The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth

Structure

Volumn 26, Issue 3, 2018, Pages 416-425.e4

  Pellegrino, Simone ^a   Meyer, Mélanie ^a   Zorbas, Christiane ^b   Bouchta, Soumaya A ^b   Saraf, Kritika ^b   Pelly, Stephen C ^c   Yusupova, Gulnara ^a   Evidente, Antonio ^d   Mathieu, Véronique ^b   Kornienko, Alexander ^e   Lafontaine, Denis L J ^b   Yusupov, Marat ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c STELLENBOSCH UNIVERSITY   (South Africa)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e Texas State University   (United States)

Author keywords

Amaryllidaceae alkaloids; cancer; haemanthamine; nucleolar stress response; p53; peptidyl transferase center; ribosome; ribosome biogenesis; translation elongation; X ray crystallography

Indexed keywords

BACTERIAL RNA; CYCLOHEXIMIDE; FLUOROURACIL; HAEMANTHAMINE; HAEMANTHIDINE; LYCORINE; NARCICLASINE; PEPTIDYLTRANSFERASE; PROTEIN P53; RIBOSOME RNA; AMARYLLIDACEAE ALKALOID; ANTINEOPLASTIC AGENT; PHENANTHRIDINE DERIVATIVE; SACCHAROMYCES CEREVISIAE PROTEIN; TP53 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CANCER INHIBITION; CELL STRESS; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC50; LARGE RIBOSOMAL SUBUNIT; NONHUMAN; ORGANELLE BIOGENESIS; PRIORITY JOURNAL; PROTEIN STABILITY; RNA PROCESSING; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION; CELL PROLIFERATION; CHEMISTRY; COLON TUMOR; CONFORMATION; DRUG EFFECT; HCT 116 CELL LINE; METABOLISM; MOLECULAR MODEL; RIBOSOME; X RAY CRYSTALLOGRAPHY;

AMARYLLIDACEAE ALKALOIDS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL PROLIFERATION; COLONIC NEOPLASMS; CRYSTALLOGRAPHY, X-RAY; HCT116 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHENANTHRIDINES; RIBOSOMES; RNA, RIBOSOMAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85041200620     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2018.01.009     Document Type: Article

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