Opposite vascular activity of (R)-apomorphine and its oxidised derivatives. Endothelium-dependent vasoconstriction induced by the auto-oxidation metabolite

European Journal of Medicinal Chemistry

Volumn 38, Issue 5, 2003, Pages 501-511

  Abarca, Belén ^a   Ballesteros, Rafael ^a   Bielsa, Patricia ^a   Moragues, Juan ^a   D'Ocon, Pilar ^a   García Zaragozá, Eugenia ^a   Noguera, M Antonia ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Apomorphine derivatives; Endothelium; Oxidation; Rat aorta; Vasoconstriction

Indexed keywords

ACETYLCHOLINE; APOMORPHINE; CALCIUM CHANNEL; CALCIUM ION; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; MORPHINE DERIVATIVE; NITRIC OXIDE SYNTHASE; RADIOLIGAND; VASODILATOR AGENT;

ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; AUTOOXIDATION; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; MALE; METABOLITE; NONHUMAN; OXIDATION; RADIOENZYMATIC ASSAY; RAT; VASOCONSTRICTION;

EID: 0037722937     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(03)00057-6     Document Type: Article

References (18)

1. Ivorra M.D., Chuliá S., Lugnier C., D'Ocon M.P. Eur. J. Pharmacol. 231:1993;165-174.
2. Anselmi E., Chuliá S., Catret C., Noguera M.A., Ivorra M.D., D'Ocon M.P. Methods Find. Exp. Clin. Pharmacol. 16:(1):1994;142.
3. Gassen M., Glinka Y., Pinchasi B., Youdim M.B.H. Eur. J. Pharmacol. 308:1996;219-225.
4. Neef C., van Laar T. Clin. Pharmacokinet. 37:1999;251-257.
5. Linde H.H.A., Ragab M.S. Helv. Chim. Acta. 51:1968;683-687.
6. Rehse K. Arch. Pharmacol. Ber. Dtsch. Pharm. Ges. 302:1969;487-494.
7. Sam E., Augustijns P., Verbeke N. J. Chromatogr. B. 658:1994;311-317.
8. Sing S., Dryhurst G. J. Med. Chem. 33:1990;3035-3044.
9. Jackson W.F. Hypertension. 35:2000;173-178.
10. Moncada S., Palmer R.M.J., Higgs E.A. Pharmacol. Rev. 43:1991;109-142.
11. Luscher T.F., Barton M. Clin. Cardiol. 20:1997;II3-II10.
12. De Vriese A.S., Verbeuren T.J., Van de Voorde J., Lameire N.H., Vanhoutte P.M. Br. J. Pharmacol. 130:2000;963-974.
13. Rodriguez-Martinez M.A., García-Cohen E.C., Baena A.B., González R., Salaices M., Marín J. Br. J. Pharmacol. 125:1998;1329-1335.
14. Bolger G.T., Liard F., Jodoin A., Jaramillo J. Can. J. Physiol. Pharmacol. 69:1991;406-413.
15. Gao Y.J., Lee R.M.K.W. Br. J. Pharmacol. 134:2001;1639-1646.
16. Yang D., Félétou M., Boulanger C.M., Wu H.F., Levens N., Zhang J.N., Vanhoutte P.M. Br. J. Pharmacol. 136:2002;104-110.
17. Furchgott R.F., Zawadzki J.V. Nature. 288:1980;373-376.
18. Salter M., Knowles R.G., Moncada S. FEBS Lett. 291:1990;145-149.