-
1
-
-
33646033137
-
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
-
Moffat, J., Grueneberg, D.A., Yang, X., Kim, S.Y., Kloepfer, A.M., Hinkle, G., Piqani, B., Eisenhaure, T.M., Luo, B., Grenier, J.K. et al. (2006) A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell, 124, 1283-1298.
-
(2006)
Cell
, vol.124
, pp. 1283-1298
-
-
Moffat, J.1
Grueneberg, D.A.2
Yang, X.3
Kim, S.Y.4
Kloepfer, A.M.5
Hinkle, G.6
Piqani, B.7
Eisenhaure, T.M.8
Luo, B.9
Grenier, J.K.10
-
2
-
-
15844431376
-
Full-genome RNAi profling of early embryogenesis in Caenorhabditis elegans
-
Sonnichsen, B., Koski, L.B., Walsh, A., Marschall, P., Neumann, B., Brehm, M., Alleaume, A.M., Artelt, J., Bettencourt, P., Cassin, E. et al. (2005) Full-genome RNAi profling of early embryogenesis in Caenorhabditis elegans. Nature, 434, 462-469.
-
(2005)
Nature
, vol.434
, pp. 462-469
-
-
Sonnichsen, B.1
Koski, L.B.2
Walsh, A.3
Marschall, P.4
Neumann, B.5
Brehm, M.6
Alleaume, A.M.7
Artelt, J.8
Bettencourt, P.9
Cassin, E.10
-
3
-
-
33749023011
-
Minimizing the risk of reporting false positives in large-scale RNAi screens
-
Echeverri, C.J., Beachy, P.A., Baum, B., Boutros, M., Buchholz, F., Chanda, S.K., Downward, J., Ellenberg, J., Fraser, A.G., Hacohen, N. et al. (2006) Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat. Methods, 3, 777-779.
-
(2006)
Nat. Methods
, vol.3
, pp. 777-779
-
-
Echeverri, C.J.1
Beachy, P.A.2
Baum, B.3
Boutros, M.4
Buchholz, F.5
Chanda, S.K.6
Downward, J.7
Ellenberg, J.8
Fraser, A.G.9
Hacohen, N.10
-
4
-
-
33646187810
-
High-throughput RNAi screening in cultured cells: A user's guide
-
Echeverri, C.J. and Perrimon, N. (2006) High-throughput RNAi screening in cultured cells: a user's guide. Nat. Rev. Genet., 7, 373-384.
-
(2006)
Nat. Rev. Genet.
, vol.7
, pp. 373-384
-
-
Echeverri, C.J.1
Perrimon, N.2
-
5
-
-
33947592830
-
Off-target effects associated with long dsRNAs in Drosophila RNAi screens
-
Moffat, J., Reiling, J.H. and Sabatini, D.M. (2007) Off-target effects associated with long dsRNAs in Drosophila RNAi screens. Trends Pharmacol. Sci., 28, 149-151.
-
(2007)
Trends Pharmacol. Sci.
, vol.28
, pp. 149-151
-
-
Moffat, J.1
Reiling, J.H.2
Sabatini, D.M.3
-
6
-
-
84864326893
-
Molecular biology. Use and abuse of RNAi to study mammalian gene function
-
Kaelin, W.G. Jr (2012) Molecular biology. Use and abuse of RNAi to study mammalian gene function. Science, 337, 421-422.
-
(2012)
Science
, vol.337
, pp. 421-422
-
-
Kaelin, W.G.1
-
7
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L., Ran, F.A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P.D., Wu, X., Jiang, W., Marraffni, L.A. et al. (2013) Multiplex genome engineering using CRISPR/Cas systems. Science, 339, 819-823.
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
Ran, F.A.2
Cox, D.3
Lin, S.4
Barretto, R.5
Habib, N.6
Hsu, P.D.7
Wu, X.8
Jiang, W.9
Marraffni, L.A.10
-
8
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali, P., Yang, L., Esvelt, K.M., Aach, J., Guell, M., DiCarlo, J.E., Norville, J.E. and Church, G.M. (2013) RNA-guided human genome engineering via Cas9. Science, 339, 823-826.
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
Yang, L.2
Esvelt, K.M.3
Aach, J.4
Guell, M.5
DiCarlo, J.E.6
Norville, J.E.7
Church, G.M.8
-
9
-
-
84892749369
-
Genetic screens in human cells using the CRISPR-Cas9 system
-
Wang, T., Wei, J.J., Sabatini, D.M. and Lander, E.S. (2014) Genetic screens in human cells using the CRISPR-Cas9 system. Science, 343, 80-84.
-
(2014)
Science
, vol.343
, pp. 80-84
-
-
Wang, T.1
Wei, J.J.2
Sabatini, D.M.3
Lander, E.S.4
-
10
-
-
84892765883
-
Genome-scale CRISPR-Cas9 knockout screening in human cells
-
Shalem, O., Sanjana, N.E., Hartenian, E., Shi, X., Scott, D.A., Mikkelson, T., Heckl, D., Ebert, B.L., Root, D.E., Doench, J.G. et al. (2014) Genome-scale CRISPR-Cas9 knockout screening in human cells. Science, 343, 84-87.
-
(2014)
Science
, vol.343
, pp. 84-87
-
-
Shalem, O.1
Sanjana, N.E.2
Hartenian, E.3
Shi, X.4
Scott, D.A.5
Mikkelson, T.6
Heckl, D.7
Ebert, B.L.8
Root, D.E.9
Doench, J.G.10
-
11
-
-
85008257169
-
CRISPRi-based genome-scale identifcation of functional long noncoding RNA loci in human cells
-
Liu, S.J., Horlbeck, M.A., Cho, S.W., Birk, H.S., Malatesta, M., He, D., Attenello, F.J., Villalta, J.E., Cho, M.Y., Chen, Y. et al. (2017) CRISPRi-based genome-scale identifcation of functional long noncoding RNA loci in human cells. Science, 355, aah7111.
-
(2017)
Science
, vol.355
, pp. aah7111
-
-
Liu, S.J.1
Horlbeck, M.A.2
Cho, S.W.3
Birk, H.S.4
Malatesta, M.5
He, D.6
Attenello, F.J.7
Villalta, J.E.8
Cho, M.Y.9
Chen, Y.10
-
12
-
-
85003712738
-
Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library
-
Zhu, S., Li, W., Liu, J., Chen, C.H., Liao, Q., Xu, P., Xu, H., Xiao, T., Cao, Z., Peng, J. et al. (2016) Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library. Nat. Biotechnol., 34, 1279-1286.
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 1279-1286
-
-
Zhu, S.1
Li, W.2
Liu, J.3
Chen, C.H.4
Liao, Q.5
Xu, P.6
Xu, H.7
Xiao, T.8
Cao, Z.9
Peng, J.10
-
13
-
-
84908352138
-
Genome-scale CRISPR-mediated control of gene repression and activation
-
Gilbert, L.A., Horlbeck, M.A., Adamson, B., Villalta, J.E., Chen, Y., Whitehead, E.H., Guimaraes, C., Panning, B., Ploegh, H.L., Bassik, M.C. et al. (2014) Genome-scale CRISPR-mediated control of gene repression and activation. Cell, 159, 647-661.
-
(2014)
Cell
, vol.159
, pp. 647-661
-
-
Gilbert, L.A.1
Horlbeck, M.A.2
Adamson, B.3
Villalta, J.E.4
Chen, Y.5
Whitehead, E.H.6
Guimaraes, C.7
Panning, B.8
Ploegh, H.L.9
Bassik, M.C.10
-
14
-
-
84923096541
-
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
-
Konermann, S., Brigham, M.D., Trevino, A.E., Joung, J., Abudayyeh, O.O., Barcena, C., Hsu, P.D., Habib, N., Gootenberg, J.S., Nishimasu, H. et al. (2015) Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature, 517, 583-588.
-
(2015)
Nature
, vol.517
, pp. 583-588
-
-
Konermann, S.1
Brigham, M.D.2
Trevino, A.E.3
Joung, J.4
Abudayyeh, O.O.5
Barcena, C.6
Hsu, P.D.7
Habib, N.8
Gootenberg, J.S.9
Nishimasu, H.10
-
15
-
-
84874687019
-
Repurposing CRISPR as an RNA-guided platform for sequence-specifc control of gene expression
-
Qi, L.S., Larson, M.H., Gilbert, L.A., Doudna, J.A., Weissman, J.S., Arkin, A.P. and Lim, W.A. (2013) Repurposing CRISPR as an RNA-guided platform for sequence-specifc control of gene expression. Cell, 152, 1173-1183.
-
(2013)
Cell
, vol.152
, pp. 1173-1183
-
-
Qi, L.S.1
Larson, M.H.2
Gilbert, L.A.3
Doudna, J.A.4
Weissman, J.S.5
Arkin, A.P.6
Lim, W.A.7
-
16
-
-
84929135130
-
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
-
Hilton, I.B., D'Ippolito, A.M., Vockley, C.M., Thakore, P.I., Crawford, G.E., Reddy, T.E. and Gersbach, C.A. (2015) Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat. Biotechnol, 33, 510-517.
-
(2015)
Nat. Biotechnol
, vol.33
, pp. 510-517
-
-
Hilton, I.B.1
D'Ippolito, A.M.2
Vockley, C.M.3
Thakore, P.I.4
Crawford, G.E.5
Reddy, T.E.6
Gersbach, C.A.7
-
17
-
-
85021812886
-
Genetic interaction mapping in mammalian cells using CRISPR interference
-
Du, D., Roguev, A., Gordon, D.E., Chen, M., Chen, S.H., Shales, M., Shen, J.P., Ideker, T., Mali, P., Qi, L.S. et al. (2017) Genetic interaction mapping in mammalian cells using CRISPR interference. Nat. Methods, 14, 577-580.
-
(2017)
Nat. Methods
, vol.14
, pp. 577-580
-
-
Du, D.1
Roguev, A.2
Gordon, D.E.3
Chen, M.4
Chen, S.H.5
Shales, M.6
Shen, J.P.7
Ideker, T.8
Mali, P.9
Qi, L.S.10
-
18
-
-
84994850910
-
A CRISPR dropout screen identifes genetic vulnerabilities and therapeutic targets in acute myeloid leukemia
-
Tzelepis, K., Koike-Yusa, H., De Braekeleer, E., Li, Y., Metzakopian, E., Dovey, O.M., Mupo, A., Grinkevich, V., Li, M., Mazan, M. et al. (2016) A CRISPR dropout screen identifes genetic vulnerabilities and therapeutic targets in acute myeloid leukemia. Cell Rep., 17, 1193-1205.
-
(2016)
Cell Rep.
, vol.17
, pp. 1193-1205
-
-
Tzelepis, K.1
Koike-Yusa, H.2
De Braekeleer, E.3
Li, Y.4
Metzakopian, E.5
Dovey, O.M.6
Mupo, A.7
Grinkevich, V.8
Li, M.9
Mazan, M.10
-
19
-
-
84947471999
-
Identifcation and characterization of essential genes in the human genome
-
Wang, T., Birsoy, K., Hughes, N.W., Krupczak, K.M., Post, Y., Wei, J.J., Lander, E.S. and Sabatini, D.M. (2015) Identifcation and characterization of essential genes in the human genome. Science, 350, 1096-1101.
-
(2015)
Science
, vol.350
, pp. 1096-1101
-
-
Wang, T.1
Birsoy, K.2
Hughes, N.W.3
Krupczak, K.M.4
Post, Y.5
Wei, J.J.6
Lander, E.S.7
Sabatini, D.M.8
-
20
-
-
84996605473
-
Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
-
Steinhart, Z., Pavlovic, Z., Chandrashekhar, M., Hart, T., Wang, X., Zhang, X., Robitaille, M., Brown, K.R., Jaksani, S., Overmeer, R. et al. (2017) Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nat. Med., 23, 60-68.
-
(2017)
Nat. Med.
, vol.23
, pp. 60-68
-
-
Steinhart, Z.1
Pavlovic, Z.2
Chandrashekhar, M.3
Hart, T.4
Wang, X.5
Zhang, X.6
Robitaille, M.7
Brown, K.R.8
Jaksani, S.9
Overmeer, R.10
-
21
-
-
85011268687
-
Gene essentiality profling reveals gene networks and synthetic lethal interactions with oncogenic Ras
-
Wang, T., Yu, H., Hughes, N.W., Liu, B., Kendirli, A., Klein, K., Chen, W.W., Lander, E.S. and Sabatini, D.M. (2017) Gene essentiality profling reveals gene networks and synthetic lethal interactions with oncogenic Ras. Cell, 168, 890-903.
-
(2017)
Cell
, vol.168
, pp. 890-903
-
-
Wang, T.1
Yu, H.2
Hughes, N.W.3
Liu, B.4
Kendirli, A.5
Klein, K.6
Chen, W.W.7
Lander, E.S.8
Sabatini, D.M.9
-
22
-
-
84982918709
-
Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting
-
Aguirre, A.J., Meyers, R.M., Weir, B.A., Vazquez, F., Zhang, C.Z., Ben-David, U., Cook, A., Ha, G., Harrington, W.F., Doshi, M.B. et al. (2016) Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting. Cancer Discov., 6, 914-929.
-
(2016)
Cancer Discov.
, vol.6
, pp. 914-929
-
-
Aguirre, A.J.1
Meyers, R.M.2
Weir, B.A.3
Vazquez, F.4
Zhang, C.Z.5
Ben-David, U.6
Cook, A.7
Ha, G.8
Harrington, W.F.9
Doshi, M.B.10
-
23
-
-
85026428627
-
Project DRIVE: A compendium of cancer dependencies and synthetic lethal relationships uncovered by large-scale, deep RNAi screening
-
McDonald, E.R. 3rd, de Weck, A., Schlabach, M.R., Billy, E., Mavrakis, K.J., Hoffman, G.R., Belur, D., Castelletti, D., Frias, E., Gampa, K. et al. (2017) Project DRIVE: a compendium of cancer dependencies and synthetic lethal relationships uncovered by large-scale, deep RNAi screening. Cell, 170, 577-592.
-
(2017)
Cell
, vol.170
, pp. 577-592
-
-
McDonald, R.E.1
De Weck, A.2
Schlabach, M.R.3
Billy, E.4
Mavrakis, K.J.5
Hoffman, G.R.6
Belur, D.7
Castelletti, D.8
Frias, E.9
Gampa, K.10
-
24
-
-
85026422523
-
Defning a cancer dependency map
-
Tsherniak, A., Vazquez, F., Montgomery, P.G., Weir, B.A., Kryukov, G., Cowley, G.S., Gill, S., Harrington, W.F., Pantel, S., Krill-Burger, J.M. et al. (2017) Defning a cancer dependency map. Cell, 170, 564-576.
-
(2017)
Cell
, vol.170
, pp. 564-576
-
-
Tsherniak, A.1
Vazquez, F.2
Montgomery, P.G.3
Weir, B.A.4
Kryukov, G.5
Cowley, G.S.6
Gill, S.7
Harrington, W.F.8
Pantel, S.9
Krill-Burger, J.M.10
-
25
-
-
84963595182
-
BAGEL: A computational framework for identifying essential genes from pooled library screens
-
Hart, T. and Moffat, J. (2016) BAGEL: a computational framework for identifying essential genes from pooled library screens. BMC Bioinformatics, 17, 164.
-
(2016)
BMC Bioinformatics
, vol.17
, pp. 164
-
-
Hart, T.1
Moffat, J.2
-
26
-
-
84865202966
-
Essential gene profles in breast, pancreatic, and ovarian cancer cells
-
Marcotte, R., Brown, K.R., Suarez, F., Sayad, A., Karamboulas, K., Krzyzanowski, P.M., Sircoulomb, F., Medrano, M., Fedyshyn, Y., Koh, J.L.Y. et al. (2012) Essential gene profles in breast, pancreatic, and ovarian cancer cells. Cancer Discov., 2, 172-189.
-
(2012)
Cancer Discov.
, vol.2
, pp. 172-189
-
-
Marcotte, R.1
Brown, K.R.2
Suarez, F.3
Sayad, A.4
Karamboulas, K.5
Krzyzanowski, P.M.6
Sircoulomb, F.7
Medrano, M.8
Fedyshyn, Y.9
Koh, J.L.Y.10
-
27
-
-
84954290430
-
Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance
-
Marcotte, R., Sayad, A., Brown, K.R., Sanchez-Garcia, F., Reimand, J., Haider, M., Virtanen, C., Bradner, J.E., Bader, G.D., Mills, G.B. et al. (2016) Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance. Cell, 164, 293-309.
-
(2016)
Cell
, vol.164
, pp. 293-309
-
-
Marcotte, R.1
Sayad, A.2
Brown, K.R.3
Sanchez-Garcia, F.4
Reimand, J.5
Haider, M.6
Virtanen, C.7
Bradner, J.E.8
Bader, G.D.9
Mills, G.B.10
-
28
-
-
85014580000
-
Interrogation of functional cell-surface markers identifes CD151 dependency in high-grade serous ovarian cancer
-
Medrano, M., Communal, L., Brown, K.R., Iwanicki, M., Normand, J., Paterson, J., Sircoulomb, F., Krzyzanowski, P., Novak, M., Doodnauth, S.A. et al. (2017) Interrogation of functional cell-surface markers identifes CD151 dependency in high-grade serous ovarian cancer. Cell Rep., 18, 2343-2358.
-
(2017)
Cell Rep.
, vol.18
, pp. 2343-2358
-
-
Medrano, M.1
Communal, L.2
Brown, K.R.3
Iwanicki, M.4
Normand, J.5
Paterson, J.6
Sircoulomb, F.7
Krzyzanowski, P.8
Novak, M.9
Doodnauth, S.A.10
-
29
-
-
85027283916
-
Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens
-
Hart, T., Tong, A.H.Y., Chan, K., Van Leeuwen, J., Seetharaman, A., Aregger, M., Chandrashekhar, M., Hustedt, N., Seth, S., Noonan, A. et al. (2017) Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens. G3 (Bethesda), 7, 2719-2727.
-
(2017)
G3 (Bethesda)
, vol.7
, pp. 2719-2727
-
-
Hart, T.1
Tong, A.H.Y.2
Chan, K.3
Van Leeuwen, J.4
Seetharaman, A.5
Aregger, M.6
Chandrashekhar, M.7
Hustedt, N.8
Seth, S.9
Noonan, A.10
-
30
-
-
17444441460
-
International system for human gene nomenclature (1979) ISGN (1979)
-
Shows, T.B., Alper, C.A., Bootsma, D., Dorf, M., Douglas, T., Huisman, T., Kit, S., Klinger, H.P., Kozak, C., Lalley, P.A. et al. (1980) International system for human gene nomenclature (1979) ISGN (1979). Birth Defects Orig. Artic. Ser., 15, 96-116.
-
(1980)
Birth Defects Orig. Artic. Ser.
, vol.15
, pp. 96-116
-
-
Shows, T.B.1
Alper, C.A.2
Bootsma, D.3
Dorf, M.4
Douglas, T.5
Huisman, T.6
Kit, S.7
Klinger, H.P.8
Kozak, C.9
Lalley, P.A.10
|