메뉴 건너뛰기




Volumn 12, Issue 8, 2016, Pages 441-451

The role of diet and exercise in the transgenerational epigenetic landscape of T2DM

Author keywords

[No Author keywords available]

Indexed keywords

DIET; EPIGENETICS; EXERCISE; HETEROZYGOSITY; HUMAN; INHERITANCE; LIFESTYLE; METABOLIC DISORDER; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; DNA METHYLATION; FEMALE; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE; MALE; PATHOPHYSIOLOGY; ROLE PLAYING;

EID: 84975127135     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2016.87     Document Type: Review
Times cited : (153)

References (112)
  • 1
    • 84978914053 scopus 로고    scopus 로고
    • World Health Organization
    • World Health Organization. Global report on diabetes. http://www.who.int/diabetes/global-report/en/(2006).
    • (2006) Global Report on Diabetes
  • 2
    • 33846049659 scopus 로고    scopus 로고
    • Insulin and insulin resistance
    • Wilcox, G. Insulin and insulin resistance. Clin. Biochem. Rev. 26, 19-39 (2005).
    • (2005) Clin. Biochem. Rev , vol.26 , pp. 19-39
    • Wilcox, G.1
  • 3
    • 13544253065 scopus 로고    scopus 로고
    • Metabolic Syndrome: A clinical and molecular perspective
    • Moller, D. E., Kaufman, K. D. Metabolic syndrome: a clinical and molecular perspective. Annu. Rev. Med. 56, 45-62 (2005).
    • (2005) Annu. Rev. Med , vol.56 , pp. 45-62
    • Moller, D.E.1    Kaufman, K.D.2
  • 4
    • 84876802154 scopus 로고    scopus 로고
    • Gene-environment and gene-treatment interactions in type 2 diabetes: Progress, pitfalls, and prospects
    • Franks, P. W., Pearson, E., Florez, J. C. Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects. Diabetes Care 36, 1413-1421 (2013).
    • (2013) Diabetes Care , vol.36 , pp. 1413-1421
    • Franks, P.W.1    Pearson, E.2    Florez, J.C.3
  • 5
    • 78649468820 scopus 로고    scopus 로고
    • The genetics of type 2 diabetes: What have we learned from GWAS?
    • Billings, L. K., Florez, J. C. The genetics of type 2 diabetes: what have we learned from GWAS? Ann. NY Acad. Sci. 1212, 59-77 (2010).
    • (2010) Ann. NY Acad. Sci , vol.1212 , pp. 59-77
    • Billings, L.K.1    Florez, J.C.2
  • 6
    • 84924545632 scopus 로고    scopus 로고
    • Rare and common genetic events in type 2 diabetes: What should biologists know?
    • Bonnefond, A., Froguel, P. Rare and common genetic events in type 2 diabetes: what should biologists know? Cell Metab. 21, 357-368 (2015).
    • (2015) Cell Metab , vol.21 , pp. 357-368
    • Bonnefond, A.1    Froguel, P.2
  • 7
    • 84925347828 scopus 로고    scopus 로고
    • Genetics of type 2 diabetes-pitfalls and possibilities
    • Prasad, R. B., Groop, L. Genetics of type 2 diabetes-pitfalls and possibilities. Genes (Basel) 6, 87-123 (2015).
    • (2015) Genes (Basel) , vol.6 , pp. 87-123
    • Prasad, R.B.1    Groop, L.2
  • 8
    • 84937500990 scopus 로고    scopus 로고
    • Genomic medicine at the heart of diabetes management
    • McCarthy, M. I. Genomic medicine at the heart of diabetes management. Diabetologia 58, 1725-1729 (2015).
    • (2015) Diabetologia , vol.58 , pp. 1725-1729
    • McCarthy, M.I.1
  • 9
    • 84888321284 scopus 로고    scopus 로고
    • Genetics of diabetes-are we missing the genes or the disease?
    • Groop, L., Pociot, F. Genetics of diabetes-are we missing the genes or the disease? Mol. Cell. Endocrinol. 382, 726-739 (2014).
    • (2014) Mol. Cell. Endocrinol , vol.382 , pp. 726-739
    • Groop, L.1    Pociot, F.2
  • 10
    • 84876784115 scopus 로고    scopus 로고
    • Epigenetic flexibility in metabolic regulation: Disease cause and prevention?
    • Kirchner, H., Osler, M. E., Krook, A., Zierath, J. R. Epigenetic flexibility in metabolic regulation: disease cause and prevention? Trends Cell Biol. 23, 203-209 (2013).
    • (2013) Trends Cell Biol , vol.23 , pp. 203-209
    • Kirchner, H.1    Osler, M.E.2    Krook, A.3    Zierath, J.R.4
  • 11
    • 73249133400 scopus 로고    scopus 로고
    • Epigenetics: A molecular link between environmental factors and type 2 diabetes
    • Ling, C., Groop, L. Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 58, 2718-2725 (2009).
    • (2009) Diabetes , vol.58 , pp. 2718-2725
    • Ling, C.1    Groop, L.2
  • 12
    • 84942813387 scopus 로고    scopus 로고
    • Developmental programming of type 2 diabetes: Early nutrition and epigenetic mechanisms
    • Ong, T. P., Ozanne, S. E. Developmental programming of type 2 diabetes: early nutrition and epigenetic mechanisms. Curr. Opin. Clin. Nutr. Metab. Care 18, 354-360 (2015).
    • (2015) Curr. Opin. Clin. Nutr. Metab. Care , vol.18 , pp. 354-360
    • Ong, T.P.1    Ozanne, S.E.2
  • 13
    • 84875638440 scopus 로고    scopus 로고
    • Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
    • Tracey, R., Manikkam, M., Guerrero-Bosagna, C., Skinner, M. K. Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. Reprod. Toxicol. 36, 104-116 (2013).
    • (2013) Reprod. Toxicol , vol.36 , pp. 104-116
    • Tracey, R.1    Manikkam, M.2    Guerrero-Bosagna, C.3    Skinner, M.K.4
  • 14
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird, A. Perceptions of epigenetics. Nature 447, 396-398 (2007).
    • (2007) Nature , vol.447 , pp. 396-398
    • Bird, A.1
  • 15
    • 79251504319 scopus 로고    scopus 로고
    • Epigenomics in cancer management
    • Costa, F. F. Epigenomics in cancer management. Cancer Manag. Res. 2, 255-265 (2010).
    • (2010) Cancer Manag. Res , vol.2 , pp. 255-265
    • Costa, F.F.1
  • 17
    • 31344434726 scopus 로고    scopus 로고
    • Sex-specific, male-line transgenerational responses in humans
    • Pembrey, M. E. et al. Sex-specific, male-line transgenerational responses in humans. Eur. J. Hum. Genet. 14, 159-166 (2006).
    • (2006) Eur. J. Hum. Genet , vol.14 , pp. 159-166
    • Pembrey, M.E.1
  • 18
    • 12344319192 scopus 로고    scopus 로고
    • Maternal protein restriction leads to hyperinsulinemia and reduced insulin-signaling protein expression in 21-mo-old female rat offspring
    • Fernandez-Twinn, D. S. et al. Maternal protein restriction leads to hyperinsulinemia and reduced insulin-signaling protein expression in 21-mo-old female rat offspring. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R368-R373 (2005).
    • (2005) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.288 , pp. R368-R373
    • Fernandez-Twinn, D.S.1
  • 19
    • 0026772772 scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis
    • Hales, C. N., Barker, D. J. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35, 595-601 (1992).
    • (1992) Diabetologia , vol.35 , pp. 595-601
    • Hales, C.N.1    Barker, D.J.2
  • 20
    • 84886443077 scopus 로고    scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis 1992
    • Hales, C. N., Barker, D. J. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. 1992. Int. J. Epidemiol. 42, 1215-1222 (2013).
    • (2013) Int. J. Epidemiol , vol.42 , pp. 1215-1222
    • Hales, C.N.1    Barker, D.J.2
  • 21
    • 80053099289 scopus 로고    scopus 로고
    • Maternal diet, aging and diabetes meet at a chromatin loop
    • (Albany NY)
    • Ozanne, S. E., Sandovici, I., Constancia, M. Maternal diet, aging and diabetes meet at a chromatin loop. Aging (Albany NY) 3, 548-554 (2011).
    • (2011) Aging , vol.3 , pp. 548-554
    • Ozanne, S.E.1    Sandovici, I.2    Constancia, M.3
  • 23
    • 79955096234 scopus 로고    scopus 로고
    • Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets
    • Sandovici, I. et al. Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc. Natl Acad. Sci. USA 108, 5449-5454 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 5449-5454
    • Sandovici, I.1
  • 24
    • 0026316923 scopus 로고
    • Islet function in offspring of mothers on low-protein diet during gestation
    • Dahri, S., Snoeck, A., Reusens-Billen, B., Remacle, C., Hoet, J. J. Islet function in offspring of mothers on low-protein diet during gestation. Diabetes 40 (Suppl. 2), 115-120 (1991).
    • (1991) Diabetes , vol.40 , pp. 115-120
    • Dahri, S.1    Snoeck, A.2    Reusens-Billen, B.3    Remacle, C.4    Hoet, J.J.5
  • 25
    • 0032539468 scopus 로고    scopus 로고
    • Glucose tolerance in adults after prenatal exposure to famine
    • Ravelli, A. C. et al. Glucose tolerance in adults after prenatal exposure to famine. Lancet 351, 173-177 (1998).
    • (1998) Lancet , vol.351 , pp. 173-177
    • Ravelli, A.C.1
  • 26
    • 37049020951 scopus 로고    scopus 로고
    • Cohort profile: The Dutch Hunger Winter families study
    • Lumey, L. H. et al. Cohort profile: the Dutch Hunger Winter families study. Int. J. Epidemiol. 36, 1196-1204 (2007).
    • (2007) Int. J. Epidemiol , vol.36 , pp. 1196-1204
    • Lumey, L.H.1
  • 27
    • 77957591910 scopus 로고    scopus 로고
    • Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood
    • Li, Y. et al. Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood. Diabetes 59, 2400-2406 (2010).
    • (2010) Diabetes , vol.59 , pp. 2400-2406
    • Li, Y.1
  • 28
    • 84941804501 scopus 로고    scopus 로고
    • Association between type 2 diabetes and prenatal exposure to the Ukraine famine of 1932-33 A retrospective cohort study
    • Lumey, L. H., Khalangot, M. D., Vaiserman, A. M. Association between type 2 diabetes and prenatal exposure to the Ukraine famine of 1932-33: a retrospective cohort study. Lancet Diabetes Endocrinol. 3, 787-794 (2015).
    • (2015) Lancet Diabetes Endocrinol , vol.3 , pp. 787-794
    • Lumey, L.H.1    Khalangot, M.D.2    Vaiserman, A.M.3
  • 29
    • 84875269038 scopus 로고    scopus 로고
    • Quantification of excess risk for diabetes for those born in times of hunger, in an entire population of a nation, across a century
    • Thurner, S. et al. Quantification of excess risk for diabetes for those born in times of hunger, in an entire population of a nation, across a century. Proc. Natl Acad. Sci. USA 110, 4703-4707 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 4703-4707
    • Thurner, S.1
  • 30
    • 0036862451 scopus 로고    scopus 로고
    • Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period
    • Kaati, G., Bygren, L. O., Edvinsson, S. Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period. Eur. J. Hum. Genet. 10, 682-688 (2002).
    • (2002) Eur. J. Hum. Genet , vol.10 , pp. 682-688
    • Kaati, G.1    Bygren, L.O.2    Edvinsson, S.3
  • 31
    • 84885015451 scopus 로고    scopus 로고
    • Early-life lead exposure results in dose-and sex-specific effects on weight and epigenetic gene regulation in weanling mice
    • Faulk, C., Barks, A., Liu, K., Goodrich, J. M., Dolinoy, D. C. Early-life lead exposure results in dose-and sex-specific effects on weight and epigenetic gene regulation in weanling mice. Epigenomics 5, 487-500 (2013).
    • (2013) Epigenomics , vol.5 , pp. 487-500
    • Faulk, C.1    Barks, A.2    Liu, K.3    Goodrich, J.M.4    Dolinoy, D.C.5
  • 32
    • 84959083268 scopus 로고    scopus 로고
    • High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring
    • de Castro Barbosa, T. et al. High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Mol. Metab. 5, 184-197 (2016).
    • (2016) Mol. Metab , vol.5 , pp. 184-197
    • De Castro Barbosa, T.1
  • 33
    • 77958596171 scopus 로고    scopus 로고
    • Chronic high-fat diet in fathers programs ?-cell dysfunction in female rat offspring
    • Ng, S. F. et al. Chronic high-fat diet in fathers programs ?-cell dysfunction in female rat offspring. Nature 467, 963-966 (2010).
    • (2010) Nature , vol.467 , pp. 963-966
    • Ng, S.F.1
  • 34
    • 0021249781 scopus 로고
    • Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers
    • Warram, J. H., Krolewski, A. S., Gottlieb, M. S., Kahn, C. R. Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N. Engl. J. Med. 311, 149-152 (1984).
    • (1984) N. Engl. J. Med , vol.311 , pp. 149-152
    • Warram, J.H.1    Krolewski, A.S.2    Gottlieb, M.S.3    Kahn, C.R.4
  • 35
    • 84875177348 scopus 로고    scopus 로고
    • X-Inactivation Imprinting, and long noncoding RNAs in health and disease
    • Lee, J. T., Bartolomei, M. S. X-inactivation, imprinting, and long noncoding RNAs in health and disease. Cell 152, 1308-1323 (2013).
    • (2013) Cell , vol.152 , pp. 1308-1323
    • Lee, J.T.1    Bartolomei, M.S.2
  • 36
    • 3342989681 scopus 로고    scopus 로고
    • Epigenetic programming by maternal behavior
    • Weaver, I. C. et al. Epigenetic programming by maternal behavior. Nat. Neurosci. 7, 847-854 (2004).
    • (2004) Nat. Neurosci , vol.7 , pp. 847-854
    • Weaver, I.C.1
  • 37
    • 12344333357 scopus 로고    scopus 로고
    • Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats
    • Drake, A. J. et al. Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats. Endocrinology 146, 913-919 (2005).
    • (2005) Endocrinology , vol.146 , pp. 913-919
    • Drake, A.J.1
  • 38
    • 84938741329 scopus 로고    scopus 로고
    • Multigenerational undernutrition increases susceptibility to obesity and diabetes that is not reversed after dietary recuperation
    • Hardikar, A. A. et al. Multigenerational undernutrition increases susceptibility to obesity and diabetes that is not reversed after dietary recuperation. Cell Metab. 22, 312-319 (2015).
    • (2015) Cell Metab , vol.22 , pp. 312-319
    • Hardikar, A.A.1
  • 39
    • 70350313230 scopus 로고    scopus 로고
    • Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice
    • Dunn, G. A., Bale, T. L. Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology 150, 4999-5009 (2009).
    • (2009) Endocrinology , vol.150 , pp. 4999-5009
    • Dunn, G.A.1    Bale, T.L.2
  • 40
    • 84900560787 scopus 로고    scopus 로고
    • Maternal high-fat diet induces insulin resistance and deterioration of pancreatic ?-cell function in adult offspring with sex differences in mice
    • Yokomizo, H. et al. Maternal high-fat diet induces insulin resistance and deterioration of pancreatic ?-cell function in adult offspring with sex differences in mice. Am. J. Physiol. Endocrinol. Metab. 306, E1163-E1175 (2014).
    • (2014) Am. J. Physiol. Endocrinol. Metab , vol.306 , pp. E1163-E1175
    • Yokomizo, H.1
  • 41
    • 84893470415 scopus 로고    scopus 로고
    • Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals
    • Wei, Y. et al. Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals. Proc. Natl Acad. Sci. USA 111, 1873-1878 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 1873-1878
    • Wei, Y.1
  • 42
    • 84885151895 scopus 로고    scopus 로고
    • Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content
    • Fullston, T. et al. Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB J. 27, 4226-4243 (2013).
    • (2013) FASEB J , vol.27 , pp. 4226-4243
    • Fullston, T.1
  • 43
    • 84883872095 scopus 로고    scopus 로고
    • Evidence for transgenerational metabolic programming in Drosophila
    • Buescher, J. L. et al. Evidence for transgenerational metabolic programming in Drosophila. Dis. Model. Mech. 6, 1123-1132 (2013).
    • (2013) Dis. Model. Mech , vol.6 , pp. 1123-1132
    • Buescher, J.L.1
  • 44
    • 78650446334 scopus 로고    scopus 로고
    • Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals
    • Carone, B. R. et al. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 143, 1084-1096 (2010).
    • (2010) Cell , vol.143 , pp. 1084-1096
    • Carone, B.R.1
  • 45
    • 84906088773 scopus 로고    scopus 로고
    • In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism
    • Radford, E. J. et al. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. Science 345, 1255903 (2014).
    • (2014) Science , vol.345 , pp. 1255903
    • Radford, E.J.1
  • 46
    • 84887980478 scopus 로고    scopus 로고
    • Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity
    • Skinner, M. K. et al. Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity. BMC Med. 11, 228 (2013).
    • (2013) BMC Med , vol.11 , pp. 228
    • Skinner, M.K.1
  • 47
    • 0023503627 scopus 로고
    • Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse
    • Sanford, J. P., Clark, H. J., Chapman, V. M., Rossant, J. Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. Genes Dev. 1, 1039-1046 (1987).
    • (1987) Genes Dev , vol.1 , pp. 1039-1046
    • Sanford, J.P.1    Clark, H.J.2    Chapman, V.M.3    Rossant, J.4
  • 48
    • 84946201119 scopus 로고    scopus 로고
    • Transgenerational developmental programming of ovarian reserve
    • Aiken, C. E., Tarry-Adkins, J. L., Ozanne, S. E. Transgenerational developmental programming of ovarian reserve. Sci. Rep. 5, 16175 (2015).
    • (2015) Sci. Rep , vol.5 , pp. 16175
    • Aiken, C.E.1    Tarry-Adkins, J.L.2    Ozanne, S.E.3
  • 49
    • 84954553347 scopus 로고    scopus 로고
    • Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression
    • Terashima, M. et al. Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression. Epigenetics 10, 861-871 (2015).
    • (2015) Epigenetics , vol.10 , pp. 861-871
    • Terashima, M.1
  • 50
    • 84873378527 scopus 로고    scopus 로고
    • Exercise metabolism and the molecular regulation of skeletal muscle adaptation
    • Egan, B., Zierath, J. R. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 17, 162-184 (2013).
    • (2013) Cell Metab , vol.17 , pp. 162-184
    • Egan, B.1    Zierath, J.R.2
  • 52
    • 33646534840 scopus 로고    scopus 로고
    • Impact of physical activity during pregnancy and postpartum on chronic disease risk
    • [No authors listed.]
    • [No authors listed.] Impact of physical activity during pregnancy and postpartum on chronic disease risk. Med. Sci. Sports Exerc. 38, 989-1006 (2006).
    • (2006) Med. Sci. Sports Exerc , vol.38 , pp. 989-1006
  • 53
    • 84925293507 scopus 로고    scopus 로고
    • Maternal lifestyle characteristics during pregnancy, and the risk of obesity in the offspring: A study of 5,125 children
    • Mourtakos, S. P. et al. Maternal lifestyle characteristics during pregnancy, and the risk of obesity in the offspring: a study of 5,125 children. BMC Pregnancy Childbirth 15, 66 (2015).
    • (2015) BMC Pregnancy Childbirth , vol.15 , Issue.66
    • Mourtakos, S.P.1
  • 54
    • 84899128768 scopus 로고    scopus 로고
    • Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1? Gene and age-dependent metabolic dysfunction in the offspring
    • Laker, R. C. et al. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1? gene and age-dependent metabolic dysfunction in the offspring. Diabetes 63, 1605-1611 (2014).
    • (2014) Diabetes , vol.63 , pp. 1605-1611
    • Laker, R.C.1
  • 55
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin, J., Handschin, C., Spiegelman, B. M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1, 361-370 (2005).
    • (2005) Cell Metab , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 56
    • 84921923804 scopus 로고    scopus 로고
    • Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring
    • Stanford, K. I. et al. Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring. Diabetes 64, 427-433 (2015).
    • (2015) Diabetes , vol.64 , pp. 427-433
    • Stanford, K.I.1
  • 57
    • 84953302262 scopus 로고    scopus 로고
    • Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis
    • Sheldon, R. D. et al. Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis. J. Hepatol. 64, 171-178 (2016).
    • (2016) J. Hepatol , vol.64 , pp. 171-178
    • Sheldon, R.D.1
  • 58
    • 84958818105 scopus 로고    scopus 로고
    • Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice
    • Murashov, A. K. et al. Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice. FASEB J. 30, 775-784 (2016).
    • (2016) FASEB J , vol.30 , pp. 775-784
    • Murashov, A.K.1
  • 59
    • 84876697145 scopus 로고    scopus 로고
    • Maternal exercise improves insulin sensitivity in mature rat offspring
    • Carter, L. G., Qi, N. R., De Cabo, R., Pearson, K. J. Maternal exercise improves insulin sensitivity in mature rat offspring. Med. Sci. Sports Exerc. 45, 832-840 (2013).
    • (2013) Med. Sci. Sports Exerc , vol.45 , pp. 832-840
    • Carter, L.G.1    Qi, N.R.2    De Cabo, R.3    Pearson, K.J.4
  • 60
    • 84884713635 scopus 로고    scopus 로고
    • Sex-specific effects of exercise ancestry on metabolic, morphological and gene expression phenotypes in multiple generations of mouse offspring
    • Guth, L. M. et al. Sex-specific effects of exercise ancestry on metabolic, morphological and gene expression phenotypes in multiple generations of mouse offspring. Exp. Physiol. 98, 1469-1484 (2013).
    • (2013) Exp. Physiol , vol.98 , pp. 1469-1484
    • Guth, L.M.1
  • 61
    • 84929664500 scopus 로고    scopus 로고
    • Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring
    • McPherson, N. O., Owens, J. A., Fullston, T., Lane, M. Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring. Am. J. Physiol. Endocrinol. Metab. 308, E805-E821 (2015).
    • (2015) Am. J. Physiol. Endocrinol. Metab , vol.308 , pp. E805-E821
    • McPherson, N.O.1    Owens, J.A.2    Fullston, T.3    Lane, M.4
  • 62
    • 84937424748 scopus 로고    scopus 로고
    • Looking ahead perspective: Where will the future of exercise biology take us?
    • Zierath, J. R., Wallberg-Henriksson, H. Looking ahead perspective: where will the future of exercise biology take us? Cell Metab. 22, 25-30 (2015).
    • (2015) Cell Metab , vol.22 , pp. 25-30
    • Zierath, J.R.1    Wallberg-Henriksson, H.2
  • 63
    • 84957964025 scopus 로고    scopus 로고
    • Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans
    • Donkin, I. et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab. 23, 369-378 (2016).
    • (2016) Cell Metab , vol.23 , pp. 369-378
    • Donkin, I.1
  • 64
    • 84944441029 scopus 로고    scopus 로고
    • Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans
    • Denham, J., O'Brien, B. J., Harvey, J. T., Charchar, F. J. Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans. Epigenomics 7, 1-15 (2015).
    • (2015) Epigenomics , vol.7 , pp. 1-15
    • Denham, J.1    O'Brien, B.J.2    Harvey, J.T.3    Charchar, F.J.4
  • 65
    • 84955611443 scopus 로고    scopus 로고
    • Trim28 haploinsufficiency triggers bi-stable epigenetic obesity
    • Dalgaard, K. et al. Trim28 haploinsufficiency triggers bi-stable epigenetic obesity. Cell 164, 353-364 (2016).
    • (2016) Cell , vol.164 , pp. 353-364
    • Dalgaard, K.1
  • 66
    • 34547856692 scopus 로고    scopus 로고
    • Twins in metabolic and diabetes research: What do they tell us?
    • Vaag, A., Poulsen, P. Twins in metabolic and diabetes research: what do they tell us? Curr. Opin. Clin. Nutr. Metab. Care 10, 591-596 (2007).
    • (2007) Curr. Opin. Clin. Nutr. Metab. Care , vol.10 , pp. 591-596
    • Vaag, A.1    Poulsen, P.2
  • 67
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga, M. F. et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA 102, 10604-10609 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 10604-10609
    • Fraga, M.F.1
  • 68
    • 23044446596 scopus 로고    scopus 로고
    • Epigenetic drift in aging identical twins
    • Martin, G. M. Epigenetic drift in aging identical twins. Proc. Natl Acad. Sci. USA 102, 10413-10414 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 10413-10414
    • Martin, G.M.1
  • 69
    • 84983084981 scopus 로고    scopus 로고
    • Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat
    • Ollikainen, M. et al. Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat. Clin. Epigenetics 7, 39 (2015).
    • (2015) Clin. Epigenetics , vol.7 , pp. 39
    • Ollikainen, M.1
  • 70
    • 84863053794 scopus 로고    scopus 로고
    • Global DNA methylation is associated with insulin resistance: A monozygotic twin study
    • Zhao, J., Goldberg, J., Bremner, J. D., Vaccarino, V. Global DNA methylation is associated with insulin resistance: a monozygotic twin study. Diabetes 61, 542-546 (2012).
    • (2012) Diabetes , vol.61 , pp. 542-546
    • Zhao, J.1    Goldberg, J.2    Bremner, J.D.3    Vaccarino, V.4
  • 71
    • 84923339459 scopus 로고    scopus 로고
    • An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins
    • Yuan, W. et al. An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nat. Commun. 5, 5719 (2014).
    • (2014) Nat. Commun , vol.5 , pp. 5719
    • Yuan, W.1
  • 72
    • 84870923467 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes
    • Ribel-Madsen, R. et al. Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. PLoS ONE 7, e51302 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e51302
    • Ribel-Madsen, R.1
  • 73
    • 84906707442 scopus 로고    scopus 로고
    • Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes
    • Nilsson, E. et al. Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes 63, 2962-2976 (2014).
    • (2014) Diabetes , vol.63 , pp. 2962-2976
    • Nilsson, E.1
  • 74
    • 84955268594 scopus 로고    scopus 로고
    • DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs
    • Pietilainen, K. H. et al. DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs. Int. J. Obes. (Lond.) 40, 654-661 (2016).
    • (2016) Int. J. Obes. (Lond.) , vol.40 , pp. 654-661
    • Pietilainen, K.H.1
  • 75
    • 84897452599 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion
    • Dayeh, T. et al. Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet. 10, e1004160 (2014).
    • (2014) PLoS Genet , vol.10 , pp. e1004160
    • Dayeh, T.1
  • 76
    • 84858800629 scopus 로고    scopus 로고
    • DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
    • Volkmar, M. et al. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J. 31, 1405-1426 (2012).
    • (2012) EMBO J , vol.31 , pp. 1405-1426
    • Volkmar, M.1
  • 77
    • 84863334811 scopus 로고    scopus 로고
    • Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes
    • Yang, B. T. et al. Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes. Mol. Endocrinol. 26, 1203-1212 (2012).
    • (2012) Mol. Endocrinol , vol.26 , pp. 1203-1212
    • Yang, B.T.1
  • 78
    • 78049446282 scopus 로고    scopus 로고
    • Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
    • Stitzel, M. L. et al. Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab. 12, 443-455 (2010).
    • (2010) Cell Metab , vol.12 , pp. 443-455
    • Stitzel, M.L.1
  • 79
    • 69149087790 scopus 로고    scopus 로고
    • Non-CpG methylation of the PGC-1? Promoter through DNMT3B controls mitochondrial density
    • Barres, R. et al. Non-CpG methylation of the PGC-1? promoter through DNMT3B controls mitochondrial density. Cell Metab. 10, 189-198 (2009).
    • (2009) Cell Metab , vol.10 , pp. 189-198
    • Barres, R.1
  • 80
    • 84856093324 scopus 로고    scopus 로고
    • Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus
    • Kulkarni, S. S. et al. Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus. Metabolism 61, 175-185 (2012).
    • (2012) Metabolism , vol.61 , pp. 175-185
    • Kulkarni, S.S.1
  • 81
    • 84876979205 scopus 로고    scopus 로고
    • Weight loss after gastric bypass surgery in human obesity remodels promoter methylation
    • Barres, R. et al. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 3, 1020-1027 (2013).
    • (2013) Cell Rep , vol.3 , pp. 1020-1027
    • Barres, R.1
  • 82
    • 84920569023 scopus 로고    scopus 로고
    • Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes
    • Multhaup, M. L. et al. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab. 21, 138-149 (2015).
    • (2015) Cell Metab , vol.21 , pp. 138-149
    • Multhaup, M.L.1
  • 83
    • 84958673442 scopus 로고    scopus 로고
    • Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels
    • Nilsson, E. et al. Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels. J. Clin. Endocrinol. Metab. 100, E1491-E1501 (2015).
    • (2015) J. Clin. Endocrinol. Metab , vol.100 , pp. E1491-E1501
    • Nilsson, E.1
  • 84
    • 84959127723 scopus 로고    scopus 로고
    • Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients
    • Kirchner, H. et al. Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients. Mol. Metab. 5, 171-183 (2016).
    • (2016) Mol. Metab , vol.5 , pp. 171-183
    • Kirchner, H.1
  • 85
    • 84877342168 scopus 로고    scopus 로고
    • A genome-wide methylation study on obesity: Differential variability and differential methylation
    • Xu, X. et al. A genome-wide methylation study on obesity: differential variability and differential methylation. Epigenetics 8, 522-533 (2013).
    • (2013) Epigenetics , vol.8 , pp. 522-533
    • Xu, X.1
  • 86
    • 84943792919 scopus 로고    scopus 로고
    • Adiposity is associated with DNA methylation profile in adipose tissue
    • Agha, G. et al. Adiposity is associated with DNA methylation profile in adipose tissue. Int. J. Epidemiol. 44, 1277-1287 (2015).
    • (2015) Int. J. Epidemiol , vol.44 , pp. 1277-1287
    • Agha, G.1
  • 87
    • 84900826502 scopus 로고    scopus 로고
    • Differential methylation in visceral adipose tissue of obese men discordant for metabolic disturbances
    • Guenard, F. et al. Differential methylation in visceral adipose tissue of obese men discordant for metabolic disturbances. Physiol. Genomics 46, 216-222 (2014).
    • (2014) Physiol. Genomics , vol.46 , pp. 216-222
    • Guenard, F.1
  • 88
    • 84919932178 scopus 로고    scopus 로고
    • Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis
    • Keller, M. et al. Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis. Diabetologia 57, 2374-2383 (2014).
    • (2014) Diabetologia , vol.57 , pp. 2374-2383
    • Keller, M.1
  • 89
    • 84908441328 scopus 로고    scopus 로고
    • Obesity accelerates epigenetic aging of human liver
    • Horvath, S. et al. Obesity accelerates epigenetic aging of human liver. Proc. Natl Acad. Sci. USA 111, 15538-15543 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 15538-15543
    • Horvath, S.1
  • 90
    • 53349101264 scopus 로고    scopus 로고
    • Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
    • El-Osta, A. et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J. Exp. Med. 205, 2409-2417 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 2409-2417
    • El-Osta, A.1
  • 91
    • 84902987423 scopus 로고    scopus 로고
    • Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets
    • Hall, E. et al. Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets. BMC Med. 12, 103 (2014).
    • (2014) BMC Med , vol.12 , pp. 103
    • Hall, E.1
  • 92
    • 84922714378 scopus 로고    scopus 로고
    • Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity
    • Ishikawa, K. et al. Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. PLoS ONE 10, e0115350 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0115350
    • Ishikawa, K.1
  • 93
    • 80053559849 scopus 로고    scopus 로고
    • Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
    • Pirola, L. et al. Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells. Genome Res. 21, 1601-1615 (2011).
    • (2011) Genome Res , vol.21 , pp. 1601-1615
    • Pirola, L.1
  • 94
    • 84868211134 scopus 로고    scopus 로고
    • Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men
    • Jacobsen, S. C. et al. Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men. Diabetologia 55, 3341-3349 (2012).
    • (2012) Diabetologia , vol.55 , pp. 3341-3349
    • Jacobsen, S.C.1
  • 95
    • 84930764622 scopus 로고    scopus 로고
    • The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
    • Dahlman, I. et al. The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes. Int. J. Obes. (Lond.) 39, 910-919 (2015).
    • (2015) Int. J. Obes. (Lond.) , vol.39 , pp. 910-919
    • Dahlman, I.1
  • 96
    • 84858055958 scopus 로고    scopus 로고
    • Acute exercise remodels promoter methylation in human skeletal muscle
    • Barres, R. et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 15, 405-411 (2012).
    • (2012) Cell Metab , vol.15 , pp. 405-411
    • Barres, R.1
  • 97
    • 12244267094 scopus 로고    scopus 로고
    • Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise
    • Yu, M. et al. Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. J. Physiol. 546, 327-335 (2003).
    • (2003) J. Physiol , vol.546 , pp. 327-335
    • Yu, M.1
  • 98
    • 2342599054 scopus 로고    scopus 로고
    • Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle
    • McGee, S. L., Hargreaves, M. Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle. Diabetes 53, 1208-1214 (2004).
    • (2004) Diabetes , vol.53 , pp. 1208-1214
    • McGee, S.L.1    Hargreaves, M.2
  • 99
    • 72549083582 scopus 로고    scopus 로고
    • Exercise-induced histone modifications in human skeletal muscle
    • McGee, S. L., Fairlie, E., Garnham, A. P., Hargreaves, M. Exercise-induced histone modifications in human skeletal muscle. J. Physiol. 587, 5951-5958 (2009).
    • (2009) J. Physiol , vol.587 , pp. 5951-5958
    • McGee, S.L.1    Fairlie, E.2    Garnham, A.P.3    Hargreaves, M.4
  • 100
    • 84870319843 scopus 로고    scopus 로고
    • Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes
    • Nitert, M. D. et al. Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes 61, 3322-3332 (2012).
    • (2012) Diabetes , vol.61 , pp. 3322-3332
    • Nitert, M.D.1
  • 101
    • 84907970598 scopus 로고    scopus 로고
    • Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in type 2 diabetic obesity
    • Rowlands, D. S. et al. Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in type 2 diabetic obesity. Physiol. Genomics 46, 747-765 (2014).
    • (2014) Physiol. Genomics , vol.46 , pp. 747-765
    • Rowlands, D.S.1
  • 102
    • 40449098009 scopus 로고    scopus 로고
    • Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism
    • Mukwevho, E. et al. Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism. Am. J. Physiol. Endocrinol. Metab. 294, E582-E588 (2008).
    • (2008) Am. J. Physiol. Endocrinol. Metab , vol.294 , pp. E582-E588
    • Mukwevho, E.1
  • 103
    • 84879678934 scopus 로고    scopus 로고
    • A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
    • Ronn, T. et al. A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet. 9, e1003572 (2013).
    • (2013) PLoS Genet , vol.9 , pp. e1003572
    • Ronn, T.1
  • 104
    • 77949857315 scopus 로고    scopus 로고
    • The microRNA miR-696 regulates PGC-1 in mouse skeletal muscle in response to physical activity
    • Aoi, W. et al. The microRNA miR-696 regulates PGC-1? in mouse skeletal muscle in response to physical activity. Am. J. Physiol. Endocrinol. Metab. 298, E799-E806 (2010).
    • (2010) Am. J. Physiol. Endocrinol. Metab , vol.298 , pp. E799-E806
    • Aoi, W.1
  • 105
    • 77958199189 scopus 로고    scopus 로고
    • Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle
    • Nielsen, S. et al. Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle. J. Physiol. 588, 4029-4037 (2010).
    • (2010) J. Physiol , vol.588 , pp. 4029-4037
    • Nielsen, S.1
  • 106
    • 84884286848 scopus 로고    scopus 로고
    • Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training
    • Russell, A. P. et al. Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. J. Physiol. 591, 4637-4653 (2013).
    • (2013) J. Physiol , vol.591 , pp. 4637-4653
    • Russell, A.P.1
  • 107
    • 84878628395 scopus 로고    scopus 로고
    • Dynamically regulated miRNA-mRNA networks revealed by exercise
    • Tonevitsky, A. G. et al. Dynamically regulated miRNA-mRNA networks revealed by exercise. BMC Physiol. 13, 9 (2013).
    • (2013) BMC Physiol , vol.13 , pp. 9
    • Tonevitsky, A.G.1
  • 108
    • 84937893652 scopus 로고    scopus 로고
    • Circulating inflammatory miRNA signature in response to different doses of aerobic exercise
    • de Gonzalo-Calvo, D. et al. Circulating inflammatory miRNA signature in response to different doses of aerobic exercise. J. Appl. Physiol. (1985) 119, 124-134 (2015).
    • (2015) J. Appl. Physiol. 1985 , vol.119 , pp. 124-134
    • De Gonzalo-Calvo, D.1
  • 109
    • 84924995986 scopus 로고    scopus 로고
    • Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention
    • Parrizas, M. et al. Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention. J. Clin. Endocrinol. Metab. 100, E407-E415 (2015).
    • (2015) J. Clin. Endocrinol. Metab , vol.100 , pp. E407-E415
    • Parrizas, M.1
  • 110
    • 84928248368 scopus 로고    scopus 로고
    • Plasma microRNA levels differ between endurance and strength athletes
    • Wardle, S. L. et al. Plasma microRNA levels differ between endurance and strength athletes. PLoS ONE 10, e0122107 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0122107
    • Wardle, S.L.1
  • 111
    • 0034597816 scopus 로고    scopus 로고
    • Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
    • McKinsey, T. A., Zhang, C. L., Lu, J., Olson, E. N. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408, 106-111 (2000).
    • (2000) Nature , vol.408 , pp. 106-111
    • McKinsey, T.A.1    Zhang, C.L.2    Lu, J.3    Olson, E.N.4
  • 112
    • 53149104368 scopus 로고    scopus 로고
    • CaMK activation during exercise is required for histone hyperacetylation and MEF2A binding at the MEF2 site on the Glut4 gene
    • Smith, J. A., Kohn, T. A., Chetty, A. K., Ojuka, E. O. CaMK activation during exercise is required for histone hyperacetylation and MEF2A binding at the MEF2 site on the Glut4 gene. Am. J. Physiol. Endocrinol. Metab. 295, E698-E704 (2008).
    • (2008) Am. J. Physiol. Endocrinol. Metab , vol.295 , pp. E698-E704
    • Smith, J.A.1    Kohn, T.A.2    Chetty, A.K.3    Ojuka, E.O.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.