 53-60.
    • (2013) J Agric Food Chem , vol.61 , pp. 53-60
    • Kohl, S.1    Behrens, M.2    Dunkel, A.3    Hofmann, T.4    Meyerhof, W.5
  • 37
    • 0037404468 scopus 로고    scopus 로고
    • Selection criteria for drug-like compounds
    • Muegge I., (2003) Selection criteria for drug-like compounds. Med Res Rev; 23: 302-321.
    • (2003) Med Res Rev , vol.23 , pp. 302-321
    • Muegge, I.1
  • 38
    • 84862662736 scopus 로고    scopus 로고
    • A physicochemical descriptor-based scoring scheme for effective and rapid filtering of kinase-like chemical space
    • Singh N., Sun H., Chaudhury S., Abdulhameed M.D., Wallqvist A., Tawa G., (2012) A physicochemical descriptor-based scoring scheme for effective and rapid filtering of kinase-like chemical space. J Cheminform; 4: 4.
    • (2012) J Cheminform , vol.4 , pp. 4
    • Singh, N.1    Sun, H.2    Chaudhury, S.3    Abdulhameed, M.D.4    Wallqvist, A.5    Tawa, G.6
  • 39
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J., (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev; 46: 3-26.
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 40
    • 0034073605 scopus 로고    scopus 로고
    • Property distribution of drug-related chemical databases
    • Oprea T.I., (2000) Property distribution of drug-related chemical databases. J Comput Aided Mol Des; 14: 251-264.
    • (2000) J Comput Aided Mol des , vol.14 , pp. 251-264
    • Oprea, T.I.1
  • 41
    • 0032600640 scopus 로고    scopus 로고
    • A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases
    • Ghose A.K., Viswanadhan V.N., Wendoloski J.J., (1999) A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases. J Comb Chem; 1: 55-68.
    • (1999) J Comb Chem , vol.1 , pp. 55-68
    • Ghose, A.K.1    Viswanadhan, V.N.2    Wendoloski, J.J.3
  • 42
    • 84872081711 scopus 로고    scopus 로고
    • Drug-likeness analysis of traditional Chinese medicines: 1. Property distributions of drug-like compounds, non-drug-like compounds and natural compounds from traditional Chinese medicines
    • Shen M., Tian S., Li Y., Li Q., Xu X., Wang J., Hou T., (2012) Drug-likeness analysis of traditional Chinese medicines: 1. property distributions of drug-like compounds, non-drug-like compounds and natural compounds from traditional Chinese medicines. J Cheminform; 4: 31.
    • (2012) J Cheminform , vol.4 , pp. 31
    • Shen, M.1    Tian, S.2    Li, Y.3    Li, Q.4    Xu, X.5    Wang, J.6    Hou, T.7
  • 43
    • 80053928594 scopus 로고    scopus 로고
    • What do medicinal chemists actually make? A 50-year retrospective
    • Walters W.P., Green J., Weiss J.R., Murcko M.A., (2011) What do medicinal chemists actually make? A 50-year retrospective. J Med Chem; 54: 6405-6416.
    • (2011) J Med Chem , vol.54 , pp. 6405-6416
    • Walters, W.P.1    Green, J.2    Weiss, J.R.3    Murcko, M.A.4
  • 44
    • 84864246506 scopus 로고    scopus 로고
    • 3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP)
    • Tan J., Abrol R., Trzaskowski B., Goddard W.A., (2012) 3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). J Chem Inf Model; 52: 1875-1885.
    • (2012) J Chem Inf Model , vol.52 , pp. 1875-1885
    • Tan, J.1    Abrol, R.2    Trzaskowski, B.3    Goddard, W.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.