Temperature-responsive polymeric micelles for optimizing drug targeting to solid tumors

Journal of Controlled Release

Volumn 193, Issue , 2014, Pages 2-8

  Akimoto, Jun ^a   Nakayama, Masamichi ^a   Okano, Teruo ^a  

^a Tokyo Women s Medical University Waseda University Joint Institution for Advanced Biomedical Sciences   (Japan)

Author keywords

Hyperthermia; Multi stimuli; Polymeric micelle; Temperature response; Tumor targeting

Indexed keywords

DRUG-TARGETING; HYPERTHERMIA; MULTI-STIMULI; POLYMERIC MICELLE; SOLID TUMORS; TEMPERATURE-RESPONSIVE; TUMOR TARGETING;

ANTINEOPLASTIC AGENT; DRUG CARRIER; MACROGOL; POLYMER; MICELLE;

CANCER CHEMOTHERAPY; CANCER STEM CELL; CIRCULATION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG RELEASE; DRUG TARGETING; GLASS TRANSITION TEMPERATURE; HUMAN; MICELLE; NONHUMAN; PHYSICAL CHEMISTRY; POLYMERIZATION; REVIEW; SOLID TUMOR; TEMPERATURE; TEMPERATURE RESPONSIVE POLYMERIC MICELLE; TEMPERATURE SENSITIVITY; CHEMISTRY; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASMS; PATHOLOGY; STIMULATION;

ANTINEOPLASTIC AGENTS; DRUG CARRIERS; DRUG LIBERATION; HUMANS; MICELLES; MOLECULAR TARGETED THERAPY; NEOPLASMS; PHYSICAL STIMULATION; POLYMERS; TEMPERATURE;

EID: 84908272276     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.06.062     Document Type: Review

References (78)

1. P. Working, M. Newman, S. Huang, E. Mayhew, J. Vaage, and D. Lasic Pharmacokinetics, biodistribution and therapeutic efficacy of doxorubicin encapsulated in Stealth® liposomes (Doxil®) J. Liposome Res. 4 1994 667 687
2. G. Kwon, S. Suwa, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-adriamycin conjugates J. Control. Release 29 1994 17 23
3. Y. Matsumura, and H. Maeda A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res. 46 1986 6387 6392
4. M. Yokoyama Drug targeting with nano-sized carrier systems J. Artif. Organs 8 2005 77 84
5. R. Krishna, and L.D. Mayer Multidrug resistance (MDR) in cancer: mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs Eur. J. Pharm. Sci. 11 2000 265 283
6. E.S. Lee, Z. Gao, and Y.H. Bae Recent progress in tumor pH targeting nanotechnology J. Control. Release 132 2008 164 170
7. W. Gao, J.M. Chan, and O.C. Farokhzad pH-responsive nanoparticles for drug delivery Mol. Pharm. 7 2010 1913 1920
8. M. Nakayama, and T. Okano Multi-targeting cancer chemotherapy using temperature-responsive drug carrier systems React. Funct. Polym. 71 2011 235 244
9. J. Kopeček, P. Kopečková, T. Minko, and Z.-R. Lu HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action Eur. J. Pharm. Biopharm. 50 2000 61 81
10. N. Rapoport Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery Prog. Polym. Sci. 32 2007 962 990
11. C. Alvarez-Lorenzo, L. Bromberg, and A. Concheiro Light-sensitive intelligent drug delivery systems Photochem. Photobiol. 85 2009 848 860
12. A.M. Ponce, Z. Vuujaskovic, F. Yuan, D. Needham, and M.W. Dewhirst Hyperthermia mediated liposomal drug delivery Int. J. Hyperthermia 22 2006 205 213
13. C. Garrido, S. Gurbuxani, L. Ravagnan, and G. Kroemer Heat shock proteins: endogenous modulators of apoptotic cell death Biochem. Biophys. Res. Commun. 286 2001 433 442
14. H. Yoshida, K. Haze, H. Yanagi, T. Yura, and K. Mori Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins: involvement of basic leucine zipper transcription factors J. Biol. Chem. 273 1998 33741 33749
15. C. Koumenis ER stress, hypoxia tolerance and tumor progression Curr. Mol. Med. 6 2006 55 69
16. P. Maxwell, G. Dachs, J. Gleadle, L. Nicholls, A. Harris, I. Stratford, O. Hankinson, C. Pugh, and P. Ratcliffe Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth Proc. Natl. Acad. Sci. U. S. A. 94 1997 8104 8109
17. J.E. Kennedy High-intensity focused ultrasound in the treatment of solid tumours Nat. Rev. Cancer 5 2005 321 327
18. K. Sasaki, M.S. Medan, T. Azuma, K. Kawabata, M. Shimoda, and S. Umemura Effect of echo-guided high-intensity focused ultrasound ablation on localized experimental tumors J. Vet. Med. Sci. 68 2006 1069 1074
19. P.L. Moseley Heat shock proteins and heat adaptation of the whole organism J. Appl. Physiol. 83 1997 1413 1417
20. M.W. Dewhirst, B.L. Viglianti, M. Lora-Michiels, M. Hanson, and P.J. Hoopes Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia Int. J. Hyperthermia 19 2003 267 294
21. H.G. Schild Poly(N-isopropylacrylamide): experimental and application Prog. Polym. Sci. 17 1992 163 249
22. T. Okano Biorelated Polymers and Gels 1998 Academic Press San Diego
23. H. Kanazawa, K. Yamamoto, Y. Matsushima, N. Takai, A. Kikuchi, Y. Sakurai, and T. Okano Temperature-responsive chromatography using poly (N-isopropylacrylamide)-modified silica Anal. Chem. 68 1996 100 105
24. M. Yamato, Y. Akiyama, J. Kobayashi, J. Yang, A. Kikuchi, and T. Okano Temperature-responsive cell culture surfaces for regenerative medicine with cell sheet engineering Prog. Polym. Sci. 32 2007 1123 1133
25. S. Aoshima, H. Oda, and E. Kobayashi Synthesis of thermally-induced phase separating polymer with well-defined polymer structure by living cationic polymerization. I. Synthesis of poly(vinyl ether)s with oxyethylene units in the pendant and its phase separation behavior in aqueous solution J. Polym. Sci. A Polym. Chem. 30 1992 2407 2413
26. M. Heskins, and J.E. Guillet Solution properties of poly (N-isopropylacrylamide) J. Macromol. Sci. Chem. 2 1968 1441 1455
27. J.S. Park, and K. Kataoka Precise control of lower critical solution temperature of thermosensitive poly (2-isopropyl-2-oxazoline) via gradient copolymerization with 2-ethyl-2-oxazoline as a hydrophilic comonomer Macromolecules 39 2006 6622 6630
28. K. Suwa, K. Morishita, A. Kishida, and M. Akashi Synthesis and functionalities of poly(N-vinylalkylamide). V. Control of a lower critical solution temperature of poly(N-vinylalkylamide) J. Polym. Sci. A Polym. Chem. 35 1997 3087 3094
29. Y.G. Takei, T. Aoki, K. Sanui, N. Ogata, T. Okano, and Y. Sakurai Temperature-responsive bioconjugates. 2. Molecular design for temperature-modulated bioseparations Bioconjug. Chem. 4 1993 341 346
30. M. Yokoyama, S. Inoue, K. Kataoka, N. Yui, T. Okano, and Y. Sakurai Molecular design for missile drug: synthesis of adriamycin conjugated with immunoglobulin G using poly(ethylene glycol)-block-poly(aspartic acid) as intermediate carrier Makromol. Chem. 190 1989 2041 2054
31. W. Li, M. Nakayama, J. Akimoto, and T. Okano Effect of block compositions of amphiphilic block copolymers on the physicochemical properties of polymeric micelles Polymer 52 2011 3783 3790
32. K. Shiraishi, M. Hamano, H. Ma, K. Kawano, Y. Maitani, T. Aoshi, K.J. Ishii, and M. Yokoyama Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon J. Control. Release 165 2013 183 190
33. Y. Matsumura, T. Hamaguchi, T. Ura, K. Muro, Y. Yamada, Y. Shimada, K. Shirao, T. Okusaka, H. Ueno, and M. Ikeda Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin Br. J. Cancer 91 2004 1775 1781
34. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. Kano, K. Miyazono, and M. Uesaka Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size Nat. Nanotechnol. 6 2011 815 823
35. Z. Ge, Q. Chen, K. Osada, X. Liu, T.A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, M. Yu, O. Makoto, R.K. Mitsunobu, I. Keiji, and K. Kazunori Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors Biomaterials 35 10 2014 3416 3426
36. K. Kato, K. Chin, T. Yoshikawa, K. Yamaguchi, Y. Tsuji, T. Esaki, K. Sakai, M. Kimura, T. Hamaguchi, and Y. Shimada Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer Invest. New Drugs 30 2012 1621 1627
37. R. Plummer, R. Wilson, H. Calvert, A. Boddy, M. Griffin, J. Sludden, M. Tilby, M. Eatock, D. Pearson, and C. Ottley A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours Br. J. Cancer 104 2011 593 598
38. A.P. Goodwin, J.L. Mynar, Y. Ma, G.R. Fleming, and J.M. Fréchet Synthetic micelle sensitive to IR light via a two-photon process J. Am. Chem. Soc. 127 2005 9952 9953
39. H.I. Lee, W. Wu, J.K. Oh, L. Mueller, G. Sherwood, L. Peteanu, T. Kowalewski, and K. Matyjaszewski Light-induced reversible formation of polymeric micelles Angew. Chem. Int. Ed. 119 2007 2505 2509
40. H. Wei, S.X. Cheng, X.Z. Zhang, and R.X. Zhuo Thermo-sensitive polymeric micelles based on poly(N-isopropylacrylamide) as drug carriers Prog. Polym. Sci. 34 2009 893 910
41. T. Lee, A. Cooper, R. Apkarian, and V. Conticello Thermo-reversible self-assembly of nanoparticles derived from elastin-mimetic polypeptides Adv. Mater. 12 2000 1105 1110
42. D. Neradovic, C. Van Nostrum, and W. Hennink Thermoresponsive polymeric micelles with controlled instability based on hydrolytically sensitive N-isopropylacrylamide copolymers Macromolecules 34 2001 7589 7591
43. S. Cammas, K. Suzuki, C. Sone, Y. Sakurai, K. Kataoka, and T. Okano Thermo-responsive polymer nanoparticles with a core-shell micelle structure as site-specific drug carriers J. Control. Release 48 1997 157 164
44. J.E. Chung, M. Yokoyama, M. Yamato, T. Aoyagi, Y. Sakurai, and T. Okano Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate) J. Control. Release 62 1999 115 127
45. J.E. Chung, M. Yokoyama, and T. Okano Inner core segment design for drug delivery control of thermo-responsive polymeric micelles J. Control. Release 65 2000 93 103
46. H. Wei, X.Z. Zhang, Y. Zhou, S.X. Cheng, and R.X. Zhuo Self-assembled thermoresponsive micelles of poly(N-isopropylacrylamide-b-methyl methacrylate) Biomaterials 27 2006 2028 2034
47. M. Nakayama, T. Okano, T. Miyazaki, F. Kohori, K. Sakai, and M. Yokoyama Molecular design of biodegradable polymeric micelles for temperature-responsive drug release J. Control. Release 115 2006 46 56
48. F. Kohori, K. Sakai, T. Aoyagi, M. Yokoyama, M. Yamato, Y. Sakurai, and T. Okano Control of adriamycin cytotoxic activity using thermally responsive polymeric micelles composed of poly(N-isopropylacrylamide-co-N, N-dimethylacrylamide)-b-poly(D, L-lactide) Colloids Surf. B: Biointerfaces 16 1999 195 205
49. Y.Y. Li, X.Z. Zhang, H. Cheng, J.L. Zhu, U.N. Li, S.X. Cheng, and R.X. Zhuo Fluorescent, thermo-responsive biotin-P(NIPAAm-co-NDAPM)-b-PCL micelles for cell-tracking and drug delivery Nanotechnology 18 2007 505101
50. S.Q. Liu, Y. Tong, and Y.-Y. Yang Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide-co-N, N-dimethylacrylamide)-b-poly(D, L-lactide-co-glycolide) with varying compositions Biomaterials 26 2005 5064 5074
51. M. Yang, Y. Ding, L. Zhang, X. Qian, X. Jiang, and B. Liu Novel thermosensitive polymeric micelles for docetaxel delivery J. Biomed. Mater. Res. A 81 2007 847 857
52. J. Akimoto, M. Nakayama, K. Sakai, and T. Okano Molecular design of outermost surface functionalized thermoresponsive polymeric micelles with biodegradable cores J. Polym. Sci. A Polym. Chem. 46 2008 7127 7137
53. R. Gref, Y. Minamitake, M.T. Peracchia, V. Trubetskoy, V. Torchilin, and R. Langer Biodegradable long-circulating polymeric nanospheres Science 263 1994 1600 1603
54. J. Akimoto, M. Nakayama, K. Sakai, and T. Okano Temperature-induced intracellular uptake of thermoresponsive polymeric micelles Biomacromolecules 10 2009 1331 1336
55. J. Akimoto, M. Nakayama, K. Sakai, and T. Okano Thermally controlled intracellular uptake system of polymeric micelles possessing poly(N-isopropylacrylamide)-based outer coronas Mol. Pharm. 7 2010 926 935
56. A. Mizutani, A. Kikuchi, M. Yamato, H. Kanazawa, and T. Okano Preparation of thermoresponsive polymer brush surfaces and their interaction with cells Biomaterials 29 2008 2073 2081
57. K. Fukumori, Y. Akiyama, Y. Kumashiro, J. Kobayashi, M. Yamato, K. Sakai, and T. Okano Characterization of ultra-thin temperature-responsive polymer layer and its polymer thickness dependency on cell attachment/detachment properties Macromol. Biosci. 10 2010 1117 1129
58. J. Rejman, A. Bragonzi, and M. Conese Role of clathrin-and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes Mol. Ther. 12 2005 468 474
59. R. Savić, L. Luo, A. Eisenberg, and D. Maysinger Micellar nanocontainers distribute to defined cytoplasmic organelles Science 300 2003 615 618
60. K. Sakai-Kato, K. Ishikura, Y. Oshima, M. Tada, T. Suzuki, A. Ishii-Watabe, T. Yamaguchi, N. Nishiyama, K. Kataoka, and T. Kawanishi Evaluation of intracellular trafficking and clearance from HeLa cells of doxorubicin-bound block copolymers Int. J. Pharm. 423 2012 401 409
61. S.B. Sieczkarski, and G.R. Whittaker Dissecting virus entry via endocytosis J. Gen. Virol. 83 2002 1535 1545
62. S.D. Conner, and S.L. Schmid Regulated portals of entry into the cell Nature 422 2003 37 44
63. K. Sakai-Kato, K. Un, K. Nanjo, N. Nishiyama, H. Kusuhara, K. Kataoka, T. Kawanishi, Y. Goda, and H. Okuda Elucidating the molecular mechanism for the intracellular trafficking and fate of block copolymer micelles and their components Biomaterials 35 2014 1347 1358
64. M. Nakayama, J.E. Chung, T. Miyazaki, M. Yokoyama, K. Sakai, and T. Okano Thermal modulation of intracellular drug distribution using thermoresponsive polymeric micelles React. Funct. Polym. 67 2007 1398 1407
65. A.H. Abouzeid, N.R. Patel, C. Sarisozen, and V.P. Torchilin Transferrin-targeted polymeric micelles co-loaded with curcumin and paclitaxel: efficient killing of paclitaxel-resistant cancer cells Pharm. Res. 2014 1 8
66. E.S. Lee, K. Na, and Y.H. Bae Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor J. Control. Release 103 2005 405 418
67. R. Cheng, F. Meng, C. Deng, H.-A. Klok, and Z. Zhong Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery Biomaterials 34 2013 3647 3657
68. J.-Z. Du, X.-J. Du, C.-Q. Mao, and J. Wang Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery J. Am. Chem. Soc. 133 2011 17560 17563
69. E.S. Lee, K. Na, and Y.H. Bae Super pH-sensitive multifunctional polymeric micelle Nano Lett. 5 2005 325 329
70. Y. Katayama, T. Sonoda, and M. Maeda A polymer micelle responding to the protein kinase A signal Macromolecules 34 2001 8569 8573
71. B. Hoang, S.N. Ekdawi, R.M. Reilly, and C. Allen Active targeting of block copolymer micelles with trastuzumab Fab fragments and nuclear localization signal leads to increased tumor uptake and nuclear localization in HER2-overexpressing xenografts Mol. Pharm. 10 2013 4229 4241
72. H. Kagaya, M. Oba, Y. Miura, H. Koyama, T. Ishii, T. Shimada, T. Takato, K. Kataoka, and T. Miyata Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions Gene Ther. 19 2012 61 69
73. F. Zeng, H. Lee, and C. Allen Epidermal growth factor-conjugated poly(ethylene glycol)-block-poly(δ-valerolactone) copolymer micelles for targeted delivery of chemotherapeutics Bioconjug. Chem. 17 2006 399 409
74. B. Liu, M. Yang, R. Li, Y. Ding, X. Qian, L. Yu, and X. Jiang The antitumor effect of novel docetaxel-loaded thermosensitive micelles Eur. J. Pharm. Biopharm. 69 2008 527 534
75. M.R. Berber, H. Mori, I.H. Hafez, K. Minagawa, M. Tanaka, T. Niidome, Y. Katayama, A. Maruyama, T. Hirano, Y. Maeda, and T. Mori Unusually large hysteresis of temperature-responsive poly(N-ethyl-2-propionamidoacrylamide) studied by microcalorimetry and FT-IR J. Phys. Chem. B 114 2010 7784 7790
76. K. Shiraishi, K. Kawano, T. Minowa, Y. Maitani, and M. Yokoyama Preparation and in vivo imaging of PEG-poly(L-lysine)-based polymeric micelle MRI contrast agents J. Control. Release 136 2009 14 20
77. V.P. Torchilin, M.D. Frank-Kamenetsky, and G.L. Wolf CT visualization of blood pool in rats by using long-circulating, iodine-containing micelles Acad. Radiol. 6 1999 61 65
78. H. Lee, B. Hoang, H. Fonge, R.M. Reilly, and C. Allen In vivo distribution of polymeric nanoparticles at the whole-body, tumor, and cellular levels Pharm. Res. 27 2010 2343 2355