Alda-1 protects against acrolein-induced acute lung injury and endothelial barrier dysfunction

American Journal of Respiratory Cell and Molecular Biology

Volumn 57, Issue 6, 2017, Pages 662-673

  Lu, Qing ^a   Mundy, Miles ^a   Chambers, Eboni ^a   Lange, Thilo ^a   Newton, Julie ^a   Borgas, Diana ^a   Yao, Hongwei ^a   Choudhary, Gaurav ^a   Basak, Rajshekhar ^a   Oldham, Mahogany ^a   Rounds, Sharon ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Acrolein; Acute lung injury; Endothelial cells; Mitochondrial aldehyde dehydrogenase 2; Mitochondrial respiration

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE DERIVATIVE; 5 AMINOIMIDAZOLE 4 CARBOXAMIDE 1 BETA 4 RIBOFURANOSIDE; ACETYLCYSTEINE; ACROLEIN; ADENYLATE KINASE; ALDA 1; APOCYNIN; ENZYME ACTIVATOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; BENZAMIDE DERIVATIVE; N-(1,3-BENZODIOXOL-5-YLMETHYL)-2,6-DICHLOROBENZAMIDE;

ADHERENS JUNCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DETOXIFICATION; ENDOTHELIAL DYSFUNCTION; ENZYME INHIBITION; FOCAL ADHESION; IN VITRO STUDY; IN VIVO STUDY; LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY; LUNG; LUNG EDEMA; LUNG PARENCHYMA; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN CONTENT; ACUTE LUNG INJURY; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYME ACTIVATION; MALE; METABOLISM; MITOCHONDRION; OXYGEN CONSUMPTION; PATHOLOGY; VASCULAR ENDOTHELIUM;

ACETYLCYSTEINE; ACROLEIN; ACUTE LUNG INJURY; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BENZAMIDES; BENZODIOXOLES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; MALE; MICE; MITOCHONDRIA; OXYGEN CONSUMPTION;

EID: 85037174044     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2016-0342OC     Document Type: Article

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