Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy

Pharmacological Research

Volumn 99, Issue , 2015, Pages 237-247

  Lu, Qian ^a   Ji, Xiao Jun ^a   Zhou, Yue Xian ^a   Yao, Xiao Qin ^a   Liu, Yu Qing ^a   Zhang, Fan ^a   Yin, Xiao Xing ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Diabetic nephropathy; Epithelial mesenchymal transition; mTORC1 p70S6K signaling; Quercetin; Renal fibrosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 4; CREATININE; GLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; NITROGEN; PROTEIN; QUERCETIN; RAPAMYCIN; S6 KINASE; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; UREA; UVOMORULIN; CADHERIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG DOSE COMPARISON; DRUG MEGADOSE; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UREA NITROGEN BLOOD LEVEL; ANIMAL; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DRUG EFFECTS; FIBROSIS; KIDNEY PROXIMAL TUBULE; METABOLISM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CADHERINS; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROSIS; GLUCOSE; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; MULTIPROTEIN COMPLEXES; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84937561370     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.06.006     Document Type: Article

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