LC-MS/MS method for the determination of haemanthamine in rat plasma, bile and urine and its application to a pilot pharmacokinetic study

Biomedical Chromatography

Volumn 30, Issue 7, 2016, Pages 1083-1091

  Hroch, Miloš ^a   Mičuda, Stanislav ^a   Havelek, Radim ^b   Cermanová, Jolana ^a   Cahlíková, Lucie ^c   Hošťálková, Anna ^c   Hulcová, Daniela ^c   Řezáčová, Martina ^a  

^a UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^b UNIVERSITY OF PARDUBICE   (Czech Republic)

^c Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Ambelline; Haemanthamine; LC MS MS assay; Pharmacokinetics

Indexed keywords

BODY FLUIDS; LIQUID CHROMATOGRAPHY;

AMBELLINE; ANTI-TUMORS; HAEMANTHAMINE; ISOQUINOLINES; ITS APPLICATIONS; LC-MS-MS; LC-MS/MS ASSAY; PHARMACOKINETIC STUDIES; RAT PLASMA; RAT URINE;

PHARMACOKINETICS;

ACETONITRILE; AMMONIUM FORMATE; HAEMANTHAMINE; METHANOL; AMARYLLIDACEAE ALKALOID; PHENANTHRIDINE DERIVATIVE;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BILE; COLLISIONALLY ACTIVATED DISSOCIATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG STABILITY; DRUG URINE LEVEL; ELIMINATION HALF-LIFE; EXTRACTION; FEMALE; LIMIT OF QUANTITATION; LIQUID; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; NONHUMAN; PRACTICE GUIDELINE; RAT; TANDEM MASS SPECTROMETRY; URINALYSIS; URINARY EXCRETION; URINE; VOLUME OF DISTRIBUTION; ANIMAL; BLOOD; LIMIT OF DETECTION; METABOLISM; PILOT STUDY; PROCEDURES; REPRODUCIBILITY; VALIDATION STUDY;

AMARYLLIDACEAE ALKALOIDS; ANIMALS; BILE; LIMIT OF DETECTION; PHENANTHRIDINES; PILOT PROJECTS; RATS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84949947276     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3653     Document Type: Article

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