Impact of consuming extra-virgin olive oil or nuts within a mediterranean diet on DNA methylation in peripheral white blood cells within the PREDIMED-navarra randomized controlled trial: A role for dietary lipids

Nutrients

Volumn 10, Issue 1, 2018, Pages

  Arpón, Ana ^a   Milagro, Fermín I ^a,b   Razquin, Cristina ^a,b,c   Corella, Dolores ^b,d   Estruch, Ramón ^b,e   Fitó, Montserrat ^b,f   Marti, Amelia ^a,b,c   Martínez González, Miguel A ^a,b,c   Ros, Emilio ^b,e   Salas Salvadó, Jordi ^b,g   Riezu Boj, José Ignacio ^a,c   Martínez, J Alfredo ^a,b,c,h  

^a UNIVERSITY OF NAVARRA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c IdiSNA Navarra Institute for Health Research   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e UNIVERSITY OF BARCELONA   (Spain)

^f HOSPITAL DEL MAR   (Spain)

^g HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

^h IMDEA FOOD INSTITUTE   (Spain)

Author keywords

Blood cells; DNA methylation; Mediterranean diet; Nuts; Olive oil

Indexed keywords

CANNABINOID 1 RECEPTOR; CARBOHYDRATE; CARNITINE PALMITOYLTRANSFERASE; EXTRA VIRGIN OLIVE OIL; FAT; GUANINE NUCLEOTIDE; MONOUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID; PROTEIN; RETINOID BINDING PROTEIN; SATURATED FATTY ACID; OLIVE OIL;

ADULT; AGED; ANALYSIS OF VARIANCE; ANTHROPOMETRIC PARAMETERS; ARTICLE; BIOCHEMICAL ANALYSIS; BODY MASS; CARDIOVASCULAR RISK; COHORT ANALYSIS; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; CPG ISLAND; DIABETES MELLITUS; DNA DAMAGE; DNA EXTRACTION; DNA METHYLATION ASSAY; EPIGENETICS; EVALUATION AND FOLLOW UP; FAT INTAKE; FEMALE; GENE EXPRESSION; GENE REGULATORY NETWORK; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INFLAMMATION; INTERVENTION STUDY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEDITERRANEAN DIET; METABOLISM; MIDDLE AGED; NUT; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; SIGNAL TRANSDUCTION; VERY ELDERLY; WAIST CIRCUMFERENCE; BLOOD; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; COMORBIDITY; COMPARATIVE STUDY; DNA METHYLATION; ENERGY METABOLISM; GENETIC EPIGENESIS; GENETICS; HEALTHY DIET; LEUKOCYTE; MULTICENTER STUDY; PROTECTION; RISK FACTOR; SPAIN; TIME FACTOR; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; COMORBIDITY; CPG ISLANDS; DIET, MEDITERRANEAN; DNA METHYLATION; ENERGY METABOLISM; EPIGENESIS, GENETIC; FEMALE; HEALTHY DIET; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; NUTS; OLIVE OIL; PROTECTIVE FACTORS; RISK FACTORS; SPAIN; TIME FACTORS; TREATMENT OUTCOME;

EID: 85039442691     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu10010015     Document Type: Article

References (38)

1. Milagro, F.I.; Campion, J.; Garcia-Diaz, D.F.; Goyenechea, E.; Paternain, L.; Martinez, J.A. High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats. J. Physiol. Biochem. 2009, 65, 1–9. [CrossRef] [PubMed]
2. Corella, D.; Ordovás, J.M. Biomarkers: Background, classification and guidelines for applications in nutritional epidemiology. Nutrición Hospitalaria 2015, 31, 177–188. [CrossRef] [PubMed]
3. Choi, S.W.; Friso, S. Epigenetics: A new bridge between nutrition and health. Adv. Nutr. 2010, 1, 8–16. [CrossRef] [PubMed]
4. Goni, L.; Cuervo, M.; Milagro, F.I.; Martinez, J.A. Future perspectives of personalized weight loss interventions based on nutrigenetic, epigenetic, and metagenomic data. J. Nutr. 2016, 146, 905S–912S. [CrossRef] [PubMed]
5. Barres, R.; Zierath, J.R. DNA methylation in metabolic disorders. Am. J. Clin. Nutr. 2011, 93, 897S–900S. [CrossRef] [PubMed]
6. Tremblay, J.; Hamet, P. Impact of genetic and epigenetic factors from early life to later disease. Metabolism 2008, 57 (Suppl 2), S27–S31. [CrossRef] [PubMed]
7. Kohlmeier, M.; De Caterina, R.; Ferguson, L.R.; Gorman, U.; Allayee, H.; Prasad, C.; Kang, J.X.; Nicoletti, C.F.; Martinez, J.A. Guide and position of the international society of nutrigenetics/nutrigenomics on personalized nutrition: Part 2—Ethics, challenges and endeavors of precision nutrition. J. Nutrigenet. Nutrigenom. 2016, 9, 28–46. [CrossRef] [PubMed]
8. Estruch, R.; Martinez-Gonzalez, M.A.; Corella, D.; Salas-Salvado, J.; Ruiz-Gutierrez, V.; Covas, M.I.; Fiol, M.; Gomez-Gracia, E.; Lopez-Sabater, M.C.; Vinyoles, E., et al. Effects of a mediterranean-style diet on cardiovascular risk factors: A randomized trial. Ann. Intern. Med. 2006, 145, 1–11. [CrossRef] [PubMed]
9. Martinez-Gonzalez, M.A.; Salas-Salvado, J.; Estruch, R.; Corella, D.; Fito, M.; Ros, E.; Predimed, I. Benefits of the mediterranean diet: Insights from the predimed study. Prog Cardiovasc. Dis. 2015, 58, 50–60. [CrossRef] [PubMed]
10. Mitjavila, M.T.; Fandos, M.; Salas-Salvado, J.; Covas, M.I.; Borrego, S.; Estruch, R.; Lamuela-Raventos, R.; Corella, D.; Martinez-Gonzalez, M.A.; Sanchez, J.M., et al. The mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial. Clin. Nutr. 2013, 32, 172–178. [CrossRef] [PubMed]
11. Corella, D.; Ordovas, J.; Sorli, J.; Asensio, E.; Ortega, C.; Carrasco, P.; Portoles, O.; Coltell, O. Effect of the mediterranean diet on DNA methylation of selected genes in the predimed-valencia intervention trial. FASEB J. 2015, 29, LB242.
12. Arpón, A.; Riezu-Boj, J.I.; Milagro, F.I.; Marti, A.; Razquin, C.; Martinez-Gonzalez, M.A.; Corella, D.; Estruch, R.; Casas, R.; Fito, M., et al. Adherence to mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells. J. Physiol. Biochem. 2017, 73, 445–455. [CrossRef]
13. Rodriguez-Miguel, C.; Moral, R.; Escrich, R.; Vela, E.; Solanas, M.; Escrich, E. The role of dietary extra virgin olive oil and corn oil on the alteration of epigenetic patterns in the rat DMBA-induced breast cancer model. PLoS ONE 2015, 10, e0138980. [CrossRef] [PubMed]
14. Poulose, S.; Bielinski, D.; Crott, J.; Roe, A.; Thangthaeng, N.; Shukitt-Hale, B. Effects of aging and walnut-rich diet on DNA methylation and expression of immediate-early genes in critical brain regions. FASEB J. 2015, 29, 749.7.
15. Estruch, R.; Ros, E.; Salas-Salvado, J.; Covas, M.I.; Corella, D.; Aros, F.; Gomez-Gracia, E.; Ruiz-Gutierrez, V.; Fiol, M.; Lapetra, J., et al. Primary prevention of cardiovascular disease with a mediterranean diet. N. Engl. J. Med. 2013, 368, 1279–1290. [CrossRef] [PubMed]
16. Martinez-Gonzalez, M.A.; Corella, D.; Salas-Salvado, J.; Ros, E.; Covas, M.I.; Fiol, M.; Warnberg, J.; Aros, F.; Ruiz-Gutierrez, V.; Lamuela-Raventos, R.M., et al. Cohort profile: Design and methods of the predimed study. Int. J. Epidemiol. 2012, 41, 377–385. [CrossRef] [PubMed]
17. Fernandez-Ballart, J.D.; Pinol, J.L.; Zazpe, I.; Corella, D.; Carrasco, P.; Toledo, E.; Perez-Bauer, M.; Martinez-Gonzalez, M.A.; Salas-Salvado, J.; Martin-Moreno, J.M. Relative validity of a semi-quantitative food-frequency questionnaire in an elderly mediterranean population of spain. Br. J. Nutr. 2010, 103, 1808–1816. [CrossRef] [PubMed]
18. Touleimat, N.; Tost, J. Complete pipeline for infinium(®) human methylation 450k beadchip data processing using subset quantile normalization for accurate DNA methylation estimation. Epigenomics 2012, 4, 325–341. [CrossRef] [PubMed]
19. Smyth, G.K. Limma: Linear Models for Microarray Data. In Bioinformatics and Computational Biology Solutions Using R and Bioconductor; Gentleman, R., Carey, V.J., Huber, W., Irizarry, R.A., Dudoit, S., Eds.; Springer: New York, NY, USA, 2005; pp. 397–420. ISBN 978-0-387-29362-2.
20. Edgar, R.; Domrachev, M.; Lash, A.E. Gene expression omnibus: Ncbi gene expression and hybridization array data repository. Nucleic Acids Res. 2002, 30, 207–210. [CrossRef] [PubMed]
21. Volkmar, M.; Dedeurwaerder, S.; Cunha, D.A.; Ndlovu, M.N.; Defrance, M.; Deplus, R.; Calonne, E.; Volkmar, U.; Igoillo-Esteve, M.; Naamane, N., et al. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J. 2012, 31, 1405–1426. [CrossRef] [PubMed]
22. Burdge, G.C.; Hoile, S.P.; Lillycrop, K.A. Epigenetics: Are there implications for personalised nutrition? Curr. Opin. Clin. Nutr. Metab. Care 2012, 15, 442–447. [CrossRef] [PubMed]
23. Casas, R.; Sacanella, E.; Urpi-Sarda, M.; Corella, D.; Castaner, O.; Lamuela-Raventos, R.M.; Salas-Salvado, J.; Martinez-Gonzalez, M.A.; Ros, E.; Estruch, R. Long-term immunomodulatory effects of a mediterranean diet in adults at high risk of cardiovascular disease in the prevencion con dieta mediterranea (predimed) randomized controlled trial. J. Nutr. 2016, 146, 1684–1693. [CrossRef] [PubMed]
24. Haynie, K.R.; Vandanmagsar, B.; Wicks, S.E.; Zhang, J.; Mynatt, R.L. Inhibition of carnitine palymitoyltransferase1b induces cardiac hypertrophy and mortality in mice. Diabetes Obes. Metab. 2014, 16, 757–760. [CrossRef] [PubMed]
25. He, L.; Kim, T.; Long, Q.; Liu, J.; Wang, P.; Zhou, Y.; Ding, Y.; Prasain, J.; Wood, P.A.; Yang, Q. Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity. Circulation 2012, 126, 1705–1716. [CrossRef] [PubMed]
26. Kulkarni, S.S.; Salehzadeh, F.; Fritz, T.; Zierath, J.R.; Krook, A.; Osler, M.E. Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus. Metabolism 2012, 61, 175–185. [CrossRef] [PubMed]
27. Cress, A.P.; Fraker, P.J.; Bieber, L.L. Carnitine and acylcarnitine levels of human peripheral blood lymphocytes and mononuclear phagocytes. Biochim. Biophys. Acta 1989, 992, 135–139. [CrossRef]
28. Weinstein, L.S.; Xie, T.; Zhang, Q.H.; Chen, M. Studies of the regulation and function of the Gsα gene Gnas using gene targeting technology. Pharmacol. Ther. 2007, 115, 271–291. [CrossRef] [PubMed]
29. Tobi, E.W.; Heijmans, B.T.; Kremer, D.; Putter, H.; Delemarre-van de Waal, H.A.; Finken, M.J.; Wit, J.M.; Slagboom, P.E. DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age. Epigenetics 2011, 6, 171–176. [CrossRef] [PubMed]
30. Burdge, G.C.; Lillycrop, K.A. Bridging the gap between epigenetics research and nutritional public health interventions. Genome Med. 2010, 2, 80. [CrossRef] [PubMed]
31. Crujeiras, A.B.; Diaz-Lagares, A.; Sandoval, J.; Milagro, F.I.; Navas-Carretero, S.; Carreira, M.C.; Gomez, A.; Hervas, D.; Monteiro, M.P.; Casanueva, F.F., et al. DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: A genome-wide analysis from non-obese and obese patients. Sci. Rep. 2017, 7, 41903. [CrossRef] [PubMed]
32. Covas, M.I. Olive oil and the cardiovascular system. Pharmacol. Res. 2007, 55, 175–186. [CrossRef] [PubMed]
33. Solà-Alberich, R.; Godàs-Bonfill, G.; Salas-Salvadó, J. Nutritional Value-Tree Nuts and Health: Effects of Tree Nuts on Cholesterol and Cardiovascular Diseases; Northern Nut Growers Association (NNGA): Notre Dame, IN, USA, 2011; Available online: http://www.nutgrowing.org/tree_nuts_and_health.htm (accessed on 9 November 2016).
34. Voisin, S.; Almen, M.S.; Moschonis, G.; Chrousos, G.P.; Manios, Y.; Schioth, H.B. Dietary fat quality impacts genome-wide DNA methylation patterns in a cross-sectional study of greek preadolescents. Eur. J. Hum. Genet. 2015, 23, 654–662. [CrossRef] [PubMed]
35. Konstantinidou, V.; Covas, M.I.; Munoz-Aguayo, D.; Khymenets, O.; de la Torre, R.; Saez, G.; Tormos Mdel, C.; Toledo, E.; Marti, A.; Ruiz-Gutierrez, V., et al. In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the mediterranean diet: A randomized controlled trial. FASEB J. 2010, 24, 2546–2557. [CrossRef] [PubMed]
36. De la Puerta, R.; Ruiz Gutierrez, V.; Hoult, J.R. Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil. Biochem. Pharma. 1999, 57, 445–449. [CrossRef]
37. Visioli, F.; Galli, C. Biological properties of olive oil phytochemicals. Crit. Rev. Food Sci. Nutr. 2002, 42, 209–221. [CrossRef] [PubMed]
38. Di Francesco, A.; Falconi, A.; Di Germanio, C.; Micioni Di Bonaventura, M.V.; Costa, A.; Caramuta, S.; Del Carlo, M.; Compagnone, D.; Dainese, E.; Cifani, C., et al. Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms. J. Nutr. Biochem. 2015, 26, 250–258. [CrossRef] [PubMed]