Modulation of radiation-induced base excision repair pathway gene expression by melatonin

Journal of Medical Physics

Volumn 42, Issue 4, 2017, Pages 245-250

  Rezapoor, Saeed ^a   Shirazi, Alireza ^b   Abbasi, Sakineh ^a   Bazzaz, Javad ^b   Izadi, Pantea ^b   Rezaeejam, Hamed ^c   Valizadeh, Majid ^d   Soleimani Mohammadi, Farid ^b   Najafi, Masoud ^e  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d ZABOL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Base excision repair; gene expression; melatonin; radiation; real time polymerase chain reaction

Indexed keywords

MELATONIN; XRCC1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APEX1 GENE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE RESPONSE; DOWN REGULATION; EXCISION REPAIR; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE REPRESSION; IONIZING RADIATION; LEUKOCYTE; LYMPHOCYTE; MALE; NONHUMAN; OGG1 GENE; RADIATION DOSE; RADIATION EXPOSURE; RADIATION PROTECTION; RADIATION TOLERANCE; RADIOTHERAPY; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WISTAR RAT; X RAY; XRCC1 GENE;

EID: 85038349816     PISSN: 09716203     EISSN: 19983913     Source Type: Journal    
DOI: 10.4103/jmp.JMP_9_17     Document Type: Article

References (45)

1. D'Amico AV, Whittington R, Malkowicz SB, Schultz D, Blank K, Broderick GA, et al. Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 1998;280:969-74.
2. Ballas LK, Elkin EB, Schrag D, Minsky BD, Bach PB. Radiation therapy facilities in the United States. Int J Radiat Oncol Biol Phys 2006;66:1204-11.
3. Jeggo P, Lavin MF. Cellular radiosensitivity: How much better do we understand it? Int J Radiat Biol 2009;85:1061-81.
4. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006;160:1-40.
5. Mohseni M, Mihandoost E, Shirazi A, Sepehrizadeh Z, Bazzaz JT, Ghazi-khansari M, et al. Melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis. Mutat Res 2012;738-739:19-27.
6. Najafi M, Shirazi A, Motevaseli E, Rezaeyan AH, Salajegheh A, Rezapoor S, et al. Melatonin as an anti-inflammatory agent in radiotherapy. Inflammopharmacology 2017;25:403-13.
7. Shirazi A, Haddadi GH, Ghazi-Khansari M, Abolhassani F, Mahdavi SR, Eshraghyan MR. Evaluation of melatonin for prevention of radiation myelopathy in irradiated cervical spinal cord. Cell J 2009;11:43-8.
8. Shirazi A, Haddadi G, Minaee B, Sepehrizadeh Z, Mahdavi S, Jaberi E, et al. Evaluation of melatonin for modulation of apoptosis-related genes in irradiated cervical spinal cord. Int J Low Radiat 2010;7:436-45.
9. Chen Y, Kubo E, Sado T, Muto M. Cytogenetic analysis of thymocytes during early stages after irradiation in mice with different susceptibilities to radiation-induced lymphomagenesis. J Radiat Res 1996;37:267-76.
10. Inoue M, Shen GP, Chaudhry MA, Galick H, Blaisdell JO, Wallace SS, et al. Expression of the oxidative base excision repair enzymes is not induced in TK6 human lymphoblastoid cells after low doses of ionizing radiation. Radiat Res 2004;161:409-17.
11. Wallace SS. DNA damages processed by base excision repair: Biological consequences. Int J Radiat Biol 1994;66:579-89.
12. Bjorâs M, Luna L, Johnsen B, Hoff E, Haug T, Rognes T, et al. Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7, 8-dihydro-8-oxoguanine and abasic sites. EMBO J 1997;16:6314-22.
13. Krokan HE, Bjørås M. Base excision repair. Cold Spring Harb Perspect Biol 2013;5:a012583.
14. Batar B, Guven G, Eroz S, Bese NS, Guven M. Decreased DNA repair gene XRCC1 expression is associated with radiotherapy-induced acute side effects in breast cancer patients. Gene 2016;582:33-7.
15. Jenner TJ, Fulford J, O'Neill P. Contribution of base lesions to radiation-induced clustered DNA damage: Implication for models of radiation response. Radiat Res 2001;156:590-3.
16. Thompson LH, West MG. XRCC1 keeps DNA from getting stranded. Mutat Res 2000;459:1-8.
17. Rodriguez C, Mayo JC, Sainz RM, Antolín I, Herrera F, Martín V, et al. Regulation of antioxidant enzymes: A significant role for melatonin. J Pineal Res 2004;36:1-9.
18. Simonneaux V, Ribelayga C. Generation of the melatonin endocrine message in mammals: A review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 2003;55:325-95.
19. Tan D, Reiter RJ, Chen LD, Poeggeler B, Manchester LC, Barlow-Walden LR, et al. Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole. Carcinogenesis 1994;15:215-8.
20. Vijayalaxmi, Meltz ML, Reiter RJ, Herman TS. Melatonin and protection from genetic damage in blood and bone marrow: Whole-body irradiation studies in mice. J Pineal Res 1999;27:221-5.
21. Jang SS, Kim WD, Park WY. Melatonin exerts differential actions on X-ray radiation-induced apoptosis in normal mice splenocytes and Jurkat leukemia cells. J Pineal Res 2009;47:147-55.
22. Yurtcu E, Guney Y, Ergun MA, Guney HZ, Uluoglu C, Hicsonmez A, et al. Lack of a time-dependent effect of melatonin on radiation-induced apoptosis in cultured rat lymphocytes. Cell Biol Int 2007;31:1144-9.
23. Reiter RJ, Acuña-Castroviejo D, Tan DX, Burkhardt S. Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann N Y Acad Sci 2001;939:200-15.
24. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
25. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(delta delta C(T)) method. Methods 2001;25:402-8.
26. Hyun JW, Cheon GJ, Kim HS, Lee YS, Choi EY, Yoon BH, et al. Radiation sensitivity depends on OGG1 activity status in human leukemia cell lines. Free Radic Biol Med 2002;32:212-20.
27. Markkanen E, Fischer R, Ledentcova M, Kessler BM, Dianov GL. Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability. Nucleic Acids Res 2015;43:3667-79.
28. Izumi T, Wiederhold LR, Roy G, Roy R, Jaiswal A, Bhakat KK, et al. Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage. Toxicology 2003;193:43-65.
29. Brem R, Hall J. XRCC1 is required for DNA single-strand break repair in human cells. Nucleic Acids Res 2005;33:2512-20.
30. Hill JW, Hazra TK, Izumi T, Mitra S. Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: Potential coordination of the initial steps in base excision repair. Nucleic Acids Res 2001;29:430-8.
31. Campalans A, Moritz E, Kortulewski T, Biard D, Epe B, Radicella JP, et al. Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stress. Mol Cell Biol 2015;35:1648-58.
32. Caldecott KW. XRCC1 and DNA strand break repair. DNA Repair (Amst) 2003;2:955-69.
33. Wink DA, Laval J. The fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo. Carcinogenesis 1994;15:2125-9.
34. Shinmura K, Kohno T, Kasai H, Koda K, Sugimura H, Yokota J, et al. Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer. Jpn J Cancer Res 1998;89:825-8.
35. Tahan G, Gramignoli R, Marongiu F, Aktolga S, Cetinkaya A, Tahan V, et al. Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats. Dig Dis Sci 2011;56:715-20.
36. Najafi M, Shirazi A, Motevaseli E, Geraily G, Norouzi F, Heidari M, et al. The melatonin immunomodulatory actions in radiotherapy. Biophys Rev 2017;9:139-48.
37. Guha M, Maity P, Choubey V, Mitra K, Reiter RJ, Bandyopadhyay U, et al. Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection. J Pineal Res 2007;43:372-81.
38. Sengupta S, Harris CC. P53: Traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Cell Biol 2005;6:44-55.
39. Manzella N, Bracci M, Strafella E, Staffolani S, Ciarapica V, Copertaro A, et al. Circadian modulation of 8-oxoguanine DNA damage repair. Sci Rep 2015;5:13752.
40. Valizadeh M, Shirazi A, Izadi P, Tavakkoly Bazzaz J, Rezaeejam H. Expression levels of two DNA repair-related genes under 8 gy ionizing radiation and 100 mg/Kg melatonin delivery in rat peripheral blood. J Biomed Phys Eng 2017;7:27-36.
41. Valizadeh M, Shirazi A, Izadi P, Bazzaz JT, Rezaeejam H, Tabesh GA. Effects of melatonin on repair of DNA double strand breaks caused by ionizing radiation in rat peripheral blood. Biosci Biotechnol Res Commun 2016;9:821-7.
42. Rezaeejam H, Shirazi A, Izadi P, Bazzaz JT, Ghazi-Khansari M, Valizadeh M, et al. Radioprotective Effect of Melatonin on Expression of Cdkn1a and Rad50 Genes in Rat Peripheral Blood; 2017. Available from: http://www. cancerjournal. net. [Epub ahead of print].
43. Deng WG, Tang ST, Tseng HP, Wu KK. Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding. Blood 2006;108:518-24.
44. Proietti S, Cucina A, Dobrowolny G, D'Anselmi F, Dinicola S, Masiello MG, et al. Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells. J Pineal Res 2014;57:120-9.
45. Achanta G, Huang P. Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents. Cancer Res 2004;64:6233-9.