KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-α production and leukopenia via endogenous adenosine in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 1, 2002, Pages 200-205

  Noji, Tohru ^a   Takayama, Makoto ^a   Mizutani, Mirai ^a   Okamura, Yuko ^a   Takai, Haruki ^a   Karasawa, Akira ^a   Kusaka, Hideaki ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 (6,7 DIETHOXY 2 MORPHOLINOQUINAZOLIN 4 YL)PIPERIDIN 4 YL] 1,6 DIMETHYL 2,4 (1H,3H)QUINAZOLINEDIONE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 8 (2 NOR 1 ADAMANTYL) 1,3 DIPROPYLXANTHINE; 8 (4 SULFOPHENYL)THEOPHYLLINE; ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ANTIINFLAMMATORY AGENT; DILAZEP; DIPYRIDAMOLE; DRAFLAZINE; KF 24345; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG STRUCTURE; ERYTHROCYTE; IC 50; LEUKOPENIA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE; ANIMALS; CRICETINAE; ERYTHROCYTES; HUMANS; LEUKOPENIA; LIPOPOLYSACCHARIDES; MESOCRICETUS; MICE; NEUROTRANSMITTER UPTAKE INHIBITORS; PYRIMIDINONES; QUINAZOLINES; RABBITS; RECEPTORS, PURINERGIC P1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036139126     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.1.200     Document Type: Article

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