메뉴 건너뛰기




Volumn 136, Issue , 2018, Pages 327-334

Insulin resistance, an unmasked culprit in depressive disorders: Promises for interventions

Author keywords

Acetyl L Carnitine; Allostatic load; Depression; Inflammation; Insulin resistance; Peroxisome proliferator activated receptor

Indexed keywords

ACETYLCARNITINE; ADIPONECTIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CANNABINOID; ENDOCANNABINOID; FOLIC ACID; GLITAZONE DERIVATIVE; GLUTAMIC ACID; KLOTHO PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTROPHIC FACTOR; NEUROTROPHIC FACTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PIOGLITAZONE; PIRINIXIC ACID; ROSIGLITAZONE; UNCLASSIFIED DRUG;

EID: 85041136151     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2017.11.038     Document Type: Review
Times cited : (56)

References (89)
  • 1
    • 84877329207 scopus 로고    scopus 로고
    • PPAR[gamma] signaling and metabolism: the good, the bad and the future
    • Ahmadian, M., et al. PPAR[gamma] signaling and metabolism: the good, the bad and the future. Nat. Med. 99:5 (2013), 557–566.
    • (2013) Nat. Med. , vol.99 , Issue.5 , pp. 557-566
    • Ahmadian, M.1
  • 2
    • 85028723500 scopus 로고    scopus 로고
    • Treatment resistant depression: a multi-scale, systems biology approach. LID - S0149-7634(17)30368-8 [pii] LID - 10.1016/j.neubiorev.2017.08.019 [doi]. (1873-7528 (Electronic)).
    • Akil, H., et al., Treatment resistant depression: a multi-scale, systems biology approach. LID - S0149-7634(17)30368-8 [pii] LID - 10.1016/j.neubiorev.2017.08.019 [doi]. (1873-7528 (Electronic)).
    • Akil, H.1
  • 3
    • 84882430142 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)beta/delta, a possible nexus of PPARalpha- and PPARgamma-dependent molecular pathways in neurodegenerative diseases: review and novel hypotheses
    • Aleshin, S., et al. Peroxisome proliferator-activated receptor (PPAR)beta/delta, a possible nexus of PPARalpha- and PPARgamma-dependent molecular pathways in neurodegenerative diseases: review and novel hypotheses. Neurochem. Int. 63:4 (2013), 322–330.
    • (2013) Neurochem. Int. , vol.63 , Issue.4 , pp. 322-330
    • Aleshin, S.1
  • 4
    • 84922725184 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus and Alzheimer's disease
    • Barbagallo, M., Dominguez, L.J., Type 2 diabetes mellitus and Alzheimer's disease. World J. Diabetes 5:6 (2014), 889–893.
    • (2014) World J. Diabetes , vol.5 , Issue.6 , pp. 889-893
    • Barbagallo, M.1    Dominguez, L.J.2
  • 5
    • 84975127135 scopus 로고    scopus 로고
    • The role of diet and exercise in the transgenerational epigenetic landscape of T2DM
    • Barres, R., Zierath, J.R., The role of diet and exercise in the transgenerational epigenetic landscape of T2DM. Nat. Rev. Endocrinol. 12:8 (2016), 441–451.
    • (2016) Nat. Rev. Endocrinol. , vol.12 , Issue.8 , pp. 441-451
    • Barres, R.1    Zierath, J.R.2
  • 6
    • 84944714835 scopus 로고    scopus 로고
    • Hippocampal insulin resistance and cognitive dysfunction
    • Biessels, G.J., Reagan, L.P., Hippocampal insulin resistance and cognitive dysfunction. Nat. Rev. Neurosci. 16:11 (2015), 660–671.
    • (2015) Nat. Rev. Neurosci. , vol.16 , Issue.11 , pp. 660-671
    • Biessels, G.J.1    Reagan, L.P.2
  • 7
    • 84978036875 scopus 로고    scopus 로고
    • Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: implications for treatment resistance
    • Bigio, B., et al. Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: implications for treatment resistance. Proc. Natl. Acad. Sci. U. S. A. 113:28 (2016), 7906–7911.
    • (2016) Proc. Natl. Acad. Sci. U. S. A. , vol.113 , Issue.28 , pp. 7906-7911
    • Bigio, B.1
  • 8
    • 84856610955 scopus 로고    scopus 로고
    • Involvement of PI3K, GSK-3beta and PPARgamma in the antidepressant-like effect of folic acid in the forced swimming test in mice
    • Budni, J., et al. Involvement of PI3K, GSK-3beta and PPARgamma in the antidepressant-like effect of folic acid in the forced swimming test in mice. J. Psychopharmacol. 26:5 (2012), 714–723.
    • (2012) J. Psychopharmacol. , vol.26 , Issue.5 , pp. 714-723
    • Budni, J.1
  • 9
    • 85049926280 scopus 로고    scopus 로고
    • Rosiglitazone increases cerebral klotho expression to reverse baroreflex in type 1-like diabetic rats Fibroblast growth factor 21: a promising therapeutic target in obesity-related diseases. (2314–6141 (Electronic)).
    • Chen, L.J., et al., Rosiglitazone increases cerebral klotho expression to reverse baroreflex in type 1-like diabetic rats Fibroblast growth factor 21: a promising therapeutic target in obesity-related diseases. (2314–6141 (Electronic)).
    • Chen, L.J.1
  • 10
    • 84929959524 scopus 로고    scopus 로고
    • Neurotrophic factor-[alpha]1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone
    • Cheng, Y., et al. Neurotrophic factor-[alpha]1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone. Mol. Psychiatry 20:6 (2015), 744–754.
    • (2015) Mol. Psychiatry , vol.20 , Issue.6 , pp. 744-754
    • Cheng, Y.1
  • 11
    • 84905977736 scopus 로고    scopus 로고
    • Carboxypeptidase E (NF-α1): a new trophic factor in neuroprotection
    • Cheng, Y., Cawley, N.X., Loh, Y.P., Carboxypeptidase E (NF-α1): a new trophic factor in neuroprotection. Neurosci. Bull. 30:4 (2014), 692–696.
    • (2014) Neurosci. Bull. , vol.30 , Issue.4 , pp. 692-696
    • Cheng, Y.1    Cawley, N.X.2    Loh, Y.P.3
  • 12
    • 84881146647 scopus 로고    scopus 로고
    • Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood
    • Clinton, S.M., Glover, M.E., Maltare, A., Laszczyk, A.M., Mehi, S.J., Simmons, R.K., King, G.D., Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood. Brain Res. 1527 (2013), 1–14 http://doi.org/10.1016/j.brainres.2013.06.044.
    • (2013) Brain Res. , vol.1527 , pp. 1-14
    • Clinton, S.M.1    Glover, M.E.2    Maltare, A.3    Laszczyk, A.M.4    Mehi, S.J.5    Simmons, R.K.6    King, G.D.7
  • 13
    • 34247507589 scopus 로고    scopus 로고
    • PPAR-gamma: therapeutic target for ischemic stroke
    • Culman, J., et al. PPAR-gamma: therapeutic target for ischemic stroke. Trends Pharmacol. Sci. 28:5 (2007), 244–249.
    • (2007) Trends Pharmacol. Sci. , vol.28 , Issue.5 , pp. 244-249
    • Culman, J.1
  • 14
    • 84957964025 scopus 로고    scopus 로고
    • Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans
    • Donkin, I., et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab. 23:2 (2016), 369–378.
    • (2016) Cell Metab. , vol.23 , Issue.2 , pp. 369-378
    • Donkin, I.1
  • 15
    • 84960193391 scopus 로고    scopus 로고
    • Promising link between selenium and peroxisome proliferator activated receptor gamma in the treatment protocols of obesity as well as depression
    • Donma, M.M., Donma, O., Promising link between selenium and peroxisome proliferator activated receptor gamma in the treatment protocols of obesity as well as depression. Med. Hypotheses 89 (2016), 79–83.
    • (2016) Med. Hypotheses , vol.89 , pp. 79-83
    • Donma, M.M.1    Donma, O.2
  • 16
    • 84978745497 scopus 로고    scopus 로고
    • Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
    • Duman, R.S., et al. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat. Med. 22:3 (2016), 238–249.
    • (2016) Nat. Med. , vol.22 , Issue.3 , pp. 238-249
    • Duman, R.S.1
  • 17
    • 70349667794 scopus 로고    scopus 로고
    • Antidepressant-like effects of rosiglitazone, a PPARgamma agonist, in the rat forced swim and mouse tail suspension tests
    • Eissa Ahmed, A.A., Al-Rasheed, N.M., Al-Rasheed, N.M., Antidepressant-like effects of rosiglitazone, a PPARgamma agonist, in the rat forced swim and mouse tail suspension tests. Behav. Pharmacol. 20:7 (2009), 635–642.
    • (2009) Behav. Pharmacol. , vol.20 , Issue.7 , pp. 635-642
    • Eissa Ahmed, A.A.1    Al-Rasheed, N.M.2    Al-Rasheed, N.M.3
  • 18
    • 79952611543 scopus 로고    scopus 로고
    • Exercise training increases size of hippocampus and improves memory
    • Erickson, K.I., et al. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. U. S. A. 108:7 (2011), 3017–3022.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , Issue.7 , pp. 3017-3022
    • Erickson, K.I.1
  • 19
    • 0032078822 scopus 로고    scopus 로고
    • Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The adverse childhood experiences (ACE) study
    • Felitti, V.J., et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The adverse childhood experiences (ACE) study. Am. J. Prev. Med. 14 (1998), 245–258.
    • (1998) Am. J. Prev. Med. , vol.14 , pp. 245-258
    • Felitti, V.J.1
  • 20
    • 84882392732 scopus 로고    scopus 로고
    • A functional genomic perspective on human well-being
    • Fredrickson, B.L., et al. A functional genomic perspective on human well-being. Proc. Natl. Acad. Sci. U. S. A. 110:33 (2013), 13684–13689.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , Issue.33 , pp. 13684-13689
    • Fredrickson, B.L.1
  • 21
    • 84929469644 scopus 로고    scopus 로고
    • High-fat diet-induced adiposity, adipose inflammation, hepatic steatosis and hyperinsulinemia in outbred CD-1 mice
    • Gao, M., Ma, Y., Liu, D., High-fat diet-induced adiposity, adipose inflammation, hepatic steatosis and hyperinsulinemia in outbred CD-1 mice. PLoS One, 10(3), 2015, e0119784.
    • (2015) PLoS One , vol.10 , Issue.3 , pp. e0119784
    • Gao, M.1    Ma, Y.2    Liu, D.3
  • 22
    • 45249083893 scopus 로고    scopus 로고
    • Inflammatory/anti-inflammatory mechanisms in the brain following exposure to stress
    • Garcia-Bueno, B., Leza, J.C., Inflammatory/anti-inflammatory mechanisms in the brain following exposure to stress. Rev. Neurol. 46:11 (2008), 675–683.
    • (2008) Rev. Neurol. , vol.46 , Issue.11 , pp. 675-683
    • Garcia-Bueno, B.1    Leza, J.C.2
  • 23
    • 79952713816 scopus 로고    scopus 로고
    • Is there a role for the nuclear receptor PPARgamma in neuropsychiatric diseases?
    • Garcia-Bueno, B., Perez-Nievas, B.G., Leza, J.C., Is there a role for the nuclear receptor PPARgamma in neuropsychiatric diseases?. Int. J. Neuropsychopharmacol. 13:10 (2010), 1411–1429.
    • (2010) Int. J. Neuropsychopharmacol. , vol.13 , Issue.10 , pp. 1411-1429
    • Garcia-Bueno, B.1    Perez-Nievas, B.G.2    Leza, J.C.3
  • 24
    • 84873060619 scopus 로고    scopus 로고
    • Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-gamma systems
    • Gold, P.W., Licinio, J., Pavlatou, M.G., Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-gamma systems. Mol. Psychiatry 18:2 (2013), 154–165.
    • (2013) Mol. Psychiatry , vol.18 , Issue.2 , pp. 154-165
    • Gold, P.W.1    Licinio, J.2    Pavlatou, M.G.3
  • 25
    • 57049139958 scopus 로고    scopus 로고
    • Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study
    • Goropashnaya, A.V., et al. Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. Metabolism 58:1 (2009), 22–29.
    • (2009) Metabolism , vol.58 , Issue.1 , pp. 22-29
    • Goropashnaya, A.V.1
  • 26
    • 0028147323 scopus 로고
    • Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus
    • Gould, E., Cameron, H., McEwen, B.S., Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus. J. Comp. Neurol. 340 (1994), 551–565.
    • (1994) J. Comp. Neurol. , vol.340 , pp. 551-565
    • Gould, E.1    Cameron, H.2    McEwen, B.S.3
  • 27
    • 85003875574 scopus 로고    scopus 로고
    • Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors
    • Guo, M., Li, C., Lei, Y., Xu, S., Zhao, D., Lu, X.Y., Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors. Mol. Psychiatry, 22, 2016, 1056.
    • (2016) Mol. Psychiatry , vol.22 , pp. 1056
    • Guo, M.1    Li, C.2    Lei, Y.3    Xu, S.4    Zhao, D.5    Lu, X.Y.6
  • 28
    • 84894904605 scopus 로고    scopus 로고
    • Lifecourse health development: past, present and future
    • Halfon, N., et al. Lifecourse health development: past, present and future. Matern. Child. Health J. 18:2 (2014), 344–365.
    • (2014) Matern. Child. Health J. , vol.18 , Issue.2 , pp. 344-365
    • Halfon, N.1
  • 29
    • 84904669363 scopus 로고    scopus 로고
    • St. John's wort promotes adipocyte differentiation and modulates NF-kappaB activation in 3T3-L1 cells
    • Hatano, T., et al. St. John's wort promotes adipocyte differentiation and modulates NF-kappaB activation in 3T3-L1 cells. Biol. Pharm. Bull. 37:7 (2014), 1132–1138.
    • (2014) Biol. Pharm. Bull. , vol.37 , Issue.7 , pp. 1132-1138
    • Hatano, T.1
  • 30
    • 85015394765 scopus 로고    scopus 로고
    • Adiponectin and depression: a meta-analysis
    • Hu, Y., Dong, X., Chen, J., Adiponectin and depression: a meta-analysis. Biomed. Rep. 3:1 (2015), 38–42.
    • (2015) Biomed. Rep. , vol.3 , Issue.1 , pp. 38-42
    • Hu, Y.1    Dong, X.2    Chen, J.3
  • 31
    • 84964705617 scopus 로고    scopus 로고
    • Hippocampal PPARdelta overexpression or activation represses stress-induced depressive behaviors and enhances neurogenesis
    • Ji, M.J., et al. Hippocampal PPARdelta overexpression or activation represses stress-induced depressive behaviors and enhances neurogenesis. Int. J. Neuropsychopharmacol., 19(1), 2016.
    • (2016) Int. J. Neuropsychopharmacol. , vol.19 , Issue.1
    • Ji, M.J.1
  • 32
    • 84939996979 scopus 로고    scopus 로고
    • WY14643 produces anti-depressant-like effects in mice via the BDNF signaling pathway
    • Jiang, B., et al. WY14643 produces anti-depressant-like effects in mice via the BDNF signaling pathway. Psychopharmacol. Berl. 232:9 (2015), 1629–1642.
    • (2015) Psychopharmacol. Berl. , vol.232 , Issue.9 , pp. 1629-1642
    • Jiang, B.1
  • 33
    • 84869854776 scopus 로고    scopus 로고
    • PPARgamma agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes
    • Kanakasabai, S., et al. PPARgamma agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. PLoS One, 7(11), 2012, e50500.
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e50500
    • Kanakasabai, S.1
  • 34
    • 84859456953 scopus 로고    scopus 로고
    • Association of depression with increased risk of dementia in patients with type 2 diabetes: the diabetes and aging study
    • Katon, W., et al. Association of depression with increased risk of dementia in patients with type 2 diabetes: the diabetes and aging study. Archives General Psychiatry 69:4 (2012), 410–417.
    • (2012) Archives General Psychiatry , vol.69 , Issue.4 , pp. 410-417
    • Katon, W.1
  • 35
    • 84903815993 scopus 로고    scopus 로고
    • PPAR-gamma agonism as a modulator of mood: proof-of-concept for pioglitazone in bipolar depression
    • Kemp, D.E., et al. PPAR-gamma agonism as a modulator of mood: proof-of-concept for pioglitazone in bipolar depression. CNS Drugs 28:6 (2014), 571–581.
    • (2014) CNS Drugs , vol.28 , Issue.6 , pp. 571-581
    • Kemp, D.E.1
  • 36
    • 39149091423 scopus 로고    scopus 로고
    • FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho
    • Kharitonenkov, A., et al. FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho. J. Cell. Physiology 215:1 (2008), 1–7.
    • (2008) J. Cell. Physiology , vol.215 , Issue.1 , pp. 1-7
    • Kharitonenkov, A.1
  • 37
    • 84911905302 scopus 로고    scopus 로고
    • Purpose in life and use of preventive health care services
    • Kim, E.S., Strecher, V.J., Ryff, C.D., Purpose in life and use of preventive health care services. Proc. Natl. Acad. Sci. U. S. A. 111:46 (2014), 16331–16336.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , Issue.46 , pp. 16331-16336
    • Kim, E.S.1    Strecher, V.J.2    Ryff, C.D.3
  • 38
    • 33846278577 scopus 로고    scopus 로고
    • Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years
    • Kral, J.G., et al. Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years. Pediatrics 118 (2006), 1644–1649.
    • (2006) Pediatrics , vol.118 , pp. 1644-1649
    • Kral, J.G.1
  • 39
    • 84973338708 scopus 로고    scopus 로고
    • Pioglitazone, a PPARgamma agonist rescues depression associated with obesity using chronic unpredictable mild stress model in experimental mice
    • Kurhe, Y., Mahesh, R., Pioglitazone, a PPARgamma agonist rescues depression associated with obesity using chronic unpredictable mild stress model in experimental mice. Neurobiol. Stress 3 (2016), 114–121.
    • (2016) Neurobiol. Stress , vol.3 , pp. 114-121
    • Kurhe, Y.1    Mahesh, R.2
  • 40
    • 0035786908 scopus 로고    scopus 로고
    • Insulin resistance and its treatment by thiazolidinediones
    • Lebovitz, H.E., Banerji, M.A., Insulin resistance and its treatment by thiazolidinediones. Recent Prog. Horm. Res. 56 (2001), 265–294.
    • (2001) Recent Prog. Horm. Res. , vol.56 , pp. 265-294
    • Lebovitz, H.E.1    Banerji, M.A.2
  • 41
    • 84947336686 scopus 로고    scopus 로고
    • Adjuvant pioglitazone for unremitted depression: clinical correlates of treatment response
    • Lin, K.W., et al. Adjuvant pioglitazone for unremitted depression: clinical correlates of treatment response. Psychiatry Res. 230:3 (2015), 846–852.
    • (2015) Psychiatry Res. , vol.230 , Issue.3 , pp. 846-852
    • Lin, K.W.1
  • 42
    • 84857083262 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex
    • Liu, R.J., et al. Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biol. Psychiatry 71:11 (2012), 996–1005.
    • (2012) Biol. Psychiatry , vol.71 , Issue.11 , pp. 996-1005
    • Liu, R.J.1
  • 43
    • 84905031971 scopus 로고    scopus 로고
    • A potential therapeutic effect of CYP2C8 overexpression on anti-TNF-alpha activity
    • Liu, W., et al. A potential therapeutic effect of CYP2C8 overexpression on anti-TNF-alpha activity. Int. J. Mol. Med. 34:3 (2014), 725–732.
    • (2014) Int. J. Mol. Med. , vol.34 , Issue.3 , pp. 725-732
    • Liu, W.1
  • 44
    • 77954614863 scopus 로고    scopus 로고
    • System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency
    • Mandal, P.K., et al. System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency. J. Biol. Chem. 285:29 (2010), 22244–22253.
    • (2010) J. Biol. Chem. , vol.285 , Issue.29 , pp. 22244-22253
    • Mandal, P.K.1
  • 45
    • 84962304419 scopus 로고    scopus 로고
    • Therapeutic potential of the dual peroxisome proliferator activated receptor (PPAR)alpha/gamma agonist aleglitazar in attenuating TNF-alpha-mediated inflammation and insulin resistance in human adipocytes
    • Massaro, M., et al. Therapeutic potential of the dual peroxisome proliferator activated receptor (PPAR)alpha/gamma agonist aleglitazar in attenuating TNF-alpha-mediated inflammation and insulin resistance in human adipocytes. Pharmacol. Res. 107 (2016), 125–136.
    • (2016) Pharmacol. Res. , vol.107 , pp. 125-136
    • Massaro, M.1
  • 46
    • 0032078238 scopus 로고    scopus 로고
    • Stress, adaptation, and disease. Allostasis and allostatic load
    • McEwen, B.S., Stress, adaptation, and disease. Allostasis and allostatic load. Ann. N. Y. Acad. Sci. 840 (1998), 33–44.
    • (1998) Ann. N. Y. Acad. Sci. , vol.840 , pp. 33-44
    • McEwen, B.S.1
  • 47
    • 0032518022 scopus 로고    scopus 로고
    • Protective and damaging effects of stress mediators
    • McEwen, B.S., Protective and damaging effects of stress mediators. N. Engl. J. Med. 338:3 (1998), 171–179.
    • (1998) N. Engl. J. Med. , vol.338 , Issue.3 , pp. 171-179
    • McEwen, B.S.1
  • 48
    • 0032912252 scopus 로고    scopus 로고
    • Stress and hippocampal plasticity
    • McEwen, B.S., Stress and hippocampal plasticity. Annu. Rev. Neurosci. 22:1 (1999), 105–122.
    • (1999) Annu. Rev. Neurosci. , vol.22 , Issue.1 , pp. 105-122
    • McEwen, B.S.1
  • 49
    • 33846234579 scopus 로고    scopus 로고
    • Protective and damaging effects of stress mediators: central role of the brain
    • McEwen, B.S., Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin. Neurosci. 8:4 (2006), 367–381.
    • (2006) Dialogues Clin. Neurosci. , vol.8 , Issue.4 , pp. 367-381
    • McEwen, B.S.1
  • 50
    • 34447629382 scopus 로고    scopus 로고
    • Physiology and neurobiology of stress and adaptation: central role of the brain
    • McEwen, B.S., Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol. Rev. 87:3 (2007), 873–904.
    • (2007) Physiol. Rev. , vol.87 , Issue.3 , pp. 873-904
    • McEwen, B.S.1
  • 51
    • 77957577240 scopus 로고    scopus 로고
    • Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
    • McEwen, B.S., Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling. Ann. N. Y. Acad. Sci. 1204 (2010), 38–59.
    • (2010) Ann. N. Y. Acad. Sci. , vol.1204 , pp. 38-59
    • McEwen, B.S.1
  • 52
    • 77957577240 scopus 로고    scopus 로고
    • Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
    • McEwen, B.S., Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling. Ann. N. Y. Acad. Sci. 1204 (2010), E38–E59.
    • (2010) Ann. N. Y. Acad. Sci. , vol.1204 , pp. E38-E59
    • McEwen, B.S.1
  • 53
    • 84921897479 scopus 로고    scopus 로고
    • Recognizing resilience: learning from the effects of stress on the brain
    • McEwen, B.S., Recognizing resilience: learning from the effects of stress on the brain. Neurobiol. Stress 1 (2015), 1–11.
    • (2015) Neurobiol. Stress , vol.1 , pp. 1-11
    • McEwen, B.S.1
  • 54
    • 85010276574 scopus 로고    scopus 로고
    • Stress-induced remodeling of hippocampal CA3 pyramidal neurons
    • McEwen, B.S., Stress-induced remodeling of hippocampal CA3 pyramidal neurons. Brain Res., 2015, 1–15.
    • (2015) Brain Res. , pp. 1-15
    • McEwen, B.S.1
  • 55
    • 84942411681 scopus 로고    scopus 로고
    • Mechanisms of stress in the brain
    • McEwen, B.S., et al. Mechanisms of stress in the brain. Nat. Neurosci. 18:10 (2015), 1353–1363.
    • (2015) Nat. Neurosci. , vol.18 , Issue.10 , pp. 1353-1363
    • McEwen, B.S.1
  • 56
    • 84942599558 scopus 로고    scopus 로고
    • 60 Years of neuroendocrinology: redefining neuroendocrinology: stress, sex and cognitive and emotional regulation
    • McEwen, B.S., Gray, J.D., Nasca, C., 60 Years of neuroendocrinology: redefining neuroendocrinology: stress, sex and cognitive and emotional regulation. J. Endocrinol. 226:2 (2015), T67–T83.
    • (2015) J. Endocrinol. , vol.226 , Issue.2 , pp. T67-T83
    • McEwen, B.S.1    Gray, J.D.2    Nasca, C.3
  • 58
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
    • Miller, A.H., Maletic, V., Raison, C.L., Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 65:9 (2009), 732–741.
    • (2009) Biol. Psychiatry , vol.65 , Issue.9 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 59
    • 84923026759 scopus 로고    scopus 로고
    • A translational worksite diabetes prevention trial improves psychosocial status, dietary intake, and step counts among employees with prediabetes: a randomized controlled trial
    • Miller, C.K., et al. A translational worksite diabetes prevention trial improves psychosocial status, dietary intake, and step counts among employees with prediabetes: a randomized controlled trial. Prev. Med. Rep. 2 (2015), 118–126.
    • (2015) Prev. Med. Rep. , vol.2 , pp. 118-126
    • Miller, C.K.1
  • 60
    • 84875278408 scopus 로고    scopus 로고
    • L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors
    • Nasca, C., et al. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. Proc. Natl. Acad. Sci. U. S. A. 110:12 (2013), 4804–4809.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , Issue.12 , pp. 4804-4809
    • Nasca, C.1
  • 61
    • 85031765586 scopus 로고    scopus 로고
    • Role of the astroglial glutamate exchanger xCT in ventral hippocampus in resilience to stress
    • e5
    • Nasca, C., et al. Role of the astroglial glutamate exchanger xCT in ventral hippocampus in resilience to stress. Neuron 96:2 (2017), 402–413 e5.
    • (2017) Neuron , vol.96 , Issue.2 , pp. 402-413
    • Nasca, C.1
  • 62
    • 85013235058 scopus 로고    scopus 로고
    • Klotho gene and selective serotonin reuptake inhibitors: response to treatment in late-life major depressive disorder
    • Paroni, G., et al. Klotho gene and selective serotonin reuptake inhibitors: response to treatment in late-life major depressive disorder. Mol. Neurobiol., 2016, 1–12.
    • (2016) Mol. Neurobiol. , pp. 1-12
    • Paroni, G.1
  • 63
    • 84924543911 scopus 로고    scopus 로고
    • Glutamatergic regulation prevents hippocampal-dependent age-related cognitive decline through dendritic spine clustering
    • Pereira, A.C., et al. Glutamatergic regulation prevents hippocampal-dependent age-related cognitive decline through dendritic spine clustering. Proc. Natl. Acad. Sci. U. S. A. 111:52 (2014), 18733–18738.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , Issue.52 , pp. 18733-18738
    • Pereira, A.C.1
  • 64
    • 84893859296 scopus 로고    scopus 로고
    • ROS and brain diseases: the good, the bad, and the ugly
    • Popa-Wagner, A., et al. ROS and brain diseases: the good, the bad, and the ugly. Oxid. Med. Cell Longev., 2013, 2013, 963520.
    • (2013) Oxid. Med. Cell Longev. , vol.2013 , pp. 963520
    • Popa-Wagner, A.1
  • 65
    • 84155160658 scopus 로고    scopus 로고
    • The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
    • Popoli, M., et al. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nat. Rev. Neurosci. 13:1 (2012), 22–37.
    • (2012) Nat. Rev. Neurosci. , vol.13 , Issue.1 , pp. 22-37
    • Popoli, M.1
  • 66
    • 84953347161 scopus 로고    scopus 로고
    • Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway
    • Quaresma, P.G., et al. Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway. Int. J. Obes. (Lond) 40:1 (2016), 138–146.
    • (2016) Int. J. Obes. (Lond) , vol.40 , Issue.1 , pp. 138-146
    • Quaresma, P.G.1
  • 67
    • 28444488872 scopus 로고    scopus 로고
    • Insulin resistance in depressive disorders and Alzheimer's disease: revisiting the missing link hypothesis
    • Rasgon, N.L., Kenna, H.A., Insulin resistance in depressive disorders and Alzheimer's disease: revisiting the missing link hypothesis. Neurobiol. Aging 26:Suppl. 1 (2005), 103–107.
    • (2005) Neurobiol. Aging , vol.26 , pp. 103-107
    • Rasgon, N.L.1    Kenna, H.A.2
  • 68
    • 84989907694 scopus 로고    scopus 로고
    • Insulin resistance-a missing link no more
    • Rasgon, N.L., McEwen, B.S., Insulin resistance-a missing link no more. Mol. Psychiatry 21:12 (2016), 1648–1652.
    • (2016) Mol. Psychiatry , vol.21 , Issue.12 , pp. 1648-1652
    • Rasgon, N.L.1    McEwen, B.S.2
  • 69
    • 47749101592 scopus 로고    scopus 로고
    • Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice
    • Rosa, A.O., et al. Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 32:6 (2008), 1549–1556.
    • (2008) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.32 , Issue.6 , pp. 1549-1556
    • Rosa, A.O.1
  • 70
    • 84890484314 scopus 로고    scopus 로고
    • Psychological well-being revisited: advances in the science and practice of eudaimonia
    • Ryff, C.D., Psychological well-being revisited: advances in the science and practice of eudaimonia. Psychother. Psychosom. 83:1 (2014), 10–28.
    • (2014) Psychother. Psychosom. , vol.83 , Issue.1 , pp. 10-28
    • Ryff, C.D.1
  • 71
    • 84866739930 scopus 로고    scopus 로고
    • NMDA receptor involvement in antidepressant-like effect of pioglitazone in the forced swimming test in mice
    • Salehi-Sadaghiani, M., et al. NMDA receptor involvement in antidepressant-like effect of pioglitazone in the forced swimming test in mice. Psychopharmacol. Berl. 223:3 (2012), 345–355.
    • (2012) Psychopharmacol. Berl. , vol.223 , Issue.3 , pp. 345-355
    • Salehi-Sadaghiani, M.1
  • 72
    • 84937469183 scopus 로고    scopus 로고
    • Carnitine acetyltransferase mitigates metabolic inertia and muscle fatigue during exercise
    • Seiler, S.E., et al. Carnitine acetyltransferase mitigates metabolic inertia and muscle fatigue during exercise. Cell Metab. 22:1 (2015), 65–76.
    • (2015) Cell Metab. , vol.22 , Issue.1 , pp. 65-76
    • Seiler, S.E.1
  • 73
    • 84863987293 scopus 로고    scopus 로고
    • Pioglitazone adjunctive therapy for moderate-to-severe major depressive disorder: randomized double-blind placebo-controlled trial
    • Sepanjnia, K., et al. Pioglitazone adjunctive therapy for moderate-to-severe major depressive disorder: randomized double-blind placebo-controlled trial. Neuropsychopharmacology 37:9 (2012), 2093–2100.
    • (2012) Neuropsychopharmacology , vol.37 , Issue.9 , pp. 2093-2100
    • Sepanjnia, K.1
  • 74
    • 66449097460 scopus 로고    scopus 로고
    • Neuroscience, molecular biology, and the childhood roots of health disparities
    • Shonkoff, J.P., Boyce, W.T., McEwen, B.S., Neuroscience, molecular biology, and the childhood roots of health disparities. JAMA 301 (2009), 2252–2259.
    • (2009) JAMA , vol.301 , pp. 2252-2259
    • Shonkoff, J.P.1    Boyce, W.T.2    McEwen, B.S.3
  • 75
    • 84891684837 scopus 로고    scopus 로고
    • High glucose represses beta-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor gamma signaling
    • So, W.Y., et al. High glucose represses beta-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor gamma signaling. Diabetes 62:11 (2013), 3751–3759.
    • (2013) Diabetes , vol.62 , Issue.11 , pp. 3751-3759
    • So, W.Y.1
  • 76
    • 84919389649 scopus 로고    scopus 로고
    • A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor
    • Szuhany, K.L., Bugatti, M., Otto, M.W., A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J. Psychiatric Res. 60:Suppl. C (2015), 56–64.
    • (2015) J. Psychiatric Res. , vol.60 , pp. 56-64
    • Szuhany, K.L.1    Bugatti, M.2    Otto, M.W.3
  • 77
    • 84935441397 scopus 로고    scopus 로고
    • Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection
    • Thouennon, E., et al. Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection. J. Neurochem. 134:3 (2015), 463–470.
    • (2015) J. Neurochem. , vol.134 , Issue.3 , pp. 463-470
    • Thouennon, E.1
  • 78
    • 84867136639 scopus 로고    scopus 로고
    • The fibroblast growth factor family: neuromodulation of affective behavior
    • Turner, C.A., Watson, S.J., Akil, H., The fibroblast growth factor family: neuromodulation of affective behavior. Neuron 76:1 (2012), 160–174.
    • (2012) Neuron , vol.76 , Issue.1 , pp. 160-174
    • Turner, C.A.1    Watson, S.J.2    Akil, H.3
  • 79
    • 0036432925 scopus 로고    scopus 로고
    • Adiponectin: a link between excess adiposity and associated comorbidities?
    • Ukkola, O., Santaniemi, M., Adiponectin: a link between excess adiposity and associated comorbidities?. J. Mol. Med. Berl. 80:11 (2002), 696–702.
    • (2002) J. Mol. Med. Berl. , vol.80 , Issue.11 , pp. 696-702
    • Ukkola, O.1    Santaniemi, M.2
  • 80
    • 82255169296 scopus 로고    scopus 로고
    • Determinants of increased cardiovascular disease in obesity and metabolic syndrome
    • Vazzana, N., et al. Determinants of increased cardiovascular disease in obesity and metabolic syndrome. Curr. Med. Chem. 18:34 (2011), 5267–5280.
    • (2011) Curr. Med. Chem. , vol.18 , Issue.34 , pp. 5267-5280
    • Vazzana, N.1
  • 81
    • 84905047389 scopus 로고    scopus 로고
    • Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study
    • Verhoeven, J.E., et al. Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study. Mol. Psychiatry 19:8 (2014), 895–901.
    • (2014) Mol. Psychiatry , vol.19 , Issue.8 , pp. 895-901
    • Verhoeven, J.E.1
  • 82
    • 84977554118 scopus 로고    scopus 로고
    • Association of a genetic risk score with body mass index across different birth cohorts
    • Walter, S., et al. Association of a genetic risk score with body mass index across different birth cohorts. JAMA 316:1 (2016), 63–69.
    • (2016) JAMA , vol.316 , Issue.1 , pp. 63-69
    • Walter, S.1
  • 83
    • 79952964129 scopus 로고    scopus 로고
    • Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress–preliminary findings
    • Wolkowitz, O.M., et al. Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress–preliminary findings. PLoS One, 6(3), 2011, e17837.
    • (2011) PLoS One , vol.6 , Issue.3 , pp. e17837
    • Wolkowitz, O.M.1
  • 84
    • 1842828544 scopus 로고    scopus 로고
    • Mental disorders affect one in four people, 2001
    • [cited 2017 15 Sept]; Available from
    • World Health Organization, Mental disorders affect one in four people, 2001. [cited 2017 15 Sept]; Available from: http://www.who.int/whr/2001/media_centre/press_release/en/, 2001.
    • (2001)
    • World Health Organization1
  • 85
    • 84918767065 scopus 로고    scopus 로고
    • Association between insulin resistance and cognition in patients with depressive disorders: exploratory analyses into age-specific effects
    • Wroolie, T.E., et al. Association between insulin resistance and cognition in patients with depressive disorders: exploratory analyses into age-specific effects. J. Psychiatr. Res. 60 (2015), 65–72.
    • (2015) J. Psychiatr. Res. , vol.60 , pp. 65-72
    • Wroolie, T.E.1
  • 86
    • 84924933470 scopus 로고    scopus 로고
    • Endocannabinoids in synaptic plasticity and neuroprotection
    • Xu, J.Y., Chen, C., Endocannabinoids in synaptic plasticity and neuroprotection. Neuroscientist 21:2 (2015), 152–168.
    • (2015) Neuroscientist , vol.21 , Issue.2 , pp. 152-168
    • Xu, J.Y.1    Chen, C.2
  • 87
    • 84863380672 scopus 로고    scopus 로고
    • Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants
    • Yu, H., et al. Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants. J. Neurosci. 32:12 (2012), 4092–4101.
    • (2012) J. Neurosci. , vol.32 , Issue.12 , pp. 4092-4101
    • Yu, H.1
  • 88
    • 84923687628 scopus 로고    scopus 로고
    • Pioglitazone adjunctive therapy for depressive episode of bipolar disorder: a randomized, double-blind, placebo-controlled trial
    • Zeinoddini, A., et al. Pioglitazone adjunctive therapy for depressive episode of bipolar disorder: a randomized, double-blind, placebo-controlled trial. Depress Anxiety 32:3 (2015), 167–173.
    • (2015) Depress Anxiety , vol.32 , Issue.3 , pp. 167-173
    • Zeinoddini, A.1
  • 89
    • 84930007555 scopus 로고    scopus 로고
    • Association of Klotho and interleukin 6 gene polymorphisms with aging in Han Chinese population
    • Zhang, W.G., et al. Association of Klotho and interleukin 6 gene polymorphisms with aging in Han Chinese population. J. Nutr. Health Aging 18:10 (2014), 900–904.
    • (2014) J. Nutr. Health Aging , vol.18 , Issue.10 , pp. 900-904
    • Zhang, W.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.