-
1
-
-
84879605541
-
Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
-
Appel-Cresswell, S., Vilarino-Guell, C., Encarnacion, M., Sherman, H., Yu, I., Shah, B., Weir, D., Thompson, C., Szu-Tu, C., Trinh, J. et al. (2013) Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. Mov. Disord., 28, 811-813
-
(2013)
Mov. Disord
, vol.28
, pp. 811-813
-
-
Appel-Cresswell, S.1
Vilarino-Guell, C.2
Encarnacion, M.3
Sherman, H.4
Yu, I.5
Shah, B.6
Weir, D.7
Thompson, C.8
Szu-Tu, C.9
Trinh, J.10
-
2
-
-
4644290985
-
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin, M.-C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M. et al. (2004) Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet, 364, 1167-1169
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.-C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
-
3
-
-
84885461450
-
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
-
Kiely, A.P., Asi, Y.T., Kara, E., Limousin, P., Ling, H., Lewis, P., Proukakis, C., Quinn, N., Lees, A.J., Hardy, J. et al. (2013) α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy? Acta Neuropathol., 125, 753-769
-
(2013)
Acta Neuropathol
, vol.125
, pp. 753-769
-
-
Kiely, A.P.1
Asi, Y.T.2
Kara, E.3
Limousin, P.4
Ling, H.5
Lewis, P.6
Proukakis, C.7
Quinn, N.8
Lees, A.J.9
Hardy, J.10
-
4
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J.T., Schöls, L. and Riess, O. (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet., 18, 106-108
-
(1998)
Nat. Genet
, vol.18
, pp. 106-108
-
-
Krüger, R.1
Kuhn, W.2
Müller, T.3
Woitalla, D.4
Graeber, M.5
Kösel, S.6
Przuntek, H.7
Epplen, J.T.8
Schöls, L.9
Riess, O.10
-
5
-
-
84878405578
-
G51D a-synuclein mutation causes a novel parkinsonian-pyramidal syndrome
-
Lesage, S., Anheim, M., Letournel, F., Bousset, L., Honoré, A., Rozas, N., Pieri, L., Madiona, K., Dürr, A., Melki, R. et al. (2013) G51D a-synuclein mutation causes a novel parkinsonian-pyramidal syndrome. Ann. Neurol., 73, 459-471
-
(2013)
Ann. Neurol
, vol.73
, pp. 459-471
-
-
Lesage, S.1
Anheim, M.2
Letournel, F.3
Bousset, L.4
Honoré, A.5
Rozas, N.6
Pieri, L.7
Madiona, K.8
Dürr, A.9
Melki, R.10
-
6
-
-
84902118984
-
A novel a-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
-
Pasanen, P., Myllykangas, L., Siitonen, M., Raunio, A., Kaakkola, S., Lyytinen, J., Tienari, P.J., Pöyhönen, M. and Paetau, A. (2014) A novel a-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology. Neurobiol. Aging, 35, 2180.e1-2185
-
(2014)
Neurobiol. Aging
, vol.35
-
-
Pasanen, P.1
Myllykangas, L.2
Siitonen, M.3
Raunio, A.4
Kaakkola, S.5
Lyytinen, J.6
Tienari, P.J.7
Pöyhönen, M.8
Paetau, A.9
-
7
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M.H., Lavedan, C., Leroy, E., Ide, S.E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R. et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science, 276, 2045-2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
-
8
-
-
84876226920
-
A novel a-synuclein missense mutation in Parkinson disease
-
Proukakis, C., Dudzik, C.G., Brier, T., MacKay, D.S., Cooper, J.M., Millhauser, G.L., Houlden, H. and Schapira, A.H. (2013) A novel a-synuclein missense mutation in Parkinson disease. Neurology, 80, 1062-1064
-
(2013)
Neurology
, vol.80
, pp. 1062-1064
-
-
Proukakis, C.1
Dudzik, C.G.2
Brier, T.3
MacKay, D.S.4
Cooper, J.M.5
Millhauser, G.L.6
Houlden, H.7
Schapira, A.H.8
-
9
-
-
0242300619
-
Alpha-synuclein locus triplication causes Parkinson's disease
-
Singleton, A.B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R. et al. (2003) Alpha-synuclein locus triplication causes Parkinson's disease. Science, 302, 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
-
10
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
Zarranz, J.J., Alegre, J., Gomez-Esteban, J.C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B. et al. (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol., 55, 164-173
-
(2004)
Ann. Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atarés, B.10
-
11
-
-
0033215063
-
Synucleins in synaptic plasticity and neurodegenerative disorders
-
Clayton, D.F. and George, J.M. (1999) Synucleins in synaptic plasticity and neurodegenerative disorders. J. Neurosci. Res., 58, 120-129
-
(1999)
J. Neurosci. Res
, vol.58
, pp. 120-129
-
-
Clayton, D.F.1
George, J.M.2
-
12
-
-
0032540327
-
Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
-
Davidson, W.S., Jonas, A., Clayton, D.F. and George, J.M. (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem., 273, 9443-9449
-
(1998)
J. Biol. Chem
, vol.273
, pp. 9443-9449
-
-
Davidson, W.S.1
Jonas, A.2
Clayton, D.F.3
George, J.M.4
-
13
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
Spillantini, M.G., Schmidt, M.L., Lee, V.M., Trojanowski, J.Q., Jakes, R. and Goedert, M. (1997) Alpha-synuclein in Lewy bodies. Nature, 388, 839-840
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
14
-
-
68649095418
-
Molecular mechanisms of alpha-synuclein neurodegeneration
-
Waxman, E.A. and Giasson, B.I. (2009) Molecular mechanisms of alpha-synuclein neurodegeneration. Biochim. Biophys. Acta, 1792, 616-624
-
(2009)
Biochim. Biophys. Acta
, vol.1792
, pp. 616-624
-
-
Waxman, E.A.1
Giasson, B.I.2
-
15
-
-
84871921766
-
100 years of Lewy pathology
-
Goedert, M., Spillantini, M.G., Del Tredici, K. and Braak, H. (2013) 100 years of Lewy pathology. Nat. Rev. Neurol., 9, 13-24
-
(2013)
Nat. Rev. Neurol
, vol.9
, pp. 13-24
-
-
Goedert, M.1
Spillantini, M.G.2
Del Tredici, K.3
Braak, H.4
-
16
-
-
22244442489
-
The biochemistry of Parkinson's disease
-
Cookson, M.R. (2005) The biochemistry of Parkinson's disease. Annu. Rev. Biochem., 74, 29-52
-
(2005)
Annu. Rev. Biochem
, vol.74
, pp. 29-52
-
-
Cookson, M.R.1
-
17
-
-
0032888789
-
Alpha-synuclein in Lewy body disease and Alzheimer's disease
-
Hashimoto, M. and Masliah, E. (1999) Alpha-synuclein in Lewy body disease and Alzheimer's disease. Brain Pathol., 9, 707-720
-
(1999)
Brain Pathol
, vol.9
, pp. 707-720
-
-
Hashimoto, M.1
Masliah, E.2
-
18
-
-
18344417178
-
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes
-
Lippa, C.F., Fujiwara, H., Mann, D.M., Giasson, B., Baba, M., Schmidt, M.L., Nee, L.E., O'Connell, B., Pollen, D.A., St George-Hyslop, P., et al. (1998) Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am. J. Pathol., 153, 1365-1370
-
(1998)
Am. J. Pathol
, vol.153
, pp. 1365-1370
-
-
Lippa, C.F.1
Fujiwara, H.2
Mann, D.M.3
Giasson, B.4
Baba, M.5
Schmidt, M.L.6
Nee, L.E.7
O'Connell, B.8
Pollen, D.A.9
St George-Hyslop, P.10
-
19
-
-
0032584686
-
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
-
Spillantini, M.G., Crowther, R.A., Jakes, R., Cairns, N.J., Lantos, P.L. and Goedert, M. (1998) Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci. Lett., 251, 205-208
-
(1998)
Neurosci. Lett
, vol.251
, pp. 205-208
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Cairns, N.J.4
Lantos, P.L.5
Goedert, M.6
-
20
-
-
0031713491
-
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein
-
Tu, P.H., Galvin, J.E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J.Q. and Lee, V.M. (1998) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Ann. Neurol., 44, 415-422
-
(1998)
Ann. Neurol
, vol.44
, pp. 415-422
-
-
Tu, P.H.1
Galvin, J.E.2
Baba, M.3
Giasson, B.4
Tomita, T.5
Leight, S.6
Nakajo, S.7
Iwatsubo, T.8
Trojanowski, J.Q.9
Lee, V.M.10
-
21
-
-
0031787871
-
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
-
Conway, K.A., Harper, J.D. and Lansbury, P.T. (1998) Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat. Med., 4, 1318-1320
-
(1998)
Nat. Med
, vol.4
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
22
-
-
84885439148
-
The Parkinson's disease-associated H50Q mutation accelerates a-synuclein aggregation in vitro
-
Ghosh, D., Mondal, M., Mohite, G.M., Singh, P.K., Ranjan, P., Anoop, A., Ghosh, S., Jha, N.N., Kumar, A. and Maji, S.K. (2013) The Parkinson's disease-associated H50Q mutation accelerates a-synuclein aggregation in vitro. Biochemistry, 52, 6925-6927
-
(2013)
Biochemistry
, vol.52
, pp. 6925-6927
-
-
Ghosh, D.1
Mondal, M.2
Mohite, G.M.3
Singh, P.K.4
Ranjan, P.5
Anoop, A.6
Ghosh, S.7
Jha, N.N.8
Kumar, A.9
Maji, S.K.10
-
23
-
-
0033583215
-
Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro
-
Giasson, B.I., Uryu, K., Trojanowski, J.Q. and Lee, V.M. (1999) Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. J. Biol. Chem., 274, 7619-7622
-
(1999)
J. Biol. Chem
, vol.274
, pp. 7619-7622
-
-
Giasson, B.I.1
Uryu, K.2
Trojanowski, J.Q.3
Lee, V.M.4
-
24
-
-
0035949542
-
Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein
-
Li, J., Uversky, V.N. and Fink, A.L. (2001) Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein. Biochemistry, 40, 11604-11613
-
(2001)
Biochemistry
, vol.40
, pp. 11604-11613
-
-
Li, J.1
Uversky, V.N.2
Fink, A.L.3
-
25
-
-
0033515471
-
Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation
-
Narhi, L., Wood, S.J., Steavenson, S., Jiang, Y., Wu, G.M., Anafi, D., Kaufman, S.A., Martin, F., Sitney, K., Denis, P. et al. (1999) Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. J. Biol. Chem., 274, 9843-9846
-
(1999)
J. Biol. Chem
, vol.274
, pp. 9843-9846
-
-
Narhi, L.1
Wood, S.J.2
Steavenson, S.3
Jiang, Y.4
Wu, G.M.5
Anafi, D.6
Kaufman, S.A.7
Martin, F.8
Sitney, K.9
Denis, P.10
-
26
-
-
84918816540
-
Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of a-synuclein
-
Rutherford, N.J., Moore, B.D., Golde, T.E. and Giasson, B.I. (2014) Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of a-synuclein. J. Neurochem., 131, 859-867
-
(2014)
J. Neurochem
, vol.131
, pp. 859-867
-
-
Rutherford, N.J.1
Moore, B.D.2
Golde, T.E.3
Giasson, B.I.4
-
27
-
-
85020240176
-
A sensitive assay reveals structural requirements for alpha-synuclein fibril growth
-
Dhavale, D.D., Tsai, C., Bagchi, D.P., Engel, L.A., Sarezky, J. and Kotzbauer, P.T. (2017) A sensitive assay reveals structural requirements for alpha-synuclein fibril growth. J. Biol. Chem., 292, 9034-9050
-
(2017)
J. Biol. Chem
, vol.292
, pp. 9034-9050
-
-
Dhavale, D.D.1
Tsai, C.2
Bagchi, D.P.3
Engel, L.A.4
Sarezky, J.5
Kotzbauer, P.T.6
-
28
-
-
84901338303
-
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of a-synuclein, and enhances its secretion and nuclear localization in cells
-
Fares, M.-B., Ait-Bouziad, N., Dikiy, I., Mbefo, M.K., Jovicić, A., Kiely, A., Holton, J.L., Lee, S.-J., Gitler, A.D., Eliezer, D., et al. (2014) The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of a-synuclein, and enhances its secretion and nuclear localization in cells. Hum. Mol. Genet., 23, 4491-4509
-
(2014)
Hum. Mol. Genet
, vol.23
, pp. 4491-4509
-
-
Fares, M.-B.1
Ait-Bouziad, N.2
Dikiy, I.3
Mbefo, M.K.4
Jovicić, A.5
Kiely, A.6
Holton, J.L.7
Lee, S.-J.8
Gitler, A.D.9
Eliezer, D.10
-
29
-
-
84908204323
-
The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates a-synuclein aggregation and membrane binding
-
Ghosh, D., Sahay, S., Ranjan, P., Salot, S., Mohite, G.M., Singh, P.K., Dwivedi, S., Carvalho, E., Banerjee, R., Kumar, A. et al. (2014) The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates a-synuclein aggregation and membrane binding. Biochemistry, 53, 6419-6421
-
(2014)
Biochemistry
, vol.53
, pp. 6419-6421
-
-
Ghosh, D.1
Sahay, S.2
Ranjan, P.3
Salot, S.4
Mohite, G.M.5
Singh, P.K.6
Dwivedi, S.7
Carvalho, E.8
Banerjee, R.9
Kumar, A.10
-
30
-
-
84928227099
-
The A53E a-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture
-
Rutherford, N.J. and Giasson, B.I. (2015) The A53E a-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture. Neurosci. Lett., 597, 43-48
-
(2015)
Neurosci. Lett
, vol.597
, pp. 43-48
-
-
Rutherford, N.J.1
Giasson, B.I.2
-
31
-
-
6344228684
-
Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein
-
Choi, W., Zibaee, S., Jakes, R., Serpell, L.C., Davletov, B., Crowther, R.A. and Goedert, M. (2004) Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein. FEBS Lett., 576, 363-368
-
(2004)
FEBS Lett
, vol.576
, pp. 363-368
-
-
Choi, W.1
Zibaee, S.2
Jakes, R.3
Serpell, L.C.4
Davletov, B.5
Crowther, R.A.6
Goedert, M.7
-
32
-
-
34250796802
-
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states
-
Fredenburg, R.A., Rospigliosi, C., Meray, R.K., Kessler, J.C., Lashuel, H.A., Eliezer, D. and Lansbury, P.T. (2007) The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. Biochemistry, 46, 7107-7118
-
(2007)
Biochemistry
, vol.46
, pp. 7107-7118
-
-
Fredenburg, R.A.1
Rospigliosi, C.2
Meray, R.K.3
Kessler, J.C.4
Lashuel, H.A.5
Eliezer, D.6
Lansbury, P.T.7
-
33
-
-
14844335694
-
The E46K mutation in alpha-synuclein increases amyloid fibril formation
-
Greenbaum, E.A., Graves, C.L., Mishizen-Eberz, A.J., Lupoli, M.A., Lynch, D.R., Englander, S.W., Axelsen, P.H. and Giasson, B.I. (2005) The E46K mutation in alpha-synuclein increases amyloid fibril formation. J. Biol. Chem., 280, 7800-7807
-
(2005)
J. Biol. Chem
, vol.280
, pp. 7800-7807
-
-
Greenbaum, E.A.1
Graves, C.L.2
Mishizen-Eberz, A.J.3
Lupoli, M.A.4
Lynch, D.R.5
Englander, S.W.6
Axelsen, P.H.7
Giasson, B.I.8
-
34
-
-
79960260042
-
Familial Parkinson disease mutations influence a-synuclein assembly
-
Ono, K., Ikeda, T., Takasaki, J. and Yamada, M. (2011) Familial Parkinson disease mutations influence a-synuclein assembly. Neurobiol. Dis., 43, 715-724
-
(2011)
Neurobiol. Dis
, vol.43
, pp. 715-724
-
-
Ono, K.1
Ikeda, T.2
Takasaki, J.3
Yamada, M.4
-
35
-
-
0032573289
-
Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease
-
El-Agnaf, O.M., Jakes, R., Curran, M.D. and Wallace, A. (1998) Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease. FEBS Lett., 440, 67-70
-
(1998)
FEBS Lett
, vol.440
, pp. 67-70
-
-
El-Agnaf, O.M.1
Jakes, R.2
Curran, M.D.3
Wallace, A.4
-
36
-
-
33847103123
-
Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis
-
Kamiyoshihara, T., Kojima, M., Uéda, K., Tashiro, M. and Shimotakahara, S. (2007) Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis. Biochem. Biophys. Res. Commun., 355, 398-403
-
(2007)
Biochem. Biophys. Res. Commun
, vol.355
, pp. 398-403
-
-
Kamiyoshihara, T.1
Kojima, M.2
Uéda, K.3
Tashiro, M.4
Shimotakahara, S.5
-
37
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy
-
Conway, K.A., Lee, S.J., Rochet, J.C., Ding, T.T., Williamson, R.E. and Lansbury, P.T. Jr (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc. Natl. Acad. Sci. U. S. A., 97, 571-576
-
(2000)
Proc. Natl. Acad. Sci. U. S. A
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.J.2
Rochet, J.C.3
Ding, T.T.4
Williamson, R.E.5
Lansbury, P.T.6
-
38
-
-
0033538541
-
Alpha-synuclein fibrillogenesis is nucleation-dependent Implications for the pathogenesis of Parkinson's disease
-
Wood, S.J., Wypych, J., Steavenson, S., Louis, J.C., Citron, M. and Biere, A.L. (1999) alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. J. Biol. Chem., 274, 19509-19512
-
(1999)
J. Biol. Chem
, vol.274
, pp. 19509-19512
-
-
Wood, S.J.1
Wypych, J.2
Steavenson, S.3
Louis, J.C.4
Citron, M.5
Biere, A.L.6
-
39
-
-
84952982352
-
Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
-
Uchihara, T. and Giasson, B.I. (2016) Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Acta Neuropathol., 131, 49-73
-
(2016)
Acta Neuropathol
, vol.131
, pp. 49-73
-
-
Uchihara, T.1
Giasson, B.I.2
-
40
-
-
84893642253
-
Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
-
Guo, J.L. and Lee, V.M.Y. (2014) Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases. Nat. Med., 20, 130-138
-
(2014)
Nat. Med
, vol.20
, pp. 130-138
-
-
Guo, J.L.1
Lee, V.M.Y.2
-
41
-
-
77954385676
-
The propagation of prion-like protein inclusions in neurodegenerative diseases
-
Goedert, M., Clavaguera, F. and Tolnay, M. (2010) The propagation of prion-like protein inclusions in neurodegenerative diseases. Trends Neurosci., 33, 317-325
-
(2010)
Trends Neurosci
, vol.33
, pp. 317-325
-
-
Goedert, M.1
Clavaguera, F.2
Tolnay, M.3
-
42
-
-
85014750154
-
Like prions: the propagation of aggregated tau and a-synuclein in neurodegeneration
-
Goedert, M., Masuda-Suzukake, M. and Falcon, B. (2017) Like prions: the propagation of aggregated tau and a-synuclein in neurodegeneration. Brain, 140, 266-278
-
(2017)
Brain
, vol.140
, pp. 266-278
-
-
Goedert, M.1
Masuda-Suzukake, M.2
Falcon, B.3
-
43
-
-
84862609075
-
Intracerebral inoculation of pathological a-synuclein initiates a rapidly progressive neurodegenerative a-synucleinopathy in mice
-
Luk, K.C., Kehm, V.M., Zhang, B., O'Brien, P., Trojanowski, J.Q. and Lee, V.M.Y. (2012) Intracerebral inoculation of pathological a-synuclein initiates a rapidly progressive neurodegenerative a-synucleinopathy in mice. J. Exp. Med., 209, 975-986
-
(2012)
J. Exp. Med
, vol.209
, pp. 975-986
-
-
Luk, K.C.1
Kehm, V.M.2
Zhang, B.3
O'Brien, P.4
Trojanowski, J.Q.5
Lee, V.M.Y.6
-
44
-
-
84988564563
-
Studies of lipopolysaccharide effects on the induction of a-synuclein pathology by exogenous fibrils in transgenic mice
-
Rutherford, N.J., Sacino, A.N., Brooks, M., Ceballos-Diaz, C., Ladd, T.B., Howard, J.K., Golde, T.E. and Giasson, B.I. (2015) Studies of lipopolysaccharide effects on the induction of a-synuclein pathology by exogenous fibrils in transgenic mice. Mol. Neurodegener., 10, 32
-
(2015)
Mol. Neurodegener
, vol.10
, pp. 32
-
-
Rutherford, N.J.1
Sacino, A.N.2
Brooks, M.3
Ceballos-Diaz, C.4
Ladd, T.B.5
Howard, J.K.6
Golde, T.E.7
Giasson, B.I.8
-
45
-
-
84899896344
-
Amyloidogenic a-synuclein seeds do not invariably induce rapid, widespread pathology in mice
-
Sacino, A.N., Brooks, M., Thomas, M.A., McKinney, A.B., McGarvey, N.H., Rutherford, N.J., Ceballos-Diaz, C., Robertson, J., Golde, T.E. and Giasson, B.I. (2014) Amyloidogenic a-synuclein seeds do not invariably induce rapid, widespread pathology in mice. Acta Neuropathol., 127, 645-665
-
(2014)
Acta Neuropathol
, vol.127
, pp. 645-665
-
-
Sacino, A.N.1
Brooks, M.2
Thomas, M.A.3
McKinney, A.B.4
McGarvey, N.H.5
Rutherford, N.J.6
Ceballos-Diaz, C.7
Robertson, J.8
Golde, T.E.9
Giasson, B.I.10
-
46
-
-
84904636970
-
Intramuscular injection of a-synuclein induces CNS a-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
-
Sacino, A.N., Brooks, M., Thomas, M.A., McKinney, A.B., Lee, S., Regenhardt, R.W., McGarvey, N.H., Ayers, J.I., Notterpek, L., Borchelt, D.R. et al. (2014) Intramuscular injection of a-synuclein induces CNS a-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc. Natl. Acad. Sci. U. S. A., 111, 10732-10737
-
(2014)
Proc. Natl. Acad. Sci. U. S. A
, vol.111
, pp. 10732-10737
-
-
Sacino, A.N.1
Brooks, M.2
Thomas, M.A.3
McKinney, A.B.4
Lee, S.5
Regenhardt, R.W.6
McGarvey, N.H.7
Ayers, J.I.8
Notterpek, L.9
Borchelt, D.R.10
-
47
-
-
0037118259
-
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
-
Giasson, B.I., Duda, J.E., Quinn, S.M., Zhang, B., Trojanowski, J.Q. and Lee, V.M.-Y. (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron, 34, 521-533
-
(2002)
Neuron
, vol.34
, pp. 521-533
-
-
Giasson, B.I.1
Duda, J.E.2
Quinn, S.M.3
Zhang, B.4
Trojanowski, J.Q.5
Lee, V.M.-Y.6
-
48
-
-
85015600070
-
Novel antibodies to phosphorylated a-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes
-
Rutherford, N.J., Brooks, M. and Giasson, B.I. (2016) Novel antibodies to phosphorylated a-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes. Acta Neuropathol. Commun., 4, 80
-
(2016)
Acta Neuropathol. Commun
, vol.4
, pp. 80
-
-
Rutherford, N.J.1
Brooks, M.2
Giasson, B.I.3
-
49
-
-
85008627431
-
Robust central nervous system pathology in transgenic mice following peripheral injection of a-synuclein fibrils
-
Ayers, J.I., Brooks, M.M., Rutherford, N.J., Howard, J.K., Sorrentino, Z.A., Riffe, C.J., Giasson, B.I. and Caughey, B. (2017) Robust central nervous system pathology in transgenic mice following peripheral injection of a-synuclein fibrils. J. Virol., 91, e02095-16
-
(2017)
J. Virol
, vol.91
-
-
Ayers, J.I.1
Brooks, M.M.2
Rutherford, N.J.3
Howard, J.K.4
Sorrentino, Z.A.5
Riffe, C.J.6
Giasson, B.I.7
Caughey, B.8
-
50
-
-
85019680183
-
Intrastriatal injection of a-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity
-
Sorrentino, Z.A., Brooks, M.M.T., Hudson, V., Rutherford, N.J., Golde, T.E., Giasson, B.I. and Chakrabarty, P. (2017) Intrastriatal injection of a-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity. Mol. Neurodegener., 12, 40
-
(2017)
Mol. Neurodegener
, vol.12
, pp. 40
-
-
Sorrentino, Z.A.1
Brooks, M.M.T.2
Hudson, V.3
Rutherford, N.J.4
Golde, T.E.5
Giasson, B.I.6
Chakrabarty, P.7
-
51
-
-
84907015989
-
Brain injection of a-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker
-
Sacino, A.N., Brooks, M., McKinney, A.B., Thomas, M.A., Shaw, G., Golde, T.E. and Giasson, B.I. (2014) Brain injection of a-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker. J. Neurosci., 34, 12368-12378
-
(2014)
J. Neurosci
, vol.34
, pp. 12368-12378
-
-
Sacino, A.N.1
Brooks, M.2
McKinney, A.B.3
Thomas, M.A.4
Shaw, G.5
Golde, T.E.6
Giasson, B.I.7
-
52
-
-
67349253824
-
E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein
-
Rospigliosi, C.C., McClendon, S., Schmid, A.W., Ramlall, T.F., Barré, P., Lashuel, H.A. and Eliezer, D. (2009) E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein. J. Mol. Biol., 388, 1022-1032
-
(2009)
J. Mol. Biol
, vol.388
, pp. 1022-1032
-
-
Rospigliosi, C.C.1
McClendon, S.2
Schmid, A.W.3
Ramlall, T.F.4
Barré, P.5
Lashuel, H.A.6
Eliezer, D.7
-
53
-
-
59649095836
-
Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers
-
Brucale, M., Sandal, M., Di Maio, S., Rampioni, A., Tessari, I., Tosatto, L., Bisaglia, M., Bubacco, L. and Samorì, B. (2009) Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers. Chembiochem, 10, 176-183
-
(2009)
Chembiochem
, vol.10
, pp. 176-183
-
-
Brucale, M.1
Sandal, M.2
Di Maio, S.3
Rampioni, A.4
Tessari, I.5
Tosatto, L.6
Bisaglia, M.7
Bubacco, L.8
Samorì, B.9
-
54
-
-
33144489150
-
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
-
McKeith, I.G., Dickson, D.W., Lowe, J., Emre, M., O'Brien, J.T., Feldman, H., Cummings, J., Duda, J.E., Lippa, C., Perry, E.K. et al. (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology, 65, 1863-1872
-
(2005)
Neurology
, vol.65
, pp. 1863-1872
-
-
McKeith, I.G.1
Dickson, D.W.2
Lowe, J.3
Emre, M.4
O'Brien, J.T.5
Feldman, H.6
Cummings, J.7
Duda, J.E.8
Lippa, C.9
Perry, E.K.10
-
55
-
-
0035951869
-
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
-
Giasson, B.I., Murray, I.V., Trojanowski, J.Q. and Lee, V.M. (2001) A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. J. Biol. Chem., 276, 2380-2386
-
(2001)
J. Biol. Chem
, vol.276
, pp. 2380-2386
-
-
Giasson, B.I.1
Murray, I.V.2
Trojanowski, J.Q.3
Lee, V.M.4
-
56
-
-
0141543878
-
A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114
-
Crystal, A.S., Giasson, B.I., Crowe, A., Kung, M.-P., Zhuang, Z.-P., Trojanowski, J.Q. and Lee, V.M.-Y. (2003) A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. J. Neurochem, 86, 1359-1368
-
(2003)
J. Neurochem
, vol.86
, pp. 1359-1368
-
-
Crystal, A.S.1
Giasson, B.I.2
Crowe, A.3
Kung, M.-P.4
Zhuang, Z.-P.5
Trojanowski, J.Q.6
Lee, V.M.-Y.7
-
57
-
-
0034651575
-
A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease
-
Giasson, B.I., Jakes, R., Goedert, M., Duda, J.E., Leight, S., Trojanowski, J.Q. and Lee, V.M. (2000) A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. J. Neurosci. Res., 59, 528-533
-
(2000)
J. Neurosci. Res
, vol.59
, pp. 528-533
-
-
Giasson, B.I.1
Jakes, R.2
Goedert, M.3
Duda, J.E.4
Leight, S.5
Trojanowski, J.Q.6
Lee, V.M.7
-
58
-
-
47749139266
-
Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions
-
Waxman, E.A., Duda, J.E. and Giasson, B.I. (2008) Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions. Acta Neuropathol., 116, 37-46
-
(2008)
Acta Neuropathol
, vol.116
, pp. 37-46
-
-
Waxman, E.A.1
Duda, J.E.2
Giasson, B.I.3
-
59
-
-
0036322266
-
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
-
Duda, J.E., Giasson, B.I., Mabon, M.E., Lee, V.M.-Y. and Trojanowski, J.Q. (2002) Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann. Neurol., 52, 205-210
-
(2002)
Ann. Neurol
, vol.52
, pp. 205-210
-
-
Duda, J.E.1
Giasson, B.I.2
Mabon, M.E.3
Lee, V.M.-Y.4
Trojanowski, J.Q.5
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