Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation

Gastroenterology

Volumn 153, Issue 5, 2017, Pages 1320-1337.e16

  Hegazy, Ahmed N ^a,b   West, Nathaniel R ^a,b   Stubbington, Michael J T ^c,d   Wendt, Emily ^a   Suijker, Kim I M ^b   Datsi, Angeliki ^a   This, Sebastien ^a   Danne, Camille ^b   Campion, Suzanne ^a   Duncan, Sylvia H ^e   Owens, Benjamin M J ^a   Uhlig, Holm H ^a,f   McMichael, Andrew ^a   Bergthaler, Andreas ^g   Teichmann, Sarah A ^c,d   Keshav, Satish ^a   Powrie, Fiona ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Italy)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e ROWETT RESEARCH INSTITUTE   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

Cytokines; Immune Regulation; Microbiota; Tissue resident Memory T cells

Indexed keywords

CD40 LIGAND; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 23P19; INTERLEUKIN 6; T LYMPHOCYTE RECEPTOR BETA CHAIN; TUMOR NECROSIS FACTOR; IL17A PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR;

ADAPTIVE IMMUNITY; ADOLESCENT; ADULT; ANTIGEN SPECIFICITY; ARTICLE; BACTEROIDES VULGATUS; BIFIDOBACTERIUM ANIMALIS; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELLULAR IMMUNITY; COMMENSAL; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; ESCHERICHIA COLI; FAECALIBACTERIUM PRAUSNITZII; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IMMUNOREGULATION; INFLAMMATORY BOWEL DISEASE; INTESTINE FLORA; INTESTINE TISSUE; LACTOBACILLUS ACIDOPHILUS; LAMINA PROPRIA; MAJOR CLINICAL STUDY; MEMORY T LYMPHOCYTE; PEPTOCLOSTRIDIUM DIFFICILE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; ROSEBURIA INTESTINALIS; RUMINOCOCCUS; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; ULCERATIVE COLITIS; BACTERIUM; BLOOD; CASE CONTROL STUDY; CD4 LYMPHOCYTE COUNT; CELL LINE; CLASSIFICATION; HOST PATHOGEN INTERACTION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INTESTINE; MICROBIOLOGY; MUCOSAL IMMUNITY; PHENOTYPE; TH17 CELL;

BACTERIA; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; COLITIS, ULCERATIVE; CROHN DISEASE; GASTROINTESTINAL MICROBIOME; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, MUCOSAL; IMMUNOLOGIC MEMORY; INTERLEUKIN-17; INTESTINES; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TH17 CELLS;

EID: 85037604346     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2017.07.047     Document Type: Article

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