Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

Journal of Physiology

Volumn 596, Issue 3, 2018, Pages 445-475

  Pizzo, Michelle E ^a   Wolak, Daniel J ^a   Kumar, Niyanta N ^a   Brunette, Eric ^e   Brunnquell, Christina L ^b   Hannocks, Melanie Jane ^f   Abbott, N Joan ^d   Meyerand, M Elizabeth ^a,b,c   Sorokin, Lydia ^f   Stanimirovic, Danica B ^e   Thorne, Robert G ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c Wisconsin Electric Machines and Power Electronics Consortium   (United States)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^f UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

brain extracellular space; cerebrospinal fluid; convection; diffusion; drug delivery; immunoglobulin G; perivascular space; single domain antibody

Indexed keywords

IMMUNOGLOBULIN G; MANNITOL; NANOBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BLOOD VESSEL; BRAIN BLOOD VESSEL; BRAIN CORTEX; BRAIN REGION; CELL SURFACE; CELL TRANSPORT; CEREBROSPINAL FLUID; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIFFUSION; DRUG DELIVERY SYSTEM; ELECTRON MICROSCOPY; EX VIVO STUDY; EXTRACELLULAR SPACE; FEMALE; FLUORESCENCE IMAGING; HYPEROSMOLARITY; IMAGE ANALYSIS; IMMUNOSURVEILLANCE; IN VIVO STUDY; INTRATHECAL DRUG ADMINISTRATION; MACROMOLECULE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSMOSIS; PARTICLE SIZE; PERIVASCULAR SPACE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SPRAGUE DAWLEY RAT; SUBARACHNOID SPACE; THREE DIMENSIONAL IMAGING; ACTIVE TRANSPORT; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; PHYSIOLOGY; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL; VASCULARIZATION;

ANIMALS; BIOLOGICAL TRANSPORT; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; BRAIN; DIFFUSION; DRUG DELIVERY SYSTEMS; EXTRACELLULAR SPACE; FEMALE; IMMUNOGLOBULIN G; INJECTIONS, SPINAL; OPTICAL IMAGING; OSMOSIS; RATS; RATS, SPRAGUE-DAWLEY; SINGLE-CHAIN ANTIBODIES; TISSUE DISTRIBUTION;

EID: 85038086624     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP275105     Document Type: Article

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