Inhibition of human glioma cell proliferation by altered Bax/Bcl-2-p53 expression and apoptosis induction by Rhaponticum carthamoides extracts from transformed and normal roots

Journal of Pharmacy and Pharmacology

Volumn 68, Issue 11, 2016, Pages 1454-1464

  Skała, Ewa ^a   Sitarek, Przemysław ^a   Toma, Monika ^b   Szemraj, Janusz ^a   Radek, Maciej ^a   Nieborowska Skorska, Malgorzata ^c   Skorski, Tomasz ^c   Wysokińska, Halina ^a   Śliwiński, Tomasz ^b  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b UNIVERSITY OF LODZ   (Poland)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

apoptosis; Bax; Bcl 2 and p53 gene expressions; caffeic acid derivatives; glioma primary cells; mitochondrial membrane potential; Rhaponticum carthamoides

Indexed keywords

ANTINEOPLASTIC AGENT; CHLOROGENIC ACID; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; RHAPONTICUM CARTHAMOIDES EXTRACT; UNCLASSIFIED DRUG; BAX PROTEIN, HUMAN; BCL2 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BAX GENE; BCL 2 GENE; CELL CYCLE ARREST; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ELECTROSPRAY MASS SPECTROMETRY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GLIOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS INHIBITION; MTT ASSAY; P53 GENE; PLANT ROOT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHAPONTICUM; RHAPONTICUM CARTHAMOIDES; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION; WESTERN BLOTTING; AGROBACTERIUM; BACTERIUM TRANSFORMATION; BRAIN NEOPLASMS; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; LEUZEA; MEDICINAL PLANT; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; PHYTOTHERAPY; SIGNAL TRANSDUCTION;

AGROBACTERIUM; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIOMA; LEUZEA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, FLUORESCENCE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSFORMATION, BACTERIAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84990250365     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12619     Document Type: Article

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