Netrin-1 prevents rat primary cortical neurons from apoptosis via the DCC/ERK pathway

Frontiers in Cellular Neuroscience

Volumn 11, Issue , 2017, Pages

  Chen, Jianhao ^a,b   Du, Houwei ^a,b   Zhang, Yixian ^a,b   Chen, Hongbin ^a,b   Zheng, Mouwei ^a,b   Lin, Peiqiang ^a,b   Lan, Quan ^a,b   Yuan, Qilin ^a,b   Lai, Yongxing ^a,b   Pan, Xiaodong ^a   Chen, Ronghua ^a,b   Liu, Nan ^a,b  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b Institute of Cerebral Vascular Disease of Fujian Province   (China)

Author keywords

DCC; DNA damage; ERK; Netrin 1; OGD; Primary cortical neurons

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; LACTATE DEHYDROGENASE; LENTIVIRUS VECTOR; MITOGEN ACTIVATED PROTEIN KINASE; NETRIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL VIABILITY; CEREBROVASCULAR ACCIDENT; COLORECTAL CANCER; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DRUG MECHANISM; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; MAPK SIGNALING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

EID: 85040923788     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2017.00387     Document Type: Article

References (41)

1. An X. Z., Zhao Z. G., Luo Y. X., Zhang R., Tang X. Q., Hao D., et al. (2016). Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget 7, 24719–24733. DOI: 10.18632/oncotarget.8348
2. Chang S., Ruan W. C., Xu Y. Z., Wang Y. J., Pang J., Zhang L. Y., et al. (2017). The natural product 4,10-aromadendranediol induces neuritogenesis in neuronal cells in vitro through activation of the ERK pathway. Acta Pharmacol. Sin. 38, 29–40. DOI: 10.1038/aps.2016.115
3. Chen C. C., Liu T. Y., Huang S. P., Ho C. T., Huang T. C. (2015). Differentiation and apoptosis induction by lovastatin and gamma-tocotrienol in HL-60 cells via Ras/ERK/NF-kappaB and Ras/Akt/NF-kappaB signaling dependent down-regulation of glyoxalase 1 and HMG-CoA reductase. Cell. Signal. 27, 2182–2190. DOI: 10.1016/j.cellsig.2015.07.014
4. Chen H., Lin W., Zhang Y., Lin L., Chen J., Zeng Y., et al. (2016). IL-10 promotes neurite outgrowth and synapse formation in cultured cortical neurons after the oxygen-glucose deprivation via JAK1/STAT3 pathway. Sci. Rep. 6:30459. DOI: 10.1038/srep30459
5. Chitikova Z. V., Gordeev S. A., Bykova T. V., Zubova S. G., Pospelov V. A., Pospelova T. V. (2014). Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers. Cell Cycle 13, 1424–1439. DOI: 10.4161/cc.28402
6. Dai Y., Chen S., Pei X. Y., Almenara J. A., Kramer L. B., Venditti C. A., et al. (2008). Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells. Blood 112, 2439–2449. DOI: 10.1182/blood-2008-05-159392
7. Delloye-Bourgeois C., Brambilla E., Coissieux M. M., Guenebeaud C., Pedeux R., Firlej V., et al. (2009a). Interference with netrin-1 and tumor cell death in non-small cell lung cancer. J. Natl. Cancer Inst. 101, 237–247. DOI: 10.1093/jnci/djn491
8. Delloye-Bourgeois C., Fitamant J., Paradisi A., Cappellen D., Douc-Rasy S., Raquin M. A., et al. (2009b). Netrin-1 acts as a survival factor for aggressive neuroblastoma. J. Exp. Med. 206, 833–847. DOI: 10.1084/jem.20082299
9. Fan Y., Shen F., Chen Y., Hao Q., Liu W., Su H., et al. (2008). Overexpression of netrin-1 induces neovascularization in the adult mouse brain. J. Cereb. Blood Flow Metab. 28, 1543–1551. DOI: 10.1038/jcbfm.2008.39
10. Forcet C., Stein E., Pays L., Corset V., Llambi F., Tessier-Lavigne M., et al. (2002). Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature 417, 443–447. DOI: 10.1038/nature748
11. Furne C., Rama N., Corset V., Chédotal A., Mehlen P. (2008). Netrin-1 is a survival factor during commissural neuron navigation. Proc. Natl. Acad. Sci. U S A 105, 14465–14470. DOI: 10.1073/pnas.0803645105
12. Gao S., Chen T., Choi M. Y., Liang Y., Xue J., Wong Y. S. (2013). Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways. Cancer Lett. 333, 36–46. DOI: 10.1016/j.canlet.2012.12.029
13. Golding S. E., Rosenberg E., Neill S., Dent P., Povirk L. F., Valerie K. (2007). Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response. Cancer Res. 67, 1046–1053. DOI: 10.1158/0008-5472.can-06-2371
14. Hamasaki T., Goto S., Nishikawa S., Ushio Y. (2001). A role of netrin-1 in the formation of the subcortical structure striatum: repulsive action on the migration of late-born striatal neurons. J. Neurosci. 21, 4272–4280.
15. Harter P. N., Zinke J., Scholz A., Tichy J., Zachskorn C., Kvasnicka H. M., et al. (2014). Netrin-1 expression is an independent prognostic factor for poor patient survival in brain metastases. PLoS One 9:e92311. DOI: 10.1371/journal.pone.0092311
16. Kalluri H. S., Eickstaedt J., Dempsey R. J. (2007). Oxygen glucose deprivation inhibits the growth and ERK phosphorylation of neural progenitor cells in vitro. Neurosci. Lett. 426, 145–148. DOI: 10.1016/j.neulet.2007.08.047
17. Lee S. J., Lee S. H., Yoon M. H., Park B. J. (2013). A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation. Neoplasia 15, 727–737. DOI: 10.1593/neo.121862
18. Lewinska A., Adamczyk-Grochala J., Kwasniewicz E., Deregowska A., Wnuk M. (2017). Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity. Toxicol. Lett. 265, 117–130. DOI: 10.1016/j.toxlet.2016.11.018
19. Li N., Li Q., Zhou X. D., Kolosov V. P., Perelman J. M. (2012). Chronic mechanical stress induces mucin 5AC expression in human bronchial epithelial cells through ERK dependent pathways. Mol. Biol. Rep. 39, 1019–1028. DOI: 10.1007/s11033-011-0827-x
20. Liao Y., Ling J., Zhang G., Liu F., Tao S., Han Z., et al. (2015). Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells. Cell Cycle 14, 761–771. DOI: 10.1080/15384101.2014.1000097
21. Lin L., Chen H., Zhang Y., Lin W., Liu Y., Li T., et al. (2015). IL-10 protects neurites in oxygen-glucose-deprived cortical neurons through the PI3K/Akt pathway. PLoS One 10:e0136959. DOI: 10.1371/journal.pone.0136959
22. Lin X., Yan J., Tang D. (2013). ERK kinases modulate the activation of PI3 kinase related kinases (PIKKs) in DNA damage response. Histol. Histopathol. 28, 1547–1554. DOI: 10.14670/HH-28.1547
23. Liu N., Huang H., Lin F., Chen A., Zhang Y., Chen R., et al. (2011). Effects of treadmill exercise on the expression of netrin-1 and its receptors in rat brain after cerebral ischemia. Neuroscience 194, 349–358. DOI: 10.1016/j.neuroscience.2011.07.037
24. Lu H., Wang Y., He X., Yuan F., Lin X., Xie B., et al. (2012). Netrin-1 hyperexpression in mouse brain promotes angiogenesis and long-term neurological recovery after transient focal ischemia. Stroke 43, 838–843. DOI: 10.1161/STROKEAHA.111.635235
25. Ma W., Shang Y., Wei Z., Wen W., Wang W., Zhang M. (2010). Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase. Structure 18, 1502–1511. DOI: 10.1016/j.str.2010.08.011
26. Mazelin L., Bernet A., Bonod-Bidaud C., Pays L., Arnaud S., Gespach C., et al. (2004). Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431, 80–84. DOI: 10.1038/nature02788
27. Nakka V. P., Gusain A., Mehta S. L., Raghubir R. (2008). Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities. Mol. Neurobiol. 37, 7–38. DOI: 10.1007/s12035-007-8013-9
28. Paradisi A., Creveaux M., Gibert B., Devailly G., Redoulez E., Neves D., et al. (2013). Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death. EMBO Mol. Med. 5, 1821–1834. DOI: 10.1002/emmm.201302654
29. Paradisi A., Mehlen P. (2010). Netrin-1, a missing link between chronic inflammation and tumor progression. Cell Cycle 9, 1253–1262. DOI: 10.4161/cc.9.7.11072
30. Sun Z., Hu W., Yin S., Lu X., Zuo W., Ge S., et al. (2017). NGF protects against oxygen and glucose deprivation-induced oxidative stress and apoptosis by up-regulation of HO-1 through MEK/ERK pathway. Neurosci. Lett. 641, 8–14. DOI: 10.1016/j.neulet.2017.01.046
31. Tan W. H., Popel A. S., Mac Gabhann F. (2013). Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking. Cell. Signal. 25, 2496–2510. DOI: 10.1016/j.cellsig.2013.08.015
32. Tan B. B., Zhang M. M., Li Y., Zhao Q., Fan L. Q., Liu Y., et al. (2016). Inhibition of Vav3 gene can promote apoptosis of human gastric cancer cell line MGC803 by regulating ERK pathway. Tumour Biol 37, 7823–7833. DOI: 10.1007/s13277-015-4505-9
33. Tentner A. R., Lee M. J., Ostheimer G. J., Samson L. D., Lauffenburger D. A., Yaffe M. B. (2012). Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol. Syst. Biol. 8:568. DOI: 10.1038/msb.2012.1
34. Thiebault K., Mazelin L., Pays L., Llambi F., Joly M. O., Scoazec J. Y., et al. (2003). The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc. Natl. Acad. Sci. U S A 100, 4173–4178. DOI: 10.1073/pnas.0738063100
35. 125I seed inhibits the cell growth, migration, and invasion of nasopharyngeal carcinoma by triggering DNA damage and inactivating VEGF-A/ERK signaling. PLoS One 8:e74038. DOI: 10.1371/journal.pone.0074038
36. Wei F., Xie Y., Tao L., Tang D. (2010). Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation. Cell. Signal. 22, 1783–1789. DOI: 10.1016/j.cellsig.2010.07.007
37. Weng L. X., Wang G. H., Yao H., Yu M. F., Lin J. (2017). Epigallocatechin gallate inhibits the growth of salivary adenoid cystic carcinoma cells via the EGFR/Erk signal transduction pathway and the mitochondria apoptosis pathway. Neoplasma 64, 563–570. DOI: 10.4149/neo_2017_410
38. Wu H., Li G. N., Xie J., Li R., Chen Q. H., Chen J. Z., et al. (2016). Resveratrol ameliorates myocardial fibrosis by inhibiting ROS/ERK/TGF-beta/periostin pathway in STZ-induced diabetic mice. BMC Cardiovasc. Disord. 16:5. DOI: 10.1186/s12872-015-0169-z
39. Yeh Y. T., Yeh H., Su S. H., Lin J. S., Lee K. J., Shyu H. W., et al. (2014). Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations. Free Radic. Biol. Med. 74, 1–13. DOI: 10.1016/j.freeradbiomed.2014.06.008
40. Yung A. R., Nishitani A. M., Goodrich L. V. (2015). Phenotypic analysis of mice completely lacking netrin 1. Development 142, 3686–3691. DOI: 10.1242/dev.128942
41. Zhang J., Cai H. (2010). Netrin-1 prevents ischemia/reperfusion-induced myocardial infarction via a DCC/ERK1/2/eNOS s1177/NO/DCC feed-forward mechanism. J. Mol. Cell. Cardiol. 48, 1060–1070. DOI: 10.1016/j.yjmcc.2009.11.020