A role of line-1 in telomere regulation

Frontiers in Bioscience - Landmark

Volumn 23, Issue 7, 2018, Pages 1310-1319

  Mueller, Catharina ^a   Aschacher, Thomas ^a   Wolf, Brigitte ^a   Bergmann, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

LINE 1; Retrotransposon; Reverse Transciptase Inhibitors; Review; Shelterin; Telomerase; Telomere

Indexed keywords

ANIMAL; CELL PROLIFERATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LONG INTERSPERSED REPEAT; MOLECULAR EVOLUTION; NEOPLASM; PATHOLOGY; TELOMERE; TELOMERE HOMEOSTASIS;

ANIMALS; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; NEOPLASMS; TELOMERE; TELOMERE HOMEOSTASIS;

EID: 85041342802     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4645     Document Type: Article

References (59)

1. K. H. Burns: Transposable elements in cancer. Nat Rev Cancer, 17(7), 415-424 (2017) DOI: 10.1038/nrc.2017.35
2. B. Brouha, J. Schustak, R. M. Badge, S. Lutz-Prigge, A. H. Farley, J. V. Moran and H. H. Kazazian, Jr.: Hot L1s account for the bulk of retrotransposition in the human population. Proc Natl Acad Sci U S A, 100(9), 5280-5 (2003) DOI: 10.1073/pnas.0831042100
3. W. W. Tang, S. Dietmann, N. Irie, H. G. Leitch, V. I. Floros, C. R. Bradshaw, J. A. Hackett, P. F. Chinnery and M. A. Surani: A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development. Cell, 161(6), 1453-67 (2015) DOI: 10.1016/j.cell.2015.04.053
4. P. Vitullo, I. Sciamanna, M. Baiocchi, P. Sinibaldi-Vallebona and C. Spadafora: LINE-1 retrotransposon copies are amplified during murine early embryo development. Mol Reprod Dev, 79(2), 118-27 (2012) DOI: 10.1002/mrd.22003
5. R. Beraldi, C. Pittoggi, I. Sciamanna, E. Mattei and C. Spadafora: Expression of LINE-1 retroposons is essential for murine preimplantation development. Mol Reprod Dev, 73(3), 279-87 (2006) DOI: 10.1002/mrd.20423
6. S. Wissing, M. Munoz-Lopez, A. Macia, Z. Yang, M. Montano, W. Collins, J. L. Garcia-Perez, J. V. Moran and W. C. Greene: Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility. Hum Mol Genet, 21(1), 208-18 (2012) DOI: 10.1093/hmg/ddr455
7. S. Klawitter, N. V. Fuchs, K. R. Upton, M. Munoz-Lopez, R. Shukla, J. Wang, M. Garcia-Canadas, C. Lopez-Ruiz, D. J. Gerhardt, A. Sebe, I. Grabundzija, S. Merkert, P. Gerdes, J. A. Pulgarin, A. Bock, U. Held, A. Witthuhn, A. Haase, B. Sarkadi, J. Lower, E. J. Wolvetang, U. Martin, Z. Ivics, Z. Izsvak, J. L. Garcia-Perez, G. J. Faulkner and G. G. Schumann: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nat Commun, 7, 10286 (2016) DOI: 10.1038/ncomms10286
8. N. Rodic, R. Sharma, R. Sharma, J. Zampella, L. Dai, M. S. Taylor, R. H. Hruban, C. A. Iacobuzio-Donahue, A. Maitra, M. S. Torbenson, M. Goggins, M. Shih Ie, A. S. Duffield, E. A. Montgomery, E. Gabrielson, G. J. Netto, T. L. Lotan, A. M. De Marzo, W. Westra, Z. A. Binder, B. A. Orr, G. L. Gallia, C. G. Eberhart, J. D. Boeke, C. R. Harris and K. H. Burns: Long interspersed element-1 protein expression is a hallmark of many human cancers. Am J Pathol, 184(5), 1280-6 (2014) DOI: 10.1016/j.ajpath.2014.01.007
9. D.T.Ting,D.Lipson,S.Paul,B.W.Brannigan, S. Akhavanfard, E. J. Coffman, G. Contino, V. Deshpande, A. J. Iafrate, S. Letovsky, M. N. Rivera, N. Bardeesy, S. Maheswaran and D. A. Haber: Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science, 331(6017), 593-6 (2011) DOI: 10.1126/science.1200801
10. C. R. Harris, R. Normart, Q. Yang, E. Stevenson, B. G. Haffty, S. Ganesan, C. Cordon-Cardo, A. J. Levine and L. H. Tang: Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes. Genes Cancer, 1(2), 115-24 (2010) DOI: 10.1177/1947601909360812
11. L. Chen, J. E. Dahlstrom, A. Chandra, P. Board and D. Rangasamy: Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer. Breast Cancer Res Treat, 136(1), 129-42 (2012) DOI: 10.1007/s10549-012-2246-7
12. E. M. Wolff, H. M. Byun, H. F. Han, S. Sharma, P. W. Nichols, K. D. Siegmund, A. S. Yang, P. A. Jones and G. Liang: Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. PLoS Genet, 6(4), e1000917 (2010) DOI: 10.1371/journal.pgen.1000917
13. Y. Miki, I. Nishisho, A. Horii, Y. Miyoshi, J. Utsunomiya, K. W. Kinzler, B. Vogelstein and Y. Nakamura: Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res, 52(3), 643-5 (1992)
14. I. Sciamanna, M. Landriscina, C. Pittoggi, M. Quirino, C. Mearelli, R. Beraldi, E. Mattei, A. Serafino, A. Cassano, P. Sinibaldi-Vallebona, E. Garaci, C. Barone and C. Spadafora: Inhibition of endogenous reverse transcriptase antagonizes human tumor growth. Oncogene, 24(24), 3923-31 (2005) DOI: 10.1038/sj.onc.1208562
15. E. Oricchio, I. Sciamanna, R. Beraldi, G. V. Tolstonog, G. G. Schumann and C. Spadafora: Distinct roles for LINE-1 and HERV-K retroelements in cell proliferation, differentiation and tumor progression. Oncogene, 26(29), 4226-33 (2007) DOI: 10.1038/sj.onc.1210214
16. D. Rangasamy, N. Lenka, S. Ohms, J. E. Dahlstrom, A. C. Blackburn and P. G. Board: Activation of LINE-1 Retrotransposon Increases the Risk of Epithelial-Mesenchymal Transition and Metastasis in Epithelial Cancer. Curr Mol Med, 15(7), 588-97 (2015) DOI: 10.2174/1566524015666150831130827
17. K. Saito, K. Kawakami, I. Matsumoto, M. Oda, G. Watanabe and T. Minamoto: Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer. Clin Cancer Res, 16(8), 2418-26 (2010) DOI: 10.1158/1078-0432.CCR-09-2819
18. A. Q. van Hoesel, C. J. van de Velde, P. J. Kuppen, G. J. Liefers, H. Putter, Y. Sato, D. A. Elashoff, R. R. Turner, J. M. Shamonki, E. M. de Kruijf, J. G. van Nes, A. E. Giuliano and D. S. Hoon: Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study. Breast Cancer Res Treat, 134(3), 1103-14 (2012) DOI: 10.1007/s10549-012-2038-0
19. C. De Luca, F. Guadagni, P. Sinibaldi-Vallebona, S. Sentinelli, M. Gallucci, A. Hoffmann, G. G. Schumann, C. Spadafora and I. Sciamanna: Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation. Oncotarget, 7(4), 4048-61 (2016) DOI: 10.18632/oncotarget.6767
20. T. Aschacher, B. Wolf, F. Enzmann, P. Kienzl, B. Messner, S. Sampl, M. Svoboda, D. Mechtcheriakova, K. Holzmann and M. Bergmann: LINE-1 induces hTERT and ensures telomere maintenance in tumour cell lines. Oncogene, 35(1), 94-104 (2016) DOI: 10.1038/onc.2015.65
21. R. K. Moyzis, J. M. Buckingham, L. S. Cram, M. Dani, L. L. Deaven, M. D. Jones, J. Meyne, R. L. Ratliff and J. R. Wu: A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A, 85(18), 6622-6 (1988) DOI: 10.1073/pnas.85.18.6622
22. D. Benarroch-Popivker, S. Pisano, A. Mendez-Bermudez, L. Lototska, P. Kaur, S. Bauwens, N. Djerbi, C. M. Latrick, V. Fraisier, B. Pei, A. Gay, E. Jaune, K. Foucher, J. Cherfils-Vicini, E. Aeby, S. Miron, A. Londono-Vallejo, J. Ye, M. H. Le Du, H. Wang, E. Gilson and M. J. Giraud-Panis: TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection. Mol Cell, 61(2), 274-86 (2016) DOI: 10.1016/j.molcel.2015.12.009
23. E. L. Denchi and T. de Lange: Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature, 448(7157), 1068-71 (2007) DOI: 10.1038/nature06065
24. T. de Lange: How telomeres solve the end-protection problem. Science, 326(5955), 948-52 (2009) DOI: 10.1126/science.1170633
25. B. Nera, H. S. Huang, T. Lai and L. Xu: Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions. Nat Commun, 6, 10132 (2015) DOI: 10.1038/ncomms10132
26. J. D. Watson: Origin of concatemeric T7 DNA. Nat New Biol, 239(94), 197-201 (1972) DOI: 10.1038/newbio239197a0
27. D. Hanahan and R. A. Weinberg: Hallmarks of cancer: the next generation. Cell, 144(5), 646-74 (2011) DOI: 10.1016/j.cell.2011.02.013
28. M. Ruden and N. Puri: Novel anticancer therapeutics targeting telomerase. Cancer Treat Rev, 39(5), 444-56 (2013) DOI: 10.1016/j.ctrv.2012.06.007
29. Z. G. Dikmen, G. C. Gellert, S. Jackson, S. Gryaznov, R. Tressler, P. Dogan, W. E. Wright and J. W. Shay: In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res, 65(17), 7866-73 (2005) doi:10.1158/0008-5472. can-05-1215 DOI: 10.1158/0008-5472.CAN-05-1215
30. A. J. Cesare and R. R. Reddel: Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet, 11(5), 319-30 (2010) DOI: 10.1038/nrg2763
31. I. Sciamanna, A. Gualtieri, C. Cossetti, E. F. Osimo, M. Ferracin, G. Macchia, E. Arico, G. Prosseda, P. Vitullo, T. Misteli and C. Spadafora: A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines. Oncotarget, 4(12), 2271-87 (2013) DOI: 10.18632/oncotarget.1403
32. J. D. Henson, A. A. Neumann, T. R. Yeager and R. R. Reddel: Alternative lengthening of telomeres in mammalian cells. Oncogene, 21(4), 598-610 (2002) DOI: 10.1038/sj.onc.1205058
33. S. S. Lee, C. Bohrson, A. M. Pike, S. J. Wheelan and C. W. Greider: ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells. Cell Rep, 13(8), 1623-32 (2015) DOI: 10.1016/j.celrep.2015.10.035
34. T. R. Yeager, A. A. Neumann, A. Englezou, L. I. Huschtscha, J. R. Noble and R. R. Reddel: Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res, 59(17), 4175-9 (1999)
35. C. E. Napier, L. I. Huschtscha, A. Harvey, K. Bower, J. R. Noble, E. A. Hendrickson and R. R. Reddel: ATRX represses alternative lengthening of telomeres. Oncotarget, 6(18), 16543-58 (2015) DOI: 10.18632/oncotarget.3846
36. M. Ramamoorthy and S. Smith: Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells. Cancer Cell, 28(3), 357-69 (2015) DOI: 10.1016/j.ccell.2015.08.003
37. S. Victorelli and J. F. Passos: Telomeres and Cell Senescence - Size Matters Not. EBioMedicine (2017) DOI: 10.1016/j.ebiom.2017.03.027
38. S. Napoli, C. Pastori, M. Magistri, G. M. Carbone and C. V. Catapano: Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells. Embo j, 28(12), 1708-19 (2009) DOI: 10.1038/emboj.2009.139
39. A. P. Smith, A. Verrecchia, G. Faga, M. Doni, D. Perna, F. Martinato, E. Guccione and B. Amati: A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition. Oncogene, 28(3), 422-30 (2009) DOI: 10.1038/onc.2008.395
40. Z. Liu, Q. Li, K. Li, L. Chen, W. Li, M. Hou, T. Liu, J. Yang, C. Lindvall, M. Bjorkholm, J. Jia and D. Xu: Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells. Oncogene, 32(36), 4203-13 (2013) DOI: 10.1038/onc.2012.441
41. I. E. Bondarev and V. K. Khavinson: [Suppression of alternative telomere lengthening in cancer cells with reverse transcriptase inhibitors]. Adv Gerontol, 29(2), 218-221 (2016) DOI: 10.1134/S2079057016040020
42. T. Aschacher, B. Wolf, K. Holzmann, M Bergmann: LINE-1 supports telomere maintenance in cancer cells, “Telomere and Telomerases”, . In: Cold Spring Harbor, NY. (2013)
43. H. C. Kopera, J. B. Moldovan, T. A. Morrish, J. L. Garcia-Perez and J. V. Moran: Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase. Proc Natl Acad Sci U S A, 108(51), 20345-50 (2011) DOI: 10.1073/pnas.1100275108
44. M. Belfort, M. J. Curcio and N. F. Lue: Telomerase and retrotransposons: reverse transcriptases that shaped genomes. Proc Natl Acad Sci U S A, 108(51), 20304-10 (2011) DOI: 10.1073/pnas.1100269109
45. M. L. Pardue and P. Debaryshe: Adapting to life at the end of the line: How Drosophila telomeric retrotransposons cope with their job. Mob Genet Elements, 1(2), 128-134 (2011) DOI: 10.4161/mge.1.2.16914
46. J. M. Mason, A. Y. Konev and H. Biessmann: Telomeric position effect in drosophila melanogaster reflects a telomere length control mechanism. Genetica, 117(2-3), 319-25 (2003) DOI: 10.1023/A:1022925003172
47. L. Zhang and Y. S. Rong: Retrotransposons at Drosophila telomeres: host domestication of a selfish element for the maintenance of genome integrity. Biochim Biophys Acta, 1819(7), 771-5 (2012) DOI: 10.1016/j.bbagrm.2012.01.018
48. J. D. Boeke: DNA repair. A little help for my ends. Nature, 383(6601), 579, 581 (1996) DOI: 10.1038/383579a0
49. H. Fujiwara, M. Osanai, T. Matsumoto and K. K. Kojima: Telomere-specific non-LTR retrotransposons and telomere maintenance in the silkworm, Bombyx mori. Chromosome Res, 13(5), 455-67 (2005) DOI: 10.1007/s10577-005-0990-9
50. H. Fujiwara: Site-specific non-LTR retrotransposons. Microbiol Spectr, 3(2), Mdna3-0001-2014 (2015) DOI: 10.1128/microbiolspec.MDNA3-0001-2014
51. Z. Deng, Z. Wang and P. M. Lieberman: Telomeres and viruses: common themes of genome maintenance. Front Oncol, 2, 201 (2012) DOI: 10.3389/fonc.2012.00201
52. T. A. Morrish, J. L. Garcia-Perez, T. D. Stamato, G. E. Taccioli, J. Sekiguchi and J. V. Moran: Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres. Nature, 446(7132), 208-12 (2007) DOI: 10.1038/nature05560
53. L. Liu, S. M. Bailey, M. Okuka, P. Munoz, C. Li, L. Zhou, C. Wu, E. Czerwiec, L. Sandler, A. Seyfang, M. A. Blasco and D. L. Keefe: Telomere lengthening early in development. Nat Cell Biol, 9(12), 1436-41 (2007) DOI: 10.1038/ncb1664
54. C. Strahl and E. H. Blackburn: The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena. Nucleic Acids Res, 22(6), 893-900 (1994) DOI: 10.1093/nar/22.6.893
55. C. Strahl and E. H. Blackburn: Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol Cell Biol, 16(1), 53-65 (1996) DOI: 10.1128/MCB.16.1.53
56. Y. Mo, Y. Gan, S. Song, J. Johnston, X. Xiao, M. G. Wientjes and J. L. Au: Simultaneous targeting of telomeres and telomerase as a cancer therapeutic approach. Cancer Res, 63(3), 579-85 (2003)
57. L. Dai, Q. Huang and J. D. Boeke: Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochem, 12, 18 (2011) DOI: 10.1186/1471-2091-12-18
58. T. Aschacher, S. Sampl, L. Kaser, D. Bernhard, A. Spittler, K. Holzmann and M. Bergmann: The combined use of known antiviral reverse transcriptase inhibitors AZT and DDI induce anticancer effects at low concentrations. Neoplasia, 14(1), 44-53 (2012) DOI: 10.1593/neo.11426
59. R. Patnala, S. H. Lee, J. E. Dahlstrom, S. Ohms, L. Chen, S. T. Dheen and D. Rangasamy: Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells. Breast Cancer Res Treat, 143(2), 239-53 (2014) DOI: 10.1007/s10549-013-2812-7