-
1
-
-
79956103081
-
Aggregates in monoclonal antibody manufacturing processes
-
Vazquez-Rey M, Lang DA (2011) Aggregates in monoclonal antibody manufacturing processes. Biotechnol Bioeng 108:1494–1508.
-
(2011)
Biotechnol Bioeng
, vol.108
, pp. 1494-1508
-
-
Vazquez-Rey, M.1
Lang, D.A.2
-
3
-
-
77953655331
-
Potential aggregation prone regions in biotherapeutics: a survey of commercial monoclonal antibodies
-
Wang X, Das TK, Singh SK, Kumar S (2009) Potential aggregation prone regions in biotherapeutics: a survey of commercial monoclonal antibodies. mAbs 1.3:254–267.
-
(2009)
mAbs
, vol.1
, Issue.3
, pp. 254-267
-
-
Wang, X.1
Das, T.K.2
Singh, S.K.3
Kumar, S.4
-
4
-
-
77951566536
-
Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis
-
Pepinsky RB, Silvian L, Berkowitz SA, Farrington G, Lugovskoy A, Walus L, Eldredge J, Capili A, Graff C, Garber E (2010) Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis. Protein Sci 19:954–966.
-
(2010)
Protein Sci
, vol.19
, pp. 954-966
-
-
Pepinsky, R.B.1
Silvian, L.2
Berkowitz, S.A.3
Farrington, G.4
Lugovskoy, A.5
Walus, L.6
Eldredge, J.7
Capili, A.8
Graff, C.9
Garber, E.10
-
5
-
-
84892946282
-
Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold
-
Perchiacca JM, Lee CC, Tessier PM (2014) Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold. Protein Eng Des Sel 27:29–39.
-
(2014)
Protein Eng Des Sel
, vol.27
, pp. 29-39
-
-
Perchiacca, J.M.1
Lee, C.C.2
Tessier, P.M.3
-
6
-
-
34548694517
-
Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange
-
van der Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martinez-Martinez P, Vermeulen E, den Bleker TH, Wiegman L, Vink T, Aarden LA, De Baets MH, van de Winkel JG, Aalberse RC, Parren PW (2007) Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science 317:1554–1557.
-
(2007)
Science
, vol.317
, pp. 1554-1557
-
-
van der Neut Kolfschoten, M.1
Schuurman, J.2
Losen, M.3
Bleeker, W.K.4
Martinez-Martinez, P.5
Vermeulen, E.6
den Bleker, T.H.7
Wiegman, L.8
Vink, T.9
Aarden, L.A.10
De Baets, M.H.11
van de Winkel, J.G.12
Aalberse, R.C.13
Parren, P.W.14
-
7
-
-
36849001338
-
Isotype selection in antibody engineering
-
Salfeld JG (2007) Isotype selection in antibody engineering. Nat Biotechnol 25:1369–1372.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1369-1372
-
-
Salfeld, J.G.1
-
9
-
-
4444302074
-
Aggregation-resistant domain antibodies selected on phage by heat denaturation
-
Jespers L, Schon O, Famm K, Winter G (2004) Aggregation-resistant domain antibodies selected on phage by heat denaturation. Nat Biotechnol 22:1161–1165.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 1161-1165
-
-
Jespers, L.1
Schon, O.2
Famm, K.3
Winter, G.4
-
10
-
-
84934441240
-
Selection of human VH single domains with improved biophysical properties by phage display
-
Dudgeon K, Rouet R, Famm K, Christ D (2012) Selection of human VH single domains with improved biophysical properties by phage display. Methods Mol Biol 911:383–397.
-
(2012)
Methods Mol Biol
, vol.911
, pp. 383-397
-
-
Dudgeon, K.1
Rouet, R.2
Famm, K.3
Christ, D.4
-
11
-
-
34548567337
-
Increasing protein conformational stability by optimizing beta-turn sequence
-
Trevino SR, Schaefer S, Scholtz JM, Pace CN (2007) Increasing protein conformational stability by optimizing beta-turn sequence. J Mol Biol 373:211–218.
-
(2007)
J Mol Biol
, vol.373
, pp. 211-218
-
-
Trevino, S.R.1
Schaefer, S.2
Scholtz, J.M.3
Pace, C.N.4
-
12
-
-
0034255454
-
Rapid mapping of protein functional epitopes by combinatorial alanine scanning
-
Weiss GA, Watanabe CK, Zhong A, Goddard A, Sidhu SS (2000) Rapid mapping of protein functional epitopes by combinatorial alanine scanning. Proc Natl Acad Sci USA 97:8950–8954.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8950-8954
-
-
Weiss, G.A.1
Watanabe, C.K.2
Zhong, A.3
Goddard, A.4
Sidhu, S.S.5
-
14
-
-
84865181878
-
T cell receptor-like recognition of tumor in vivo by synthetic antibody fragment
-
Miller KR, Koide A, Leung B, Fitzsimmons J, Yoder B, Yuan H, Jay M, Sidhu SS, Koide S, Collins EJ (2012) T cell receptor-like recognition of tumor in vivo by synthetic antibody fragment. PLoS One 7:e43746
-
(2012)
PLoS One
, vol.7
-
-
Miller, K.R.1
Koide, A.2
Leung, B.3
Fitzsimmons, J.4
Yoder, B.5
Yuan, H.6
Jay, M.7
Sidhu, S.S.8
Koide, S.9
Collins, E.J.10
-
15
-
-
84942930536
-
A high through-put platform for recombinant antibodies to folded proteins
-
Hornsby M, Paduch M, Miersch S, Saaf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, Hoey RJ, Lai D, Griffin C, Li Z, Vizeacoumar FJ, Dong D, Campbell E, Anderson S, Zhong N, Graslund S, Koide S, Moffat J, Sidhu S, Kossiakoff A, Wells J (2015) A high through-put platform for recombinant antibodies to folded proteins. Mol Cell Proteomics 14:2833–2847.
-
(2015)
Mol Cell Proteomics
, vol.14
, pp. 2833-2847
-
-
Hornsby, M.1
Paduch, M.2
Miersch, S.3
Saaf, A.4
Matsuguchi, T.5
Lee, B.6
Wypisniak, K.7
Doak, A.8
King, D.9
Usatyuk, S.10
Perry, K.11
Lu, V.12
Thomas, W.13
Luke, J.14
Goodman, J.15
Hoey, R.J.16
Lai, D.17
Griffin, C.18
Li, Z.19
Vizeacoumar, F.J.20
Dong, D.21
Campbell, E.22
Anderson, S.23
Zhong, N.24
Graslund, S.25
Koide, S.26
Moffat, J.27
Sidhu, S.28
Kossiakoff, A.29
Wells, J.30
more..
-
16
-
-
67649405075
-
Protein ionizable groups: pK values and their contribution to protein stability and solubility
-
Pace CN, Grimsley GR, Scholtz JM (2009) Protein ionizable groups: pK values and their contribution to protein stability and solubility. J Biol Chem 284:13285–13289.
-
(2009)
J Biol Chem
, vol.284
, pp. 13285-13289
-
-
Pace, C.N.1
Grimsley, G.R.2
Scholtz, J.M.3
-
17
-
-
55749096388
-
Measuring and increasing protein solubility
-
Trevino SR, Scholtz JM, Pace CN (2008) Measuring and increasing protein solubility. J Pharm Sci 97:4155–4166.
-
(2008)
J Pharm Sci
, vol.97
, pp. 4155-4166
-
-
Trevino, S.R.1
Scholtz, J.M.2
Pace, C.N.3
-
18
-
-
84863570483
-
General strategy for the generation of human antibody variable domains with increased aggregation resistance
-
Dudgeon K, Rouet R, Kokmeijer I, Schofield P, Stolp J, Langley D, Stock D, Christ D (2012) General strategy for the generation of human antibody variable domains with increased aggregation resistance. Proc Natl Acad Sci USA 109:10879–10884.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 10879-10884
-
-
Dudgeon, K.1
Rouet, R.2
Kokmeijer, I.3
Schofield, P.4
Stolp, J.5
Langley, D.6
Stock, D.7
Christ, D.8
-
19
-
-
0023278330
-
Canonical structures for the hypervariable regions of immunoglobulins
-
Chothia C, Lesk AM (1987) Canonical structures for the hypervariable regions of immunoglobulins. J Mol Biol 196:901–917.
-
(1987)
J Mol Biol
, vol.196
, pp. 901-917
-
-
Chothia, C.1
Lesk, A.M.2
-
20
-
-
34047271259
-
Hot spot occlusion from bulk water: a comprehensive study of the complex between the lysozyme HEL and the antibody FVD1.3
-
Moreira IS, Fernandes PA, Ramos MJ (2007) Hot spot occlusion from bulk water: a comprehensive study of the complex between the lysozyme HEL and the antibody FVD1.3. J Phys Chem B 111:2697–2706.
-
(2007)
J Phys Chem B
, vol.111
, pp. 2697-2706
-
-
Moreira, I.S.1
Fernandes, P.A.2
Ramos, M.J.3
-
21
-
-
0029109468
-
Protein-protein Interactions: a review of protein dimer structures
-
Jones S, Thornton JM (1995) Protein-protein Interactions: a review of protein dimer structures. Prog Biophys Molec Biol 63:31–65.
-
(1995)
Prog Biophys Molec Biol
, vol.63
, pp. 31-65
-
-
Jones, S.1
Thornton, J.M.2
-
22
-
-
0030028728
-
Principles of protein-protein interactions
-
Jones S, Thornton JM (1996) Principles of protein-protein interactions. Proc Natl Acad Sci USA 93:13–20.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13-20
-
-
Jones, S.1
Thornton, J.M.2
-
23
-
-
0032479179
-
Anatomy of hot spots in protein interfaces
-
Bogan AA, Thorn KS (1998) Anatomy of hot spots in protein interfaces. J Mol Biol 280:1–9.
-
(1998)
J Mol Biol
, vol.280
, pp. 1-9
-
-
Bogan, A.A.1
Thorn, K.S.2
-
24
-
-
72949088627
-
Cross-interaction chromatography: a rapid method to identify highly soluble monoclonal antibody candidates
-
Jacobs SA, Wu SJ, Feng Y, Bethea D, O'Neil KT (2010) Cross-interaction chromatography: a rapid method to identify highly soluble monoclonal antibody candidates. Pharm Res 27:65–71.
-
(2010)
Pharm Res
, vol.27
, pp. 65-71
-
-
Jacobs, S.A.1
Wu, S.J.2
Feng, Y.3
Bethea, D.4
O'Neil, K.T.5
-
25
-
-
1842405464
-
Studies of protein-protein interfaces: a statistical analysis of the hydrophobic effect
-
Tsai CJ, Lin SL, Wolfson HJ, Nussinov R (1997) Studies of protein-protein interfaces: a statistical analysis of the hydrophobic effect. Protein Sci 6:53–64.
-
(1997)
Protein Sci
, vol.6
, pp. 53-64
-
-
Tsai, C.J.1
Lin, S.L.2
Wolfson, H.J.3
Nussinov, R.4
-
26
-
-
0031565729
-
Analysis of protein-protein interaction sites using surface patches
-
Jones S, Thornton JM (1997) Analysis of protein-protein interaction sites using surface patches. J Mol Biol 272:121–132.
-
(1997)
J Mol Biol
, vol.272
, pp. 121-132
-
-
Jones, S.1
Thornton, J.M.2
-
27
-
-
33751080719
-
Synthetic therapeutic antibodies
-
Sidhu SS, Fellouse FA (2006) Synthetic therapeutic antibodies. Nat Chem Biol 2:682–688.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 682-688
-
-
Sidhu, S.S.1
Fellouse, F.A.2
-
28
-
-
12444264902
-
Selection of optical biosensors from chemisynthetic antibody libraries
-
Jespers L, Tonnert TP, Winter G (2004) Selection of optical biosensors from chemisynthetic antibody libraries. Protein Eng Des Sel 17:709–713.
-
(2004)
Protein Eng Des Sel
, vol.17
, pp. 709-713
-
-
Jespers, L.1
Tonnert, T.P.2
Winter, G.3
-
29
-
-
79952399087
-
Beyond natural antibodies: the power of in vitro display technologies
-
Bradbury AR, Sidhu S, Dubel S, McCafferty J (2011) Beyond natural antibodies: the power of in vitro display technologies. Nat Biotechnol 29:245–254.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 245-254
-
-
Bradbury, A.R.1
Sidhu, S.2
Dubel, S.3
McCafferty, J.4
-
30
-
-
84867016746
-
Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions
-
Perchiacca JM, Ladiwala AR, Bhattacharya M, Tessier PM (2012) Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions. Protein Eng Des Sel 25:591–601.
-
(2012)
Protein Eng Des Sel
, vol.25
, pp. 591-601
-
-
Perchiacca, J.M.1
Ladiwala, A.R.2
Bhattacharya, M.3
Tessier, P.M.4
-
31
-
-
84867024410
-
Transfer of engineered biophysical properties between different antibody formats and expression systems
-
Schaefer JV, Pluckthun A (2012) Transfer of engineered biophysical properties between different antibody formats and expression systems. Protein Eng Des Sel 25:485–506.
-
(2012)
Protein Eng Des Sel
, vol.25
, pp. 485-506
-
-
Schaefer, J.V.1
Pluckthun, A.2
-
32
-
-
84912526074
-
Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments
-
Bailey LJ, Sheehy KM, Hoey RJ, Schaefer ZP, Ura M, Kossiakoff AA (2014) Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments. J Immunol Meth 415:24–30.
-
(2014)
J Immunol Meth
, vol.415
, pp. 24-30
-
-
Bailey, L.J.1
Sheehy, K.M.2
Hoey, R.J.3
Schaefer, Z.P.4
Ura, M.5
Kossiakoff, A.A.6
-
33
-
-
70350057412
-
Design and construction of synthetic phage-displayed Fab libraries
-
Bostrom J, Fuh G (2009) Design and construction of synthetic phage-displayed Fab libraries. Methods Mol Biol 562:17–35.
-
(2009)
Methods Mol Biol
, vol.562
, pp. 17-35
-
-
Bostrom, J.1
Fuh, G.2
-
34
-
-
0023613953
-
Rapid and efficient site-specific mutagenesis without phenotypic selection
-
Kunkel TA, Roberts JD, Zakour RA (1987) Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol 154:367–382.
-
(1987)
Methods Enzymol
, vol.154
, pp. 367-382
-
-
Kunkel, T.A.1
Roberts, J.D.2
Zakour, R.A.3
-
35
-
-
44349104094
-
Design of protein function leaps by directed domain evolution
-
Huang J, Koide A, Makabe K, Koide S (2008) Design of protein function leaps by directed domain evolution. Proc Nat Acad Sci 105:6578–6583.
-
(2008)
Proc Nat Acad Sci
, vol.105
, pp. 6578-6583
-
-
Huang, J.1
Koide, A.2
Makabe, K.3
Koide, S.4
-
36
-
-
33745933955
-
HKL-3000: the integration of data reduction and structure solution–from diffraction images to an initial model in minutes
-
Minor W, Cymborowski M, Otwinowski Z, Chruszcz M (2006) HKL-3000: the integration of data reduction and structure solution–from diffraction images to an initial model in minutes. Acta Cryst 62:859–866. D
-
(2006)
Acta Cryst
, vol.62
, pp. 859-866
-
-
Minor, W.1
Cymborowski, M.2
Otwinowski, Z.3
Chruszcz, M.4
-
37
-
-
74549194551
-
Molecular replacement with MOLREP
-
Vagin A, Teplyakov A (2010) Molecular replacement with MOLREP. Acta Cryst 66:22–25. D
-
(2010)
Acta Cryst
, vol.66
, pp. 22-25
-
-
Vagin, A.1
Teplyakov, A.2
-
39
-
-
84860273177
-
Towards automated crystallographic structure refinement with phenix.refine
-
Afonine PV, Grosse-Kunstleve RW, Echols N, Headd JJ, Moriarty NW, Mustyakimov M, Terwilliger TC, Urzhumtsev A, Zwart PH, Adams PD (2012) Towards automated crystallographic structure refinement with phenix.refine. Acta Cryst 68:352–367. D
-
(2012)
Acta Cryst
, vol.68
, pp. 352-367
-
-
Afonine, P.V.1
Grosse-Kunstleve, R.W.2
Echols, N.3
Headd, J.J.4
Moriarty, N.W.5
Mustyakimov, M.6
Terwilliger, T.C.7
Urzhumtsev, A.8
Zwart, P.H.9
Adams, P.D.10
-
40
-
-
37249005205
-
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
-
Niesen FH, Berglund H, Vedadi M (2007) The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability. Nature Protoc 2:2212–2221.
-
(2007)
Nature Protoc
, vol.2
, pp. 2212-2221
-
-
Niesen, F.H.1
Berglund, H.2
Vedadi, M.3
|