Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis

Journal of the American Chemical Society

Volumn 135, Issue 47, 2013, Pages 17869-17880

  Suh, Eul Hyun ^a   Liu, Yu ^a   Connelly, Stephen ^a   Genereux, Joseph C ^a   Wilson, Ian A ^a   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID FIBRIL FORMATION; BINDING SELECTIVITY; BIOLOGICAL ENVIRONMENTS; CHEMO-SELECTIVITY; COCRYSTALLOGRAPHY; FLUOROGENIC SENSORS; MEDICINAL CHEMISTRY; SECONDARY AMINES;

ADDITION REACTIONS; AMIDES; BINDING SITES; ESCHERICHIA COLI; FLUORESCENCE; MOLECULES;

SULFUR COMPOUNDS;

AMYLOID; PREALBUMIN; STILBENE VINYL SULFONAMIDE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FLUORESCENCE; HUMAN; IN VITRO STUDY; MICHAEL ADDITION; QUANTUM YIELD; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY;

AMIDES; AMYLOID; CRYSTALLOGRAPHY, X-RAY; FLUORESCENT DYES; HUMANS; KINETICS; MODELS, MOLECULAR; PREALBUMIN; STILBENES; SULFONAMIDES;

EID: 84889244797     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja408230k     Document Type: Article

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