메뉴 건너뛰기




Volumn 20, Issue 12, 2014, Pages 2321-2329

Comprehensive intestinal T helper cell profiling reveals specific accumulation of IFN-γ+IL-17+coproducing CD4+ T cells in active inflammatory bowel disease

Author keywords

CD4+ T cell differentiation; Crohn's disease; Pathogenic TH17 cells; Regulatory T cells; TH1; TH2; Ulcerative colitis

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 22; TRANSCRIPTION FACTOR T BET;

EID: 84924617019     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0000000000000210     Document Type: Article
Times cited : (118)

References (42)
  • 1
    • 0027441514 scopus 로고
    • Interleukin-2-and interferongamma-secreting T cells in normal and diseased human intestinal mucosa
    • Breese E, Braegger CP, Corrigan CJ, et al. Interleukin-2-and interferongamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology. 1993;78:127-131.
    • (1993) Immunology. , vol.78 , pp. 127-131
    • Breese, E.1    Braegger, C.P.2    Corrigan, C.J.3
  • 2
    • 15744390341 scopus 로고    scopus 로고
    • Interleukin-21 enhances Thelper cell type i signaling and interferon-gamma production in Crohn's disease
    • Monteleone G, Monteleone I, Fina D, et al. Interleukin-21 enhances Thelper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology. 2005;128:687-694.
    • (2005) Gastroenterology. , vol.128 , pp. 687-694
    • Monteleone, G.1    Monteleone, I.2    Fina, D.3
  • 3
    • 0030995575 scopus 로고    scopus 로고
    • Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
    • Monteleone G, Biancone L, Marasco R, et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology. 1997;112:1169-1178.
    • (1997) Gastroenterology. , vol.112 , pp. 1169-1178
    • Monteleone, G.1    Biancone, L.2    Marasco, R.3
  • 4
    • 0028787818 scopus 로고
    • Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease
    • Noguchi M, Hiwatashi N, Liu Z, et al. Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease. Journal of Gastroenterology. 1995;30(Suppl 8):52-55.
    • (1995) Journal of Gastroenterology. , vol.30 , pp. 52-55
    • Noguchi, M.1    Hiwatashi, N.2    Liu, Z.3
  • 5
    • 0031057872 scopus 로고    scopus 로고
    • Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
    • Parronchi P, Romagnani P, Annunziato F, et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. The Am Journal Pathology. 1997;150:823-832.
    • (1997) The Am Journal Pathology. , vol.150 , pp. 823-832
    • Parronchi, P.1    Romagnani, P.2    Annunziato, F.3
  • 6
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • Fuss IJ, Neurath M, Boirivant M, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunology. 1996;157:1261-1270.
    • (1996) J Immunology. , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3
  • 7
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    • Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology. 2005;129:550-564.
    • (2005) Gastroenterology. , vol.129 , pp. 550-564
    • Heller, F.1    Florian, P.2    Bojarski, C.3
  • 8
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • Romagnani S. Lymphokine production by human T cells in disease states. Annu Review Immunology. 1994;12:227-257.
    • (1994) Annu Review Immunology. , vol.12 , pp. 227-257
    • Romagnani, S.1
  • 9
    • 56549104968 scopus 로고    scopus 로고
    • IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease
    • Kobayashi T, Okamoto S, Hisamatsu T, et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut. 2008; 57:1682-1689.
    • (2008) Gut. , vol.57 , pp. 1682-1689
    • Kobayashi, T.1    Okamoto, S.2    Hisamatsu, T.3
  • 10
    • 63449133361 scopus 로고    scopus 로고
    • Circulating and gutresident human Th17 cells express CD161 and promote intestinal inflammation
    • Kleinschek MA, Boniface K, Sadekova S, et al. Circulating and gutresident human Th17 cells express CD161 and promote intestinal inflammation. The J Experimental Medicine. 2009;206:525-534.
    • (2009) The J Experimental Medicine. , vol.206 , pp. 525-534
    • Kleinschek, M.A.1    Boniface, K.2    Sadekova, S.3
  • 11
    • 78649936808 scopus 로고    scopus 로고
    • Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease
    • Bogaert S, Laukens D, Peeters H, et al. Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease. BMC Immunology. 2010;11:61.
    • (2010) BMC Immunology. , vol.11 , pp. 61
    • Bogaert, S.1    Laukens, D.2    Peeters, H.3
  • 12
    • 72549107316 scopus 로고    scopus 로고
    • Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
    • Rovedatti L, Kudo T, Biancheri P, et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut. 2009;58:1629-1636.
    • (2009) Gut. , vol.58 , pp. 1629-1636
    • Rovedatti, L.1    Kudo, T.2    Biancheri, P.3
  • 13
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. The J Clinical Investigation. 2006;116:1310-1316.
    • (2006) The J Clinical Investigation. , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3
  • 14
    • 79955563439 scopus 로고    scopus 로고
    • Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    • Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140:1756-1767.
    • (2011) Gastroenterology. , vol.140 , pp. 1756-1767
    • Strober, W.1    Fuss, I.J.2
  • 17
    • 84896542936 scopus 로고    scopus 로고
    • Th17 and regulatory T cell balance in autoimmune and inflammatory diseases
    • Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Reviews. 2014;13:668-677.
    • (2014) Autoimmun Reviews. , vol.13 , pp. 668-677
    • Noack, M.1    Miossec, P.2
  • 18
    • 77950349016 scopus 로고    scopus 로고
    • Th17 and regulatory T cells in mediating and restraining inflammation
    • Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 2010;140:845-858.
    • (2010) Cell. , vol.140 , pp. 845-858
    • Littman, D.R.1    Rudensky, A.Y.2
  • 19
    • 20444434616 scopus 로고    scopus 로고
    • Peripheral and intestinal regulatory CD4+ CD25 (high) T cells in inflammatory bowel disease
    • Maul J, Loddenkemper C, Mundt P, et al. Peripheral and intestinal regulatory CD4+ CD25 (high) T cells in inflammatory bowel disease. Gastroenterology. 2005;128:1868-1878.
    • (2005) Gastroenterology. , vol.128 , pp. 1868-1878
    • Maul, J.1    Loddenkemper, C.2    Mundt, P.3
  • 20
    • 77249137663 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease
    • Eastaff-Leung N, Mabarrack N, Barbour A, et al. Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clinical Immunology. 2010;30:80-89.
    • (2010) J Clinical Immunology. , vol.30 , pp. 80-89
    • Eastaff-Leung, N.1    Mabarrack, N.2    Barbour, A.3
  • 21
    • 84868109200 scopus 로고    scopus 로고
    • Safety and efficacy of antigenspecific regulatory T-cell therapy for patients with refractory Crohn's disease
    • e1201-1202
    • Desreumaux P, Foussat A, Allez M, et al. Safety and efficacy of antigenspecific regulatory T-cell therapy for patients with refractory Crohn's disease. Gastroenterology. 2012;143:1207-1217. e1201-1202.
    • (2012) Gastroenterology. , vol.143 , pp. 1207-1217
    • Desreumaux, P.1    Foussat, A.2    Allez, M.3
  • 23
    • 79954527727 scopus 로고    scopus 로고
    • Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients
    • Reikvam DH, Perminow G, Lyckander LG, et al. Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients. Scand Journal Gastroenterology. 2011;46:550-560.
    • (2011) Scand Journal Gastroenterology. , vol.46 , pp. 550-560
    • Reikvam, D.H.1    Perminow, G.2    Lyckander, L.G.3
  • 24
    • 78149285496 scopus 로고    scopus 로고
    • Peripheral and intestinal CD4+ T cells with a regulatory phenotype in pediatric patients with inflammatory bowel disease
    • La Scaleia R, Morrone S, Stoppacciaro A, et al. Peripheral and intestinal CD4+ T cells with a regulatory phenotype in pediatric patients with inflammatory bowel disease. J Pediatric Gastroenterology Nutrition. 2010;51:563-572.
    • (2010) J Pediatric Gastroenterology Nutrition. , vol.51 , pp. 563-572
    • La Scaleia, R.1    Morrone, S.2    Stoppacciaro, A.3
  • 25
    • 79960705112 scopus 로고    scopus 로고
    • Expression of CD4+ forkhead box P3 (FOXP3)+ regulatory T cells in inflammatory bowel disease
    • Wang Y, Liu XP, Zhao ZB, et al. Expression of CD4+ forkhead box P3 (FOXP3)+ regulatory T cells in inflammatory bowel disease. J Digestive Diseases. 2011;12:286-294.
    • (2011) J Digestive Diseases. , vol.12 , pp. 286-294
    • Wang, Y.1    Liu, X.P.2    Zhao, Z.B.3
  • 26
    • 79952300978 scopus 로고    scopus 로고
    • Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases
    • Hovhannisyan Z, Treatman J, Littman DR, et al. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011;140: 957-965.
    • (2011) Gastroenterology. , vol.140 , pp. 957-965
    • Hovhannisyan, Z.1    Treatman, J.2    Littman, D.R.3
  • 27
    • 84888333449 scopus 로고    scopus 로고
    • Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4+ T cells and defective suppressive function of circulating Foxp3+ regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory bowel disease patients
    • Ueno A, Jijon H, Chan R, et al. Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4+ T cells and defective suppressive function of circulating Foxp3+ regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory bowel disease patients. Inflamm Bowel Diseases. 2013;19:2522-2534.
    • (2013) Inflamm Bowel Diseases. , vol.19 , pp. 2522-2534
    • Ueno, A.1    Jijon, H.2    Chan, R.3
  • 28
    • 84892536761 scopus 로고    scopus 로고
    • Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids
    • Ramesh R, Kozhaya L, McKevitt K, et al. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. The J Experimental Medicine. 2014;211:89-104.
    • (2014) The J Experimental Medicine. , vol.211 , pp. 89-104
    • Ramesh, R.1    Kozhaya, L.2    McKevitt, K.3
  • 29
    • 84862067258 scopus 로고    scopus 로고
    • Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26)
    • Bengsch B, Seigel B, Flecken T, et al. Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26). J Immunology. 2012;188:5438-5447.
    • (2012) J Immunology. , vol.188 , pp. 5438-5447
    • Bengsch, B.1    Seigel, B.2    Flecken, T.3
  • 30
    • 84873735168 scopus 로고    scopus 로고
    • Increased levels of circulating Th17 cells in quiescent versus active Crohn's disease
    • Dige A, Stoy S, Rasmussen TK, et al. Increased levels of circulating Th17 cells in quiescent versus active Crohn's disease. J Crohn's Colitis. 2013;7: 248-255.
    • (2013) J Crohn's Colitis. , vol.7 , pp. 248-255
    • Dige, A.1    Stoy, S.2    Rasmussen, T.K.3
  • 31
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
    • Hueber W, Sands BE, Lewitzky S, et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut. 2012;61:1693-1700.
    • (2012) Gut. , vol.61 , pp. 1693-1700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3
  • 32
    • 84896402211 scopus 로고    scopus 로고
    • The transcription factors t-bet and Runx are required for the ontogeny of pathogenic interferon-gammaproducing t helper 17 cells
    • Wang Y, Godec J, Ben-Aissa K, et al. The transcription factors t-bet and Runx are required for the ontogeny of pathogenic interferon-gammaproducing t helper 17 cells. Immunity. 2014;40:355-366.
    • (2014) Immunity. , vol.40 , pp. 355-366
    • Wang, Y.1    Godec, J.2    Ben-Aissa, K.3
  • 33
    • 2342571525 scopus 로고    scopus 로고
    • Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities
    • Lametschwandtner G, Biedermann T, Schwarzler C, et al. Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities. The J Allergy Clinical Immunology. 2004;113:987-994.
    • (2004) The J Allergy Clinical Immunology. , vol.113 , pp. 987-994
    • Lametschwandtner, G.1    Biedermann, T.2    Schwarzler, C.3
  • 34
    • 0034863956 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease
    • Hildebrandt M, Rose M, Ruter J, et al. Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease. Scand Journal Gastroenterology. 2001;36:1067-1072.
    • (2001) Scand Journal Gastroenterology. , vol.36 , pp. 1067-1072
    • Hildebrandt, M.1    Rose, M.2    Ruter, J.3
  • 35
    • 84885658881 scopus 로고    scopus 로고
    • Recent advances in inflammatory bowel disease: Mucosal immune cells in intestinal inflammation
    • Cader MZ, Kaser A. Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut. 2013;62:1653-1664.
    • (2013) Gut. , vol.62 , pp. 1653-1664
    • Cader, M.Z.1    Kaser, A.2
  • 36
    • 0033784440 scopus 로고    scopus 로고
    • CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease
    • Cosmi L, Annunziato F, Galli MIG, et al. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur Journal Immunology. 2000;30: 2972-2979.
    • (2000) Eur Journal Immunology. , vol.30 , pp. 2972-2979
    • Cosmi, L.1    Annunziato, F.2    Galli, M.I.G.3
  • 37
    • 0033790206 scopus 로고    scopus 로고
    • Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease
    • Vainer B, Nielsen OH, Hendel J, et al. Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease. Cytokine. 2000;12:1531-1536.
    • (2000) Cytokine. , vol.12 , pp. 1531-1536
    • Vainer, B.1    Nielsen, O.H.2    Hendel, J.3
  • 38
    • 4644345071 scopus 로고    scopus 로고
    • Intestinal interleukin-13 in pediatric inflammatory bowel disease patients
    • Kadivar K, Ruchelli ED, Markowitz JE, et al. Intestinal interleukin-13 in pediatric inflammatory bowel disease patients. Inflamm Bowel Diseases. 2004;10:593-598.
    • (2004) Inflamm Bowel Diseases. , vol.10 , pp. 593-598
    • Kadivar, K.1    Ruchelli, E.D.2    Markowitz, J.E.3
  • 39
    • 84886951561 scopus 로고    scopus 로고
    • Innate and adaptive immunity in inflammatory bowel disease
    • Geremia A, Biancheri P, Allan P, et al. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Reviews. 2014;13:3-10.
    • (2014) Autoimmun Reviews. , vol.13 , pp. 3-10
    • Geremia, A.1    Biancheri, P.2    Allan, P.3
  • 40
    • 73949092345 scopus 로고    scopus 로고
    • Fontolizumab in moderate to severe Crohn's disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study
    • Reinisch W, de Villiers W, Bene L, et al. Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study. Inflamm Bowel Diseases. 2010;16:233-242.
    • (2010) Inflamm Bowel Diseases. , vol.16 , pp. 233-242
    • Reinisch, W.1    De Villiers, W.2    Bene, L.3
  • 41
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • Sandborn WJ, Gasink C, Gao LL, et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. The New Engl Journal Medicine. 2012;367:1519-1528.
    • (2012) The New Engl Journal Medicine. , vol.367 , pp. 1519-1528
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.L.3
  • 42
    • 84866532132 scopus 로고    scopus 로고
    • Induction and molecular signature of pathogenic TH17 cells
    • Lee Y, Awasthi A, Yosef N, et al. Induction and molecular signature of pathogenic TH17 cells. Nat Immunology. 2012;13:991-999.
    • (2012) Nat Immunology. , vol.13 , pp. 991-999
    • Lee, Y.1    Awasthi, A.2    Yosef, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.