메뉴 건너뛰기




Volumn 8, Issue 6, 2013, Pages

Cdk4 and Nek2 Signal Binucleation and Centrosome Amplification in a Her2+ Breast Cancer Model

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN KINASE; PROTEIN KINASE NEK2; UNCLASSIFIED DRUG;

EID: 84878918789     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065971     Document Type: Article
Times cited : (33)

References (64)
  • 1
    • 0004289980 scopus 로고
    • (Jena: Fischer Verlag, 1914 (English translation by M. Boveri reprinted as The Origin of malignant tumors, The Williams and Wilkins Co., Baltimore)
    • Boveri T (1914) Zur Frage der Entstehung Maligner Tumoren (Jena: Fischer Verlag, 1914 (English translation by M. Boveri reprinted as The Origin of malignant tumors, The Williams and Wilkins Co., Baltimore), 1929.
    • (1914) Zur Frage der Entstehung Maligner Tumoren , pp. 1929
    • Boveri, T.1
  • 2
    • 0033304329 scopus 로고    scopus 로고
    • Control of centrosome reproduction: the right number at the right time
    • Sluder G, Hinchcliffe EH, (1999) Control of centrosome reproduction: the right number at the right time. Biol Cell 91: 413-427.
    • (1999) Biol Cell , vol.91 , pp. 413-427
    • Sluder, G.1    Hinchcliffe, E.H.2
  • 3
    • 0036752341 scopus 로고    scopus 로고
    • Duplicating dangerously: linking centrosome duplication and aneuploidy
    • Doxsey S, (2002) Duplicating dangerously: linking centrosome duplication and aneuploidy. Mol Cell 10: 439-440.
    • (2002) Mol Cell , vol.10 , pp. 439-440
    • Doxsey, S.1
  • 4
    • 0032170033 scopus 로고    scopus 로고
    • Centrosome defects and genetic instability in malignant tumors
    • Pihan GA, Purohit A, Wallace J, Knecht H, Woda B, et al. (1998) Centrosome defects and genetic instability in malignant tumors. Cancer Research 58: 3974-3985.
    • (1998) Cancer Research , vol.58 , pp. 3974-3985
    • Pihan, G.A.1    Purohit, A.2    Wallace, J.3    Knecht, H.4    Woda, B.5
  • 6
    • 0033580430 scopus 로고    scopus 로고
    • Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression
    • Carroll PE, Okuda M, Horn HF, Biddinger P, Stambrook PJ, et al. (1999) Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene 18: 1935-1944.
    • (1999) Oncogene , vol.18 , pp. 1935-1944
    • Carroll, P.E.1    Okuda, M.2    Horn, H.F.3    Biddinger, P.4    Stambrook, P.J.5
  • 7
    • 67649654451 scopus 로고    scopus 로고
    • Centrosome function in cancer: guilty or innocent?
    • Zyss D, Gergely F, (2009) Centrosome function in cancer: guilty or innocent? Trends Cell Biol 19: 334-346.
    • (2009) Trends Cell Biol , vol.19 , pp. 334-346
    • Zyss, D.1    Gergely, F.2
  • 8
    • 0032539868 scopus 로고    scopus 로고
    • Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity
    • Lingle WL, Lutz WH, Ingle JN, Maihle NJ, Salisbury JL, (1998) Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. Proc Natl Acad Sci U S A 95: 2950-2955.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2950-2955
    • Lingle, W.L.1    Lutz, W.H.2    Ingle, J.N.3    Maihle, N.J.4    Salisbury, J.L.5
  • 9
    • 40349089148 scopus 로고    scopus 로고
    • Analysis of the cellular centrosome in fine-needle aspirations of the breast
    • Guo HQ, Gao M, Ma J, Xiao T, Zhao LL, et al. (2007) Analysis of the cellular centrosome in fine-needle aspirations of the breast. Breast Cancer Res 9: R48.
    • (2007) Breast Cancer Res , vol.9
    • Guo, H.Q.1    Gao, M.2    Ma, J.3    Xiao, T.4    Zhao, L.L.5
  • 10
    • 0037444168 scopus 로고    scopus 로고
    • Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas
    • Pihan GA, Wallace J, Zhou Y, Doxsey SJ, (2003) Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas. Cancer Res 63: 1398-1404.
    • (2003) Cancer Res , vol.63 , pp. 1398-1404
    • Pihan, G.A.1    Wallace, J.2    Zhou, Y.3    Doxsey, S.J.4
  • 12
    • 44649117902 scopus 로고    scopus 로고
    • Centrosome amplification can initiate tumorigenesis in flies
    • Basto R, Brunk K, Vinadogrova T, Peel N, Franz A, et al. (2008) Centrosome amplification can initiate tumorigenesis in flies. Cell 133: 1032-1042.
    • (2008) Cell , vol.133 , pp. 1032-1042
    • Basto, R.1    Brunk, K.2    Vinadogrova, T.3    Peel, N.4    Franz, A.5
  • 13
    • 49649092093 scopus 로고    scopus 로고
    • Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability
    • Castellanos E, Dominguez P, Gonzalez C, (2008) Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr Biol 18: 1209-1214.
    • (2008) Curr Biol , vol.18 , pp. 1209-1214
    • Castellanos, E.1    Dominguez, P.2    Gonzalez, C.3
  • 14
    • 35948943082 scopus 로고    scopus 로고
    • Aneuploidy: instigator and inhibitor of tumorigenesis
    • Weaver BA, Cleveland DW, (2007) Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res 67: 10103-10105.
    • (2007) Cancer Res , vol.67 , pp. 10103-10105
    • Weaver, B.A.1    Cleveland, D.W.2
  • 15
    • 58249094849 scopus 로고    scopus 로고
    • Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis
    • Schliekelman M, Cowley DO, O'Quinn R, Oliver TG, Lu L, et al. (2009) Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis. Cancer Res 69: 45-54.
    • (2009) Cancer Res , vol.69 , pp. 45-54
    • Schliekelman, M.1    Cowley, D.O.2    O'Quinn, R.3    Oliver, T.G.4    Lu, L.5
  • 16
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • Ganem NJ, Godinho SA, Pellman D, (2009) A mechanism linking extra centrosomes to chromosomal instability. Nature 460: 278-282.
    • (2009) Nature , vol.460 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 17
    • 36448987217 scopus 로고    scopus 로고
    • Oncogenes and tumour suppressors take on centrosomes
    • Fukasawa K, (2007) Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 7: 911-924.
    • (2007) Nat Rev Cancer , vol.7 , pp. 911-924
    • Fukasawa, K.1
  • 18
    • 79961111636 scopus 로고    scopus 로고
    • Repeated cleavage failure does not establish centrosome amplification in untransformed human cells
    • Krzywicka-Racka A, Sluder G, (2011) Repeated cleavage failure does not establish centrosome amplification in untransformed human cells. J Cell Biol 194: 199-207.
    • (2011) J Cell Biol , vol.194 , pp. 199-207
    • Krzywicka-Racka, A.1    Sluder, G.2
  • 19
    • 27144507868 scopus 로고    scopus 로고
    • Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
    • Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, et al. (2005) Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437: 1043-1047.
    • (2005) Nature , vol.437 , pp. 1043-1047
    • Fujiwara, T.1    Bandi, M.2    Nitta, M.3    Ivanova, E.V.4    Bronson, R.T.5
  • 20
    • 27144540976 scopus 로고    scopus 로고
    • Centrosome amplification, chromosome instability and cancer development
    • Fukasawa K, (2005) Centrosome amplification, chromosome instability and cancer development. Cancer Lett 230: 6-19.
    • (2005) Cancer Lett , vol.230 , pp. 6-19
    • Fukasawa, K.1
  • 21
    • 79959719913 scopus 로고    scopus 로고
    • Established and novel Cdk/cyclin complexes regulating the cell cycle and development
    • Gopinathan L, Ratnacaram CK, Kaldis P, (2011) Established and novel Cdk/cyclin complexes regulating the cell cycle and development. Results Probl Cell Differ 53: 365-389.
    • (2011) Results Probl Cell Differ , vol.53 , pp. 365-389
    • Gopinathan, L.1    Ratnacaram, C.K.2    Kaldis, P.3
  • 22
    • 69249230769 scopus 로고    scopus 로고
    • Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
    • Satyanarayana A, Kaldis P, (2009) Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene 28: 2925-2939.
    • (2009) Oncogene , vol.28 , pp. 2925-2939
    • Satyanarayana, A.1    Kaldis, P.2
  • 23
    • 0024425887 scopus 로고
    • Checkpoints: controls that ensure the order of cell cycle events
    • Hartwell LH, Weinert TA, (1989) Checkpoints: controls that ensure the order of cell cycle events. Science 246: 629-634.
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 24
    • 0037048280 scopus 로고    scopus 로고
    • Centrosome amplification and the development of cancer
    • D'Assoro AB, Lingle WL, Salisbury JL, (2002) Centrosome amplification and the development of cancer. Oncogene 21: 6146-6153.
    • (2002) Oncogene , vol.21 , pp. 6146-6153
    • D'Assoro, A.B.1    Lingle, W.L.2    Salisbury, J.L.3
  • 25
    • 79251583730 scopus 로고    scopus 로고
    • The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
    • Harrison MK, Adon AM, Saavedra HI, (2011) The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification. Cell Div 6: 2.
    • (2011) Cell Div , vol.6 , pp. 2
    • Harrison, M.K.1    Adon, A.M.2    Saavedra, H.I.3
  • 26
    • 75149125333 scopus 로고    scopus 로고
    • Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells
    • Adon AM, Zeng X, Harrison MK, Sannem S, Kiyokawa H, et al. (2010) Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells. Mol Cell Biol 30: 694-710.
    • (2010) Mol Cell Biol , vol.30 , pp. 694-710
    • Adon, A.M.1    Zeng, X.2    Harrison, M.K.3    Sannem, S.4    Kiyokawa, H.5
  • 27
    • 12844288920 scopus 로고    scopus 로고
    • Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy
    • Nelsen CJ, Kuriyama R, Hirsch B, Negron VC, Lingle WL, et al. (2005) Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy. J Biol Chem 280: 768-776.
    • (2005) J Biol Chem , vol.280 , pp. 768-776
    • Nelsen, C.J.1    Kuriyama, R.2    Hirsch, B.3    Negron, V.C.4    Lingle, W.L.5
  • 28
    • 77956627154 scopus 로고    scopus 로고
    • The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2
    • Zeng X, Shaikh FY, Harrison MK, Adon AM, Trimboli AJ, et al. (2010) The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. Oncogene 29: 5103-5112.
    • (2010) Oncogene , vol.29 , pp. 5103-5112
    • Zeng, X.1    Shaikh, F.Y.2    Harrison, M.K.3    Adon, A.M.4    Trimboli, A.J.5
  • 29
    • 0034638925 scopus 로고    scopus 로고
    • Molecular mechanisms underlying ErbB2/HER2 action in breast cancer
    • Harari D, Yarden Y, (2000) Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene 19: 6102-6114.
    • (2000) Oncogene , vol.19 , pp. 6102-6114
    • Harari, D.1    Yarden, Y.2
  • 32
    • 0034730321 scopus 로고    scopus 로고
    • Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication
    • Okuda M, Horn HF, Tarapore P, Tokuyama Y, Smulian AG, et al. (2000) Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103: 127-140.
    • (2000) Cell , vol.103 , pp. 127-140
    • Okuda, M.1    Horn, H.F.2    Tarapore, P.3    Tokuyama, Y.4    Smulian, A.G.5
  • 34
    • 0033594469 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells
    • Matsumoto Y, Hayashi K, Nishida E, (1999) Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Current Biology 9: 429-432.
    • (1999) Current Biology , vol.9 , pp. 429-432
    • Matsumoto, Y.1    Hayashi, K.2    Nishida, E.3
  • 35
    • 0033525007 scopus 로고    scopus 로고
    • Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts
    • Hinchcliffe EH, Li C, Thompson EA, Maller JL, Sluder G, (1999) Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science 283: 851-854.
    • (1999) Science , vol.283 , pp. 851-854
    • Hinchcliffe, E.H.1    Li, C.2    Thompson, E.A.3    Maller, J.L.4    Sluder, G.5
  • 36
    • 2942619993 scopus 로고    scopus 로고
    • Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpoint
    • D'Assoro AB, Busby R, Suino K, Delva E, Almodovar-Mercado GJ, et al. (2004) Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpoint. Oncogene 23: 4068-4075.
    • (2004) Oncogene , vol.23 , pp. 4068-4075
    • D'Assoro, A.B.1    Busby, R.2    Suino, K.3    Delva, E.4    Almodovar-Mercado, G.J.5
  • 37
    • 51649122420 scopus 로고    scopus 로고
    • Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells
    • Hanashiro K, Kanai M, Geng Y, Sicinski P, Fukasawa K (2008) Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells. Oncogene.
    • (2008) Oncogene
    • Hanashiro, K.1    Kanai, M.2    Geng, Y.3    Sicinski, P.4    Fukasawa, K.5
  • 38
    • 0034972059 scopus 로고    scopus 로고
    • Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway
    • Tarapore P, Horn HF, Tokuyama Y, Fukasawa K, (2001) Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene 20: 3173-3184.
    • (2001) Oncogene , vol.20 , pp. 3173-3184
    • Tarapore, P.1    Horn, H.F.2    Tokuyama, Y.3    Fukasawa, K.4
  • 39
    • 33646710394 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication
    • Duensing A, Liu Y, Tseng M, Malumbres M, Barbacid M, et al. (2006) Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene 25: 2943-2949.
    • (2006) Oncogene , vol.25 , pp. 2943-2949
    • Duensing, A.1    Liu, Y.2    Tseng, M.3    Malumbres, M.4    Barbacid, M.5
  • 40
    • 79955871521 scopus 로고    scopus 로고
    • Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis
    • Ray D, Terao Y, Christov K, Kaldis P, Kiyokawa H, (2011) Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis. Neoplasia 13: 439-444.
    • (2011) Neoplasia , vol.13 , pp. 439-444
    • Ray, D.1    Terao, Y.2    Christov, K.3    Kaldis, P.4    Kiyokawa, H.5
  • 41
    • 28544433465 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis
    • Reddy HK, Mettus RV, Rane SG, Grana X, Litvin J, et al. (2005) Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Res 65: 10174-10178.
    • (2005) Cancer Res , vol.65 , pp. 10174-10178
    • Reddy, H.K.1    Mettus, R.V.2    Rane, S.G.3    Grana, X.4    Litvin, J.5
  • 42
    • 0033961809 scopus 로고    scopus 로고
    • Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
    • Lee RJ, Albanese C, Fu M, D'Amico M, Lin B, et al. (2000) Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol 20: 672-683.
    • (2000) Mol Cell Biol , vol.20 , pp. 672-683
    • Lee, R.J.1    Albanese, C.2    Fu, M.3    D'Amico, M.4    Lin, B.5
  • 43
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • Yu Q, Geng Y, Sicinski P, (2001) Specific protection against breast cancers by cyclin D1 ablation. Nature 411: 1017-1021.
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1    Geng, Y.2    Sicinski, P.3
  • 45
    • 0142059072 scopus 로고    scopus 로고
    • Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression
    • Schneeweiss A, Sinn HP, Ehemann V, Khbeis T, Neben K, et al. (2003) Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression. Int J Cancer 107: 346-352.
    • (2003) Int J Cancer , vol.107 , pp. 346-352
    • Schneeweiss, A.1    Sinn, H.P.2    Ehemann, V.3    Khbeis, T.4    Neben, K.5
  • 46
    • 85047696060 scopus 로고    scopus 로고
    • Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu
    • Montagna C, Andrechek ER, Padilla-Nash H, Muller WJ, Ried T, (2002) Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu. Oncogene 21: 890-898.
    • (2002) Oncogene , vol.21 , pp. 890-898
    • Montagna, C.1    Andrechek, E.R.2    Padilla-Nash, H.3    Muller, W.J.4    Ried, T.5
  • 47
    • 9144231853 scopus 로고    scopus 로고
    • Centrosome amplification and the origin of chromosomal instability in breast cancer
    • Salisbury JL, D'Assoro AB, Lingle WL, (2004) Centrosome amplification and the origin of chromosomal instability in breast cancer. J Mammary Gland Biol Neoplasia 9: 275-283.
    • (2004) J Mammary Gland Biol Neoplasia , vol.9 , pp. 275-283
    • Salisbury, J.L.1    D'Assoro, A.B.2    Lingle, W.L.3
  • 48
    • 80054712443 scopus 로고    scopus 로고
    • Chromosome aberrations associated with centrosome defects: a study of comparative genomic hybridization in breast cancer
    • Gao Y, Niu Y, Wang X, Wei L, Zhang R, et al. (2011) Chromosome aberrations associated with centrosome defects: a study of comparative genomic hybridization in breast cancer. Hum Pathol 42: 1693-1701.
    • (2011) Hum Pathol , vol.42 , pp. 1693-1701
    • Gao, Y.1    Niu, Y.2    Wang, X.3    Wei, L.4    Zhang, R.5
  • 49
    • 35649022639 scopus 로고    scopus 로고
    • Paclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype
    • Bouchet BP, Bertholon J, Falette N, Audoynaud C, Lamblot C, et al. (2007) Paclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype. Br J Cancer 97: 1218-1224.
    • (2007) Br J Cancer , vol.97 , pp. 1218-1224
    • Bouchet, B.P.1    Bertholon, J.2    Falette, N.3    Audoynaud, C.4    Lamblot, C.5
  • 51
    • 77956627154 scopus 로고    scopus 로고
    • The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2
    • Zeng X, Shaikh FY, Harrison MK, Adon AM, Trimboli AJ, et al. (2010) The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. Oncogene.
    • (2010) Oncogene
    • Zeng, X.1    Shaikh, F.Y.2    Harrison, M.K.3    Adon, A.M.4    Trimboli, A.J.5
  • 53
    • 0032518798 scopus 로고    scopus 로고
    • A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators
    • Fry AM, Meraldi P, Nigg EA, (1998) A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. Embo J 17: 470-481.
    • (1998) Embo J , vol.17 , pp. 470-481
    • Fry, A.M.1    Meraldi, P.2    Nigg, E.A.3
  • 54
    • 72449178334 scopus 로고    scopus 로고
    • Division and apoptosis of E2f-deficient retinal progenitors
    • Chen D, Pacal M, Wenzel P, Knoepfler PS, Leone G, et al. (2009) Division and apoptosis of E2f-deficient retinal progenitors. Nature 462: 925-929.
    • (2009) Nature , vol.462 , pp. 925-929
    • Chen, D.1    Pacal, M.2    Wenzel, P.3    Knoepfler, P.S.4    Leone, G.5
  • 55
    • 72449177341 scopus 로고    scopus 로고
    • E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells
    • Chong JL, Wenzel PL, Saenz-Robles MT, Nair V, Ferrey A, et al. (2009) E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 462: 930-934.
    • (2009) Nature , vol.462 , pp. 930-934
    • Chong, J.L.1    Wenzel, P.L.2    Saenz-Robles, M.T.3    Nair, V.4    Ferrey, A.5
  • 56
    • 5644280152 scopus 로고    scopus 로고
    • The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer
    • Hayward DG, Clarke RB, Faragher AJ, Pillai MR, Hagan IM, et al. (2004) The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Cancer Res 64: 7370-7376.
    • (2004) Cancer Res , vol.64 , pp. 7370-7376
    • Hayward, D.G.1    Clarke, R.B.2    Faragher, A.J.3    Pillai, M.R.4    Hagan, I.M.5
  • 57
    • 0035877719 scopus 로고    scopus 로고
    • Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication
    • Tokuyama Y, Horn HF, Kawamura K, Tarapore P, Fukasawa K, (2001) Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. Journal of Biological Chemistry 276: 21529-21537.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 21529-21537
    • Tokuyama, Y.1    Horn, H.F.2    Kawamura, K.3    Tarapore, P.4    Fukasawa, K.5
  • 59
    • 0034632702 scopus 로고    scopus 로고
    • The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway
    • Saavedra HI, Knauf JA, Shirokawa JM, Wang J, Ouyang B, et al. (2000) The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway. Oncogene 19: 3948-3954.
    • (2000) Oncogene , vol.19 , pp. 3948-3954
    • Saavedra, H.I.1    Knauf, J.A.2    Shirokawa, J.M.3    Wang, J.4    Ouyang, B.5
  • 61
    • 51649092237 scopus 로고    scopus 로고
    • p53, cyclin-dependent kinase and abnormal amplification of centrosomes
    • Fukasawa K (2008) p53, cyclin-dependent kinase and abnormal amplification of centrosomes. Biochim Biophys Acta.
    • (2008) Biochim Biophys Acta
    • Fukasawa, K.1
  • 62
    • 33646839443 scopus 로고    scopus 로고
    • Nek2 kinase in chromosome instability and cancer
    • Hayward DG, Fry AM, (2006) Nek2 kinase in chromosome instability and cancer. Cancer Lett 237: 155-166.
    • (2006) Cancer Lett , vol.237 , pp. 155-166
    • Hayward, D.G.1    Fry, A.M.2
  • 63
    • 9644273824 scopus 로고    scopus 로고
    • Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure
    • Prigent C, Glover DM, Giet R, (2005) Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure. Exp Cell Res 303: 1-13.
    • (2005) Exp Cell Res , vol.303 , pp. 1-13
    • Prigent, C.1    Glover, D.M.2    Giet, R.3
  • 64
    • 58149284063 scopus 로고    scopus 로고
    • Nek2 as a novel molecular target for the treatment of breast carcinoma
    • Tsunoda N, Kokuryo T, Oda K, Senga T, Yokoyama Y, et al. (2009) Nek2 as a novel molecular target for the treatment of breast carcinoma. Cancer Sci 100: 111-116.
    • (2009) Cancer Sci , vol.100 , pp. 111-116
    • Tsunoda, N.1    Kokuryo, T.2    Oda, K.3    Senga, T.4    Yokoyama, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.