Carbapenem resistance in Enterobacteriaceae: Here is the storm!

Trends in Molecular Medicine

Volumn 18, Issue 5, 2012, Pages 263-272

  Nordmann, Patrice ^a   Dortet, Laurent ^a   Poirel, Laurent ^a  

^a BICÊTRE HOSPITAL   (France)

Author keywords

lactamases; Antibiotic; Carbapenemase; Gram negative bacteria

Indexed keywords

AMINOGLYCOSIDE; AZTREONAM; BETA LACTAMASE AMPC; BLEOMYCIN; CARBAPENEM DERIVATIVE; CARBAPENEMASE; CEPHALOSPORIN DERIVATIVE; CHLORAMPHENICOL; CLAVULANIC ACID; DORIPENEM; ERTAPENEM; EXTENDED SPECTRUM BETA LACTAMASE; IMIPENEM; MACROLIDE; MEROPENEM; METALLO BETA LACTAMASE; PENICILLIN DERIVATIVE; PORIN; RIFAMPICIN; SULBACTAM; SULFAMETHOXAZOLE; SULFONAMIDE; TAZOBACTAM;

ANTIBIOTIC RESISTANCE; BACTERIAL OUTER MEMBRANE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CYSTITIS; DEVICE INFECTION; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG UPTAKE; ENTEROBACTER; ENTEROBACTERIACEAE; ESCHERICHIA COLI; HOSPITAL INFECTION; HUMAN; KLEBSIELLA PNEUMONIAE; MENINGITIS; MULTIDRUG RESISTANCE; NONHUMAN; PERITONITIS; PNEUMONIA; PROTEIN EXPRESSION; PYELONEPHRITIS; REVIEW; SALMONELLA; SEPTICEMIA; SHEWANELLA; STREPTOMYCES;

ANIMALS; ANTI-BACTERIAL AGENTS; CARBAPENEMS; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; HUMANS;

ENTEROBACTERIACEAE; NEGIBACTERIA;

EID: 84860516573     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2012.03.003     Document Type: Review

References (88)

1. Partridge S.R. Analysis of antibiotic resistance regions in Gram-negative bacteria. FEMS Microbiol. Rev. 2011, 35:820-855.
2. Stokes H.W., Gillings M.R. Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens. FEMS Microbiol. Rev. 2011, 35:790-819.
3. Toleman M.A., Walsh T.R. Combinatorial events of insertion sequences and ICE in Gram-negative bacteria. FEMS Microbiol. Rev. 2011, 35:912-935.
4. Pitout J.D., Laupland K.B. Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect. Dis. 2008, 8:159-166.
5. Koebnik R., et al. Structure and function of bacterial outer membrane proteins: barrels in a nutshell. Mol. Microbiol. 2000, 37:239-253.
6. Pages J.M., et al. The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria. Nat. Rev. Microbiol. 2008, 6:893-903.
7. Nikaido H. Molecular basis of bacterial outer membrane permeability revisited. Microbiol. Mol. Biol. Rev. 2003, 67:593-656.
8. Doumith M., et al. Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK. J. Antimicrob. Chemother. 2009, 63:659-667.
9. Lavigne J.P., et al. Membrane permeability, a pivotal function involved in antibiotic resistance and virulence in Enterobacter aerogenes clinical isolates. Clin. Microbiol. Infect. 2011, 10.1111/j.1469-0691.2011.03607.x.
10. Martinez-Martinez L. Extended-spectrum β-lactamases and the permeability barrier. Clin. Microbiol. Infect. 2008, 14(Suppl. 1):82-89.
11. Tzouvelekis L.S., et al. Consecutive mutations leading to the emergence in vivo of imipenem resistance in a clinical strain of Enterobacter aerogenes. J. Med. Microbiol. 1994, 40:403-407.
12. Armand-Lefevre L., et al. Imipenem resistance in Salmonella enterica serovar Wien related to porin loss and CMY-4 β-lactamase production. Antimicrob. Agents Chemother. 2003, 47:1165-1168.
13. Chia J.H., et al. Emergence of carbapenem-resistant Escherichia coli in Taiwan: resistance due to combined CMY-2 production and porin deficiency. J. Chemother. 2009, 21:621-626.
14. Shin S.Y., et al. Resistance to carbapenems in sequence type 11 Klebsiella pneumoniae is related to DHA-1 and loss of OmpK35 and/or OmpK36. J. Med. Microbiol. 2011, 61:239-245.
15. Bidet P., et al. In vivo transfer of plasmid-encoded ACC-1 AmpC from Klebsiella pneumoniae to Escherichia coli in an infant and selection of impermeability to imipenem in K. pneumoniae. Antimicrob. Agents Chemother. 2005, 49:3562-3565.
16. Bradford P.A., et al. Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC β-lactamase, and the foss of an outer membrane protein. Antimicrob. Agents Chemother. 1997, 41:563-569.
17. Lee K., et al. Reduced imipenem susceptibility in Klebsiella pneumoniae clinical isolates with plasmid-mediated CMY-2 and DHA-1 β-lactamases co-mediated by porin loss. Int. J. Antimicrob. Agents 2007, 29:201-206.
18. Jacoby G.A. AmpC β-lactamases. Clin. Microbiol. Rev. 2009, 22:161-182.
19. Lartigue M.F., et al. Ertapenem resistance of Escherichia coli. Emerg. Infect. Dis. 2007, 13:315-317.
20. Garcia-Fernandez A., et al. An ertapenem-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. Antimicrob. Agents Chemother. 2010, 54:4178-4184.
21. Bornet C., et al. Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes. Biochem. Biophys. Res. Commun. 2003, 301:985-990.
22. Yang Y.J., et al. Biochemical characterization of a β-lactamase that hydrolyzes penems and carbapenems from two Serratia marcescens isolates. Antimicrob. Agents Chemother. 1990, 34:755-758.
23. Rasmussen B.A., et al. Characterization of IMI-1 β-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae. Antimicrob. Agents Chemother. 1996, 40:2080-2086.
24. Naas T., Nordmann P. Analysis of a carbapenem-hydrolyzing class A β-lactamase from Enterobacter cloacae and of its LysR-type regulatory protein. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:7693-7697.
25. Queenan A.M., Bush K. Carbapenemases: the versatile β-lactamases. Clin. Microbiol. Rev. 2007, 20:440-458.
26. Walther-Rasmussen J., Hoiby N. Class A carbapenemases. J. Antimicrob. Chemother. 2007, 60:470-482.
27. Ambler R.P., et al. A standard numbering scheme for the class A β-lactamases. Biochem. J. 1991, 276:269-270.
28. Naas T., et al. Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A β-lactamase, Sme-1, from Serratia marcescens S6. Antimicrob. Agents Chemother. 1994, 38:1262-1270.
29. Fairfax M.R., et al. Detection of 2 SME-1 carbapenemase-producing Serratia marcescens in Detroit. Diagn. Microbiol. Infect. Dis. 2011, 71:325-326.
30. Queenan A.M., et al. SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing β-lactamases. Antimicrob. Agents Chemother. 2006, 50:3485-3487.
31. Radice M., et al. First class A carbapenemase isolated from Enterobacteriaceae in Argentina. Antimicrob. Agents Chemother. 2004, 48:1068-1069.
32. Aubron C., et al. Carbapenemase-producing Enterobacteriaceae, U.S., rivers. Emerg. Infect. Dis. 2005, 11:260-264.
33. IMI-2 in an Enterobacter cloacae clinical isolate from China. Antimicrob. Agents Chemother. 2006, 50:1610-1611.
34. Poirel L., et al. Biochemical sequence analyses of GES-1, a novel class A extended-spectrum β-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae. Antimicrob. Agents Chemother. 2000, 44:622-632.
35. Poirel L., et al. Carbapenemases: molecular diversity and clinical consequences. Future Microbiol. 2007, 2:501-512.
36. Kotsakis S.D., et al. Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. Antimicrob. Agents Chemother. 2010, 54:4864-4871.
37. Picao R.C., et al. Detection of GES-5-producing Klebsiella pneumoniae in Brazil. J. Antimicrob. Chemother. 2010, 65:796-797.
38. Vourli S., et al. Novel GES/IBC extended-spectrum β-lactamase variants with carbapenemase activity in clinical enterobacteria. FEMS Microbiol. Lett. 2004, 234:209-213.
39. Yigit H., et al. Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 2001, 45:1151-1161.
40. Navon-Venezia S., et al. First report on a hyperepidemic clone of KPC-3-producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States. Antimicrob. Agents Chemother. 2009, 53:818-820.
41. Nordmann P., et al. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect. Dis. 2009, 9:228-236.
42. Borer A., et al. Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia. Infect. Control Hosp. Epidemiol. 2009, 30:972-976.
43. Patel G., et al. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect. Control Hosp. Epidemiol. 2008, 29:1099-1106.
44. Schwaber M.J., et al. Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality. Antimicrob. Agents Chemother. 2008, 52:1028-1033.
45. KPC-2 gene. Emerg. Infect. Dis. 2010, 16:1349-1356.
46. KPC gene mobilization. Antimicrob. Agents Chemother. 2011, 55:5370-5373.
47. Kuwabara S., Abraham E.P. Some properties of two extracellular β-lactamases from Bacillus cereus 569/H. Biochem. J. 1967, 103:27C-30C.
48. Lim H.M., et al. Cloning, nucleotide sequence, and expression of the Bacillus cereus 5/B/6 β-lactamase II structural gene. J. Bacteriol. 1988, 170:2873-2878.
49. Iaconis J.P., Sanders C.C. Purification and characterization of inducible β-lactamases in Aeromonas spp. Antimicrob. Agents Chemother. 1990, 34:44-51.
50. Yang Y., Bush K. Biochemical characterization of the carbapenem-hydrolyzing β-lactamase AsbM1 from Aeromonas sobria AER 14M: a member of a novel subgroup of metallo-β-lactamases. FEMS Microbiol. Lett. 1996, 137:193-200.
51. Saino Y., et al. Purification and properties of inducible penicillin β-lactamase isolated from Pseudomonas maltophilia. Antimicrob. Agents Chemother. 1982, 22:564-570.
52. Walsh T.R., et al. Metallo-β-lactamases: the quiet before the storm?. Clin. Microbiol. Rev. 2005, 18:306-325.
53. Daikos G.L., et al. Prospective observational study of the impact of VIM-1 metallo-β-lactamase on the outcome of patients with Klebsiella pneumoniae bloodstream infections. Antimicrob. Agents Chemother. 2009, 53:1868-1873.
54. Watanabe M., et al. Transferable imipenem resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 1991, 35:147-151.
55. Zhao W.H., Hu Z.Q. IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons. Crit. Rev. Microbiol. 2011, 37:214-226.
56. IMP among clinically isolated strains of Serratia marcescens. Antimicrob. Agents Chemother. 1995, 39:824-829.
57. VIM, a new integron-borne metallo-β-lactamase gene from a Pseudomonas aeruginosa clinical isolate. Antimicrob. Agents Chemother. 1999, 43:1584-1590.
58. Poirel L., et al. Characterization of VIM-2, a carbapenem-hydrolyzing metallo-β-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France. Antimicrob. Agents Chemother. 2000, 44:891-897.
59. Zhao W.H., Hu Z.Q. Epidemiology and genetics of VIM-type metallo-β-lactamases in Gram-negative bacilli. Future Microbiol. 2011, 6:317-333.
60. Gupta V. Metallo-β-lactamases in Pseudomonas aeruginosa and Acinetobacter species. Expert Opin. Investig. Drugs 2008, 17:131-143.
61. Sekiguchi J., et al. KHM-1, a novel plasmid-mediated metallo-β-lactamase from a Citrobacter freundii clinical isolate. Antimicrob. Agents Chemother. 2008, 52:4194-4197.
62. NDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob. Agents Chemother. 2009, 53:5046-5054.
63. Kumarasamy K.K., et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 2010, 10:597-602.
64. Nordmann P., et al. Does broad-spectrum β-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?. J. Antimicrob. Chemother. 2011, 66:689-692.
65. Livermore D.M., et al. Balkan NDM-1: escape or transplant?. Lancet Infect. Dis. 2011, 11:164.
66. Poirel L., et al. NDM-1-producing Klebsiella pneumoniae isolated in the Sultanate of Oman. J. Antimicrob. Chemother. 2010, 66:304-306.
67. NDM-1-positive Enterobacteriaceae. Antimicrob. Agents Chemother. 2011, 55:5403-5407.
68. Bercot B., et al. In vitro evaluation of antibiotic synergy for NDM-1-producing Enterobacteriaceae. J. Antimicrob. Chemother. 2011, 66:2295-2297.
69. Nordmann P., et al. Emergence of an autochthonous and community-acquired NDM-1-producing Klebsiella pneumoniae in Europe. Clin. Infect. Dis. 2012, 54:150-151.
70. Perry J.D., et al. Prevalence of faecal carriage of Enterobacteriaceae with NDM-1 carbapenemase at military hospitals in Pakistan, and evaluation of two chromogenic media. J. Antimicrob. Chemother. 2011, 66:2288-2294.
71. Walsh T.R., et al. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect. Dis. 2011, 11:355-362.
72. Kaase M., et al. NDM-2 carbapenemase in Acinetobacter baumannii from Egypt. J. Antimicrob. Chemother. 2011, 66:1260-1262.
73. Dortet L., et al. Association of the emerging carbapenemase NDM-1 to bleomycin resistance protein in Enterobacteriaceae and Acinetobacter baumannii. Antimicrob. Agents Chemother. 2012, 56:1693-1697.
74. Mussi M.A., et al. Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of β-barrel outer membrane proteins. Antimicrob. Agents Chemother. 2005, 49:1432-1440.
75. Coque T.M., et al. Dissemination of clonally related Escherichia coli strains expressing extended-spectrum β-lactamase CTX-M-15. Emerg. Infect. Dis. 2008, 14:195-200.
76. Poirel L., et al. Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect. Dis. 2010, 10:832.
77. Poirel L., et al. Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 2004, 48:15-22.
78. Carrer A., et al. Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. Antimicrob. Agents Chemother. 2008, 52:2950-2954.
79. Nordmann P., et al. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg. Infect. Dis. 2011, 17:1791-1798.
80. Potron A., et al. European dissemination of a single OXA-48-producing Klebsiella pneumoniae clone. Clin. Microbiol. Infect. 2011, 17:E24-E26.
81. Poirel L., et al. Genetic features of the widespread plasmid coding for the carbapenemase OXA-48. Antimicrob. Agents Chemother. 2012, 56:559-562.
82. Castanheira M., et al. Early dissemination of NDM-1- and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006-2007. Antimicrob. Agents Chemother. 2011, 55:1274-1278.
83. Kalpoe J.S., et al. Detection of an Ambler class D OXA-48-type β-lactamase in a Klebsiella pneumoniae strain in The Netherlands. J. Med. Microbiol. 2011, 60:677-678.
84. Potron A., et al. Characterization of OXA-181, a carbapenem-hydrolyzing class D β-lactamase from Klebsiella pneumoniae. Antimicrob. Agents Chemother. 2011, 55:4896-4899.
85. OXA-48 in the environment in Morocco. Antimicrob. Agents Chemother. 2011, 55:5413-5414.
86. Poirel L., et al. Chromosome-encoded ambler class D β-lactamase of Shewanella oneidensis as a progenitor of carbapenem-hydrolyzing oxacillinase. Antimicrob. Agents Chemother. 2004, 48:348-351.
87. Potron A., et al. Origin of OXA-181, an emerging carbapenem-hydrolyzing oxacillinase, as a chromosomal gene in Shewanella xiamenensis. Antimicrob. Agents Chemother. 2011, 55:4405-4407.
88. Endimiani A., et al. Evaluation of ceftazidime and NXL 104 in two murine models of infection due to a KPC-producing Klebsiella pneumoniae. Antimicrob. Agents Chemother. 2011, 55:82-85.