Cord blood monocyte subsets are similar to adult and show potent peptidoglycan-stimulated cytokine responses

Immunology

Volumn 133, Issue 1, 2011, Pages 41-50

  Sohlberg, Ebba ^a   Saghafian Hedengren, Shanie ^a   Bremme, Katarina ^b   Sverremark Ekström, Eva ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

CD14++CD16 cells; CD14+CD16+ cells; Interleukin 12p70; Neonatal immunity; Tumour necrosis factor

Indexed keywords

B7 ANTIGEN; CD14 ANTIGEN; CD16 ANTIGEN; CD163 ANTIGEN; CD86 ANTIGEN; GLYCOPROTEIN P 15095; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE P38; PEPTIDOGLYCAN;

ADAPTIVE IMMUNITY; ADULT; ANTIGEN EXPRESSION; ARTICLE; BIRTH; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; IMMUNOMODULATION; INNATE IMMUNITY; MONOCYTE; NEWBORN; NEWBORN PERIOD; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UMBILICAL CORD BLOOD;

ADULT; ANTIGENS, CD14; CELL SEPARATION; CYTOKINES; FETAL BLOOD; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; INFANT, NEWBORN; MONOCYTES; PEPTIDOGLYCAN; RECEPTORS, IGG;

EID: 79953310936     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2011.03407.x     Document Type: Article

References (44)

1. Adkins B, Leclerc C, Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev Immunol 2004; 4:553-64.
2. Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein RA, Bazan F, Liu YJ. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001; 194:863-9.
3. Passlick B, Flieger D, Ziegler-Heitbrock HW. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 1989; 74:2527-34.
4. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005; 5:953-64.
5. + blood monocytes: their role in infection and inflammation. J Leukoc Biol 2007; 81:584-92.
6. - monocyte subsets. BMC Genomics 2009; 10:403.
7. Krutzik SR, Tan B, Li H et al. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med 2005; 11:653-60.
8. + T cells. Int Immunol 2001; 13:1571-81.
9. ++ monocytes are a major source of TNF. J Immunol 2002; 168:3536-42.
10. Amoudruz P, Holmlund U, Saghafian-Hedengren S, Nilsson C, Sverremark-Ekstrom E. Impaired toll-like receptor 2 signalling in monocytes from 5-year-old allergic children. Clin Exp Immunol 2009; 155:387-94.
11. Zhao C, Zhang H, Wong WC et al. Identification of novel functional differences in monocyte subsets using proteomic and transcriptomic methods. J Proteome Res 2009; 8:4028-38.
12. + blood monocytes is expanded in sepsis patients. Blood 1993; 82:3170-6.
13. + monocytes in the course of sepsis in neonates and small children: monitoring and functional studies. Scand J Immunol 2002; 55:629-38.
14. + blood monocytes and synovial tissue macrophages in rheumatoid arthritis. Arthritis Rheum 2004; 50:1457-67.
15. Novak N, Allam P, Geiger E, Bieber T. Characterization of monocyte subtypes in the allergic form of atopic eczema/dermatitis syndrome. Allergy 2002; 57:931-5.
16. Kollmann TR, Crabtree J, Rein-Weston A et al. Neonatal innate TLR-mediated responses are distinct from those of adults. J Immunol 2009; 183:7150-60.
17. Vanden Eijnden S, Goriely S, De Wit D, Goldman M, Willems F. Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns. Eur J Immunol 2006; 36:21-6.
18. Angelone DF, Wessels MR, Coughlin M, Suter EE, Valentini P, Kalish LA, Levy O. Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo. Pediatr Res 2006; 60:205-9.
19. Yerkovich ST, Wikstrom ME, Suriyaarachchi D, Prescott SL, Upham JW, Holt PG. Postnatal development of monocyte cytokine responses to bacterial lipopolysaccharide. Pediatr Res 2007; 62:547-52.
20. Levy O, Coughlin M, Cronstein BN, Roy RM, Desai A, Wessels MR. The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. J Immunol 2006; 177:1956-66.
21. Levy O, Zarember KA, Roy RM, Cywes C, Godowski PJ, Wessels MR. Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. J Immunol 2004; 173:4627-34.
22. Royet J, Dziarski R. Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences. Nat Rev Microbiol 2007; 5:264-77.
23. Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 2001; 276:4812-8.
24. + monocytes from 2-year-old children. Clin Exp Allergy 2008; 38:449-57.
25. Buechler C, Ritter M, Orso E, Langmann T, Klucken J, Schmitz G. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J Leukoc Biol 2000; 67:97-103.
26. Fabriek BO, van Bruggen R, Deng DM et al. The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria. Blood 2009; 113:887-92.
27. Nguyen M, Leuridan E, Zhang T, De Wit D, Willems F, Van Damme P, Goldman M, Goriely S. Acquisition of adult-like TLR4 and TLR9 responses during the first year of life. PLoS ONE 2010; 5:e10407.
28. De Wit D, Tonon S, Olislagers V, Goriely S, Boutriaux M, Goldman M, Willems F. Impaired responses to toll-like receptor 4 and toll-like receptor 3 ligands in human cord blood. J Autoimmun 2003; 21:277-81.
29. Cros J, Cagnard N, Woollard K et al. Human CD14(dim) monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 2010; doi:10.1016/j.immuni.2010.08.012.
30. Upham JW, Lee PT, Holt BJ, Heaton T, Prescott SL, Sharp MJ, Sly PD, Holt PG. Development of interleukin-12-producing capacity throughout childhood. Infect Immun 2002; 70:6583-8.
31. Aksoy E, Albarani V, Nguyen M et al. Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells. Blood 2007; 109:2887-93.
32. Lee SM, Suen Y, Chang L et al. Decreased interleukin-12 (IL-12) from activated cord versus adult peripheral blood mononuclear cells and upregulation of interferon-gamma, natural killer, and lymphokine-activated killer activity by IL-12 in cord blood mononuclear cells. Blood 1996; 88:945-54.
33. Grage-Griebenow E, Flad HD, Ernst M. Heterogeneity of human peripheral blood monocyte subsets. J Leukoc Biol 2001; 69:11-20.
34. Saghafian-Hedengren S, Sundstrom Y, Sohlberg E, Nilsson C, Linde A, Troye-Blomberg M, Berg L, Sverremark-Ekstrom E. Herpesvirus seropositivity in childhood associates with decreased monocyte-induced NK cell IFN-gamma production. J Immunol 2009; 182:2511-7.
35. Yan SR, Qing G, Byers DM, Stadnyk AW, Al-Hertani W, Bortolussi R. Role of MyD88 in diminished tumor necrosis factor alpha production by newborn mononuclear cells in response to lipopolysaccharide. Infect Immun 2004; 72:1223-9.
36. Sadeghi K, Berger A, Langgartner M et al. Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling. J Infect Dis 2007; 195:296-302.
37. Bohnenkamp HR, Papazisis KT, Burchell JM, Taylor-Papadimitriou J. Synergism of toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses. Cell Immunol 2007; 247:72-84.
38. Rescigno M, Martino M, Sutherland CL, Gold MR, Ricciardi-Castagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 1998; 188:2175-80.
39. Puig-Kroger A, Relloso M, Fernandez-Capetillo O, Zubiaga A, Silva A, Bernabeu C, Corbi AL. Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 2001; 98:2175-82.
40. Belderbos ME, van Bleek GM, Levy O, Blanken MO, Houben ML, Schuijff L, Kimpen JL, Bont L. Skewed pattern of toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life. Clin Immunol 2009; 133:228-37.
41. Shames BD, McIntyre RC Jr, Bensard DD, Pulido EJ, Selzman CH, Reznikov LL, Harken AH, Meng X. Suppression of tumor necrosis factor alpha production by cAMP in human monocytes: dissociation with mRNA level and independent of interleukin-10. J Surg Res 2001; 99:187-93.
42. Vitoratos N, Papadias C, Economou E, Makrakis E, Panoulis C, Creatsas G. Elevated circulating IL-1beta and TNF-alpha, and unaltered IL-6 in first-trimester pregnancies complicated by threatened abortion with an adverse outcome. Mediators Inflamm 2006; 2006:30485.
43. Amoudruz P, Holmlund U, Malmstrom V, Trollmo C, Bremme K, Scheynius A, Sverremark-Ekstrom E. Neonatal immune responses to microbial stimuli: is there an influence of maternal allergy? J Allergy Clin Immunol 2005; 115:1304-10.
44. Willems F, Vollstedt S, Suter M. Phenotype and function of neonatal DC. Eur J Immunol 2009; 39:26-35.