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Volumn 303, Issue 1, 2005, Pages 1-13

Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure

Author keywords

Centrosome; Cytokinesis; Kinase; Mitosis

Indexed keywords

PROTEIN KINASE; PROTEIN KINASE NEK2; UNCLASSIFIED DRUG;

EID: 9644273824     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2004.04.052     Document Type: Article
Times cited : (42)

References (37)
  • 1
    • 0025861473 scopus 로고
    • Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint
    • A.H. Osmani, K. O'Donnell, R.T. Pu, and S.A. Osmani Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint EMBO J. 10 1991 2669 2679
    • (1991) EMBO J. , vol.10 , pp. 2669-2679
    • Osmani, A.H.1    O'Donnell, K.2    Pu, R.T.3    Osmani, S.A.4
  • 2
    • 0026389815 scopus 로고
    • Role of the cell-cycle-regulated NIMA protein kinase during G2 and mitosis: Evidence for two pathways of mitotic regulation
    • A.H. Osmani, S.L. McGuire, K.L. O'Donnell, R.T. Pu, and S.A. Osmani Role of the cell-cycle-regulated NIMA protein kinase during G2 and mitosis: evidence for two pathways of mitotic regulation Cold Spring Harbor Symp. Quant. Biol. 56 1991 549 555
    • (1991) Cold Spring Harbor Symp. Quant. Biol. , vol.56 , pp. 549-555
    • Osmani, A.H.1    McGuire, S.L.2    O'Donnell, K.L.3    Pu, R.T.4    Osmani, S.A.5
  • 3
    • 0031297715 scopus 로고    scopus 로고
    • Regulation of p34cdc2/cyclinB H1 and NIMA kinases during the G2/M transition and checkpoint responses in Aspergillus nidulans
    • X.S. Ye, and S.A. Osmani Regulation of p34cdc2/cyclinB H1 and NIMA kinases during the G2/M transition and checkpoint responses in Aspergillus nidulans Prog. Cell Cycle Res. 3 1997 221 232
    • (1997) Prog. Cell Cycle Res. , vol.3 , pp. 221-232
    • Ye, X.S.1    Osmani, S.A.2
  • 4
    • 0038739131 scopus 로고    scopus 로고
    • Never say never. The NIMA-related protein kinases in mitotic control
    • M.J. O'Connell, M.J. Krien, and T. Hunter Never say never. The NIMA-related protein kinases in mitotic control Trends Cell Biol. 13 2003 221 228
    • (2003) Trends Cell Biol. , vol.13 , pp. 221-228
    • O'Connell, M.J.1    Krien, M.J.2    Hunter, T.3
  • 5
    • 0037048312 scopus 로고    scopus 로고
    • The Nek2 protein kinase: A novel regulator of centrosome structure
    • A.M. Fry The Nek2 protein kinase: a novel regulator of centrosome structure Oncogene 21 2002 6184 6194
    • (2002) Oncogene , vol.21 , pp. 6184-6194
    • Fry, A.M.1
  • 6
    • 0028058885 scopus 로고
    • Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans
    • S.J. Schultz, A.M. Fry, C. Sutterlin, T. Ried, and E.A. Nigg Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans Cell Growth Differ. 5 1994 625 635
    • (1994) Cell Growth Differ. , vol.5 , pp. 625-635
    • Schultz, S.J.1    Fry, A.M.2    Sutterlin, C.3    Ried, T.4    Nigg, E.A.5
  • 7
    • 0032518798 scopus 로고    scopus 로고
    • A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators
    • A.M. Fry, P. Meraldi, and E.A. Nigg A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators EMBO J. 17 1998 470 481
    • (1998) EMBO J. , vol.17 , pp. 470-481
    • Fry, A.M.1    Meraldi, P.2    Nigg, E.A.3
  • 8
    • 0032578008 scopus 로고    scopus 로고
    • C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2
    • A.M. Fry, T. Mayor, P. Meraldi, Y.D. Stierhof, K. Tanaka, and E.A. Nigg C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 J. Cell Biol. 141 1998 1563 1574
    • (1998) J. Cell Biol. , vol.141 , pp. 1563-1574
    • Fry, A.M.1    Mayor, T.2    Meraldi, P.3    Stierhof, Y.D.4    Tanaka, K.5    Nigg, E.A.6
  • 9
    • 0037101950 scopus 로고    scopus 로고
    • The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles
    • T. Mayor, U. Hacker, Y.D. Stierhof, and E.A. Nigg The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles J. Cell Sci. 115 2002 3275 3284
    • (2002) J. Cell Sci. , vol.115 , pp. 3275-3284
    • Mayor, T.1    Hacker, U.2    Stierhof, Y.D.3    Nigg, E.A.4
  • 10
    • 0037769884 scopus 로고    scopus 로고
    • Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles
    • A.J. Faragher, and A.M. Fry Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles Mol. Biol. Cell 14 2003 2876 2889
    • (2003) Mol. Biol. Cell , vol.14 , pp. 2876-2889
    • Faragher, A.J.1    Fry, A.M.2
  • 11
    • 0036558294 scopus 로고    scopus 로고
    • DdNek2, the first non-vertebrate homologue of human Nek2, is involved in the formation of microtubule-organizing centers
    • R. Graf DdNek2, the first non-vertebrate homologue of human Nek2, is involved in the formation of microtubule-organizing centers J. Cell Sci. 115 2002 1919 1929
    • (2002) J. Cell Sci. , vol.115 , pp. 1919-1929
    • Graf, R.1
  • 12
    • 0035911159 scopus 로고    scopus 로고
    • Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
    • R. Giet, and D.M. Glover Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis J. Cell Biol. 152 2001 669 682
    • (2001) J. Cell Biol. , vol.152 , pp. 669-682
    • Giet, R.1    Glover, D.M.2
  • 13
    • 0037084462 scopus 로고    scopus 로고
    • Domains of the Pavarotti kinesin-like protein that direct its subcellular distribution: Effects of mislocalisation on the tubulin and actin cytoskeleton during Drosophila oogenesis
    • G. Minestrini, E. Mathe, and D.M. Glover Domains of the Pavarotti kinesin-like protein that direct its subcellular distribution: effects of mislocalisation on the tubulin and actin cytoskeleton during Drosophila oogenesis J. Cell Sci. 115 2002 725 736
    • (2002) J. Cell Sci. , vol.115 , pp. 725-736
    • Minestrini, G.1    Mathe, E.2    Glover, D.M.3
  • 14
    • 0037017398 scopus 로고    scopus 로고
    • Drosophila Aurora a kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules
    • R. Giet, D. McLean, S. Descamps, M.J. Lee, J.W. Raff, C. Prigent, and D.M. Glover Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules J. Cell Biol. 156 2002 437 451
    • (2002) J. Cell Biol. , vol.156 , pp. 437-451
    • Giet, R.1    McLean, D.2    Descamps, S.3    Lee, M.J.4    Raff, J.W.5    Prigent, C.6    Glover, D.M.7
  • 15
    • 0032615809 scopus 로고    scopus 로고
    • Isolation of centrosomes from Drosophila embryos
    • M. Moritz, and B.M. Alberts Isolation of centrosomes from Drosophila embryos Methods Cell Biol. 61 1999 1 12
    • (1999) Methods Cell Biol. , vol.61 , pp. 1-12
    • Moritz, M.1    Alberts, B.M.2
  • 16
    • 0031938231 scopus 로고    scopus 로고
    • The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly
    • C. Roghi, R. Giet, R. Uzbekov, N. Morin, I. Chartrain, R. Le Guellec, A. Couturier, M. Doree, M. Philippe, and C. Prigent The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly J. Cell Sci. 111 Pt. 5 1998 557 572
    • (1998) J. Cell Sci. , vol.111 , Issue.5 , pp. 557-572
    • Roghi, C.1    Giet, R.2    Uzbekov, R.3    Morin, N.4    Chartrain, I.5    Le Guellec, R.6    Couturier, A.7    Doree, M.8    Philippe, M.9    Prigent, C.10
  • 17
    • 0028892753 scopus 로고
    • The 190 kDa centrosome-associated protein of Drosophila melanogaster contains four zinc finger motifs and binds to specific sites on polytene chromosomes
    • W.G. Whitfield, M.A. Chaplin, K. Oegema, H. Parry, and D.M. Glover The 190 kDa centrosome-associated protein of Drosophila melanogaster contains four zinc finger motifs and binds to specific sites on polytene chromosomes J. Cell Sci. 108 Pt. 11 1995 3377 3387
    • (1995) J. Cell Sci. , vol.108 , Issue.11 , pp. 3377-3387
    • Whitfield, W.G.1    Chaplin, M.A.2    Oegema, K.3    Parry, H.4    Glover, D.M.5
  • 18
    • 0029154616 scopus 로고
    • Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex
    • C.M. Field, and B.M. Alberts Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex J. Cell Biol. 131 1995 165 178
    • (1995) J. Cell Biol. , vol.131 , pp. 165-178
    • Field, C.M.1    Alberts, B.M.2
  • 19
    • 0032523956 scopus 로고    scopus 로고
    • Pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis
    • R.R. Adams, A.A. Tavares, A. Salzberg, H.J. Bellen, and D.M. Glover Pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis Genes Dev. 12 1998 1483 1494
    • (1998) Genes Dev. , vol.12 , pp. 1483-1494
    • Adams, R.R.1    Tavares, A.A.2    Salzberg, A.3    Bellen, H.J.4    Glover, D.M.5
  • 20
    • 0028784065 scopus 로고
    • The Drosophila homeotic target gene centrosomin (cnn) encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis
    • J.G. Heuer, K. Li, and T.C. Kaufman The Drosophila homeotic target gene centrosomin (cnn) encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis Development 121 1995 3861 3876
    • (1995) Development , vol.121 , pp. 3861-3876
    • Heuer, J.G.1    Li, K.2    Kaufman, T.C.3
  • 21
    • 0033523093 scopus 로고    scopus 로고
    • Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif
    • A.M. Fry, L. Arnaud, and E.A. Nigg Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif J. Biol. Chem. 274 1999 16304 16310
    • (1999) J. Biol. Chem. , vol.274 , pp. 16304-16310
    • Fry, A.M.1    Arnaud, L.2    Nigg, E.A.3
  • 22
    • 0037182592 scopus 로고    scopus 로고
    • MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity
    • H. Maiato, P. Sampaio, C.L. Lemos, J. Findlay, M. Carmena, W.C. Earnshaw, and C.E. Sunkel MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity J. Cell Biol. 157 2002 749 760
    • (2002) J. Cell Biol. , vol.157 , pp. 749-760
    • Maiato, H.1    Sampaio, P.2    Lemos, C.L.3    Findlay, J.4    Carmena, M.5    Earnshaw, W.C.6    Sunkel, C.E.7
  • 23
    • 0030462914 scopus 로고    scopus 로고
    • Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
    • H.A. Lane, and E.A. Nigg Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes J. Cell Biol. 135 1996 1701 1713
    • (1996) J. Cell Biol. , vol.135 , pp. 1701-1713
    • Lane, H.A.1    Nigg, E.A.2
  • 24
    • 0035858876 scopus 로고    scopus 로고
    • Metaphase arrest with centromere separation in polo mutants of Drosophila
    • M.M. Donaldson, A.A. Tavares, H. Ohkura, P. Deak, and D.M. Glover Metaphase arrest with centromere separation in polo mutants of Drosophila J. Cell Biol. 153 2001 663 676
    • (2001) J. Cell Biol. , vol.153 , pp. 663-676
    • Donaldson, M.M.1    Tavares, A.A.2    Ohkura, H.3    Deak, P.4    Glover, D.M.5
  • 27
    • 0036329002 scopus 로고    scopus 로고
    • Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells
    • M.P. Somma, B. Fasulo, G. Cenci, E. Cundari, and M. Gatti Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells Mol. Biol. Cell 13 2002 2448 2460
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2448-2460
    • Somma, M.P.1    Fasulo, B.2    Cenci, G.3    Cundari, E.4    Gatti, M.5
  • 28
    • 0034091353 scopus 로고    scopus 로고
    • The NIMA-related kinase X-Nek2B is required for efficient assembly of the zygotic centrosome in Xenopus laevis
    • A.M. Fry, P. Descombes, C. Twomey, R. Bacchieri, and E.A. Nigg The NIMA-related kinase X-Nek2B is required for efficient assembly of the zygotic centrosome in Xenopus laevis J. Cell Sci. 2000
    • (2000) J. Cell Sci.
    • Fry, A.M.1    Descombes, P.2    Twomey, C.3    Bacchieri, R.4    Nigg, E.A.5
  • 29
    • 0034678923 scopus 로고    scopus 로고
    • Nek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos
    • K. Uto, and N. Sagata Nek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos EMBO J. 19 2000 1816 1826
    • (2000) EMBO J. , vol.19 , pp. 1816-1826
    • Uto, K.1    Sagata, N.2
  • 30
    • 0037007211 scopus 로고    scopus 로고
    • The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity
    • M.J. Krien, R.R. West, U.P. John, K. Koniaras, J.R. McIntosh, and M.J. O'Connell The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity EMBO J. 21 2002 1713 1722
    • (2002) EMBO J. , vol.21 , pp. 1713-1722
    • Krien, M.J.1    West, R.R.2    John, U.P.3    Koniaras, K.4    McIntosh, J.R.5    O'Connell, M.J.6
  • 32
    • 0037124319 scopus 로고    scopus 로고
    • Schizosaccharomyces pombe NIMA-related kinase, Fin1, regulates spindle formation and an affinity of Polo for the SPB
    • A. Grallert, and I.M. Hagan Schizosaccharomyces pombe NIMA-related kinase, Fin1, regulates spindle formation and an affinity of Polo for the SPB EMBO J. 21 2002 3096 3107
    • (2002) EMBO J. , vol.21 , pp. 3096-3107
    • Grallert, A.1    Hagan, I.M.2
  • 33
    • 0036290778 scopus 로고    scopus 로고
    • Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle
    • Y. Ha Kim, J. Yeol Choi, Y. Jeong, D.J. Wolgemuth, and K. Rhee Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle Biochem. Biophys. Res. Commun. 290 2002 730 736
    • (2002) Biochem. Biophys. Res. Commun. , vol.290 , pp. 730-736
    • Ha Kim, Y.1    Yeol Choi, J.2    Jeong, Y.3    Wolgemuth, D.J.4    Rhee, K.5
  • 35
    • 0035795415 scopus 로고    scopus 로고
    • Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression
    • A. Khodjakov, and C.L. Rieder Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression J. Cell Biol. 153 2001 237 242
    • (2001) J. Cell Biol. , vol.153 , pp. 237-242
    • Khodjakov, A.1    Rieder, C.L.2
  • 36
    • 0036500492 scopus 로고    scopus 로고
    • A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila
    • M.G. Riparbelli, G. Callaini, D.M. Glover, and C. Avides Mdo A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila J. Cell Sci. 115 2002 913 922
    • (2002) J. Cell Sci. , vol.115 , pp. 913-922
    • Riparbelli, M.G.1    Callaini, G.2    Glover, D.M.3    Avides Mdo, C.4


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