In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats

Journal of Biological Chemistry

Volumn 290, Issue 4, 2015, Pages 2244-2250

  Morrow, Gregory P ^a   MacMillan, Luke ^a   Lamarre, Simon G ^b   Young, Sara K ^a   MacFarlane, Amanda J ^c   Brosnan, Margaret E ^a   Brosnan, John T ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b UNIVERSITÉ DE MONCTON   (Canada)

^c HEALTH CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CARBON; FORMALDEHYDE; MITOCHONDRIA; NUTRITION; RATS;

AMINO ACID OXIDATIONS; DIMETHYLGLYCINE; FORMALDEHYDE DEHYDROGENASE; HIGH PROTEIN DIET; MITOCHONDRIAL PRODUCTION; RAT LIVER MITOCHONDRIA; STEADY STATE; TETRAHYDROFOLATES;

SUBSTRATES;

CHOLINE; DIMETHYLGLYCINE; DIMETHYLGLYCINE DEHYDROGENASE; FORMALDEHYDE; FORMALDEHYDE DEHYDROGENASE; FORMIC ACID; GLYCINE; HISTIDINE; METHIONINE; SARCOSINE; SARCOSINE DEHYDROGENASE; SERINE; TETRAHYDROFOLIC ACID; TRYPTOPHAN; 5,6,7,8-TETRAHYDROFOLIC ACID; FOLIC ACID; FORMIC ACID DERIVATIVE; OXYGEN; TETRAHYDROFOLIC ACID DERIVATIVE;

ADULT; AMINO ACID ANALYSIS; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON DYNAMICS; CARBON METABOLISM; CARBON UTILIZATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYMATIC ASSAY; FOLIC ACID DEFICIENCY; FORMATE METABOLISM; IN VIVO STUDY; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION KINETICS; PROTEIN DIET; RAT; ANIMAL; CHEMISTRY; LIVER; METABOLISM; MITOCHONDRION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; CHOLINE; DIMETHYLGLYCINE DEHYDROGENASE; FOLIC ACID; FOLIC ACID DEFICIENCY; FORMALDEHYDE; FORMATES; GLYCINE; HISTIDINE; LIVER; MALE; METHIONINE; MITOCHONDRIA; MITOCHONDRIA, LIVER; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; SARCOSINE DEHYDROGENASE; SERINE; TETRAHYDROFOLATES;

EID: 84961291647     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.600718     Document Type: Article

References (31)

1. Barlowe, C. K., and Appling, D. R. (1988) In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units. Biofactors 1, 171-176
2. Tibbetts, A. S., and Appling, D. R. (2010) Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu. Rev. Nutr. 30, 57-81
3. Lamarre, S. G., Morrow, G., Macmillan, L., Brosnan, M. E., and Brosnan, J. T. (2013) Formate: an essential metabolite, a biomarker, or more? Clin. Chem. Lab. Med. 51, 571-578
4. MacFarlane, A. J., Liu, X., Perry, C. A., Flodby, P., Allen, R. H., Stabler, S. P., and Stover, P. J. (2008) Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J. Biol. Chem. 283, 25846-25853
5. Momb, J., Lewandowski, J. P., Bryant, J. D., Fitch, R., Surman, D. R., Vokes, S. A., and Appling D. R. (2013) Deletion of Mthfd1l causes embryonic lethality and neural tube and faciocranial defects in mice. Proc. Natl. Acad. Sci. U.S.A. 110, 549-554
6. Narisawa, A., Komatsuzaki, S., Kikuchi, A., Niihori, T., Aoki, Y., Fujiwara, K., Tanemura, M., Hata, A., Suzuki, Y., Relton, C. L., Grinham, J., Leung, K. Y., Partridge, D., Robinson, A., Stone, V., Gustavsson, P., Stanier, P., Copp, A. J., Greene, N. D., Tominaga, T., Matsubara, Y., and Kure, S. (2012) Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. Hum. Mol. Genet. 21, 1496-1503
7. Damian, P., and Raabe, O. G. (1996) Toxicokinetic modeling of dose-dependent formate elimination in rats: in vivo-in vitro correlations using the perfused rat liver. Toxicol. Appl. Pharmacol. 139, 22-32
8. Lamarre, S. G., Molloy, A. M., Reinke, S. N., Sykes, B. D., Brosnan, M. E., and Brosnan, J. T. (2012) Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. Am. J. Physiol. Endocrinol. Metab. 302, E61-E67
9. Annison, E. F., and White, R. R. (1962) Formate metabolism in sheep. Biochem. J. 84, 552-557
10. Bills, N. D., Koury, M. J., Clifford, A. J., and Dessypris, E. N. (1992) Ineffective hematopoiesis in folate-deficient mice. Blood 79, 2273-2280
11. Reeves, P. G., Nielsen, F. H., and Fahey, G. C. Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123, 1939-1951
12. Horne, D. W., and Patterson D. (1988) Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates. Clin. Chem. 34, 2357-2359
13. Bensadoun, A., and Weinstein, D. (1976) Assay of proteins in the presence of interfering materials. Anal. Biochem. 70, 241-250
14. Lamarre, S. G., MacMillan, L., Morrow, G. P., Randell, E., Pongnopparat, T., Brosnan, M. E., and Brosnan, J. T. (2014) An isotope-dilution, GC-MS assay for formate and its application to human and animal metabolism. Amino Acids 46, 1885-1891
15. Wolfe, R. R. (1992) in Radioactive and Stable Isotope Tracers in Biomedicine, pp. 258-259, Wiley-Liss, New York
16. Wolfe, R. R., Goodenough, R. D., Wolfe, M. H., Royle, G. T., and Nadel, E. R. (1982) Isotopic analysis of leucine and urea metabolism in exercising humans. J. Appl. Physiol. 52, 458-466
17. Brosnan, J. T., Man, K.-C., Hall, D. E., Colbourne S. A., and Brosnan, M. E. (1983) Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic rat. Am. J. Physiol. 244, E151-E158
18. Qian, D., and Brosnan, J. T. (1996) Administration of Escherichia coli endotoxin to rat increases liver mass and hepatocyte volume in vivo. Biochem. J. 313, 479-486
19. Grady, S., and Osterloh, J. (1986) Improved enzymatic assay for serum formate with colorimetric end-point. J. Anal Toxicol. 10, 1-5
20. Ferrell, C. L., and Koong, K. J. (1986) Influence of plane of nutrition on body composition, organ size and energy utilization of Sprague-Dawley rats. J. Nutr. 116, 2525-2535
21. Rafecas, I., Esteve, M., Fernández-López, J. A., Remesar, X., and Alemany, M. (1994) Whole-rat protein content estimation: applicability of the N x 6.25 factor. Brit. J. Nutr. 72, 199-209
22. Davis, S. R., Stacpoole, P. W., Williamson, J., Kick, L. S., Quinlivan E. P., Coats, B. S., Shane, B., Bailey, L. B., Gregory, J. F., 3rd (2004) Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am. J. Physiol. Endocrinol. Metab. 286, E272-E279
23. 3]serine allows in vivo kinetic measurement of serine turnover, homocysteine remethylation, and transsulfuration processes in human one-carbon metabolism. Am. J. Clin. Nutr. 72, 1535-1541
24. Herbig, K., Chiang, E. P., Lee, L. R., Hills, J., Shane, B., Stover, P. J. (2002) Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosynthesis. J. Biol. Chem. 277, 38381-38389
25. Pike, S. T., Rajendra, R., Artzt, K., Appling, D. R. (2010) Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos. J. Biol. Chem. 285, 4612-4620
26. Porter, D. H., Cook, R. J., and Wagner, C. (1985) Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver. Arch. Biochem. Biophys. 243, 396-407
27. Waydhas, C., Weigl, K., and Sies, H. (1978) The disposition of formaldehyde and formate arising from drug N-demethylations dependent on cytochrome P-450 in hepatocytes and in perfused rat liver. Eur. J. Biochem. 89, 143-150
28. Kalhan, S. C., Uppal, S. O., Moorman, J. L., Bennett, C., Gruca, L. L., Parimi, P. S., Dasarathy, S., Serre, D., and Hanson, R. W. (2011) Metabolic and genomic response to dietary isocaloric protein restriction in the rat. J. Biol. Chem. 286, 5266-5277
29. Krebs, H. A., Hems, R., and Tyler, B. (1976) The regulation of folate and methionine metabolism. Biochem. J. 158, 341-353
30. García-Martínez, L. F., and Appling, D. R. (1993) Characterization of the folate-dependent mitochondrial oxidation of carbon 3 of serine. Biochemistry 32, 4671-4676
31. Sonne, J. C., Buchanan, J. M., and Delluva A. M. (1948) Biological precursors of uric acid: I, the role of lactate, acetate, and formate in the synthesis of the ureide groups of uric acid. J. Biol. Chem. 173, 69-79