The role of CD73 in the generation of extracellular adenosine for adenosine receptor signaling

Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases

Volumn , Issue , 2006, Pages 39-48

  Takedachi, Masahide ^a   Colgan, Sean P ^b   Thompson, Linda F ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85040594092     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (48)

1. Olsson, R.A. and Pearson, D., Cardiovascular purinoceptors, Physiol. Rev., 70, 761, 1990.
2. Ramkumar, V., Pierson, G., and Stiles, G., Adenosine receptors: clinical implications and biochemical mechanisms, Prog. Drug Res., 32, 195, 1988.
3. Stiles, G.L., Adenosine receptors, J. Biol. Chem., 267, 6451, 1992.
4. Cronstein, B.N., Adenosine, an endogenous anti-inflammatory agent, J. Appl. Physiol., 76, 5, 1994.
5. 2a receptor-dependent and independent mechanisms, FASEB J., 14, 2065, 2000.
6. Panther, E. et al., Expression and function of adenosine receptors in human dendritic cells, FASEB J., 15, 1963, 2001.
7. Palmer, T.M. and Stiles, G.L., Adenosine receptors, Neuropharmacology, 34, 683, 1995.
8. Thompson, L.F. et al., Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5′-nucleotidase (CD73), Tissue Antigens, 35, 9, 1990.
9. 2B receptors, J. Exp. Med., 198, 783, 2003.
10. Snyder, F.F. and Henderson, J.F., Alternative pathways of deoxyadenosine and adenosine metabolism, J. Biol. Chem., 248, 5899, 1973.
11. Kameoka, J. et al., Direct association of adenosine deaminase with a T cell activation antigen, CD26, Science, 261, 466, 1993.
12. Morrison, M.E. et al., A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase, J. Exp. Med., 177, 1135, 1993.
13. Martin, M. et al., Surface expression of adenosine deaminase in mitogen-stimulated lymphocytes, Clin. Exp. Immunol., 93, 286, 1993.
14. 1 adenosine receptors internalize together following agonist-induced receptor desensitization, J. Biol. Chem., 273, 17610, 1998.
15. 2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells, Mol. Pharmacol., 59, 127, 2001.
16. Pacheco, R. et al., CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse, Proc. Natl. Acad. Sci. USA, 102, 9583, 2005.
17. Inbe, H. et al., Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine, J. Biol. Chem., 279, 19790, 2004.
18. He, W. et al., Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors, Nature, 429, 188, 2004.
19. Qi, A., Harden, T.K., and Nicholas, R.A., GPR980/99, proposed to be the P2Y15 receptor activated by adenosine and AMP, is not a P2Y receptor, Purinergic Signaling, 1, 67, 2004.
20. Abbracchio, M.P. et al., The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor, Trends Pharmacol. Sci., 26, 8, 2005.
21. Firestein, G.S. et al., Protective effect of an adenosine kinase inhibitor in septic shock, J. Immunol., 152, 5853, 1994.
22. Siegmund, B. et al., Adenosine kinase inhibitor GP515 improves experimental colitis in mice, J. Pharmacol. Exp. Ther., 296, 99, 2001.
23. Boyle, D.L. et al., Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis, J. Pharmacol. Exp. Ther., 296, 495, 2001.
24. Cronstein, B.N., Naime, D., and Firestein, G., The anti-inflammatory effects of an adenosine kinase inhibitor are mediated by adenosine, Arthritis Rheum., 38, 1040, 1995.
25. Adanin, S. et al., Inhibiting adenosine deaminase modulates the systemic inflammatory response syndrome in endotoxemia and sepsis, Am. J. Physiol. Regul. Integr. Comp. Physiol., 282, R1324, 2002.
26. Hashikawa, T. et al., Regulation of adenosine receptor engagement by ecto-adenosine deaminase, FASEB J., 18, 131, 2004.
27. Noji, T. et al., KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide- induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice, J. Pharmacol. Exp. Ther., 300, 200, 2002.
28. Thompson, L.F. et al., Crucial role for ecto-5′-nucleotidase (CD73) in vascular leakage during hypoxia, J. Exp. Med., 200, 1395, 2004.
29. Koszalka, P. et al., Targeted disruption of cd73/ecto-5′-nucleotidase alters thromboregulation and augments vascular inflammatory response, Circ. Res., 95, 814, 2004.
30. Castrop, H. et al., Impairment of tubuloglomerular feedback regulation of GFR in ecto-5′-nucleotidase/CD73-deficient mice, J. Clin. Invest., 114, 634, 2004.
31. Gutensohn, W. et al., Ecto-5′-nucleotidase activity is not required for T cell activation through CD73, Cell. Immunol., 161, 213, 1995.
32. Blackburn, M.R. et al., Adenosine levels in the postimplantation mouse uterus: quantitation by HPLC-fluorometric detection and spatiotemporal regulation by 5′-nucleotidase and adenosine deaminase, Dev. Dyn., 194, 155, 1992.
33. 2b adenosine receptor during implantation chamber development, Dev. Dyn., 216, 127, 1999.
34. Resta, R., Yamashita, Y., and Thompson, L.F., Ecto-enzyme and signaling functions of lymphocyte CD73, Immunol. Rev., 161, 95, 1998.
35. Ledoux, S. et al., Hypoxia enhances ecto-5′-nucleotidase activity and cell surface expression in endothelial cells: role of membrane lipids, Circ. Res., 92, 848, 2003.
36. Kobayashi, S., Zimmermann, H., and Millhorn, D.E., Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport, J. Neurochem., 74, 621, 2000.
37. Synnestvedt, K. et al., Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia, J. Clin. Invest., 110, 993, 2002.
38. 2B receptor activation, J. Exp. Med., 188, 1433, 1998.
39. Eltzschig, H.K. et al., Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism, Blood, 104, 3986, 2004.
40. Burger, R.M. and Lowenstein, J.M., 5-Nucleotidase from smooth muscle of small intestine and from brain. Inhibition by nucleotides, Biochemistry, 14, 2362, 1975.
41. Narravula, S. et al., Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier function, J. Immunol., 165, 5262, 2000.
42. Morabito, L. et al., Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5′-nucleotidase-mediated conversion of adenine nucleotides, J. Clin. Invest., 101, 295, 1998.
43. Kitakaze, M. et al., Infarct size-limiting effect of ischemic preconditioning is blunted by inhibition of 5′-nucleotidase activity and attenuation of adenosine release, Circulation, 89, 1237, 1994.
44. 3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice, J. Immunol., 173, 1380, 2004.
45. Gallos, G. et al., A1 adenosine receptor knockout mice exhibit increased mortality, renal dysfunction, and hepatic injury in murine septic peritonitis, Am. J. Physiol. Renal Physiol., 289, F369, 2005.
46. Liaudet, L. et al., Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture, Am. J. Respir. Crit. Care Med., 164, 1213, 2001.
47. as-linked) receptors, J. Exp. Med., 186, 1615, 1997.
48. 2A receptors, Am. J. Pathol., 160, 2009, 2002.