The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy

Molecular and Cellular Endocrinology

Volumn 473, Issue , 2018, Pages 31-43

  Lu, Qian ^a   Zhou, Yuexian ^a   Hao, Meng ^a   Li, Chengcheng ^a   Wang, Jin ^a   Shu, Fanglin ^a   Du, Lei ^a   Zhu, Xia ^a   Zhang, Qiaoli ^b   Yin, Xiaoxing ^a  

^a Affiliated Xuzhou Hospital of Dongnan   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Diabetic nephropathy; Mesangial cells; mTOR signaling; Oxidative stress

Indexed keywords

CASPASE 3; GLUCOSE; GLUTATHIONE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE; NOX4 PROTEIN, RAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TARGET OF RAPAMYCIN KINASE;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GLOMERULUS; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY CORTEX; KIDNEY FUNCTION; MALE; MESANGIUM CELL; MTOR SIGNALING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CELL LINE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; KIDNEY FUNCTION TEST; METABOLISM; MITOCHONDRION; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; GLUCOSE; KIDNEY CORTEX; KIDNEY FUNCTION TESTS; MALE; MESANGIAL CELLS; MITOCHONDRIA; MODELS, BIOLOGICAL; NADPH OXIDASE 4; OXIDATIVE STRESS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 85039163552     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2017.12.012     Document Type: Article

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