Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms

Journal of Nutritional Biochemistry

Volumn 26, Issue 3, 2015, Pages 250-258

  di Francesco, Andrea ^a   Falconi, Anastasia ^a   di Germanio, Clara ^a   Micioni Di Bonaventura, Maria Vittoria ^b   Costa, Antonio ^c   Caramuta, Stefano ^d   Del Carlo, Michele ^a   Compagnone, Dario ^a   Dainese, Enrico ^a,e   Cifani, Carlo ^b   Maccarrone, Mauro ^c,e   D'Addario, Claudio ^a,d  

^a UNIVERSITY OF TERAMO   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

^c UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^d KAROLINSKA INSTITUTE   (Sweden)

^e IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Bioactive lipids; Colon; Endocannabinoid system; Epigenetics; Hydroxytyrosol; Olive oil; Phenolic compounds

Indexed keywords

CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; EXTRAVIRGIN OLIVE OIL; OLIVE OIL; PHENOL DERIVATIVE; UNCLASSIFIED DRUG; 3,4-DIHYDROXYPHENYLETHANOL; CNR1 PROTEIN, HUMAN; CNR1 PROTEIN, RAT; EDIBLE OIL; PHENETHYL ALCOHOL; PLANT EXTRACT; TUMOR PROTEIN; VEGETABLE OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CACO 2 CELL LINE; CANCER PREVENTION; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; COLON CANCER; COLON MUCOSA; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; FEMALE; GENE EXPRESSION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; NONHUMAN; PHENOTYPE; PROMOTER REGION; RAT; RECEPTOR UPREGULATION; TRANSCRIPTION INITIATION SITE; TUMOR SUPPRESSOR GENE; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CHEMISTRY; COLON; COLONIC NEOPLASMS; COMPARATIVE STUDY; CYTOLOGY; FRUIT; GENETIC EPIGENESIS; GENETICS; INTESTINE MUCOSA; METABOLISM; OLIVE TREE; PATHOLOGY; SPRAGUE DAWLEY RAT; STANDARDS; UPREGULATION;

RATTUS;

ANIMALS; CACO-2 CELLS; CELL LINE; CELL PROLIFERATION; COLON; COLONIC NEOPLASMS; DIETARY FATS, UNSATURATED; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FRUIT; HUMANS; INTESTINAL MUCOSA; NEOPLASM PROTEINS; OLEA; OLIVE OIL; PHENYLETHYL ALCOHOL; PLANT EXTRACTS; PLANT OILS; PROMOTER REGIONS, GENETIC; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; UP-REGULATION;

EID: 84927698878     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2014.10.013     Document Type: Article

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