메뉴 건너뛰기




Volumn 26, Issue 24, 2017, Pages 4906-4915

Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; MUTANT PROTEIN; SNCA PROTEIN, MOUSE;

EID: 85039158302     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddx371     Document Type: Article
Times cited : (21)

References (59)
  • 11
    • 0033215063 scopus 로고    scopus 로고
    • Synucleins in synaptic plasticity and neurodegenerative disorders
    • Clayton, D.F. and George, J.M. (1999) Synucleins in synaptic plasticity and neurodegenerative disorders. J. Neurosci. Res., 58, 120-129
    • (1999) J. Neurosci. Res , vol.58 , pp. 120-129
    • Clayton, D.F.1    George, J.M.2
  • 12
    • 0032540327 scopus 로고    scopus 로고
    • Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
    • Davidson, W.S., Jonas, A., Clayton, D.F. and George, J.M. (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem., 273, 9443-9449
    • (1998) J. Biol. Chem , vol.273 , pp. 9443-9449
    • Davidson, W.S.1    Jonas, A.2    Clayton, D.F.3    George, J.M.4
  • 14
    • 68649095418 scopus 로고    scopus 로고
    • Molecular mechanisms of alpha-synuclein neurodegeneration
    • Waxman, E.A. and Giasson, B.I. (2009) Molecular mechanisms of alpha-synuclein neurodegeneration. Biochim. Biophys. Acta, 1792, 616-624
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 616-624
    • Waxman, E.A.1    Giasson, B.I.2
  • 16
    • 22244442489 scopus 로고    scopus 로고
    • The biochemistry of Parkinson's disease
    • Cookson, M.R. (2005) The biochemistry of Parkinson's disease. Annu. Rev. Biochem., 74, 29-52
    • (2005) Annu. Rev. Biochem , vol.74 , pp. 29-52
    • Cookson, M.R.1
  • 17
    • 0032888789 scopus 로고    scopus 로고
    • Alpha-synuclein in Lewy body disease and Alzheimer's disease
    • Hashimoto, M. and Masliah, E. (1999) Alpha-synuclein in Lewy body disease and Alzheimer's disease. Brain Pathol., 9, 707-720
    • (1999) Brain Pathol , vol.9 , pp. 707-720
    • Hashimoto, M.1    Masliah, E.2
  • 18
    • 18344417178 scopus 로고    scopus 로고
    • Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes
    • Lippa, C.F., Fujiwara, H., Mann, D.M., Giasson, B., Baba, M., Schmidt, M.L., Nee, L.E., O'Connell, B., Pollen, D.A., St George-Hyslop, P., et al. (1998) Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am. J. Pathol., 153, 1365-1370
    • (1998) Am. J. Pathol , vol.153 , pp. 1365-1370
    • Lippa, C.F.1    Fujiwara, H.2    Mann, D.M.3    Giasson, B.4    Baba, M.5    Schmidt, M.L.6    Nee, L.E.7    O'Connell, B.8    Pollen, D.A.9    St George-Hyslop, P.10
  • 19
    • 0032584686 scopus 로고    scopus 로고
    • Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
    • Spillantini, M.G., Crowther, R.A., Jakes, R., Cairns, N.J., Lantos, P.L. and Goedert, M. (1998) Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci. Lett., 251, 205-208
    • (1998) Neurosci. Lett , vol.251 , pp. 205-208
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Cairns, N.J.4    Lantos, P.L.5    Goedert, M.6
  • 20
    • 0031713491 scopus 로고    scopus 로고
    • Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein
    • Tu, P.H., Galvin, J.E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J.Q. and Lee, V.M. (1998) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Ann. Neurol., 44, 415-422
    • (1998) Ann. Neurol , vol.44 , pp. 415-422
    • Tu, P.H.1    Galvin, J.E.2    Baba, M.3    Giasson, B.4    Tomita, T.5    Leight, S.6    Nakajo, S.7    Iwatsubo, T.8    Trojanowski, J.Q.9    Lee, V.M.10
  • 21
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
    • Conway, K.A., Harper, J.D. and Lansbury, P.T. (1998) Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat. Med., 4, 1318-1320
    • (1998) Nat. Med , vol.4 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 23
    • 0033583215 scopus 로고    scopus 로고
    • Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro
    • Giasson, B.I., Uryu, K., Trojanowski, J.Q. and Lee, V.M. (1999) Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. J. Biol. Chem., 274, 7619-7622
    • (1999) J. Biol. Chem , vol.274 , pp. 7619-7622
    • Giasson, B.I.1    Uryu, K.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 24
    • 0035949542 scopus 로고    scopus 로고
    • Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein
    • Li, J., Uversky, V.N. and Fink, A.L. (2001) Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein. Biochemistry, 40, 11604-11613
    • (2001) Biochemistry , vol.40 , pp. 11604-11613
    • Li, J.1    Uversky, V.N.2    Fink, A.L.3
  • 26
    • 84918816540 scopus 로고    scopus 로고
    • Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of a-synuclein
    • Rutherford, N.J., Moore, B.D., Golde, T.E. and Giasson, B.I. (2014) Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of a-synuclein. J. Neurochem., 131, 859-867
    • (2014) J. Neurochem , vol.131 , pp. 859-867
    • Rutherford, N.J.1    Moore, B.D.2    Golde, T.E.3    Giasson, B.I.4
  • 27
    • 85020240176 scopus 로고    scopus 로고
    • A sensitive assay reveals structural requirements for alpha-synuclein fibril growth
    • Dhavale, D.D., Tsai, C., Bagchi, D.P., Engel, L.A., Sarezky, J. and Kotzbauer, P.T. (2017) A sensitive assay reveals structural requirements for alpha-synuclein fibril growth. J. Biol. Chem., 292, 9034-9050
    • (2017) J. Biol. Chem , vol.292 , pp. 9034-9050
    • Dhavale, D.D.1    Tsai, C.2    Bagchi, D.P.3    Engel, L.A.4    Sarezky, J.5    Kotzbauer, P.T.6
  • 28
    • 84901338303 scopus 로고    scopus 로고
    • The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of a-synuclein, and enhances its secretion and nuclear localization in cells
    • Fares, M.-B., Ait-Bouziad, N., Dikiy, I., Mbefo, M.K., Jovicić, A., Kiely, A., Holton, J.L., Lee, S.-J., Gitler, A.D., Eliezer, D., et al. (2014) The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of a-synuclein, and enhances its secretion and nuclear localization in cells. Hum. Mol. Genet., 23, 4491-4509
    • (2014) Hum. Mol. Genet , vol.23 , pp. 4491-4509
    • Fares, M.-B.1    Ait-Bouziad, N.2    Dikiy, I.3    Mbefo, M.K.4    Jovicić, A.5    Kiely, A.6    Holton, J.L.7    Lee, S.-J.8    Gitler, A.D.9    Eliezer, D.10
  • 29
    • 84908204323 scopus 로고    scopus 로고
    • The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates a-synuclein aggregation and membrane binding
    • Ghosh, D., Sahay, S., Ranjan, P., Salot, S., Mohite, G.M., Singh, P.K., Dwivedi, S., Carvalho, E., Banerjee, R., Kumar, A. et al. (2014) The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates a-synuclein aggregation and membrane binding. Biochemistry, 53, 6419-6421
    • (2014) Biochemistry , vol.53 , pp. 6419-6421
    • Ghosh, D.1    Sahay, S.2    Ranjan, P.3    Salot, S.4    Mohite, G.M.5    Singh, P.K.6    Dwivedi, S.7    Carvalho, E.8    Banerjee, R.9    Kumar, A.10
  • 30
    • 84928227099 scopus 로고    scopus 로고
    • The A53E a-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture
    • Rutherford, N.J. and Giasson, B.I. (2015) The A53E a-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture. Neurosci. Lett., 597, 43-48
    • (2015) Neurosci. Lett , vol.597 , pp. 43-48
    • Rutherford, N.J.1    Giasson, B.I.2
  • 31
    • 6344228684 scopus 로고    scopus 로고
    • Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein
    • Choi, W., Zibaee, S., Jakes, R., Serpell, L.C., Davletov, B., Crowther, R.A. and Goedert, M. (2004) Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein. FEBS Lett., 576, 363-368
    • (2004) FEBS Lett , vol.576 , pp. 363-368
    • Choi, W.1    Zibaee, S.2    Jakes, R.3    Serpell, L.C.4    Davletov, B.5    Crowther, R.A.6    Goedert, M.7
  • 34
    • 79960260042 scopus 로고    scopus 로고
    • Familial Parkinson disease mutations influence a-synuclein assembly
    • Ono, K., Ikeda, T., Takasaki, J. and Yamada, M. (2011) Familial Parkinson disease mutations influence a-synuclein assembly. Neurobiol. Dis., 43, 715-724
    • (2011) Neurobiol. Dis , vol.43 , pp. 715-724
    • Ono, K.1    Ikeda, T.2    Takasaki, J.3    Yamada, M.4
  • 35
    • 0032573289 scopus 로고    scopus 로고
    • Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease
    • El-Agnaf, O.M., Jakes, R., Curran, M.D. and Wallace, A. (1998) Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease. FEBS Lett., 440, 67-70
    • (1998) FEBS Lett , vol.440 , pp. 67-70
    • El-Agnaf, O.M.1    Jakes, R.2    Curran, M.D.3    Wallace, A.4
  • 36
    • 33847103123 scopus 로고    scopus 로고
    • Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis
    • Kamiyoshihara, T., Kojima, M., Uéda, K., Tashiro, M. and Shimotakahara, S. (2007) Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis. Biochem. Biophys. Res. Commun., 355, 398-403
    • (2007) Biochem. Biophys. Res. Commun , vol.355 , pp. 398-403
    • Kamiyoshihara, T.1    Kojima, M.2    Uéda, K.3    Tashiro, M.4    Shimotakahara, S.5
  • 37
    • 0034681163 scopus 로고    scopus 로고
    • Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy
    • Conway, K.A., Lee, S.J., Rochet, J.C., Ding, T.T., Williamson, R.E. and Lansbury, P.T. Jr (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc. Natl. Acad. Sci. U. S. A., 97, 571-576
    • (2000) Proc. Natl. Acad. Sci. U. S. A , vol.97 , pp. 571-576
    • Conway, K.A.1    Lee, S.J.2    Rochet, J.C.3    Ding, T.T.4    Williamson, R.E.5    Lansbury, P.T.6
  • 38
    • 0033538541 scopus 로고    scopus 로고
    • Alpha-synuclein fibrillogenesis is nucleation-dependent Implications for the pathogenesis of Parkinson's disease
    • Wood, S.J., Wypych, J., Steavenson, S., Louis, J.C., Citron, M. and Biere, A.L. (1999) alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. J. Biol. Chem., 274, 19509-19512
    • (1999) J. Biol. Chem , vol.274 , pp. 19509-19512
    • Wood, S.J.1    Wypych, J.2    Steavenson, S.3    Louis, J.C.4    Citron, M.5    Biere, A.L.6
  • 39
    • 84952982352 scopus 로고    scopus 로고
    • Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
    • Uchihara, T. and Giasson, B.I. (2016) Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Acta Neuropathol., 131, 49-73
    • (2016) Acta Neuropathol , vol.131 , pp. 49-73
    • Uchihara, T.1    Giasson, B.I.2
  • 40
    • 84893642253 scopus 로고    scopus 로고
    • Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
    • Guo, J.L. and Lee, V.M.Y. (2014) Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases. Nat. Med., 20, 130-138
    • (2014) Nat. Med , vol.20 , pp. 130-138
    • Guo, J.L.1    Lee, V.M.Y.2
  • 41
    • 77954385676 scopus 로고    scopus 로고
    • The propagation of prion-like protein inclusions in neurodegenerative diseases
    • Goedert, M., Clavaguera, F. and Tolnay, M. (2010) The propagation of prion-like protein inclusions in neurodegenerative diseases. Trends Neurosci., 33, 317-325
    • (2010) Trends Neurosci , vol.33 , pp. 317-325
    • Goedert, M.1    Clavaguera, F.2    Tolnay, M.3
  • 42
    • 85014750154 scopus 로고    scopus 로고
    • Like prions: the propagation of aggregated tau and a-synuclein in neurodegeneration
    • Goedert, M., Masuda-Suzukake, M. and Falcon, B. (2017) Like prions: the propagation of aggregated tau and a-synuclein in neurodegeneration. Brain, 140, 266-278
    • (2017) Brain , vol.140 , pp. 266-278
    • Goedert, M.1    Masuda-Suzukake, M.2    Falcon, B.3
  • 43
    • 84862609075 scopus 로고    scopus 로고
    • Intracerebral inoculation of pathological a-synuclein initiates a rapidly progressive neurodegenerative a-synucleinopathy in mice
    • Luk, K.C., Kehm, V.M., Zhang, B., O'Brien, P., Trojanowski, J.Q. and Lee, V.M.Y. (2012) Intracerebral inoculation of pathological a-synuclein initiates a rapidly progressive neurodegenerative a-synucleinopathy in mice. J. Exp. Med., 209, 975-986
    • (2012) J. Exp. Med , vol.209 , pp. 975-986
    • Luk, K.C.1    Kehm, V.M.2    Zhang, B.3    O'Brien, P.4    Trojanowski, J.Q.5    Lee, V.M.Y.6
  • 47
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    • Giasson, B.I., Duda, J.E., Quinn, S.M., Zhang, B., Trojanowski, J.Q. and Lee, V.M.-Y. (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron, 34, 521-533
    • (2002) Neuron , vol.34 , pp. 521-533
    • Giasson, B.I.1    Duda, J.E.2    Quinn, S.M.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.-Y.6
  • 48
    • 85015600070 scopus 로고    scopus 로고
    • Novel antibodies to phosphorylated a-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes
    • Rutherford, N.J., Brooks, M. and Giasson, B.I. (2016) Novel antibodies to phosphorylated a-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes. Acta Neuropathol. Commun., 4, 80
    • (2016) Acta Neuropathol. Commun , vol.4 , pp. 80
    • Rutherford, N.J.1    Brooks, M.2    Giasson, B.I.3
  • 51
    • 84907015989 scopus 로고    scopus 로고
    • Brain injection of a-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker
    • Sacino, A.N., Brooks, M., McKinney, A.B., Thomas, M.A., Shaw, G., Golde, T.E. and Giasson, B.I. (2014) Brain injection of a-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker. J. Neurosci., 34, 12368-12378
    • (2014) J. Neurosci , vol.34 , pp. 12368-12378
    • Sacino, A.N.1    Brooks, M.2    McKinney, A.B.3    Thomas, M.A.4    Shaw, G.5    Golde, T.E.6    Giasson, B.I.7
  • 55
    • 0035951869 scopus 로고    scopus 로고
    • A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
    • Giasson, B.I., Murray, I.V., Trojanowski, J.Q. and Lee, V.M. (2001) A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. J. Biol. Chem., 276, 2380-2386
    • (2001) J. Biol. Chem , vol.276 , pp. 2380-2386
    • Giasson, B.I.1    Murray, I.V.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 57
    • 0034651575 scopus 로고    scopus 로고
    • A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease
    • Giasson, B.I., Jakes, R., Goedert, M., Duda, J.E., Leight, S., Trojanowski, J.Q. and Lee, V.M. (2000) A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. J. Neurosci. Res., 59, 528-533
    • (2000) J. Neurosci. Res , vol.59 , pp. 528-533
    • Giasson, B.I.1    Jakes, R.2    Goedert, M.3    Duda, J.E.4    Leight, S.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 58
    • 47749139266 scopus 로고    scopus 로고
    • Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions
    • Waxman, E.A., Duda, J.E. and Giasson, B.I. (2008) Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions. Acta Neuropathol., 116, 37-46
    • (2008) Acta Neuropathol , vol.116 , pp. 37-46
    • Waxman, E.A.1    Duda, J.E.2    Giasson, B.I.3
  • 59
    • 0036322266 scopus 로고    scopus 로고
    • Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
    • Duda, J.E., Giasson, B.I., Mabon, M.E., Lee, V.M.-Y. and Trojanowski, J.Q. (2002) Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann. Neurol., 52, 205-210
    • (2002) Ann. Neurol , vol.52 , pp. 205-210
    • Duda, J.E.1    Giasson, B.I.2    Mabon, M.E.3    Lee, V.M.-Y.4    Trojanowski, J.Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.