HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency

Blood

Volumn 131, Issue 4, 2018, Pages 450-461

  Zhang, Shuping ^a   Macias Garcia, Alejandra ^a   Velazquez, Jason ^a   Paltrinieri, Elena ^a   Kaufman, Randal J ^b   Chen, Jane Jane ^a  

^a Massachusetts Institute of Technology   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; HEME; HEME REGULATED EIF2ALPHA KINASE; HEMOGLOBIN; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 2ALPHA P; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; UNCLASSIFIED DRUG; ATF4 PROTEIN, MOUSE; EIF2ALPHA KINASE, MOUSE; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ARTICLE; ERYTHROCYTE COUNT; ERYTHROID CELL; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; FEMALE; HEMOGLOBIN BLOOD LEVEL; IN VIVO STUDY; IRON DEFICIENCY; IRON INTAKE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SPLENOMEGALY; TRANSLATION REGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; IRON DEFICIENCY ANEMIA; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANEMIA, IRON-DEFICIENCY; ANIMALS; CELLS, CULTURED; ERYTHROPOIESIS; FEMALE; MALE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 85041093175     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2017-08-799908     Document Type: Article

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