-
1
-
-
0027441514
-
Interleukin-2-and interferongamma-secreting T cells in normal and diseased human intestinal mucosa
-
Breese E, Braegger CP, Corrigan CJ, et al. Interleukin-2-and interferongamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology. 1993;78:127-131.
-
(1993)
Immunology.
, vol.78
, pp. 127-131
-
-
Breese, E.1
Braegger, C.P.2
Corrigan, C.J.3
-
2
-
-
15744390341
-
Interleukin-21 enhances Thelper cell type i signaling and interferon-gamma production in Crohn's disease
-
Monteleone G, Monteleone I, Fina D, et al. Interleukin-21 enhances Thelper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology. 2005;128:687-694.
-
(2005)
Gastroenterology.
, vol.128
, pp. 687-694
-
-
Monteleone, G.1
Monteleone, I.2
Fina, D.3
-
3
-
-
0030995575
-
Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
-
Monteleone G, Biancone L, Marasco R, et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology. 1997;112:1169-1178.
-
(1997)
Gastroenterology.
, vol.112
, pp. 1169-1178
-
-
Monteleone, G.1
Biancone, L.2
Marasco, R.3
-
4
-
-
0028787818
-
Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease
-
Noguchi M, Hiwatashi N, Liu Z, et al. Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease. Journal of Gastroenterology. 1995;30(Suppl 8):52-55.
-
(1995)
Journal of Gastroenterology.
, vol.30
, pp. 52-55
-
-
Noguchi, M.1
Hiwatashi, N.2
Liu, Z.3
-
5
-
-
0031057872
-
Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
-
Parronchi P, Romagnani P, Annunziato F, et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. The Am Journal Pathology. 1997;150:823-832.
-
(1997)
The Am Journal Pathology.
, vol.150
, pp. 823-832
-
-
Parronchi, P.1
Romagnani, P.2
Annunziato, F.3
-
6
-
-
0030209985
-
Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
-
Fuss IJ, Neurath M, Boirivant M, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunology. 1996;157:1261-1270.
-
(1996)
J Immunology.
, vol.157
, pp. 1261-1270
-
-
Fuss, I.J.1
Neurath, M.2
Boirivant, M.3
-
7
-
-
23244455992
-
Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
-
Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology. 2005;129:550-564.
-
(2005)
Gastroenterology.
, vol.129
, pp. 550-564
-
-
Heller, F.1
Florian, P.2
Bojarski, C.3
-
8
-
-
0028288179
-
Lymphokine production by human T cells in disease states
-
Romagnani S. Lymphokine production by human T cells in disease states. Annu Review Immunology. 1994;12:227-257.
-
(1994)
Annu Review Immunology.
, vol.12
, pp. 227-257
-
-
Romagnani, S.1
-
9
-
-
56549104968
-
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease
-
Kobayashi T, Okamoto S, Hisamatsu T, et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut. 2008; 57:1682-1689.
-
(2008)
Gut.
, vol.57
, pp. 1682-1689
-
-
Kobayashi, T.1
Okamoto, S.2
Hisamatsu, T.3
-
10
-
-
63449133361
-
Circulating and gutresident human Th17 cells express CD161 and promote intestinal inflammation
-
Kleinschek MA, Boniface K, Sadekova S, et al. Circulating and gutresident human Th17 cells express CD161 and promote intestinal inflammation. The J Experimental Medicine. 2009;206:525-534.
-
(2009)
The J Experimental Medicine.
, vol.206
, pp. 525-534
-
-
Kleinschek, M.A.1
Boniface, K.2
Sadekova, S.3
-
11
-
-
78649936808
-
Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease
-
Bogaert S, Laukens D, Peeters H, et al. Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease. BMC Immunology. 2010;11:61.
-
(2010)
BMC Immunology.
, vol.11
, pp. 61
-
-
Bogaert, S.1
Laukens, D.2
Peeters, H.3
-
12
-
-
72549107316
-
Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
-
Rovedatti L, Kudo T, Biancheri P, et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut. 2009;58:1629-1636.
-
(2009)
Gut.
, vol.58
, pp. 1629-1636
-
-
Rovedatti, L.1
Kudo, T.2
Biancheri, P.3
-
13
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. The J Clinical Investigation. 2006;116:1310-1316.
-
(2006)
The J Clinical Investigation.
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
-
14
-
-
79955563439
-
Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
-
Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140:1756-1767.
-
(2011)
Gastroenterology.
, vol.140
, pp. 1756-1767
-
-
Strober, W.1
Fuss, I.J.2
-
17
-
-
84896542936
-
Th17 and regulatory T cell balance in autoimmune and inflammatory diseases
-
Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Reviews. 2014;13:668-677.
-
(2014)
Autoimmun Reviews.
, vol.13
, pp. 668-677
-
-
Noack, M.1
Miossec, P.2
-
18
-
-
77950349016
-
Th17 and regulatory T cells in mediating and restraining inflammation
-
Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 2010;140:845-858.
-
(2010)
Cell.
, vol.140
, pp. 845-858
-
-
Littman, D.R.1
Rudensky, A.Y.2
-
19
-
-
20444434616
-
Peripheral and intestinal regulatory CD4+ CD25 (high) T cells in inflammatory bowel disease
-
Maul J, Loddenkemper C, Mundt P, et al. Peripheral and intestinal regulatory CD4+ CD25 (high) T cells in inflammatory bowel disease. Gastroenterology. 2005;128:1868-1878.
-
(2005)
Gastroenterology.
, vol.128
, pp. 1868-1878
-
-
Maul, J.1
Loddenkemper, C.2
Mundt, P.3
-
20
-
-
77249137663
-
Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease
-
Eastaff-Leung N, Mabarrack N, Barbour A, et al. Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clinical Immunology. 2010;30:80-89.
-
(2010)
J Clinical Immunology.
, vol.30
, pp. 80-89
-
-
Eastaff-Leung, N.1
Mabarrack, N.2
Barbour, A.3
-
21
-
-
84868109200
-
Safety and efficacy of antigenspecific regulatory T-cell therapy for patients with refractory Crohn's disease
-
e1201-1202
-
Desreumaux P, Foussat A, Allez M, et al. Safety and efficacy of antigenspecific regulatory T-cell therapy for patients with refractory Crohn's disease. Gastroenterology. 2012;143:1207-1217. e1201-1202.
-
(2012)
Gastroenterology.
, vol.143
, pp. 1207-1217
-
-
Desreumaux, P.1
Foussat, A.2
Allez, M.3
-
23
-
-
79954527727
-
Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients
-
Reikvam DH, Perminow G, Lyckander LG, et al. Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients. Scand Journal Gastroenterology. 2011;46:550-560.
-
(2011)
Scand Journal Gastroenterology.
, vol.46
, pp. 550-560
-
-
Reikvam, D.H.1
Perminow, G.2
Lyckander, L.G.3
-
24
-
-
78149285496
-
Peripheral and intestinal CD4+ T cells with a regulatory phenotype in pediatric patients with inflammatory bowel disease
-
La Scaleia R, Morrone S, Stoppacciaro A, et al. Peripheral and intestinal CD4+ T cells with a regulatory phenotype in pediatric patients with inflammatory bowel disease. J Pediatric Gastroenterology Nutrition. 2010;51:563-572.
-
(2010)
J Pediatric Gastroenterology Nutrition.
, vol.51
, pp. 563-572
-
-
La Scaleia, R.1
Morrone, S.2
Stoppacciaro, A.3
-
25
-
-
79960705112
-
Expression of CD4+ forkhead box P3 (FOXP3)+ regulatory T cells in inflammatory bowel disease
-
Wang Y, Liu XP, Zhao ZB, et al. Expression of CD4+ forkhead box P3 (FOXP3)+ regulatory T cells in inflammatory bowel disease. J Digestive Diseases. 2011;12:286-294.
-
(2011)
J Digestive Diseases.
, vol.12
, pp. 286-294
-
-
Wang, Y.1
Liu, X.P.2
Zhao, Z.B.3
-
26
-
-
79952300978
-
Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases
-
Hovhannisyan Z, Treatman J, Littman DR, et al. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011;140: 957-965.
-
(2011)
Gastroenterology.
, vol.140
, pp. 957-965
-
-
Hovhannisyan, Z.1
Treatman, J.2
Littman, D.R.3
-
27
-
-
84888333449
-
Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4+ T cells and defective suppressive function of circulating Foxp3+ regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory bowel disease patients
-
Ueno A, Jijon H, Chan R, et al. Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4+ T cells and defective suppressive function of circulating Foxp3+ regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory bowel disease patients. Inflamm Bowel Diseases. 2013;19:2522-2534.
-
(2013)
Inflamm Bowel Diseases.
, vol.19
, pp. 2522-2534
-
-
Ueno, A.1
Jijon, H.2
Chan, R.3
-
28
-
-
84892536761
-
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids
-
Ramesh R, Kozhaya L, McKevitt K, et al. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. The J Experimental Medicine. 2014;211:89-104.
-
(2014)
The J Experimental Medicine.
, vol.211
, pp. 89-104
-
-
Ramesh, R.1
Kozhaya, L.2
McKevitt, K.3
-
29
-
-
84862067258
-
Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26)
-
Bengsch B, Seigel B, Flecken T, et al. Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26). J Immunology. 2012;188:5438-5447.
-
(2012)
J Immunology.
, vol.188
, pp. 5438-5447
-
-
Bengsch, B.1
Seigel, B.2
Flecken, T.3
-
30
-
-
84873735168
-
Increased levels of circulating Th17 cells in quiescent versus active Crohn's disease
-
Dige A, Stoy S, Rasmussen TK, et al. Increased levels of circulating Th17 cells in quiescent versus active Crohn's disease. J Crohn's Colitis. 2013;7: 248-255.
-
(2013)
J Crohn's Colitis.
, vol.7
, pp. 248-255
-
-
Dige, A.1
Stoy, S.2
Rasmussen, T.K.3
-
31
-
-
84868680312
-
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
-
Hueber W, Sands BE, Lewitzky S, et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut. 2012;61:1693-1700.
-
(2012)
Gut.
, vol.61
, pp. 1693-1700
-
-
Hueber, W.1
Sands, B.E.2
Lewitzky, S.3
-
32
-
-
84896402211
-
The transcription factors t-bet and Runx are required for the ontogeny of pathogenic interferon-gammaproducing t helper 17 cells
-
Wang Y, Godec J, Ben-Aissa K, et al. The transcription factors t-bet and Runx are required for the ontogeny of pathogenic interferon-gammaproducing t helper 17 cells. Immunity. 2014;40:355-366.
-
(2014)
Immunity.
, vol.40
, pp. 355-366
-
-
Wang, Y.1
Godec, J.2
Ben-Aissa, K.3
-
33
-
-
2342571525
-
Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities
-
Lametschwandtner G, Biedermann T, Schwarzler C, et al. Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities. The J Allergy Clinical Immunology. 2004;113:987-994.
-
(2004)
The J Allergy Clinical Immunology.
, vol.113
, pp. 987-994
-
-
Lametschwandtner, G.1
Biedermann, T.2
Schwarzler, C.3
-
34
-
-
0034863956
-
Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease
-
Hildebrandt M, Rose M, Ruter J, et al. Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease. Scand Journal Gastroenterology. 2001;36:1067-1072.
-
(2001)
Scand Journal Gastroenterology.
, vol.36
, pp. 1067-1072
-
-
Hildebrandt, M.1
Rose, M.2
Ruter, J.3
-
35
-
-
84885658881
-
Recent advances in inflammatory bowel disease: Mucosal immune cells in intestinal inflammation
-
Cader MZ, Kaser A. Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut. 2013;62:1653-1664.
-
(2013)
Gut.
, vol.62
, pp. 1653-1664
-
-
Cader, M.Z.1
Kaser, A.2
-
36
-
-
0033784440
-
CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease
-
Cosmi L, Annunziato F, Galli MIG, et al. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur Journal Immunology. 2000;30: 2972-2979.
-
(2000)
Eur Journal Immunology.
, vol.30
, pp. 2972-2979
-
-
Cosmi, L.1
Annunziato, F.2
Galli, M.I.G.3
-
37
-
-
0033790206
-
Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease
-
Vainer B, Nielsen OH, Hendel J, et al. Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease. Cytokine. 2000;12:1531-1536.
-
(2000)
Cytokine.
, vol.12
, pp. 1531-1536
-
-
Vainer, B.1
Nielsen, O.H.2
Hendel, J.3
-
38
-
-
4644345071
-
Intestinal interleukin-13 in pediatric inflammatory bowel disease patients
-
Kadivar K, Ruchelli ED, Markowitz JE, et al. Intestinal interleukin-13 in pediatric inflammatory bowel disease patients. Inflamm Bowel Diseases. 2004;10:593-598.
-
(2004)
Inflamm Bowel Diseases.
, vol.10
, pp. 593-598
-
-
Kadivar, K.1
Ruchelli, E.D.2
Markowitz, J.E.3
-
39
-
-
84886951561
-
Innate and adaptive immunity in inflammatory bowel disease
-
Geremia A, Biancheri P, Allan P, et al. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Reviews. 2014;13:3-10.
-
(2014)
Autoimmun Reviews.
, vol.13
, pp. 3-10
-
-
Geremia, A.1
Biancheri, P.2
Allan, P.3
-
40
-
-
73949092345
-
Fontolizumab in moderate to severe Crohn's disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study
-
Reinisch W, de Villiers W, Bene L, et al. Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study. Inflamm Bowel Diseases. 2010;16:233-242.
-
(2010)
Inflamm Bowel Diseases.
, vol.16
, pp. 233-242
-
-
Reinisch, W.1
De Villiers, W.2
Bene, L.3
-
41
-
-
84871701834
-
Ustekinumab induction and maintenance therapy in refractory Crohn's disease
-
Sandborn WJ, Gasink C, Gao LL, et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. The New Engl Journal Medicine. 2012;367:1519-1528.
-
(2012)
The New Engl Journal Medicine.
, vol.367
, pp. 1519-1528
-
-
Sandborn, W.J.1
Gasink, C.2
Gao, L.L.3
-
42
-
-
84866532132
-
Induction and molecular signature of pathogenic TH17 cells
-
Lee Y, Awasthi A, Yosef N, et al. Induction and molecular signature of pathogenic TH17 cells. Nat Immunology. 2012;13:991-999.
-
(2012)
Nat Immunology.
, vol.13
, pp. 991-999
-
-
Lee, Y.1
Awasthi, A.2
Yosef, N.3
|