Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination

Journal of Molecular Biology

Volumn 430, Issue 3, 2018, Pages 337-347

  Bailey, Lucas J ^a   Sheehy, Kimberly M ^a   Dominik, Pawel K ^a   Liang, Wenguang G ^a   Rui, Huan ^a   Clark, Michael ^a   Jaskolowski, Mateusz ^a,b   Kim, Yejoon ^a   Deneka, Dawid ^a,c   Tang, Wei Jen ^a   Kossiakoff, Anthony A ^a,d  

^a UNIVERSITY OF CHICAGO   (United States)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c JAGIELLONIAN UNIVERSITY   (Poland)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

antibody engineering; cryo EM fiducial mark; crystallization chaperone; Fab elbow angle; Fab protein complex

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; IMMUNOGLOBULIN F(AB) FRAGMENT; INSULINASE; ION CHANNEL; PROTEIN CORA; PROTEIN KCSA; UNCLASSIFIED DRUG; ANTIGEN; ASF1 PROTEIN, S CEREVISIAE; CELL CYCLE PROTEIN; CHAPERONE; SACCHAROMYCES CEREVISIAE PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; CHEMISTRY; CRYOELECTRON MICROSCOPY; GENETICS; HUMAN; MOLECULAR MODEL; PEPTIDE LIBRARY; PROCEDURES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SACCHAROMYCES CEREVISIAE; ULTRASTRUCTURE;

ANTIGENS; CELL CYCLE PROTEINS; CRYOELECTRON MICROSCOPY; CRYSTALLIZATION; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MODELS, MOLECULAR; MOLECULAR CHAPERONES; PEPTIDE LIBRARY; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 85039556412     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2017.12.012     Document Type: Article

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