Light-Responsive Nanoparticles for Highly Efficient Cytoplasmic Delivery of Anticancer Agents

ACS Nano

Volumn 11, Issue 12, 2017, Pages 12134-12144

  Wang, Yangyun ^a   Deng, Yibin ^b   Luo, Huanhuan ^b   Zhu, Aijun ^b   Ke, Hengte ^b   Yang, Hong ^a   Chen, Huabing ^a,b  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

cytoplasmic delivery; light responsive nanoparticles; micelles; photothermal therapy; synergistic therapy

Indexed keywords

CHEMOTHERAPY; INFRARED DEVICES; MICELLES; NANOPARTICLES; SELENIUM; TUMORS;

CONTINUOUS DRUG RELEASE; CYTOPLASMIC DELIVERY; INTRACELLULAR DELIVERY; IRREVERSIBLE DISSOCIATION; PHOTOTHERMAL THERAPY; POLYMERIC NANOPARTICLES; REACTIVE OXYGEN SPECIES; SYNERGISTIC THERAPY;

NANOSTRUCTURES;

ANTINEOPLASTIC AGENT; DOXORUBICIN; NANOPARTICLE; POLYMER; REACTIVE OXYGEN METABOLITE; SELENIUM;

ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CYTOPLASM; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG SCREENING; EXPERIMENTAL MAMMARY NEOPLASM; HUMAN; INFRARED RADIATION; METABOLISM; MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOPLASM; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INFRARED RAYS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; NANOPARTICLES; POLYMERS; REACTIVE OXYGEN SPECIES; SELENIUM;

EID: 85040071280     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.7b05214     Document Type: Article

References (84)

1. Xu, X.; Ho, W.; Zhang, X.; Bertrand, N.; Farokhzad, O. Cancer Nanomedicine: From Targeted Delivery to Combination Therapy Trends Mol. Med. 2015, 21, 223-232 10.1016/j.molmed.2015.01.001
2. Shi, J. J.; Kantoff, P. W.; Wooster, R.; Farokhzad, O. C. Cancer Nanomedicine: Progress, Challenges and Opportunities Nat. Rev. Cancer 2017, 17, 20-37 10.1038/nrc.2016.108
3. Chen, G. Y.; Roy, I.; Yang, C. H.; Prasad, P. N. Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy Chem. Rev. 2016, 116, 2826-2885 10.1021/acs.chemrev.5b00148
4. Bourzac, K. Cancer Nanomedicine, Reengineered After Recent Setbacks, Researchers Hope to Find Approaches More Attuned to the Complexities of Cancer Biology Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 12600-12603 10.1073/pnas.1616895113
5. Molina, M.; Asadian-Birjand, M.; Balach, J.; Bergueiro, J.; Miceli, E.; Calderon, M. Stimuli-Responsive Nanogel Composites and Their Application in Nanomedicine Chem. Soc. Rev. 2015, 44, 6161-6186 10.1039/C5CS00199D
6. Sun, T.; Zhang, Y. S.; Pang, B.; Hyun, D. C.; Yang, M.; Xia, Y. Engineered Nanoparticles for Drug Delivery in Cancer Therapy Angew. Chem., Int. Ed. 2014, 53, 12320-12364 10.1002/anie.201403036
7. Hoffman, A. S. Biomaterials in the Nano-Era Chin. Sci. Bull. 2013, 58, 4337-4341 10.1007/s11434-013-6090-x
8. Sun, Q.; Zhou, Z.; Qiu, N.; Shen, Y. Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization Adv. Mater. 2017, 29, 1606628 10.1002/adma.201606628
9. Mura, S.; Nicolas, J.; Couvreur, P. Stimuli-Responsive Nanocarriers for Drug Delivery Nat. Mater. 2013, 12, 991-1003 10.1038/nmat3776
10. Lu, C. H.; Willner, I. Stimuli-Responsive DNA-Functionalized Nano-/Microcontainers for Switchable and Controlled Release Angew. Chem., Int. Ed. 2015, 54, 12212-12235 10.1002/anie.201503054
11. Cheng, R.; Meng, F.; Deng, C.; Zhong, Z. Bioresponsive Polymeric Nanotherapeutics for Targeted Cancer Chemotherapy Nano Today 2015, 10, 656-670 10.1016/j.nantod.2015.09.005
12. Karimi, M.; Ghasemi, A.; Zangabad, P. S.; Rahighi, R.; Basri, S. M. M.; Mirshekari, H.; Amiri, M.; Pishabad, Z. S.; Aslani, A.; Bozorgomid, M. et al. Smart Micro/Nanoparticles in Stimulus-Responsive Drug/Gene Delivery Systems Chem. Soc. Rev. 2016, 45, 1457-1501 10.1039/C5CS00798D
13. Yang, K.; Feng, L.; Liu, Z. Stimuli Responsive Drug Delivery Systems based on Nano-Graphene for Cancer Therapy Adv. Drug Delivery Rev. 2016, 105, 228-241 10.1016/j.addr.2016.05.015
14. Li, H.-J.; Du, J.-Z.; Du, X.-J.; Xu, C.-F.; Sun, C.-Y.; Wang, H.-X.; Cao, Z.-T.; Yang, X.-Z.; Zhu, Y.-H.; Nie, S. et al. Stimuli-Responsive Clustered Nanoparticles for Improved Tumor Penetration and Therapeutic Efficacy Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 4164-4169 10.1073/pnas.1522080113
15. Li, F.; Lu, J.; Kong, X.; Hyeon, T.; Ling, D. Dynamic Nanoparticle Assemblies for Biomedical Applications Adv. Mater. 2017, 29, 1605897 10.1002/adma.201605897
16. Du, J.; Lane, L. A.; Nie, S. Stimuli-Responsive Nanoparticles for Targeting the Tumor Microenvironment J. Controlled Release 2015, 219, 205-214 10.1016/j.jconrel.2015.08.050
17. Fleige, E.; Quadir, M. A.; Haag, R. Stimuli-Responsive Polymeric Nanocarriers for the Controlled Transport of Active Compounds: Concepts and Applications Adv. Drug Delivery Rev. 2012, 64, 866-884 10.1016/j.addr.2012.01.020
18. Ganta, S.; Devalapally, H.; Shahiwala, A.; Amiji, M. A Review of Stimuli-Responsive Nanocarriers for Drug and Gene Delivery J. Controlled Release 2008, 126, 187-204 10.1016/j.jconrel.2007.12.017
19. Timko, B. P.; Dvir, T.; Kohane, D. S. Remotely Triggerable Drug Delivery Systems Adv. Mater. 2010, 22, 4925-4943 10.1002/adma.201002072
20. Akimoto, J.; Nakayama, M.; Okano, T. Temperature-Responsive Polymeric Micelles for Optimizing Drug Targeting to Solid Tumors J. Controlled Release 2014, 193, 2-8 10.1016/j.jconrel.2014.06.062
21. Wang, Y. C.; Shim, M. S.; Levinson, N. S.; Sung, H. W.; Xia, Y. N. Stimuli-Responsive Materials for Controlled Release of Theranostic Agents Adv. Funct. Mater. 2014, 24, 4206-4220 10.1002/adfm.201400279
22. Zhang, W.; Gao, C. Recent Advances in Cell Imaging and Cytotoxicity of Intracellular Stimuli-Responsive Nanomaterials Sci. Bull. 2015, 60, 1973-1979 10.1007/s11434-015-0952-3
23. Liu, X.; Xiang, J.; Zhu, D.; Jiang, L.; Zhou, Z.; Tang, J.; Liu, X.; Huang, Y.; Shen, Y. Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery Adv. Mater. 2016, 28, 1743-1752 10.1002/adma.201504288
24. 2 Bubbles to Induce Transient Cavitation, Lysosomal Rupturing, and Cell Necrosis Angew. Chem., Int. Ed. 2012, 51, 10089-10093 10.1002/anie.201205482
25. Bao, C. Y.; Zhu, L. Y.; Lin, Q. N.; Tian, H. Building Biomedical Materials using Photochemical Bond Cleavage Adv. Mater. 2015, 27, 1647-1662 10.1002/adma.201403783
26. Wang, J. X.; Liu, Y.; Ma, Y. C.; Sun, C. Y.; Tao, W.; Wang, Y. C.; Yang, X. Z.; Wang, J. NIR-Activated Supersensitive Drug Release Using Nanoparticles with a Flow Core Adv. Funct. Mater. 2016, 26, 7516-7525 10.1002/adfm.201603195
27. Sun, X.; Wang, C.; Gao, M.; Hu, A.; Liu, Z. Remotely Controlled Red Blood Cell Carriers for Cancer Targeting and Near-Infrared Light-Triggered Drug Release in Combined Photothermal-Chemotherapy Adv. Funct. Mater. 2015, 25, 2386-2394 10.1002/adfm.201500061
28. Hoare, T.; Timko, B. P.; Santamaria, J.; Goya, G. F.; Irusta, S.; Lau, S.; Stefanescu, C. F.; Lin, D. B.; Langer, R.; Kohane, D. S. Magnetically Triggered Nanocomposite Membranes: A Versatile Platform for Triggered Drug Release Nano Lett. 2011, 11, 1395-1400 10.1021/nl200494t
29. Rwei, A. Y.; Wang, W. P.; Kohane, D. S. Photoresponsive nanoparticles for drug delivery Nano Today 2015, 10, 451-467 10.1016/j.nantod.2015.06.004
30. Ma, M.; Chen, H. R.; Shi, J. L. Construction of Smart Inorganic Nanoparticle-based Ultrasound Contrast Agents and Their Biomedical Applications Sci. Bull. 2015, 60, 1170-1183 10.1007/S11434-015-0829-5
31. Cheng, R.; Meng, F.; Deng, C.; Klok, H.-A.; Zhong, Z. Dual and Multi-Stimuli Responsive Polymeric Nanoparticles for Programmed Site-Specific Drug Delivery Biomaterials 2013, 34, 3647-3657 10.1016/j.biomaterials.2013.01.084
32. Yoon, S.; Kim, W. J.; Yoo, H. S. Dual-Responsive Breakdown of Nanostructures with High Doxorubicin Payload for Apoptotic Anticancer Therapy Small 2013, 9, 284-293 10.1002/smll.201200997
33. Dai, J.; Lin, S.; Cheng, D.; Zou, S.; Shuai, X. Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release Angew. Chem., Int. Ed. 2011, 50, 9404-9408 10.1002/anie.201103806
34. Fang, W. J.; Yang, J.; Gong, J. W.; Zheng, N. F. Photo- and pH-Triggered Release of Anticancer Drugs from Mesoporous Silica-Coated Pd@Ag Nanoparticles Adv. Funct. Mater. 2012, 22, 842-848 10.1002/adfm.201101960
35. Nahire, R.; Paul, S.; Scott, M. D.; Singh, R. K.; Muhonen, W. W.; Shabb, J.; Gange, K. N.; Srivastava, D. K.; Sarkar, K.; Mallik, S. Ultrasound Enhanced Matrix Metalloproteinase-9 Triggered Release of Contents from Echogenic Liposomes Mol. Pharmaceutics 2012, 9, 2554-2564 10.1021/mp300165s
36. Li, F.; Chen, W. L.; You, B. G.; Liu, Y.; Yang, S. D.; Yuan, Z. Q.; Zhu, W. J.; Li, J. Z.; Qu, C. X.; Zhou, Y. J. et al. Enhanced Cellular Internalization and On-Demand Intracellular Release of Doxorubicin by Stepwise pH-/Reduction-Responsive Nanoparticles ACS Appl. Mater. Interfaces 2016, 8, 32146-32158 10.1021/acsami.6b09604
37. Wang, Z.; Chen, Z.; Liu, Z.; Shi, P.; Dong, K.; Ju, E.; Ren, J.; Qu, X. A Multi-Stimuli Responsive Gold Nanocage-Hyaluronic Platform for Targeted Photothermal and Chemotherapy Biomaterials 2014, 35, 9678-9688 10.1016/j.biomaterials.2014.08.013
38. Liu, G. H.; Wang, X. R.; Hu, J. M.; Zhang, G. Y.; Liu, S. Y. Self-Immolative Polymersomes for High-Efficiency Triggered Release and Programmed Enzymatic Reactions J. Am. Chem. Soc. 2014, 136, 7492-7497 10.1021/ja5030832
39. Zhu, A. J.; Miao, K.; Deng, Y. B.; Ke, H. T.; He, H.; Yang, T.; Guo, M.; Li, Y. L.; Guo, Z. Q.; Wang, Y. Y. et al. Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation ACS Nano 2015, 9, 7874-7885 10.1021/acsnano.5b02843
40. An, X.; Zhu, A.; Luo, H.; Ke, H.; Chen, H.; Zhao, Y. Rational Design of Multi-Stimuli-Responsive Nanoparticles for Precise Cancer Therapy ACS Nano 2016, 10, 5947-58 10.1021/acsnano.6b01296
41. Wang, S.; Huang, P.; Chen, X. Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization Adv. Mater. 2016, 28, 7340-7364 10.1002/adma.201601498
42. Lee, E. S.; Kim, D.; Youn, Y. S.; Oh, K. T.; Bae, Y. H. A Virus-Mimetic Nanogel Vehicle Angew. Chem., Int. Ed. 2008, 47, 2418-2421 10.1002/anie.200704121
43. Chu, Z. Q.; Zhang, S. L.; Zhang, B. K.; Zhang, C. Y.; Fang, C. Y.; Rehor, I.; Cigler, P.; Chang, H. C.; Lin, G.; Liu, R. B. et al. Unambiguous Observation of Shape Effects on Cellular Fate of Nanoparticles Sci. Rep. 2015, 4, 4495 10.1038/srep04495
44. Frohlich, E.; Meindl, C.; Roblegg, E.; Ebner, B.; Absenger, M.; Pieber, T. R. Action of Polystyrene Nanoparticles of Different Sizes on Lysosomal Function and Integrity Part. Fibre Toxicol. 2012, 9, 26 10.1186/1743-8977-9-26
45. Barua, S.; Mitragotri, S. Challenges Associated with Penetration of Nanoparticles Across Cell and Tissue Barriers: A Review of Current Status and Future Prospects Nano Today 2014, 9, 223-243 10.1016/j.nantod.2014.04.008
46. Fiszer-Szafarz, B.; Nadal, C. Lysosomal Enzyme Activities in the Regenerating Rat Liver Cancer Res. 1977, 37, 354-357
47. Katayama, K.; Kapoor, K.; Ohnuma, S.; Patel, A.; Swaim, W.; Ambudkar, I. S.; Ambudkar, S. V. Revealing the Fate of Cell Surface Human P-glycoprotein (ABCB1): The Lysosomal Degradation Pathway Biochim. Biophys. Acta, Mol. Cell Res. 2015, 1853, 2361-2370 10.1016/j.bbamcr.2015.06.001
48. Shanmugam, V.; Selvakumar, S.; Yeh, C.-S. Near-Infrared Light-Responsive Nanomaterials in Cancer Therapeutics Chem. Soc. Rev. 2014, 43, 6254-6287 10.1039/C4CS00011K
49. Zhang, Z.; Wang, J.; Chen, C. Near-Infrared Light-Mediated Nanoplatforms for Cancer Thermo-Chemotherapy and Optical Imaging Adv. Mater. 2013, 25, 3869-3880 10.1002/adma.201301890
50. Yang, G. B.; Liu, J. J.; Wu, Y. F.; Feng, L. Z.; Liu, Z. Near-Infrared-Light Responsive Nanoscale Drug Delivery Systems for Cancer Treatment Coord. Chem. Rev. 2016, 320, 100-117 10.1016/j.ccr.2016.04.004
51. Yuan, Y.; Liu, J.; Liu, B. Conjugated-Polyelectrolyte-Based Polyprodrug: Targeted and Image-Guided Photodynamic and Chemotherapy with On-Demand Drug Release upon Irradiation with a Single Light Source Angew. Chem., Int. Ed. 2014, 53, 7163-7168 10.1002/anie.201402189
52. Tan, X. Y.; Li, B. B.; Lu, X. G.; Jia, F.; Santori, C.; Menon, P.; Li, H.; Zhang, B. H.; Zhao, J. J.; Zhang, K. Light-Triggered, Self-Immolative Nucleic Acid-Drug Nanostructures J. Am. Chem. Soc. 2015, 137, 6112-6115 10.1021/jacs.5b00795
53. Wong, P. T.; Choi, S. K. Mechanisms of Drug Release in Nanotherapeutic Delivery Systems Chem. Rev. 2015, 115, 3388-3432 10.1021/cr5004634
54. Cao, J.; Huang, S.; Chen, Y.; Li, S.; Li, X.; Deng, D.; Qian, Z.; Tang, L.; Gu, Y. Near-Infrared Light-Triggered Micelles for Fast Controlled Drug Release in Deep Tissue Biomaterials 2013, 34, 6272-6283 10.1016/j.biomaterials.2013.05.008
55. Forbes, N.; Pallaoro, A.; Reich, N. O.; Zasadzinski, J. A. Rapid, Reversible Release from Thermosensitive Liposomes Triggered by Near-Infra-Red Light Part. Part. Syst. Char. 2014, 31, 1158-1167 10.1002/ppsc.201400035
56. Luo, D. D.; Li, N.; Carter, K. A.; Lin, C. Y.; Geng, J. M.; Shao, S.; Huang, W. C.; Qin, Y. L.; Atilla-Gokcumen, G. E.; Lovell, J. F. Rapid Light-Triggered Drug Release in Liposomes Containing Small Amounts of Unsaturated and Porphyrin-Phospholipids Small 2016, 12, 3039-3047 10.1002/smll.201503966
57. Tian, Y. F.; Zheng, J.; Tang, X. L.; Ren, Q. G.; Wang, Y. J.; Yang, W. L. Near-Infrared Light-Responsive Nanogels with Diselenide-Cross-Linkers for On-Demand Degradation and Triggered Drug Release Part. Part. Syst. Char. 2015, 32, 547-551 10.1002/ppsc.201400244
58. Luo, D. D.; Carter, K. A.; Razi, A.; Geng, J. M.; Shao, S.; Giraldo, D.; Sunar, U.; Ortega, J.; Lovell, J. F. Doxorubicin Encapsulated in Stealth Liposomes Conferred with Light-Triggered Drug Release Biomaterials 2016, 75, 193-202 10.1016/j.biomaterials.2015.10.027
59. Qian, C. G.; Yu, J. C.; Chen, Y. L.; Hu, Q. Y.; Xiao, X. Z.; Sun, W. J.; Wang, C.; Feng, P. J.; Shen, Q. D.; Gu, Z. Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy Adv. Mater. 2016, 28, 3313-3320 10.1002/adma.201505869
60. Su, J.; Sun, H.; Meng, Q.; Yin, Q.; Zhang, P.; Zhang, Z.; Yu, H.; Li, Y. Bioinspired Nanoparticles with NIR-Controlled Drug Release for Synergetic Chemophotothermal Therapy of Metastatic Breast Cancer Adv. Funct. Mater. 2016, 26, 7495-7506 10.1002/adfm.201603381
61. Meng, Z.; Wei, F.; Wang, R.; Xia, M.; Chen, Z.; Wang, H.; Zhu, M. NIR-Laser-Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors Adv. Mater. 2016, 28, 245-253 10.1002/adma.201502669
62. Li, D.; Ma, Y.; Du, J.; Tao, W.; Du, X.; Yang, X.; Wang, J. Tumor Acidity/NIR Controlled Interaction of Transformable Nanoparticle with Biological Systems for Cancer Therapy Nano Lett. 2017, 17, 2871-2878 10.1021/acs.nanolett.6b05396
63. Chen, G.; Jaskula-Sztul, R.; Esquibel, C. R.; Lou, I.; Zheng, Q.; Dammalapati, A.; Harrison, A.; Eliceiri, K. W.; Tang, W.; Chen, H. et al. Neuroendocrine Tumor-Targeted Upconversion Nanoparticle-Based Micelles for Simultaneous NIR-Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging Adv. Funct. Mater. 2017, 27, 1604671 10.1002/adfm.201604671
64. Sun, W.; Li, S.; Haupler, B.; Liu, J.; Jin, S.; Steffen, W.; Schubert, U. S.; Butt, H. J.; Liang, X. J.; Wu, S. An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy Adv. Mater. 2017, 29, 1603702 10.1002/adma.201603702
65. Li, H.; Yang, X.; Zhou, Z.; Wang, K.; Li, C.; Qiao, H.; Oupicky, D.; Sun, M. Near-Infrared Light-Triggered Drug Release From a Multiple Lipid Carrier Complex using an All-in-One Strategy J. Controlled Release 2017, 261, 126-137 10.1016/j.jconrel.2017.06.029
66. Li, F.; Li, T.; Cao, W.; Wang, L.; Xu, H. Near-Infrared Light Stimuli-Responsive Synergistic Therapy Nanoplatforms based on the Coordination of Tellurium-Containing Block Polymer and Cisplatin for Cancer Treatment Biomaterials 2017, 133, 208-218 10.1016/j.biomaterials.2017.04.032
67. Dong, K.; Liu, Z.; Li, Z. H.; Ren, J. S.; Qu, X. G. Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells Adv. Mater. 2013, 25, 4452-4458 10.1002/adma.201301232
68. Yang, X. J.; Liu, X.; Liu, Z.; Pu, F.; Ren, J. S.; Qu, X. G. Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles Adv. Mater. 2012, 24, 2890-2895 10.1002/adma.201104797
69. Ma, Y. F.; Huang, J.; Song, S. J.; Chen, H. B.; Zhang, Z. J. Cancer-Targeted Nanotheranostics: Recent Advances and Perspectives Small 2016, 12, 4936-4954 10.1002/smll.201600635
70. Deng, Y.; Huang, L.; Yang, H.; Ke, H.; He, H.; Guo, Z.; Yang, T.; Zhu, A.; Wu, H.; Chen, H. Cyanine-Anchored Silica Nanochannels for Light-Driven Synergistic Thermo-Chemotherapy Small 2017, 13, 1602747 10.1002/smll.201602747
71. Yang, H.; Mao, H.; Wan, Z.; Zhu, A.; Guo, M.; Li, Y.; Li, X.; Wan, J.; Yang, X.; Shuai, X. et al. Micelles Assembled with Carbocyanine Dyes for Theranostic Near-Infrared Fluorescent Cancer Imaging and Photothermal Therapy Biomaterials 2013, 34, 9124-9133 10.1016/j.biomaterials.2013.08.022
72. Wan, Z. H.; Mao, H. J.; Guo, M.; Li, Y. L.; Zhu, A. J.; Yang, H.; He, H.; Shen, J. K.; Zhou, L. J.; Jiang, Z. et al. Highly Efficient Hierarchical Micelles Integrating Photothermal Therapy and Singlet Oxygen-Synergized Chemotherapy for Cancer Eradication Theranostics 2014, 4, 399-411 10.7150/thno.8171
73. Wang, Y.; Yang, T.; Ke, H. T.; Zhu, A. J.; Wang, Y. Y.; Wang, J. X.; Shen, J. K.; Liu, G.; Chen, C. Y.; Zhao, Y. L. et al. Smart Albumin-Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation Adv. Mater. 2015, 27, 3874-3882 10.1002/adma.201500229
74. Li, Y. L.; Deng, Y. B.; Tian, X.; Ke, H. T.; Guo, M.; Zhu, A. J.; Yang, T.; Guo, Z. Q.; Ge, Z. S.; Yang, X. L. et al. Multipronged Design of Light-Triggered Nanoparticles To Overcome Cisplatin Resistance for Efficient Ablation of Resistant Tumor ACS Nano 2015, 9, 9626-9637 10.1021/acsnano.5b05097
75. Yang, T.; Wang, Y.; Ke, H.; Wang, Q.; Lv, X.; Wu, H.; Tang, Y.; Yang, X.; Chen, C.; Zhao, Y. et al. Protein-Nanoreactor-Assisted Synthesis of Semiconductor Nanocrystals for Efficient Cancer Theranostics Adv. Mater. 2016, 28, 5923-5930 10.1002/adma.201506119
76. Ren, H. F.; Wu, Y. T.; Ma, N.; Xu, H. P.; Zhang, X. Side-Chain Selenium-Containing Amphiphilic Block Copolymers: Redox-Controlled Self-Assembly and Disassembly Soft Matter 2012, 8, 1460-1466 10.1039/C1SM06673K
77. Ma, N.; Li, Y.; Ren, H. F.; Xu, H. P.; Li, Z. B.; Zhang, X. Selenium-Containing Block Copolymers and Their Oxidation-Responsive Aggregates Polym. Chem. 2010, 1, 1609-1614 10.1039/c0py00144a
78. Liu, J. Y.; Pang, Y.; Zhu, Z. Y.; Wang, D. L.; Li, C. T.; Huang, W.; Zhu, X. Y.; Yan, D. Y. Therapeutic Nanocarriers with Hydrogen Peroxide-Triggered Drug Release for Cancer Treatment Biomacromolecules 2013, 14, 1627-1636 10.1021/bm4002574
79. Cao, W.; Li, Y.; Yi, Y.; Ji, S. B.; Zeng, L. W.; Sun, Z. W.; Xu, H. P. Coordination-Responsive Selenium-Containing Polymer Micelles for Controlled Drug Release Chem. Sci. 2012, 3, 3403-3408 10.1039/c2sc21315j
80. Tan, X. X.; Yu, Y.; Liu, K.; Xu, H. P.; Liu, D. S.; Wang, Z. Q.; Zhang, X. Single-Molecule Force Spectroscopy of Selenium-Containing Amphiphilic Block Copolymer: Toward Disassembling the Polymer Micelles Langmuir 2012, 28, 9601-9605 10.1021/la301703t
81. Yang, T.; Ke, H.; Wang, Q.; Tang, Y.; Deng, Y.; Yang, H.; Yang, X.; Yang, P.; Ling, D.; Chen, C. et al. Bifunctional Tellurium Nanodots for Photo-Induced Synergistic Cancer Therapy ACS Nano 2017, 11, 10012-10024 10.1021/acsnano.7b04230
82. Selbo, P. K.; Weyergang, A.; Hogset, A.; Norum, O.-J.; Berstad, M. B.; Vikdal, M.; Berg, K. Photochemical Internalization Provides Time- and Space-Controlled Endolysosomal Escape of Therapeutic Molecules J. Controlled Release 2010, 148, 2-12 10.1016/j.jconrel.2010.06.008
83. Ji, T.; Zhao, Y.; Ding, Y.; Nie, G. Using Functional Nanomaterials to Target and Regulate the Tumor Microenvironment: Diagnostic and Therapeutic Applications Adv. Mater. 2013, 25, 3508-3525 10.1002/adma.201300299
84. Zhao, R.; Han, X.; Li, Y.; Wang, H.; Ji, T.; Zhao, Y.; Nie, G. Photothermal Effect Enhanced Cascade Targeting Strategy for Improved Pancreatic Cancer Therapy by Gold Nanoshell@Mesoporous Silica Nanorod ACS Nano 2017, 11, 8103-8113 10.1021/acsnano.7b02918