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Volumn 8, Issue 32, 2017, Pages 52948-52959

MiR-486-5p negatively regulates oncogenic NEK2 in hepatocellular carcinoma

Author keywords

Hepatocellular carcinoma; MiR 486 5p; NEK2; Prognosis; Tumor progression

Indexed keywords


EID: 85037371208     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.17635     Document Type: Article
Times cited : (27)

References (38)
  • 1
    • 84859212951 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet. 2012; 379:1245-1255.
    • (2012) Lancet , vol.379 , pp. 1245-1255
    • Forner, A1    Llovet, JM2    Bruix, J.3
  • 2
    • 47249128185 scopus 로고    scopus 로고
    • Trends in mortality from hepatocellular carcinoma in Europe, 1980-2004
    • Bosetti C, Levi F, Boffetta P, Lucchini F, Negri E, La Vecchia C. Trends in mortality from hepatocellular carcinoma in Europe, 1980-2004. Hepatology. 2008; 48:137-145.
    • (2008) Hepatology , vol.48 , pp. 137-145
    • Bosetti, C1    Levi, F2    Boffetta, P3    Lucchini, F4    Negri, E5    La Vecchia, C.6
  • 3
    • 84873606312 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer, 1975-2009, featuring the burden and trends in human papillomavirus (HPV)associated cancers and HPV vaccination coverage levels
    • Jemal A, Simard EP, Dorell C, Noone AM, Markowitz LE, Kohler B, Eheman C, Saraiya M, Bandi P, Saslow D, Cronin KA, Watson M, Schiffman M, et al. Annual report to the nation on the status of cancer, 1975-2009, featuring the burden and trends in human papillomavirus (HPV)associated cancers and HPV vaccination coverage levels. J Natl Cancer Inst. 2013; 105:175-201.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 175-201
    • Jemal, A1    Simard, EP2    Dorell, C3    Noone, AM4    Markowitz, LE5    Kohler, B6    Eheman, C7    Saraiya, M8    Bandi, P9    Saslow, D10    Cronin, KA11    Watson, M12    Schiffman, M13
  • 4
    • 63049111543 scopus 로고    scopus 로고
    • Asia Pacific Working Party on Prevention of Hepatocellular Carcinoma, Hepatocellular carcinoma in the Asia-Pacific region
    • Yuen MF, Hou JL, Chutaputti A. Asia Pacific Working Party on Prevention of Hepatocellular Carcinoma, Hepatocellular carcinoma in the Asia-Pacific region. J Gastroenterol Hepatol. 2009; 24:346-353.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 346-353
    • Yuen, MF1    Hou, JL2    Chutaputti, A.3
  • 5
    • 84872171489 scopus 로고    scopus 로고
    • Cell cycle regulation by the NEK family of protein kinases
    • Fry AM, O’Regan L, Sabir SR, Bayliss R. Cell cycle regulation by the NEK family of protein kinases. J Cell Sci. 2012; 125:4423-4433.
    • (2012) J Cell Sci , vol.125 , pp. 4423-4433
    • Fry, AM1    O’Regan, L2    Sabir, SR3    Bayliss, R.4
  • 6
    • 0037048312 scopus 로고    scopus 로고
    • The Nek2 protein kinase: a novel regulator of centrosome structure
    • Fry AM. The Nek2 protein kinase: a novel regulator of centrosome structure. Oncogene. 2002; 21:6184-6194.
    • (2002) Oncogene , vol.21 , pp. 6184-6194
    • Fry, AM.1
  • 7
    • 9244263076 scopus 로고    scopus 로고
    • Aneuploidy and cancer
    • Rajagopalan H, Lengauer C. Aneuploidy and cancer. Nature. 2004; 432:338-341.
    • (2004) Nature , vol.432 , pp. 338-341
    • Rajagopalan, H1    Lengauer, C.2
  • 8
    • 84872373803 scopus 로고    scopus 로고
    • NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers
    • Zhou W, Yang Y, Xia J, Wang H, Salama ME, Xiong W, Xu H, Shetty S, Chen T, Zeng Z, Shi L, Zangari M, Miles R, et al. NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers. Cancer Cell. 2013; 23:48-62.
    • (2013) Cancer Cell , vol.23 , pp. 48-62
    • Zhou, W1    Yang, Y2    Xia, J3    Wang, H4    Salama, ME5    Xiong, W6    Xu, H7    Shetty, S8    Chen, T9    Zeng, Z10    Shi, L11    Zangari, M12    Miles, R13
  • 10
    • 4143051237 scopus 로고    scopus 로고
    • Inhibition of centrosome separation after DNA damage: a role for Nek2
    • Fletcher L, Cerniglia GJ, Nigg EA, Yend TJ, Muschel RJ. Inhibition of centrosome separation after DNA damage: a role for Nek2. Radiat Res. 2004; 162:128-135.
    • (2004) Radiat Res , vol.162 , pp. 128-135
    • Fletcher, L1    Cerniglia, GJ2    Nigg, EA3    Yend, TJ4    Muschel, RJ.5
  • 11
    • 9644273824 scopus 로고    scopus 로고
    • Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure
    • Prigent C, Glover DM, Giet R. Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure. Exp Cell Res. 2005; 303:1-13.
    • (2005) Exp Cell Res , vol.303 , pp. 1-13
    • Prigent, C1    Glover, DM2    Giet, R.3
  • 12
    • 5644280152 scopus 로고    scopus 로고
    • The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer
    • Hayward DG, Clarke RB, Faragher AJ, Pillai MR, Hagan IM, Fry AM. The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Cancer Res. 2004; 64:7370-7376.
    • (2004) Cancer Res , vol.64 , pp. 7370-7376
    • Hayward, DG1    Clarke, RB2    Faragher, AJ3    Pillai, MR4    Hagan, IM5    Fry, AM.6
  • 13
    • 84902438323 scopus 로고    scopus 로고
    • Abnormal expression of Nek2 in pancreatic ductal adenocarcinoma: a novel marker for prognosis
    • Ning Z, Wang A, Liang J, Liu J, Zhou T, Yan Q, Wang Z. Abnormal expression of Nek2 in pancreatic ductal adenocarcinoma: a novel marker for prognosis. Int J Clin Exp Pathol. 2014; 7:2462-2469.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 2462-2469
    • Ning, Z1    Wang, A2    Liang, J3    Liu, J4    Zhou, T5    Yan, Q6    Wang, Z.7
  • 17
    • 35448935555 scopus 로고    scopus 로고
    • Hamaguchi, Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma
    • Kokuryo T, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M. Hamaguchi, Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma. Cancer Res. 2007; 67:9637-9642.
    • (2007) Cancer Res , vol.67 , pp. 9637-9642
    • Kokuryo, T1    Senga, T2    Yokoyama, Y3    Nagino, M4    Nimura, Y5    Hamaguchi, M.6
  • 18
    • 77953210455 scopus 로고    scopus 로고
    • Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin
    • Suzuki K, Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M. Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin. Cancer Sci. 2010; 101:1163-1169.
    • (2010) Cancer Sci , vol.101 , pp. 1163-1169
    • Suzuki, K1    Kokuryo, T2    Senga, T3    Yokoyama, Y4    Nagino, M5    Hamaguchi, M.6
  • 19
    • 84892399773 scopus 로고    scopus 로고
    • Cancer: a target for drug resistance
    • Harrison C. Cancer: a target for drug resistance. Nat Rev Drug Discov. 2013; 12:190.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 190
    • Harrison, C.1
  • 20
    • 84940704106 scopus 로고    scopus 로고
    • Effect of silencing NEK2 on biological behaviors of HepG2 in human hepatoma cells and MAPK signal pathway
    • Zhang M, Xu X, Zhang P, Han NN, Deng JJ, Yu TT, Gan YY, He XQ, Long ZX. Effect of silencing NEK2 on biological behaviors of HepG2 in human hepatoma cells and MAPK signal pathway. Tumor Biol. 2016; 37:2023-2035.
    • (2016) Tumor Biol , vol.37 , pp. 2023-2035
    • Zhang, M1    Xu, X2    Zhang, P3    Han, NN4    Deng, JJ5    Yu, TT6    Gan, YY7    He, XQ8    Long, ZX.9
  • 21
    • 84976473581 scopus 로고    scopus 로고
    • NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma
    • Lin S, Zhou S, Jiang S, Liu X, Wang Y, Zheng X, Zhou H, Li X, Cai X. NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma. Oncol Rep. 2016; 36:853-862.
    • (2016) Oncol Rep , vol.36 , pp. 853-862
    • Lin, S1    Zhou, S2    Jiang, S3    Liu, X4    Wang, Y5    Zheng, X6    Zhou, H7    Li, X8    Cai, X.9
  • 23
    • 0016789438 scopus 로고
    • Mitotic mutants of Aspergillus nidulans
    • Morris NR. Mitotic mutants of Aspergillus nidulans. Genet Res. 1975; 26:237-254.
    • (1975) Genet Res , vol.26 , pp. 237-254
    • Morris, NR.1
  • 24
    • 0032518798 scopus 로고    scopus 로고
    • A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators
    • Fry AM, Meraldi P, Nigg EA. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. Embo J. 1998; 17:470-481.
    • (1998) Embo J , vol.17 , pp. 470-481
    • Fry, AM1    Meraldi, P2    Nigg, EA.3
  • 25
    • 33646839443 scopus 로고    scopus 로고
    • Nek2 kinase in chromosome instability and cancer
    • Hayward DG, Fry AM. Nek2 kinase in chromosome instability and cancer. Cancer Lett. 2006; 237:155–166.
    • (2006) Cancer Lett , vol.237 , pp. 155-166
    • Hayward, DG1    Fry, AM.2
  • 26
    • 84963595190 scopus 로고    scopus 로고
    • Targeting NEK2 as a promising therapeutic approach for cancer treatment
    • Fang YF, Zhang XW. Targeting NEK2 as a promising therapeutic approach for cancer treatment. Cell Cycle. 2016; 15:895-907.
    • (2016) Cell Cycle , vol.15 , pp. 895-907
    • Fang, YF1    Zhang, XW.2
  • 27
    • 84878918789 scopus 로고    scopus 로고
    • Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model
    • Harrison Pitner MK, Saavedra HI. Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model. PLoS One. 2013; 8:e65971.
    • (2013) PLoS One , vol.8 , pp. e65971
    • Harrison Pitner, MK1    Saavedra, HI.2
  • 28
    • 79751484450 scopus 로고    scopus 로고
    • Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma
    • Hou J, Lin L, Zhou W, Wang Z, Ding G, Dong Q, Qin L, Wu X, Zheng Y, Yang Y, Tian W, Zhang Q, Wang C, et al. Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma. Cancer Cell. 2011; 19:232-243.
    • (2011) Cancer Cell , vol.19 , pp. 232-243
    • Hou, J1    Lin, L2    Zhou, W3    Wang, Z4    Ding, G5    Dong, Q6    Qin, L7    Wu, X8    Zheng, Y9    Yang, Y10    Tian, W11    Zhang, Q12    Wang, C13
  • 29
    • 84969528949 scopus 로고    scopus 로고
    • miR-486-5p attenuates tumor growth and lymphangiogenesis by targeting neuropilin-2 in colorectal carcinoma
    • Liu C, Li M, Hu Y, Shi N, Yu H, Liu H, Lian H. miR-486-5p attenuates tumor growth and lymphangiogenesis by targeting neuropilin-2 in colorectal carcinoma. Onco Targets Ther. 2016; 9:2865-2871.
    • (2016) Onco Targets Ther , vol.9 , pp. 2865-2871
    • Liu, C1    Li, M2    Hu, Y3    Shi, N4    Yu, H5    Liu, H6    Lian, H.7
  • 30
    • 84896702937 scopus 로고    scopus 로고
    • Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer
    • Wang J, Tian X, Han R, Zhang X, Wang X, Shen H, Xue L, Liu Y, Yan X, Shen J, Mannoor K, Deepak J, Donahue JM, et al. Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer. Oncogene. 2014;33:1181-1189.
    • (2014) Oncogene , vol.33 , pp. 1181-1189
    • Wang, J1    Tian, X2    Han, R3    Zhang, X4    Wang, X5    Shen, H6    Xue, L7    Liu, Y8    Yan, X9    Shen, J10    Mannoor, K11    Deepak, J12    Donahue, JM13
  • 31
    • 84921693751 scopus 로고    scopus 로고
    • MicroRNA-486-5p, which is downregulated in hepatocellular carcinoma, suppresses tumor growth by targeting PIK3R1
    • Huang XP, Hou J, Shen XY, Huang CY, Zhang XH, Xie YA, Luo XL. MicroRNA-486-5p, which is downregulated in hepatocellular carcinoma, suppresses tumor growth by targeting PIK3R1. FEBS J. 2015; 282:579-594
    • (2015) FEBS J , vol.282 , pp. 579-594
    • Huang, XP1    Hou, J2    Shen, XY3    Huang, CY4    Zhang, XH5    Xie, YA6    Luo, XL.7
  • 33
    • 84954101077 scopus 로고    scopus 로고
    • Prognostic value of preoperative peripheral monocyte count in patients with hepatocellular carcinoma after liver transplantation
    • Ren QQ, Fu SJ, Zhao Q, Guo ZY, Ji F, Chen MG, Wu LW, He XS. Prognostic value of preoperative peripheral monocyte count in patients with hepatocellular carcinoma after liver transplantation. Tumour Biol. 2016; 37:8973-8978.
    • (2016) Tumour Biol , vol.37 , pp. 8973-8978
    • Ren, QQ1    Fu, SJ2    Zhao, Q3    Guo, ZY4    Ji, F5    Chen, MG6    Wu, LW7    He, XS.8
  • 34
    • 84977547704 scopus 로고    scopus 로고
    • Elevated preoperative serum gamma-glutamyltranspeptidase predicts poor prognosis for hepatocellular carcinoma after liver transplantation
    • Fu SJ, Zhao Q, Ji F, Chen MG, Wu LW, Ren QQ, Guo ZY, He XS. Elevated preoperative serum gamma-glutamyltranspeptidase predicts poor prognosis for hepatocellular carcinoma after liver transplantation. Sci Rep. 2016; 6:28835.
    • (2016) Sci Rep , vol.6 , pp. 28835
    • Fu, SJ1    Zhao, Q2    Ji, F3    Chen, MG4    Wu, LW5    Ren, QQ6    Guo, ZY7    He, XS.8
  • 35
    • 84883226956 scopus 로고    scopus 로고
    • Glypican-3 is a potential prognostic biomarker for hepatocellular carcinoma after curative resection
    • Fu SJ, Qi CY, Xiao WK, Li SQ, Peng BG, Liang LJ. Glypican-3 is a potential prognostic biomarker for hepatocellular carcinoma after curative resection. Surgery. 2013; 154:536-544.
    • (2013) Surgery , vol.154 , pp. 536-544
    • Fu, SJ1    Qi, CY2    Xiao, WK3    Li, SQ4    Peng, BG5    Liang, LJ.6
  • 36
    • 0025344972 scopus 로고
    • Immunohistochemical staining of Ha-ras oncogene product in normal, benign, and malignant human pancreatic tissues
    • Shimizu M, Saitoh Y, Itoh H. Immunohistochemical staining of Ha-ras oncogene product in normal, benign, and malignant human pancreatic tissues. Hum Pathol. 1990; 21:607-612.
    • (1990) Hum Pathol , vol.21 , pp. 607-612
    • Shimizu, M1    Saitoh, Y2    Itoh, H.3
  • 37
    • 84876738280 scopus 로고    scopus 로고
    • S100A7 enhances invasion of human breast cancerMDA-MB-468 cells through activation of nuclear factor-κB signaling
    • Liu H, Wang L, Wang X, Cao Z, Yang Q, Zhang K. S100A7 enhances invasion of human breast cancerMDA-MB-468 cells through activation of nuclear factor-κB signaling. World J Surg Oncol. 2013; 11:1–8.
    • (2013) World J Surg Oncol , vol.11 , pp. 1-8
    • Liu, H1    Wang, L2    Wang, X3    Cao, Z4    Yang, Q5    Zhang, K.6
  • 38
    • 84962232304 scopus 로고    scopus 로고
    • PKCε inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ ERK signaling in renal cell carcinoma cell line 769P
    • Huang B, Fu SJ, Fan WZ, Wang ZH, Chen ZB, Guo SJ, Chen JX, Qiu SP. PKCε inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ ERK signaling in renal cell carcinoma cell line 769P. Cancer Lett. 2016; 376:148–154.
    • (2016) Cancer Lett , vol.376 , pp. 148-154
    • Huang, B1    Fu, SJ2    Fan, WZ3    Wang, ZH4    Chen, ZB5    Guo, SJ6    Chen, JX7    Qiu, SP.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.