Mechanism of intracellular allosteric β 2 AR antagonist revealed by X-ray crystal structure

Nature

Volumn 548, Issue 7668, 2017, Pages 480-484

  Liu, Xiangyu ^a   Ahn, Seungkirl ^b   Kahsai, Alem W ^b   Meng, Kai Cheng ^c   Latorraca, Naomi R ^d   Pani, Biswaranjan ^b   Venkatakrishnan, A J ^d,e   Masoudi, Ali ^b   Weis, William I ^e   Dror, Ron O ^d   Chen, Xin ^c   Lefkowitz, Robert J ^b   Kobilka, Brian K ^a,e  

^a Tsinghua University   (China)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c CHANGZHOU UNIVERSITY   (China)

^d Stanford University   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CARAZOLOL; DIPEPTIDE; PROPANOLAMINE DERIVATIVE;

ALLOSTERIC SITE; ALLOSTERISM; CHEMISTRY; CONSERVED SEQUENCE; DRUG EFFECTS; GENETICS; HUMAN; INTRACELLULAR SPACE; METABOLISM; MOLECULAR MODEL; MUTAGENESIS; PROTEIN CONFORMATION; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

ADRENERGIC BETA-2 RECEPTOR ANTAGONISTS; ALLOSTERIC REGULATION; ALLOSTERIC SITE; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; HUMANS; INTRACELLULAR SPACE; MODELS, MOLECULAR; MUTAGENESIS; PROPANOLAMINES; PROTEIN CONFORMATION; PROTEIN STABILITY; RECEPTORS, ADRENERGIC, BETA-2;

EID: 85028324189     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature23652     Document Type: Article

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