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Volumn 282, Issue 3, 2015, Pages 579-594

MicroRNA-486-5p, which is downregulated in hepatocellular carcinoma, suppresses tumor growth by targeting PIK3R1

Author keywords

hepatocellular carcinoma; metastasis; microRNA 486 5p; p85 ; phosphatidylinositol 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; MICRORNA; MICRORNA 486 5P; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B; PROTEIN PIK3R1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; MIRN486 MICRORNA, HUMAN; PIK3R1 PROTEIN, HUMAN;

EID: 84921693751     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13167     Document Type: Article
Times cited : (97)

References (42)
  • 1
    • 63049133092 scopus 로고    scopus 로고
    • Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
    • Altekruse SF, McGlynn KA, &, Reichman ME, (2009) Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 27, 1485-1491.
    • (2009) J Clin Oncol , vol.27 , pp. 1485-1491
    • Altekruse, S.F.1    McGlynn, K.A.2    Reichman, M.E.3
  • 3
    • 79951648906 scopus 로고    scopus 로고
    • Emerging roles of microRNA in the intracellular signaling networks of hepatocellular carcinoma
    • Law PT, &, Wong N, (2011) Emerging roles of microRNA in the intracellular signaling networks of hepatocellular carcinoma. J Gastroenterol Hepatol 26, 437-449.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 437-449
    • Law, P.T.1    Wong, N.2
  • 6
    • 84859497852 scopus 로고    scopus 로고
    • Risk factors, clinical features, and prognosis of the hepatocellular carcinoma with peritoneal metastasis
    • Kwak MS, Lee JH, Yoon JH, Yu SJ, Cho EJ, Jang ES, Kim YJ, &, Lee HS, (2012) Risk factors, clinical features, and prognosis of the hepatocellular carcinoma with peritoneal metastasis. Dig Dis Sci 57, 813-819.
    • (2012) Dig Dis Sci , vol.57 , pp. 813-819
    • Kwak, M.S.1    Lee, J.H.2    Yoon, J.H.3    Yu, S.J.4    Cho, E.J.5    Jang, E.S.6    Kim, Y.J.7    Lee, H.S.8
  • 7
    • 84863227127 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a tissue biomarker for detection of early hepatocellular carcinoma in patients with cirrhosis
    • Guo Y, Zhao J, Bi J, Wu Q, Wang X, &, Lai Q, (2012) Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a tissue biomarker for detection of early hepatocellular carcinoma in patients with cirrhosis. J Hematol Oncol 5, 37.
    • (2012) J Hematol Oncol , vol.5 , pp. 37
    • Guo, Y.1    Zhao, J.2    Bi, J.3    Wu, Q.4    Wang, X.5    Lai, Q.6
  • 8
    • 77953629046 scopus 로고    scopus 로고
    • Regulation of mRNA translation and stability by microRNAs
    • Fabian MR, Sonenberg N, &, Filipowicz W, (2010) Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 79, 351-379.
    • (2010) Annu Rev Biochem , vol.79 , pp. 351-379
    • Fabian, M.R.1    Sonenberg, N.2    Filipowicz, W.3
  • 9
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, &, Bartel DP, (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 10
    • 80055047968 scopus 로고    scopus 로고
    • MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression
    • Fang JH, Zhou HC, Zeng C, Yang J, Liu Y, Huang X, Zhang JP, Guan XY, &, Zhuang SM, (2011) MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology 54, 1729-1740.
    • (2011) Hepatology , vol.54 , pp. 1729-1740
    • Fang, J.H.1    Zhou, H.C.2    Zeng, C.3    Yang, J.4    Liu, Y.5    Huang, X.6    Zhang, J.P.7    Guan, X.Y.8    Zhuang, S.M.9
  • 12
    • 79751484450 scopus 로고    scopus 로고
    • Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma
    • Hou J, Lin L, Zhou W, Wang Z, Ding G, Dong Q, Qin L, Wu X, Zheng Y, Yang Y, et al,. (2011) Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell 19, 232-243.
    • (2011) Cancer Cell , vol.19 , pp. 232-243
    • Hou, J.1    Lin, L.2    Zhou, W.3    Wang, Z.4    Ding, G.5    Dong, Q.6    Qin, L.7    Wu, X.8    Zheng, Y.9    Yang, Y.10
  • 13
    • 78649561463 scopus 로고    scopus 로고
    • Hsa-let-7 g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A)
    • Lan FF, Wang H, Chen YC, Chan CY, Ng SS, Li K, Xie D, He ML, Lin MC, &, Kung HF, (2011) Hsa-let-7 g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A). Int J Cancer 128, 319-331.
    • (2011) Int J Cancer , vol.128 , pp. 319-331
    • Lan, F.F.1    Wang, H.2    Chen, Y.C.3    Chan, C.Y.4    Ng, S.S.5    Li, K.6    Xie, D.7    He, M.L.8    Lin, M.C.9    Kung, H.F.10
  • 14
    • 59149098054 scopus 로고    scopus 로고
    • MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity
    • Su H, Yang JR, Xu T, Huang J, Xu L, Yuan Y, &, Zhuang SM, (2009) MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res 69, 1135-1142.
    • (2009) Cancer Res , vol.69 , pp. 1135-1142
    • Su, H.1    Yang, J.R.2    Xu, T.3    Huang, J.4    Xu, L.5    Yuan, Y.6    Zhuang, S.M.7
  • 15
    • 77957982588 scopus 로고    scopus 로고
    • MicroRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity
    • Zhang J, Yang Y, Yang T, Liu Y, Li A, Fu S, Wu M, Pan Z, &, Zhou W, (2010) microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer 103, 1215-1220.
    • (2010) Br J Cancer , vol.103 , pp. 1215-1220
    • Zhang, J.1    Yang, Y.2    Yang, T.3    Liu, Y.4    Li, A.5    Fu, S.6    Wu, M.7    Pan, Z.8    Zhou, W.9
  • 16
    • 72849121740 scopus 로고    scopus 로고
    • A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans
    • Li H, Xie H, Liu W, Hu R, Huang B, Tan YF, Xu K, Sheng ZF, Zhou HD, Wu XP, et al,. (2009) A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest 119, 3666-3677.
    • (2009) J Clin Invest , vol.119 , pp. 3666-3677
    • Li, H.1    Xie, H.2    Liu, W.3    Hu, R.4    Huang, B.5    Tan, Y.F.6    Xu, K.7    Sheng, Z.F.8    Zhou, H.D.9    Wu, X.P.10
  • 17
    • 77957311397 scopus 로고    scopus 로고
    • The clinical potential of microRNAs
    • Budhu A, Ji J, &, Wang XW, (2010) The clinical potential of microRNAs. J Hematol Oncol 3, 37.
    • (2010) J Hematol Oncol , vol.3 , pp. 37
    • Budhu, A.1    Ji, J.2    Wang, X.W.3
  • 18
    • 78751513089 scopus 로고    scopus 로고
    • PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras-Raf-MAPK and PI3K-AKT-mTOR pathways
    • Gedaly RA, Angulo P, Hundley J, Daily MF, Chen C, Koch A, &, Evers BM, (2010) PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras-Raf-MAPK and PI3K-AKT-mTOR pathways. Anticancer Res 30, 4951-4958.
    • (2010) Anticancer Res , vol.30 , pp. 4951-4958
    • Gedaly, R.A.1    Angulo, P.2    Hundley, J.3    Daily, M.F.4    Chen, C.5    Koch, A.6    Evers, B.M.7
  • 20
    • 77956627711 scopus 로고    scopus 로고
    • The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    • Whittaker S, Marais R, &, Zhu AX, (2010) The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 29, 4989-5005.
    • (2010) Oncogene , vol.29 , pp. 4989-5005
    • Whittaker, S.1    Marais, R.2    Zhu, A.X.3
  • 21
    • 51849128358 scopus 로고    scopus 로고
    • Class i PI3K in oncogenic cellular transformation
    • Zhao L, &, Vogt PK, (2008) Class I PI3K in oncogenic cellular transformation. Oncogene 27, 5486-5496.
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 22
    • 84866393036 scopus 로고    scopus 로고
    • MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA
    • Lang Q, &, Ling C, (2012) MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA. Biochem Biophys Res Commun 426, 247-252.
    • (2012) Biochem Biophys Res Commun , vol.426 , pp. 247-252
    • Lang, Q.1    Ling, C.2
  • 24
    • 80054694898 scopus 로고    scopus 로고
    • MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma
    • Li D, Liu X, Lin L, Hou J, Li N, Wang C, Wang P, Zhang Q, Zhang P, Zhou W, et al,. (2011) MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. J Biol Chem 286, 36677-36685.
    • (2011) J Biol Chem , vol.286 , pp. 36677-36685
    • Li, D.1    Liu, X.2    Lin, L.3    Hou, J.4    Li, N.5    Wang, C.6    Wang, P.7    Zhang, Q.8    Zhang, P.9    Zhou, W.10
  • 29
    • 71049172899 scopus 로고    scopus 로고
    • Novel rank-based statistical methods reveal microRNAs with differential expression in multiple cancer types
    • Navon R, Wang H, Steinfeld I, Tsalenko A, Ben-Dor A, &, Yakhini Z, (2009) Novel rank-based statistical methods reveal microRNAs with differential expression in multiple cancer types. PLoS One 4, e8003.
    • (2009) PLoS One , vol.4 , pp. e8003
    • Navon, R.1    Wang, H.2    Steinfeld, I.3    Tsalenko, A.4    Ben-Dor, A.5    Yakhini, Z.6
  • 31
    • 84896702937 scopus 로고    scopus 로고
    • Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer
    • Wang J, Tian X, Han R, Zhang X, Wang X, Shen H, Xue L, Liu Y, Yan X, Shen J, et al,. (2014) Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer. Oncogene 33, 1181-1189.
    • (2014) Oncogene , vol.33 , pp. 1181-1189
    • Wang, J.1    Tian, X.2    Han, R.3    Zhang, X.4    Wang, X.5    Shen, H.6    Xue, L.7    Liu, Y.8    Yan, X.9    Shen, J.10
  • 33
    • 80054778946 scopus 로고    scopus 로고
    • High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability
    • Cheung LW, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Dyer MD, Zhang F, et al,. (2011) High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov 1, 170-185.
    • (2011) Cancer Discov , vol.1 , pp. 170-185
    • Cheung, L.W.1    Hennessy, B.T.2    Li, J.3    Yu, S.4    Myers, A.P.5    Djordjevic, B.6    Lu, Y.7    Stemke-Hale, K.8    Dyer, M.D.9    Zhang, F.10
  • 35
    • 77957258073 scopus 로고    scopus 로고
    • Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha
    • Sun M, Hillmann P, Hofmann BT, Hart JR, &, Vogt PK, (2010) Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha. Proc Natl Acad Sci USA 107, 15547-15552.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15547-15552
    • Sun, M.1    Hillmann, P.2    Hofmann, B.T.3    Hart, J.R.4    Vogt, P.K.5
  • 36
    • 79958820962 scopus 로고    scopus 로고
    • PIK3R1 (p85alpha) is somatically mutated at high frequency in primary endometrial cancer
    • Urick ME, Rudd ML, Godwin AK, Sgroi D, Merino M, &, Bell DW, (2011) PIK3R1 (p85alpha) is somatically mutated at high frequency in primary endometrial cancer. Cancer Res 71, 4061-4067.
    • (2011) Cancer Res , vol.71 , pp. 4061-4067
    • Urick, M.E.1    Rudd, M.L.2    Godwin, A.K.3    Sgroi, D.4    Merino, M.5    Bell, D.W.6
  • 37
    • 70449363850 scopus 로고    scopus 로고
    • Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells
    • Sun Y, Zhao S, Tian H, Xie X, Xiao F, Li K, &, Song Y, (2009) Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells. Oncol Rep 22, 1435-1442.
    • (2009) Oncol Rep , vol.22 , pp. 1435-1442
    • Sun, Y.1    Zhao, S.2    Tian, H.3    Xie, X.4    Xiao, F.5    Li, K.6    Song, Y.7
  • 38
    • 79955944293 scopus 로고    scopus 로고
    • Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase
    • Hong M, Wilkes MC, Penheiter SG, Gupta SK, Edens M, &, Leof EB, (2011) Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem 286, 17841-17850.
    • (2011) J Biol Chem , vol.286 , pp. 17841-17850
    • Hong, M.1    Wilkes, M.C.2    Penheiter, S.G.3    Gupta, S.K.4    Edens, M.5    Leof, E.B.6
  • 42
    • 68149165370 scopus 로고    scopus 로고
    • MicroRNA-146a feedback inhibits RIG-I-dependent Type i IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2
    • Hou J, Wang P, Lin L, Liu X, Ma F, An H, Wang Z, &, Cao X, (2009) MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol 183, 2150-2158.
    • (2009) J Immunol , vol.183 , pp. 2150-2158
    • Hou, J.1    Wang, P.2    Lin, L.3    Liu, X.4    Ma, F.5    An, H.6    Wang, Z.7    Cao, X.8


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