Radioactive 125I Seed Inhibits the Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Triggering DNA Damage and Inactivating VEGF-A/ERK Signaling

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Tian, Yunhong ^a,b   Xie, Qiang ^b,c   Tian, Yunming ^d,e   Liu, Ying ^b   Huang, Zuoping ^b   Fan, Cundong ^f   Hou, Bing ^b   Sun, Dan ^b   Yao, Kaitai ^a   Chen, Tianfeng ^f  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Guangdong Armed Police Hospital   (China)

^c MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^d Laboratory of Oncology in Southern China   (China)

^e SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^f JINAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; IODINE 125; MITOGEN ACTIVATED PROTEIN KINASE; VASCULOTROPIN A; RADIOACTIVE IODINE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER RADIOTHERAPY; CARCINOMA CELL; CELL GROWTH; CELL MIGRATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; SIGNAL TRANSDUCTION; TUMOR INVASION; X IRRADIATION; ANIMAL; CELL CYCLE CHECKPOINT; CELL MOTION; CELL PROLIFERATION; DISEASE MODEL; DRUG SCREENING; GENETICS; METABOLISM; NASOPHARYNX TUMOR; PATHOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE; TUMOR VOLUME; X RAY;

ANIMALS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DNA DAMAGE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; IODINE RADIOISOTOPES; MICE; NASOPHARYNGEAL NEOPLASMS; NEOPLASM INVASIVENESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; X-RAYS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84883785533     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074038     Document Type: Article

References (38)

1. Hua YJ, Han F, Lu LX, Mai HQ, Guo X, et al. (2012) Long-term treatment outcome of recurrent nasopharyngeal carcinoma treated with salvage intensity modulated radiotherapy. Eur J Cancer 48: 3422-3428. doi:10.1016/j.ejca.2012.06.016. PubMed: 22835782.
2. Ye J, Rong X, Xiang Y, Xing Y, Tang Y, (2012) A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis. PLOS ONE 7: e42890. doi:10.1371/journal.pone.0042890. PubMed: 22912759.
3. Suárez C, Rodrigo JP, Rinaldo A, Langendijk JA, Shaha AR, et al. (2010) Current treatment options for recurrent nasopharyngeal cancer. Eur Arch Otorhinolaryngol 267: 1811-1824. doi:10.1007/s00405-010-1385-x. PubMed: 20865269.
4. Jiang YL, Meng N, Wang JJ, Ran WQ, Yuan HS, et al. (2010) Percutaneous computed tomography/ultrasonography-guided permanent iodine-125 implantation as salvage therapy for recurrent squamous cell cancers of head and neck. Cancer Biol Ther 9: 959-966. doi:10.4161/cbt.9.12.11700. PubMed: 20873398.
5. Meng N, Jiang YL, Wang JJ, Ran WQ, Yuan HS, et al. (2012) Permanent implantation of iodine-125 seeds as a salvage therapy for recurrent head and neck carcinoma after radiotherapy. Cancer Invest 30: 236-242. doi:10.3109/07357907.2012.654869. PubMed: 22360363.
6. Wang JJ, Yuan HS, Li JN, Jiang WJ, Jiang YL, et al. (2009) Interstitial permanent implantation of 125I seeds as salvage therapy for re-recurrent rectal carcinoma. Int J Colorectal Dis 24: 391-399. doi:10.1007/s00384-008-0628-4. PubMed: 19084969.
7. Coatmeur O, Truc G, Barillot I, Horiot JC, Maingon P, (2004) Treatment of T1-T2 rectal tumors by contact therapy and interstitial brachytherapy. Radiother Oncol 70: 177-182. doi:10.1016/j.radonc.2004.01.016. PubMed: 15028405.
8. Wang J, Liao A, Zhuang H, Zhao Y, (2009) The direct biologic effects of radioactive 125I seeds on pancreatic cancer cells PANC-1, at continuous low-dose rates. Cancer Biother Radiopharm 24: 409-416. doi:10.1089/cbr.2008.0563. PubMed: 19694575.
9. Zhuang HQ, Wang JJ, Liao AY, Wang JD, Zhao Y, (2009) The biological effect of 125I seed continuous low dose rate irradiation in CL187 cells. J Exp Clin Cancer Res 28: 12. doi:10.1186/1756-9966-28-12. PubMed: 19175942.
10. Liao A, Wang J, Zhuang H, Zhao Y, (2010) Relative biological effectiveness and cell-killing efficacy of continuous low-dose-rate 125I seeds on prostate carcinoma cells in vitro. Integr Cancer Ther 9: 59-65. doi:10.1177/1534735409357758. PubMed: 20150222.
11. Feng J, Zhang Y, Xing D, (2012) Low-power laser irradiation (LPLI) promotes VEGF expression and vascular endothelial cell proliferation through the activation of ERK/Sp1 pathway. Cell Signal 24: 1116-1125. doi:10.1016/j.cellsig.2012.01.013. PubMed: 22326662.
12. Sassoli C, Pini A, Chellini F, Mazzanti B, Nistri S, et al. (2012) Bone marrow mesenchymal stromal cells stimulate skeletal myoblast proliferation through the paracrine release of VEGF. PLOS ONE 7: e37512. doi:10.1371/journal.pone.0037512. PubMed: 22815682.
13. Shi D, Guo W, Chen W, Fu L, Wang J, et al. (2012) Nicotine Promotes Proliferation of Human Nasopharyngeal Carcinoma Cells by Regulating alpha7AChR, ERK, HIF-1alpha and VEGF/PEDF Signaling. PLOS ONE 7: e43898. doi:10.1371/journal.pone.0043898. PubMed: 22952803.
14. Wu Y, Hooper AT, Zhong Z, Witte L, Bohlen P, et al. (2006) The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma. Int J Cancer 119: 1519-1529. doi:10.1002/ijc.21865. PubMed: 16671089.
15. Pan J, Tang T, Xu L, Lu JJ, Lin S, et al. (2012) Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma. Head Neck, 35: 1238-47. doi:10.1002/hed.23116. PubMed: 22972415. PubMed: 22972415.
16. Li YH, Hu CF, Shao Q, Huang MY, Hou JH, et al. (2008) Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma. J Transl Med 6: 1. doi:10.1186/1479-5876-6-1. PubMed: 18171482.
17. Du J, Xu R, Hu Z, Tian Y, Zhu Y, et al. (2011) PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1alpha expression in MCF-7 breast cancer cells. PLOS ONE 6: e25213. doi:10.1371/journal.pone.0025213. PubMed: 21980400.
18. Kil WJ, Tofilon PJ, Camphausen K, (2012) Post-radiation increase in VEGF enhances glioma cell motility in vitro. Radiol Oncol 7: 25. doi:10.1186/1748-717X-7-25. PubMed: 22356893.
19. Chen T, Wong YS, (2009) Selenocystine induces reactive oxygen species-mediated apoptosis in human cancer cells. Biomed Pharmacother 63: 105-113. doi:10.1016/j.biopha.2008.03.009. PubMed: 18511231.
20. Cheng C, Kong X, Wang H, Gan H, Hao Y, et al. (2009) Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration. J Biol Chem 284: 8786-8796. PubMed: 19136554.
21. Liang Y, Lin SY, Brunicardi FC, Goss J, Li K, (2009) DNA damage response pathways in tumor suppression and cancer treatment. World J Surg 33: 661-666. doi:10.1007/s00268-008-9840-1. PubMed: 19034564.
22. Yan Y, Cao PT, Greer PM, Nagengast ES, Kolb RH, et al. (2010) Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response. Oncogene 29: 4317-4329. doi:10.1038/onc.2010.187. PubMed: 20498628.
23. Kurz EU, Lees-Miller SP, (2004) DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst) 3: 889-900. doi:10.1016/j.dnarep.2004.03.029. PubMed: 15279774.
24. Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, et al. (2002) Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J 8: 47-54. doi:10.1097/00130404-200201000-00009. PubMed: 11895203.
25. Lee AW, Ng WT, Chan YH, Sze H, Chan C, et al. (2012) The battle against nasopharyngeal cancer. Radiother Oncol, 104: 272-278. doi:10.1016/j.radonc.2012.08.001. PubMed: 22938727.
26. Wu CW, Dong YJ, Liang QY, He XQ, Ng SS, et al. (2013) MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer. PLOS ONE 8: e57036. doi:10.1371/journal.pone.0057036. PubMed: 23437304.
27. Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, et al. (2013) Overexpression of CDCA2 in Human Squamous Cell Carcinoma: Correlation with Prevention of G1 Phase Arrest and Apoptosis. PLOS ONE 8: e56381. doi:10.1371/journal.pone.0056381. PubMed: 23418564.
28. Fei P, El-Deiry WS, (2003) P53 and radiation responses. Oncogene 22: 5774-5783. doi:10.1038/sj.onc.1206677. PubMed: 12947385.
29. Deckbar D, Jeggo PA, Löbrich M, (2011) Understanding the limitations of radiation-induced cell cycle checkpoints. Crit Rev Biochem Mol Biol 46: 271-283. doi:10.3109/10409238.2011.575764. PubMed: 21524151.
30. Bucher N, Britten CD, (2008) G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer. Br J Cancer 98: 523-528. doi:10.1038/sj.bjc.6604208. PubMed: 18231106.
31. Spruck CH 3rd, Tsai YC, Huang DP, Yang AS, Rideout WM 3rd, et al. (1992) Absence of p53 gene mutations in primary nasopharyngeal carcinomas. Cancer Res 52: 4787-4790. PubMed: 1511442.
32. Wild-Bode C, Weller M, Rimner A, Dichgans J, Wick W, (2001) Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. Cancer Res 61: 2744-2750. PubMed: 11289157.
33. Ogata T, Teshima T, Kagawa K, Hishikawa Y, Takahashi Y, et al. (2005) Particle irradiation suppresses metastatic potential of cancer cells. Cancer Res 65: 113-120. PubMed: 15665286.
34. Liu C, Lin J, Zhao L, Yang Y, Gao F, et al. (2011) Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis. Int J Biol Sci 7: 168-179. PubMed: 21383953.
35. Timoshenko AV, Rastogi S, Lala PK, (2007) Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells. Br J Cancer 97: 1090-1098. doi:10.1038/sj.bjc.6603993. PubMed: 17912247.
36. Wang F, Yamauchi M, Muramatsu M, Osawa T, Tsuchida R, et al. (2011) RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway. J Biol Chem 286: 9097-9106. doi:10.1074/jbc.M110.165605. PubMed: 21212275.
37. Moeller BJ, Cao Y, Li CY, Dewhirst MW, (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429-441. doi:10.1016/S1535-6108(04)00115-1. PubMed: 15144951.
38. Mitchell CR, Folkard M, Joiner MC, (2002) Effects of exposure to low-dose-rate (60)co gamma rays on human tumor cells in vitro. Radiat Res 158: 311-318. doi:10.1667/0033-7587(2002)158[0311:EOETLD]2.0.CO;2. PubMed: 12175308.