Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires Ecto-5'-nucleotidase-mediated conversion of adenine nucleotides

Journal of Clinical Investigation

Volumn 101, Issue 2, 1998, Pages 295-300

  Morabito, Lance ^a   Montesinos, M Carmen ^a   Schreibman, David M ^a   Balter, Laurence ^a   Thompson, Linda F ^b   Resta, Regina ^b   Carlin, Gunnar ^c   Huie, Mary Ann ^a   Cronstein, Bruce N ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^c PFIZER INC   (United States)

Author keywords

Adenosine; Ecto 5' nucleotidase; Inflammation; Methotrexate; Sulfasalazine

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE; ADENOSINE PHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; CARRAGEENAN; ECTO 5' NUCLEOTIDASE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; METHOTREXATE; SALAZOSULFAPYRIDINE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKOCYTE ACTIVATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 0032518281     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1554     Document Type: Article

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