The anesthetic mechanism of urethane: The effects on neurotransmitter-gated ion channels

Anesthesia and Analgesia

Volumn 94, Issue 2, 2002, Pages 313-318

  Hara, Koji ^a   Harris, R Adron ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLYCINE; GLYCINE RECEPTOR; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; NICOTINIC RECEPTOR; URETHAN;

ANESTHESIA; ANIMAL CELL; ARTICLE; CARDIOVASCULAR SYSTEM; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; FEMALE; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SPINAL REFLEX; XENOPUS LAEVIS;

EID: 0036148853     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/00000539-200202000-00015     Document Type: Article

References (26)

1. Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1. General considerations
2. Anesthetic and analgesic considerations in the experimental animal
3. Molecular and cellular mechanisms of general anesthesia
4. General anesthetic actions on ligand-gated ion channels
5. A receptors: Relevance to theories of narcosis
6. A receptors: Influence of receptor subtmits
7. Subunit-dependent interaction of the general anaesthetic etomidate with the γ-aminobutyric acid type A receptor
8. Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists
9. Subunit-dependent inhibition of human neuronal nicotinic acetylcholine receptors and other ligand-gated ion channels by dissociative anesthetics ketamine and dizocilpine
10. Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics
11. Effects of thiopental and its optical isomers on nicotinic acetylcholine receptors
12. Reversal of the action of amino acid antagonists by barbiturates and anesthetic drugs
13. Effect of urethane on synaptic and amino acid-induced excitation in isolated spinal cord preparation
14. A receptor activity by α-chloralose
15. Anesthetics and ion channels: Molecular models and sites of action
16. Potentiation of γ-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia
17. Expression of exogenous DNA in Xenopus oocytes
18. Comparison of ethanol sensitivity of rat brain kainate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes
19. Effect of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels
20. Cloned glutamate receptors
21. The general anesthetic potency of propofol and its dependence on hydrostatic pressure
22. A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors
23. The sensitivity of AMPA-selective glutamate receptor channels to pentobarbital is determined by a single amino acid residue of the α2 subunit
24. Effects of propofol on various AMPA-, kainate- and NMDA-selective glutamate receptor channels expressed in Xenopus oocytes
25. Effects of inhalational general anesthetics on native glycine receptors in rat medullary neurons and recombinant glycine receptors in Xenopus oocytes
26. Ethanol actions on multiple ion channels: Which are important?