Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion

Experimental Neurology

Volumn 231, Issue 2, 2011, Pages 261-271

  Ziegler, Robin J ^a   Salegio, Ernesto A ^b   Dodge, James C ^a   Bringas, John ^b   Treleaven, Christopher M ^a   Bercury, Scott D ^a   Tamsett, Thomas J ^a   Shihabuddin, Lamya ^a   Hadaczek, Piotr ^b   Fiandaca, Massimo ^b   Bankiewicz, Krystof ^b   Scheule, Ronald K ^a  

^a GENZYME CORPORATION   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acid sphingomyelinase; Brain; Distribution; Infusion; Intracerebroventricular; Primate; Rat

Indexed keywords

RECOMBINANT SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PARENCHYMA; BRAIN TISSUE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RESPONSE; FEMALE; KNOCKOUT MOUSE; MACACA; MALE; NIEMANN PICK DISEASE; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE RESEARCH; QUANTITATIVE STUDY; RAT; RHESUS MONKEY; SPECIES COMPARISON; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; FEMALE; INFUSIONS, INTRAVENTRICULAR; MACACA MULATTA; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 80052517346     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.06.019     Document Type: Article

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